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Serum Ferritin

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5801. Augmentation in restless legs syndrome is associated with low ferritin. (Abstract)

to patients who did not experience augmentation.Augmentation symptoms causing premature discontinuation from the study or which were tolerated (n=36, ferritin: 85+59 ng/ml) were associated with lower levels of serum ferritin compared to patients without augmentation (n=302, ferritin: 118+108 ng/ml, p=0.0062).Ferritin as a marker of iron storage may play an important role in the pathophysiology of RLS and may prove to be a biomarker for the development of augmentation under dopaminergic therapy. (...) Augmentation in restless legs syndrome is associated with low ferritin. Augmentation is a major problem with dopaminergic therapy for restless legs syndrome (RLS), and predictors of augmentation have not yet been identified. We aimed to analyze the relationship between baseline ferritin level and occurrence of augmentation in a retrospective analysis of a prospective double-blind trial of cabergoline versus levodopa on augmentation in RLS.Patients who experienced augmentation were compared

2008 Sleep medicine Controlled trial quality: uncertain

5802. Factors accounting for high ferritin levels in obesity. Full Text available with Trip Pro

Factors accounting for high ferritin levels in obesity. Ferritin is a widely used marker of iron status. A relationship between iron stores, obesity and metabolic syndrome (METs) has been proposed.To compare serum ferritin between obese women with and without METs, and to evaluate the main factors accounting for ferritin levels.Prospective study.A total of 239 consecutive postmenopausal women with body mass index (BMI) > or =30 kg/m(2) were included. Exclusion criteria were conditions (...) that could influence body iron stores. In addition to ferritin, serum iron, transferrin, transferrin saturation index and the soluble transferrin receptor were measured. METs was defined according to the International Diabetes Federation guidelines. Multiple regression analyses were performed taking into account ferritin as the dependent variable.Serum ferritin levels were significantly higher in obese women with METs (n=169) in comparison with obese women without METs (n=70): 81.00 (17-648) vs 48.50 (11

2008 International Journal of Obesity

5803. The long-term impact of ferritin level on treatment and complications of type 2 diabetes. (Abstract)

triglyceride, blood pressure and liver enzyme levels at the end of follow up. However, ferritin level had no impact on the initial or final requirements for diabetic medication and the development of diabetic complications.Although elevated serum ferritin is a marker of insulin resistance and chronic inflammation, it is not necessarily a bad prognostic indicator that should affect the clinician's approach to management. (...) The long-term impact of ferritin level on treatment and complications of type 2 diabetes. To investigate if high-serum ferritin has long-term impact on response to treatment and the development of diabetic complications in patients with type 2 diabetes.We analysed the record of 90 consecutive type 2 diabetic subjects who had serum ferritin level determined soon after diagnosis of diabetes and who also had long-term follow-up data.Patients with higher serum ferritin level had slightly worse

2008 obesity & metabolism

5804. The fascinating but deceptive ferritin: to measure it or not to measure it in chronic kidney disease? Full Text available with Trip Pro

associations of Fe with infection and oxidative stress have fueled the "iron apprehension." To date, no reliable marker of Fe stores in CKD has been agreed on. Serum ferritin continues to be the focus of attention. Almost half of all maintenance hemodialysis patients have a serum ferritin >500 ng/ml. In this ferritin range, Fe supplementation currently is not encouraged, although most reported hemochromatosis cases had a serum ferritin >2000 ng/ml. The moderate-range hyperferritinemia (500 to 2000 ng/ml (...) ) seems to be due mostly to non-Fe-related conditions, including inflammation, malnutrition, liver disease, infection, and malignancy. Recent epidemiologic studies have shown that a low, rather than a high, serum Fe is associated with a poor survival in maintenance hemodialysis patients. In multivariate adjusted models that mitigate the confounding effect of malnutrition-inflammation, serum ferritin <1200 ng/ml and Fe saturation ratio in 30 to 50% range are associated with the greatest survival

2006 Clinical Journal of the American Society of Nephrology

5805. Conditional deletion of ferritin H in mice induces loss of iron storage and liver damage. Full Text available with Trip Pro

their cellular iron stores indicating the requirement of ferritin H in iron deposition. Serum iron and transferrin saturation were slightly increased and correlated with a two-fold increased liver hepcidin 1 mRNA and a reduced duodenal DcytB mRNA level. Under a normal iron regimen, deleted mice survived for 2 years without visible disadvantage. Mice fed on a high iron diet prior to ferritin H deletion suffered from severe liver damage. Similarly, ferritin H deleted mouse embryonic fibroblasts showed rapid (...) Conditional deletion of ferritin H in mice induces loss of iron storage and liver damage. Ferritin plays a central role in iron metabolism by acting both as iron storage and a detoxifying protein. We generated a ferritin H allele with loxP sites and studied the conditional ferritin H deletion in adult mice. Ten days after Mx-Cre induced deletion, ferritin H messenger RNA (mRNA) was below 5% in the liver, spleen, and bone marrow of deleted mice compared to control littermates. Mice lost

2009 Hepatology

5806. Association between transferrin receptor-ferritin index and conventional measures of iron responsiveness in hemodialysis patients. Full Text available with Trip Pro

erythropoietin (rHuEPO) therapy for longer than 6 months were enrolled for intravenous iron (IVFE) supplementation (100 mg of iron polymaltose 3 times/wk for 4 weeks, then 100 mg every 2 weeks for 5 months). Routine iron tests (ie, serum ferritin and transferrin saturation [TSAT]), TfR-F index calculated by the ratio of soluble TfR to log ferritin level, hematocrit, hemoglobin, red blood cell count, and serum high-sensitive C-reactive protein were examined at baseline. Hematocrit and hemoglobin were followed (...) Association between transferrin receptor-ferritin index and conventional measures of iron responsiveness in hemodialysis patients. The diagnostic power of the transferrin receptor-ferritin (TfR-F) index for identification of iron responsiveness in long-term hemodialysis (HD) patients compared with the routine markers recommended by the current US and European guidelines was appraised.Initially, 121 long-term HD patients with a serum ferritin level less than 800 microg/L and on recombinant

2006 American Journal of Kidney Diseases

5807. Ferritin levels and their association with regional brain volumes in Tourette's syndrome. Full Text available with Trip Pro

Ferritin levels and their association with regional brain volumes in Tourette's syndrome. A previous small study showed lower serum ferritin levels in subjects with Tourette's syndrome than in healthy subjects. The authors measured peripheral iron indices in a large group of Tourette's syndrome and comparison subjects and explored associations of ferritin levels with regional brain volumes.Ferritin was measured in 107 children and adults (63 Tourette's syndrome, 44 comparison); serum iron (...) was measured in 73 (41 Tourette's syndrome, 32 comparison). Magnetic resonance imaging scans were used to measure volumes of the basal ganglia and cortical gray matter.Ferritin and serum iron were significantly lower in the Tourette's syndrome subjects, although still within the normal range. No association was found between tic severity and either iron index. In the Tourette's syndrome subjects, ferritin did not correlate significantly with caudate volume but did correlate positively with putamen volume

2006 American Journal of Psychiatry

5808. Low glycosylated ferritin, a good marker for the diagnosis of hemophagocytic syndrome. (Abstract)

Low glycosylated ferritin, a good marker for the diagnosis of hemophagocytic syndrome. A very low percentage of glycosylated ferritin (<20%) has only been reported in association with adult-onset Still's disease (AOSD), a disease classically associated with hemophagocytic syndrome. We undertook this study to determine whether hemophagocytic syndrome outside the context of AOSD is also associated with a very low percentage of glycosylated ferritin.From October 2006 to September 2007, the serum (...) (14 with confirmed hemophagocytic syndrome, 7 with suspected but unconfirmed hemophagocytic syndrome, and 21 controls). The median level (interquartile range [IQR]) of total serum ferritin was significantly higher in patients with confirmed hemophagocytic syndrome (3,344 microg/liter [2,074-7,334]) than in patients with suspected but unconfirmed hemophagocytic syndrome (555 microg/liter [464-1,420]) (P = 0.02) or in controls (451 microg/liter [126-929]) (P < 0.001). The median (IQR) percentage

2008 Arthritis and Rheumatism

5809. Oxidative stress and ferritin levels in haemodialysis patients. Full Text available with Trip Pro

patients on erythropoietin therapy and 22 healthy controls. HD patients were divided into two groups: 17 with normal (<800 ng/ml) and 17 with high (>800 ng/ml) ferritin levels, and we measured lipid profile, albumin, highly sensitive C-reactive protein (hsCRP), anti-oxidant enzymes [whole blood glutathione peroxidase (Gpx), serum superoxide dismutase (SOD), paraoxonase, arylestherase (AE) and total anti-oxidant status (TAOC)], anti-oxidants (vitamin C) and lipid peroxidation products [red blood cell (...) malondialdehyde (RBC MDA)].Compared with controls, the HD patients had higher serum urea, blood pressure, triglyceride, hsCRP, RBC MDA, SOD and TAOC values and lower albumin, low-density lipoprotein cholesterol, apolipoprotein AI, paraoxonase, AE and whole blood Gpx activities. Serum vitamin C, uric acid, apolipoprotein B, total- and high-density lipoprotein cholesterol, apolipoprotein B MDA, and lymphocyte levels in the HD patients with normal and high ferritin levels were similar. The OS markers of HD

2007 Transplantation

5810. Soluble transferrin receptors and ferritin in Type 2 diabetic patients. (Abstract)

Soluble transferrin receptors and ferritin in Type 2 diabetic patients. To determine circulating transferrin receptor levels (sTfR) in Type 2 diabetic patients to evaluate whether serum ferritin reflects iron body stores or inflammation in diabetic population.A total of 84 consecutive Type 2 diabetic patients and 60 healthy subjects matched by age and gender were included in this case-control study. Ferritin concentration was measured by a turbidimetric method and sTfR concentration were (...) determined by nephelometry.Diabetic patients have higher serum ferritin levels than control subjects [114 ng/ml (12-831) vs. 74 ng/ml (11-697); P = 0.006]. However, no differences in sTfR concentrations were observed between both groups [1.27 mg/l (0.69-2.47) vs. 1.24 mg/l (0.77-2.80); P = NS]. A negative correlation between ferritin and sTfR concentration was detected in control subjects but not in diabetic patients.Serum ferritin levels are increased in Type 2 diabetic patients in the absence

2005 Diabetic Medicine

5811. Ferritin and transferrin are associated with metabolic syndrome abnormalities and their change over time in a general population: Data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR). Full Text available with Trip Pro

Data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) cohort, aged 30-65 years, were followed over 6 years.Higher concentrations of both ferritin and transferrin were associated with the International Diabetes Federation (IDF) and the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults Adult Treatment Panel III original and revised definitions of the metabolic syndrome at baseline: for the IDF (...) Ferritin and transferrin are associated with metabolic syndrome abnormalities and their change over time in a general population: Data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR). The aim of this work was to study cross-sectional and longitudinal relations between iron stocks (ferritin) and the iron transport protein (transferrin) with the metabolic syndrome and its abnormalities.A total of 469 men and 278 premenopausal and 197 postmenopausal women from the French

2007 Diabetes Care

5812. A novel ferritin light chain gene mutation in a Japanese family with neuroferritinopathy: Description of clinical features and implications for genotype-phenotype correlations. (Abstract)

with insertions in the 3' portion of exon 4 develop early-onset tremor, suggesting genotype-phenotype correlations. In this family, male predominance and normal serum ferritin levels are characteristic.(c) 2008 Movement Disorder Society. (...) A novel ferritin light chain gene mutation in a Japanese family with neuroferritinopathy: Description of clinical features and implications for genotype-phenotype correlations. Neuroferritinopathy is a hereditary neurodegenerative disorder caused by mutations in the ferritin light chain gene (FTL1). The cardinal features are progressive movement disturbance, hypoferritinemia, and iron deposition in the brain. To date, five mutations have been described in Caucasian and Japanese families

2008 Movement Disorders

5813. Variability of ferritin measurements in chronic kidney disease; implications for iron management. Full Text available with Trip Pro

Variability of ferritin measurements in chronic kidney disease; implications for iron management. Serum ferritin levels are a proxy measure of iron stores; and existing guidelines for managing anemia in hemodialysis patients suggest that serum ferritin concentrations should be maintained at >200 ng/ml. The KDOQI recommendations further state there is insufficient evidence advocating routine intravenous iron when ferritin levels exceed 500 ng/ml. Here we determined the interassay differences (...) and short-term intraindividual variability of serum ferritin measurements in patients on chronic hemodialysis to illustrate how these variances may affect treatment decisions. Intermethod variations of up to 150 ng/ml were found comparing six commonly used ferritin assays that evaluated thirteen pools of serum from hemodialysis and nonhemodialysis patients. The intraindividual variability for ferritin in 60 stable hemodialysis patients ranged between 2-62% measured over an initial two-week period

2008 Kidney International

5814. Oxidative stress and ferritin expression in the skin of patients with rosacea. (Abstract)

Oxidative stress and ferritin expression in the skin of patients with rosacea. Rosacea is a common chronic light-sensitive inflammatory skin disease of unknown origin. The purpose of this work was to determine the parameters of oxidative stress, antioxidative capacity, and the pathophysiologic role of ferritin expression in skin cells of patients with rosacea.The investigation consisted of measurements of serum peroxide levels, serum total antioxidative potential levels, and immunohistochemical (...) analyses of ferritin in skin tissue samples.Serum peroxide levels were significantly higher and serum total antioxidative potential levels were significantly lower in patients with rosacea than in healthy control subjects (P < .05). Compared with control subjects, the number of ferritin-positive cells was significantly higher (P < .001) in skin samples from patients with rosacea, especially those with severe disease.Patients with rosacea in the study were aged 30 to 70 years (average age was 56 years

2008 Journal of American Academy of Dermatology

5815. To exclude haemachromatosis developing I understand it is useful to check ferritin levels, but how often should a patient with a family history of haemochromatosis have a ferritin level checked?

haemachromatosis developing I understand it is useful to check ferritin levels, but how often should a patient with a family history of haemochromatosis have a ferritin level checked? Although we found a number of guidelines supporting the testing of relatives of patients with hereditary haemochromatosis, none specified how often transferrin saturation and serum ferritin tests should be performed on an individual in whom initial normal levels were confirmed. However, the American Haemochromatosis Society web (...) To exclude haemachromatosis developing I understand it is useful to check ferritin levels, but how often should a patient with a family history of haemochromatosis have a ferritin level checked? To exclude haemachromatosis developing I understand it is useful to check ferritin levels, but how often should a patient with a family history of haemochromatosis have a ferritin level checked? - Trip Database or use your Google+ account Liberating the literature ALL of these words: Title only Anywhere

2006 TRIP Answers

5816. Ferritin

Ferritin Ferritin Produced by In partnership with User Top Links Menu Search User Top Links Search Ferritin Test Also Known As Serum ferritin Formal Name Ferritin, serum This article was last reviewed on 12 January 2017. This article was last modified on 27 July 2018. At a Glance Why Get Tested? To help assess the levels of iron stored in your body When To Get Tested? When your doctor suspects that you have either too little or too much iron in your system Sample Required? A blood sample taken (...) . Accordion Title Common Questions The ferritin blood test is requested to see how much iron your body has stored for future use. It is the most useful indicator of iron deficiency, as the ferritin stores can be significantly decreased before any fall in serum iron occurs. If iron excess is suspected, ferritin may be requested in combination with an and either , , or transferrin saturation (TSAT). An elevated ferritin in combination with a high iron level and either a low TIBC, low UIBC or an elevated

2004 Lab Tests Online UK

5817. Ferritin

. As iron deficiency continues, all of the stored iron is used and the body tries to compensate by producing more transferrin to increase iron transport. The serum iron level continues to decrease and transferrin and TIBC and UIBC increase. As this stage progresses, fewer and smaller red blood cells are produced, eventually resulting in . Transferrin saturation is decreased with iron deficiency. Iron overload If the iron level and transferrin saturation are high, the TIBC, UIBC and ferritin are normal (...) Ferritin Ferritin - Understand the Test User Top Links Menu Search User Top Links Search Ferritin Also Known As Serum Ferritin Formal Name Ferritin, serum This article was last reviewed on March 28, 2018. This article was last modified on December 19, 2018. At a Glance Why Get Tested? To determine your body's total iron storage capacity; to help diagnose iron deficiency or iron overload When To Get Tested? When you have low hemoglobin and hematocrit on a ; when your healthcare practitioner

2004 Lab Tests Online USA

5818. In an elderly patient with CCF has a microcytic hypochromic blood picture with Hb 9.1 but ferritin is in the normal range (28 units). Can the anaemia still be accounted for by iron deficiency?

In an elderly patient with CCF has a microcytic hypochromic blood picture with Hb 9.1 but ferritin is in the normal range (28 units). Can the anaemia still be accounted for by iron deficiency? In an elderly patient with CCF has a microcytic hypochromic blood picture with Hb 9.1 but ferritin is in the normal range (28 units). Can the anaemia still be accounted for by iron deficiency? - Trip Database or use your Google+ account Liberating the literature ALL of these words: Title only Anywhere (...) patient with CCF has a microcytic hypochromic blood picture with Hb 9.1 but ferritin is in the normal range (28 units). Can the anaemia still be accounted for by iron deficiency? The CKS guideline on iron deficiency anaemia discusses how the full blood count should be interpreted and notes: “ People who are not pregnant: • Haemoglobin level: o The World Health Organization defines anaemia as [WHO et al, 2001]: ? In men over 15 years of age: haemoglobin (Hb) below 13 g/dL. ? In non-pregnant women over

2008 TRIP Answers

5819. Can you tell me what a low ferritin and low blood count indicates?

pathological approach. Thus, the NLH Q & A Service would recommend discussing this issue with an haematologist who will be able to advise on the likely cause and offer a possible diagnosis given these parameters. We did, however, locate a PRODIGY guideline on iron deficiency anaemia containing a section on diagnostic investigations describing low blood counts and low serum ferritin levels. • “ Full blood count: o Low haemoglobin (Hb) concentration, less than 13 g/dl for men and less than 12 g/dl for women (...) o Low MCV, MCH, and MCHC (mean cell volume, mean cell Hb, mean cell Hb concentration) o Reticulocyte count low for the degree of anaemia o There may be a mild thrombocytosis (raised platelet concentration) • Blood film: microcytic hypochromic red cells, with occasional target cells and pencil-shaped poikilocytes. • Serum ferritin level: low (an indicator of reduced body-iron stores). However, as ferritin is an acute-phase protein, levels may be normal or elevated in infective, inflammatory

2006 TRIP Answers

5820. Female (mid 40s) with occasional PR bleed. She's had blood tests (high MCV, low B12, low folate, high ferritin and normal HB. What other investigations might be useful in arriving at a diagnosis?

Female (mid 40s) with occasional PR bleed. She's had blood tests (high MCV, low B12, low folate, high ferritin and normal HB. What other investigations might be useful in arriving at a diagnosis? Female (mid 40s) with occasional PR bleed. She's had blood tests (high MCV, low B12, low folate, high ferritin and normal HB. What other investigations might be useful in arriving at a diagnosis? - Trip Database or use your Google+ account Liberating the literature ALL of these words: Title only (...) Female (mid 40s) with occasional PR bleed. She's had blood tests (high MCV, low B12, low folate, high ferritin and normal HB. What other investigations might be useful in arriving at a diagnosis? We were unable to trace clinical guidelines (in English, 1) on management of patients presenting with rectal bleeding without other symptoms. The guidance on referral for suspected cancer considers rectal bleeding of significance when coupled with ‘change in bowel habits’ (2). GP notebook has a section

2006 TRIP Answers

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