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Serum Ferritin

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5821. The effect of interferon and desferrioxamine on serum ferritin and hepatic iron concentrations in chronic hepatitis B. (Abstract)

The effect of interferon and desferrioxamine on serum ferritin and hepatic iron concentrations in chronic hepatitis B. Recent reports indicate that an individual's iron status might affect the response rate achieved with Interferon therapy for the treatment of chronic viral hepatitis.Forty individuals, 29 men and 11 women, with chronic viral hepatitis B, who had elevated serum ferritin levels, were randomized to receive either Interferon (IFN) 5 MU TIW SQ for 6 months alone (n=21) or Interferon (...) in combination with repetitive cycles of desferrioxamine infused at a dose of 80 mg/kg per cycle (n=19) over 3 consecutive days in an effort to reduce their metabolically active iron pool during the course of IFN treatment. These cycles were continued until a serum ferritin level of less than 250 ng/ml (normal values <220 ng/ml) was achieved. Additionally, all desferrioxamine treated subjects were placed on a low iron containing diet. An interferon response was defined as normalization of the serum ALT

1999 Hepato-gastroenterology Controlled trial quality: uncertain

5822. The effect of iron treatment on serum ferritin concentrations and bone marrow stainable iron in iron deficient out-patients with gastritis, gastric ulcer and duodenal ulcer. (Abstract)

The effect of iron treatment on serum ferritin concentrations and bone marrow stainable iron in iron deficient out-patients with gastritis, gastric ulcer and duodenal ulcer. Serum ferritin concentrations and bone marrow stainable iron were determined in 122 adult out-patients (seventy males) with gastritis, gastric ulcer and duodenal ulcer. Half of the forty-four patients with iron deficiency (serum ferritin level below 20 micrograms/l) received peroral iron therapy (200 mg Fe++ daily). In most (...) of the treated patients serum ferritin levels increased and the amount of bone marrow stainable iron in half of them also increased. Measurement of body iron stores by serum ferritin determinations and restoration of low body iron stores in these patients is of practical importance.

1984 The Journal of international medical research Controlled trial quality: uncertain

5823. Effects of low-dose iron supplementation in women with low serum ferritin concentration. (Abstract)

group (27 mg iron x day-1, n = 19). The supplement consisted of 11% heme and 89% inorganic iron. In FE-27, serum ferritin increased from (mean, 95% confidence interval) 11.8 (9.7; 14.4) to 25.3 (18.6; 34.4) micrograms x l-1 in 1 month, and remained stable after that (ANOVA: group effect, P = 0.0003). In both FE-9 and FE-27, blood haemoglobin levels increased from 136 (132; 140) to 142 (139; 145) g x l-1 in 1 month, remaining constant after that (group effect, P = 0.001). Hence, the 27 mg daily dose (...) Effects of low-dose iron supplementation in women with low serum ferritin concentration. We studied effects of dose and treatment duration during low-dose iron supplementation in premenopausal, non-pregnant women, with initial serum ferritin and haemoglobin concentrations < 20 micrograms x l-1 and > or = 120 g x l-1, respectively. The study was randomized, double-blind and placebo-controlled. Three groups completed a 6-month study: placebo (n = 27), FE-9 (9 mg iron x day-1, n = 18) and FE-27

1994 European journal of clinical nutrition Controlled trial quality: predicted high

5824. Serum ferritin and heart disease: the effect of moderate exercise on stored iron levels in postmenopausal women. (Abstract)

Serum ferritin and heart disease: the effect of moderate exercise on stored iron levels in postmenopausal women. To determine the effect of a moderate exercise regimen on stored iron as measured by serum ferritin in previously sedentary postmenopausal women.Randomized assignment to one of three groups: a five day/week walking group (five-day group, n = 27); a three day/week walking group (three-day group, n = 27) or a sedentary group (control group, n = 25).Community-based intervention.Women (...) are reported for 56 subjects (five-day group, n = 17; three-day group, n = 19; control group, n = 20) who completed the study. Their mean age was 61.3 +/- 5.8 years.The five-day group and the three-day group walked an average of 279 +/- 20 and 171 +/- 7 mins/week, respectively. Participants were counselled not to change their dietary intake.Following 24 weeks of walking, mean serum ferritin decreased significantly in the five-day group (P < 0.03), but not in the three-day group (P < 0.09) compared

1996 The Canadian journal of cardiology Controlled trial quality: uncertain

5825. Iron status in young Danes. Evaluation by serum ferritin and haemoglobin in a population survey of 634 individuals aged 14-23 yr. (Abstract)

Iron status in young Danes. Evaluation by serum ferritin and haemoglobin in a population survey of 634 individuals aged 14-23 yr. Iron status was assessed by serum ferritin and haemoglobin in a population survey comprising 634 randomly selected urban Danes (312 males, 322 females) 14-23 yr old. At all ages, males had significantly higher serum ferritin and haemoglobin values than females. Males: median serum ferritin displayed a steady increase with age from 33 to 109 micrograms/l (rs = 0.53, p (...) < 0.0001). The prevalence of absent mobilizable body iron stores (serum ferritin < 13 micrograms/l) was 3.5% at 16-17 yr of age, gradually declining to 0% at 22-23 yr. None of the males had iron deficiency anaemia (serum ferritin < 13 micrograms/l and haemoglobin < 129 g/l). Females: median ferritin values displayed a slight increase with age from 28 to 39 micrograms/l (rs = 0.19, p < 0.001). The prevalence of absent iron stores was 12.5% at 16-17 yr of age, declining to 6.6% at 22-23 yr

1997 European journal of haematology

5826. Serum ferritin concentration and recurrence of colorectal adenoma. (Abstract)

Serum ferritin concentration and recurrence of colorectal adenoma. Both body iron stores and dietary iron intake have been reported to increase risk of colorectal neoplasms. We assessed whether serum ferritin concentration was associated with recurrence of colorectal adenomas among 733 individuals with baseline determinations of ferritin as part of a multicenter clinical trial of antioxidant supplements for adenoma prevention. All study participants had at least one adenoma removed within 3 (...) months before enrollment, and 269 of them developed one or more adenomas between follow-up colonoscopies conducted 1 and 4 years after enrollment. Baseline serum ferritin concentrations were analyzed both as a log-transformed continuous variable and as a categorical variable, defined as whether iron stores were nonreplete and low (ferritin < or =30 microg/liter), nonreplete and borderline (31-70 microg/liter), replete and adequate (71-160 microg/liter), or replete and high (>160 microg/liter

2000 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology Controlled trial quality: uncertain

5827. Impact of anaemia prophylaxis in pregnancy on maternal haemoglobin, serum ferritin & birth weight. (Abstract)

Impact of anaemia prophylaxis in pregnancy on maternal haemoglobin, serum ferritin & birth weight. A total of 418 pregnant women at 16-24 wk of gestation, from six subcentres of a rural block of Varanasi district were selected. Pregnant women (137 of 215) from 3 subcentres received the supplementation of 60 mg elemental iron as ferrous sulphate combined with 500 micrograms folic acid, daily for 100 days (study group) and 123 (of 203) pregnant women from the other 3 subcentres without (...) supplementation (control group) could be evaluated for their pregnancy outcome. The haemoglobin and serum ferritin levels increased significantly in the study group. In the latter, the mean birth weight was 2.88 +/- 0.41 kg with low birth weight incidence of 20.4 per cent as compared to the control figures of 2.59 +/- 0.34 kg and 37.9 per cent respectively. The incidence of low birth weight was further reduced to 12.1 per cent if the supplementation could be started by 16-19 wk of gestation.

1991 The Indian journal of medical research Controlled trial quality: uncertain

5828. Effect of laparoscopic sterilization and insertion of Multiload Cu 250 and Progestasert IUDs on serum ferritin levels. (Abstract)

Effect of laparoscopic sterilization and insertion of Multiload Cu 250 and Progestasert IUDs on serum ferritin levels. Blood haemoglobin and serum ferritin levels were measured at the initial visit and 12 months following sterilization and IUD insertion. Ferritin levels were unaltered in Progestasert users after 12 months but haemoglobin values increased though not significantly. Ferritin levels fell in Multiload Cu 250 users and in sterilized women; haemoglobin levels were also observed (...) acceptability. Menstrual blood loss studies may help explain why anaemia develops after sterilization.

1983 Contraception Controlled trial quality: uncertain

5829. Effect of wine ethanol on serum iron and ferritin levels in patients with coronary heart disease. (Abstract)

ferritin, iron and gamma glutamyl transferase (GGT) in patients enrolled in the Lyon Diet Heart Study, a secondary prevention trial designed to test whether a Mediterranean-type diet may protect against CHD. The intake of wine ethanol was evaluated in the 24 hours preceding blood sampling, and expressed as a percentage of the total daily energy intake. Data were obtained from 437 consecutive patients. There was a positive relationship (Spearman statistics) between wine ethanol and the serum levels (...) Effect of wine ethanol on serum iron and ferritin levels in patients with coronary heart disease. The association between high body iron stores and coronary heart disease (CHD) is a subject of intense debate whereas wine consumption is known to be associated with a low CHD rate. It has been suggested that the inhibition of iron absorption is one of the possible mechanisms of the CHD-protective effects of drinking.We analysed the interrelationships of wine ethanol intake and fasting serum

2001 Nutrition, metabolism, and cardiovascular diseases : NMCD Controlled trial quality: uncertain

5830. Selective iron supplementation based on serum ferritin values early in pregnancy: are the Norwegian recommendations satisfactory? (Abstract)

Selective iron supplementation based on serum ferritin values early in pregnancy: are the Norwegian recommendations satisfactory? The aims of the present study were to evaluate the recommendations by comparing compliance and adequacy of iron status at 6 weeks postpartum between one group given advice only and one group given advice plus iron supplement. In the latter group the efficacies of two iron preparations of different strengths and types were compared.Ninety-three women had been given (...) was measured in all the women at 6 weeks postpartum.At 6 weeks postpartum median s-ferritin was 28 and 34 microg/L in Groups I and II, respectively, and a significantly higher mean s-ferritin (46.5 vs. 37.3 microg/L; p < 0.05) was found in women taking the highest dose. There were no correlations between s-ferritin in early pregnancy and at 6 weeks postpartum. Peripartum blood loss was the main indicator for iron status at 6 weeks postpartum.Iron supplementation based on iron status early in pregnancy

2003 Acta Obstetricia et Gynecologica Scandinavica Controlled trial quality: uncertain

5831. Anthelmintic treatment improves the hemoglobin and serum ferritin concentrations of Tanzanian schoolchildren. (Abstract)

Anthelmintic treatment improves the hemoglobin and serum ferritin concentrations of Tanzanian schoolchildren. To investigate the relationships between helminth infections and iron status among school-aged children, 1,115 Tanzanian children in grades 2 through 5 were randomly assigned to treatment or control groups. The children in the treatment group were screened for infection with Schistosoma haematobium and hookworm at baseline, 3 months, and 15 months; infected children were given (...) and schistosomiasis. The ferritin concentration also improved in children treated for schistosomiasis (p = .001) or hookworm (p = .019). Second, a longitudinal analysis of the data from the children in the control group showed that hookworm and schistosomiasis loads were negatively associated with hemoglobin and ferritin concentrations. Moreover, ferritin concentrations increased as C-reactive protein levels increased. Overall, the results showed that anthelmintic treatment is a useful tool for reducing anemia

2003 Food and nutrition bulletin Controlled trial quality: uncertain

5832. Serum ferritin concentration is associated with plasma levels of cholesterol oxidation products in man. (Abstract)

Serum ferritin concentration is associated with plasma levels of cholesterol oxidation products in man. Cholesterol oxidation products, oxysterols, are thought to play a part in the initiation and development of human atherosclerotic lesions. Excessive body iron has been suggested to promote atherosclerosis and coronary heart disease through its pro-oxidative properties. In the present study, the associations between serum ferritin and plasma oxysterol concentrations were examined in 669 (...) eastern Finnish men. Serum ferritin concentration had statistically significant (p <.05) direct correlations with most of the measured oxysterols. In multivariate adjusted regression models, serum ferritin concentration predicted significantly the levels of 27-hydroxycholesterol (beta = 0.13, p <.001), 7alpha-hydroxycholesterol (beta = 0.11, p =.005), 25-hydroxycholesterol (beta = 0.10, p =.007), 7-ketocholesterol (beta = 0.10, p =.009), and 7beta-hydroxycholesterol (beta = 0.10, p =.02

2003 Free radical biology & medicine Controlled trial quality: uncertain

5833. Serum ferritin levels after multivitamin iron ingestion during teenage pregnancy. (Abstract)

ferritin levels. Each woman was randomly tested following the ingestion of one of three different tablets, both in a fed and a fasting state. Blood samples were obtained for ferritin measurement immediately prior to ingestion of the prenatal tablet, with or without a standard meal, and at 1, 3, 6, and 8 hours postabsorption. The group mean serum ferritin levels increased dramatically during the fasting state following ingestion of the Stuart Prenatal tablet and decreased when the Stuartnatal 1 + 1 (...) Serum ferritin levels after multivitamin iron ingestion during teenage pregnancy. The postabsorptive serum ferritin levels following normal dosages of prenatal multivitamin/multimineral supplements were studied in 17 pregnant teenagers, whose fetuses were between 16 and 20 weeks gestational age. The purpose of the study was to determine the effect of a single oral dose of differing prenatal multivitamin/multimineral tablets containing 60 or 65 mg of elemental iron on the postabsorptive serum

1989 Clinical therapeutics

5834. Evaluation of serum ferritin as a marker for adult Still's disease activity. Full Text available with Trip Pro

Evaluation of serum ferritin as a marker for adult Still's disease activity. Extremely high serum ferritin values (greater than 10,000 micrograms/l) were detected in two patients with adult Still's disease. The ferritin concentrations decreased to normal after adequate treatment. During a one year follow up ferritin concentration was helpful in monitoring disease activity and guiding decisions about treatment. Raised concentrations of soluble interleukin 2 receptors (sCD25) were also found (...) . Detection of ferritin values above 3000 micrograms/l should lead to the consideration of Still's disease when there is an acute febrile illness without evidence for bacterial or viral infections, serum ferritin being suitable for monitoring treatment.

1992 Annals of the Rheumatic Diseases

5835. Logarithmic quantitation model using serum ferritin to estimate iron overload in secondary haemochromatosis. Full Text available with Trip Pro

Logarithmic quantitation model using serum ferritin to estimate iron overload in secondary haemochromatosis. Nineteen children and adolescents receiving repeated transfusions and subcutaneous desferrioxamine treatment were investigated in an attempt to quantitate iron overload non-invasively. Before patients were started on desferrioxamine individual relationships were correlated for 12 to 36 months between transfused iron, absorbed iron estimated gastrointestinally, and increasing serum (...) ferritin concentrations. Patients with inflammation, increased liver enzymes, or haemolysis were excluded from analysis. The relationship between the variables could be described by a logarithmic regression curve (y = transfused iron [plus eventually gastrointestinally absorbed iron] = iron overload = a+b log [x = serum ferritin]) for each individual patient. All patients showed close correlation (R2) between x and y (median R2 of 0.909, 0.98, and 0.92 in thalassaemia, aplastic anaemia, and sickle cell

1996 Archives of Disease in Childhood

5836. Serum ferritin, liver iron stores, and liver histology in children with thalassaemia. Full Text available with Trip Pro

Serum ferritin, liver iron stores, and liver histology in children with thalassaemia. Serum ferritin, liver iron stores, and liver histology were studied in 38 children with thalassaemia major who were being treated by regular blood transfusions. There was no correlation between serum ferritin levels and either the number of transfusions or the amount of iron deposited in the liver. However, for a given level of iron stores, ferritin levels were higher in patients with chronic hepatitis (...) (including chronic aggressive and chronic persistent forms) than in those with hepatic siderosis only. We conclude that serum ferritin reflects tissue iron deposits in regularly transfused thalassaemic patients, only in the absence of hepatitis.

1980 Archives of Disease in Childhood

5837. Binding of serum ferritin to concanavalin A in patients with iron overload and with chronic liver disease. Full Text available with Trip Pro

related than either the non-binding or the concanavalin A binding ferritin, to the liver iron concentration in all patients with iron overload, and with the units of blood transfused in non-chelated thalassaemic patients. The total serum ferritin showed a significant correlation with serum aminotransferase for the group of 84 patients. In the thalassaemic patients the ferritin binding to concanavalin A also correlated with aminotransferase. However, in the other groups it was the ferritin not binding (...) Binding of serum ferritin to concanavalin A in patients with iron overload and with chronic liver disease. Total serum ferritin and the proportion of serum ferritin binding to concanavalin A (glycosylated ferritin) was measured in 18 healthy volunteers and in 84 patients, eight with primary haemochromatosis, 43 with beta-thalassaemia major and secondary iron overload and 33 with chronic liver diseases without iron overload. The total serum ferritin was either equally or even more closely

1982 Journal of Clinical Pathology

5838. Effect of ascorbic acid deficiency on serum ferritin concentration in patients with beta-thalassaemia major and iron overload. Full Text available with Trip Pro

Effect of ascorbic acid deficiency on serum ferritin concentration in patients with beta-thalassaemia major and iron overload. The incidence of ascorbic acid (AA) deficiency and its effect on serum ferritin concentration relative to body iron stores was studied in 61 unchelated patients with beta-thalassaemia major. Thirty-nine (64%) of patients had subnormal leucocyte ascorbate concentrations without clinical evidence of scurvy. The lowest leucocyte ascorbate concentrations tended to occur (...) in the most transfused patients. No correlation was found between the units transfused and serum ferritin concentration in the AA-deficient patients but a close correlation (r = +0.82; p less than 0.005) existed for the AA-replete group. Similarly a close correlation (r = +0.77; p less than 0.005) was obtained between liver iron concentration and serum ferritin in AA-replete patients but only a weak correlation (r = +0.385; p less than 0.025) existed for the AA-deficient group. When AA-deficient patients

1982 Journal of Clinical Pathology

5839. Lack of correlation between free erythrocyte porphyrin and serum ferritin values at birth and at 2 months of life in low birthweight infants. Full Text available with Trip Pro

Lack of correlation between free erythrocyte porphyrin and serum ferritin values at birth and at 2 months of life in low birthweight infants. Red cell free erythrocyte porphyrin and serum ferritin determinations were performed on capillary blood specimens from 63 healthy infants weighing 2500 g or less at birth, during the first week of life, and, from 44 of them, again at 8-10 weeks. Free erythrocyte porphyrin values were high both at 3-7 days (mean 156 microgram/100 ml RBC) and at 8-10 weeks (...) (mean 128 microgram/100 ml RBC). The respective serum ferritin values were also high (mean 226 and 107 ng/ml), excluding a depletion in iron stores. In addition, no correlation was found between free erythrocyte porphyrin and serum ferritin values either at birth or at age 2 months. These findings are consistent with an earlier hypothesis that in the presence of iron stores, the rate of iron release from the stores in low birthweight infants may not be sufficient to maintain optimal erythropoiesis

1983 Archives of Disease in Childhood

5840. EDTA plasma rather than serum for B12, folate and ferritin estimations? Full Text available with Trip Pro

EDTA plasma rather than serum for B12, folate and ferritin estimations? 4056074 1985 12 03 2018 11 13 0021-9746 38 10 1985 Oct Journal of clinical pathology J. Clin. Pathol. EDTA plasma rather than serum for B12, folate and ferritin estimations? 1197 Sviland L L Rodger R S RS Fail J B JB Hamilton P J PJ eng Letter England J Clin Pathol 0376601 0021-9746 9007-73-2 Ferritins 935E97BOY8 Folic Acid P6YC3EG204 Vitamin B 12 AIM IM Ferritins blood Folic Acid blood Humans Plasma Vitamin B 12 blood 1985

1985 Journal of Clinical Pathology

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