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Serum Ferritin

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5781. Hepatocellular fat accumulation and low serum cholesterol in patients infected with HCV-3a. (Abstract)

< 0.01). Steatosis in HCV-3a-infected patients did not correlate with the body mass index, hepatic iron content, ferritin, or transferrin saturation. At baseline, serum cholesterol was lower in patients infected with HCV-3a (147 +/- 42 mg/dl; p < 0.01) compared with HCV-1 (188 +/- 36) or HCV-4 (172 +/- 35). In contrast to HCV-1- or HCV-4-infected patients, serum cholesterol increased in HCV-3a virological responders at the end of treatment and 6 months after therapy (baseline 146 +/- 38, end (...) Hepatocellular fat accumulation and low serum cholesterol in patients infected with HCV-3a. The aim of this study was to prospectively investigate the prevalence of hepatic steatosis in chronic hepatitis C patients with respect to viral genotype, hepatic iron concentration, total body iron, body mass index, and serum lipid parameters. Furthermore, the effect of hepatitis C virus (HCV) eradication by antiviral therapy on serum cholesterol levels was studied.Hepatocellular fat and hepatic iron

2002 American Journal of Gastroenterology

5782. Serum thioredoxin levels as a predictor of steatohepatitis in patients with nonalcoholic fatty liver disease. (Abstract)

TRX levels (medians and (ranges), ng/ml) were significantly elevated in patients with NASH (60.3 (17.6-104.7)), compared to those in patients with simple steatosis (24.6 (16.6-69.7), P=0.0009) and in healthy controls (23.5 (1.3-50.7), P<0.0001). Serum ferritin levels in patients with NASH were also significantly higher than the levels in patients with simple steatosis. The receiver operating characteristic curve confirmed that serum TRX and ferritin levels were predictors for distinguishing NASH (...) Serum thioredoxin levels as a predictor of steatohepatitis in patients with nonalcoholic fatty liver disease. Thioredoxin (TRX) is a stress-inducible thiol-containing protein. The aim of this study was to evaluate the clinical significance of serum TRX in patients with nonalcoholic steatohepatitis (NASH) or simple steatosis.Serum TRX levels were determined using an enzyme-linked immunosorbent assay kit in 25 patients with NASH, 15 patients with simple steatosis, and 17 healthy volunteers.Serum

2003 Journal of Hepatology

5783. Ferric gluconate treatment provides cost savings in patients with high ferritin and low transferrin saturation Full Text available with Trip Pro

Ferric gluconate treatment provides cost savings in patients with high ferritin and low transferrin saturation A subgroup of hemodialysis patients experience high serum ferritin and low tansferrin saturation for reasons not clearly understood. Here we determined the economic impact of administering sodium ferric gluconate complex to patients with serum ferritin levels higher than 500 ng/ml and a transferrin saturation less than 25% based on the Dialysis Patients Response to IV Iron (...) with Elevated Ferritin (DRIVE) study and its extension, DRIVE II. A cost effectiveness model was developed, consistent with the DRIVE studies, using decision analysis with a 12-week time horizon. The primary effectiveness measure was the mean hemoglobin increase in the intent to treat patient groups comparing epoetin with or without sodium ferric gluconate complex. Costs were computed using projected 2007 US Medicare reimbursements for the treatments and for serious adverse events, with the effectiveness

2009 EvidenceUpdates

5784. What are the likely causes of a raised ferritin with reduced iron binding?

ferritin with reduced iron binding?’ With regard to serum ferritin GP Notebook states the following [1] “Ferritin is an iron-protein complex found in most tissues, but particularly the bone marrow and reticuloendothelial system. Clinically, its importance is: - as an acute phase protein - as a non-specific index of liver disease - its close relationship to body stores of iron. Thus a low serum ferritin implies iron deficiency. Conversely, high ferritin can imply iron overload states. However, given (...) the first two points in the list, ferritin levels must be interpreted in the light of ongoing inflammation and liver disease.” The GP Notebook chapter on iron binding capacity [2], states: “TIBC is increased in iron deficiency, pregnancy and by oral contraceptive therapy. TIBC is decreased in: - iron overload - protein losing states } due to the fall in - infections } plasma transferrin - inflammation } - neoplastic disease } TIBC saturation tends to fall as serum ferritin increases and vice versa

2006 TRIP Answers

5785. A lady with terrible restless legs and a low ferritin of 7.5 (ref range 12-230) but a normal Hb. is it worth putting her on iron?

.” The review also discussed ferritin, including the statement: “The possibility that RLS might be associated with iron metabolism has quite a long history. For instance, the observation that serum ferritin was lower in patients with RLS than in those without RLS suggested some link, albeit that the study had only 18 elderly patients. The inverse correlation of severity of RLS with serum ferritin levels, and improved symptoms after two months of treatment with oral iron salts helped to underline any (...) A lady with terrible restless legs and a low ferritin of 7.5 (ref range 12-230) but a normal Hb. is it worth putting her on iron? A lady with terrible restless legs and a low ferritin of 7.5 (ref range 12-230) but a normal Hb. is it worth putting her on iron? - Trip Database or use your Google+ account Turning Research Into Practice ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere

2006 TRIP Answers

5786. In a patient with an asymptomatic mild normocytic normochromic anaemia, (Hb 11.5 in a male aged 65), when iron levels are low, but ferritin levels are normal, is it safe to monitor without investigati

be normal or elevated in infective, inflammatory or malignant disease despite iron deficiency. Serum ferritin level is also increased by excessive alcohol consumption.” It later says: “A reason for iron deficiency should always be sought. History-taking should attempt to determine whether gastrointestinal (GI) blood loss, menstrual loss, malabsorption, or nutritional deficiency is likely. Drug history of nonsteroidal anti-inflammatory use is particularly important, as this might point to possible GI (...) summary of the guidelines says: “Background: Colonic cancer, gastric cancer and coeliac disease are the most important gastrointestinal causes of iron deficiency anaemia. Definitions: The lower limit of the normal range should be used to define anaemia. Iron deficiency should be confirmed by a low serum ferritin, red cell microcytosis or hypochromia in the absence of chronic disease or haemoglobinopathies. Any level of iron deficiency anaemia should be investigated. Investigations: Rectal examination

2006 TRIP Answers

5787. If a patient has symptoms of anemia eg. fatigue, menorrhagia and a low ferritin but normal haemoglobin, should she be given ferrous sulphate?

at serum ferritin levels [2] References 1) PRODIGY. Anaemia - iron deficiency. 2005 ( ) 2) NLH Q&A Service. At what levels of serum ferritin should I start to replace (Iron with Iron supplements) Normal values range for women 20 - 200 ng/ml and for men from 20 - 300 ng/ml. When does onestart to replace even with a normal Haemoglobin? 2005 ( ) Answered 5 July 2006 Follow us: © 2019 Trip Database Ltd. company number 04316414. Trip is proud to be made in the UK. (...) If a patient has symptoms of anemia eg. fatigue, menorrhagia and a low ferritin but normal haemoglobin, should she be given ferrous sulphate? If a patient has symptoms of anemia eg. fatigue, menorrhagia and a low ferritin but normal haemoglobin, should she be given ferrous sulphate? - Trip Database or use your Google+ account Liberating the literature ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only

2006 TRIP Answers

5788. Can patients be screened for carrier status of Heamochromatosis? I have a 40 year old woman with a first degree relative who has the condition. Her ferritin is low.

a minority will go on to develop clinical symptoms. Additional causative agents seem to be involved but have not yet been clearly demonstrated. A raised transferrin saturation is an early indication of a risk of iron accumulation. A raised serum ferritin will confirm increased iron stores but ferritin may be elevated in many other conditions.” [2] An American clinical guideline on screening for hereditary haemachromatosis emphasises: “ The lack of information on the natural history of the disease makes (...) individuals who are homozygous for the mutation but do not develop iron overload is controversial. The psychological and social implications of identifying such individuals must be considered. Issues such as the impact on insurability and the anxiety of being labeled with a hereditary illness need to be considered when comparing the benefits and risks of screening (21). The recently published HEIRS Study indicates that C282Y mutation does not explain high transferrin saturation and serum ferritin level

2007 TRIP Answers

5789. Do patients with coeliacs need blind supplementation ie calcium/folic acid or is it enough to check yearly calcium/fbc/folate/b12 and ferritin?

] The British Society of Gastroenterology notes: “Dietary Supplements: Many patients will be found to be suffering from dietary deficiencies at the time of diagnosis, the commonest being iron, folic acid, calcium and vitamin B12. Although these usually resolve spontaneously once on a GFD, it seems reasonable to ensure rapid correction with appropriate supplements.” And: “A number of routine blood tests should be carried out to identify nutritional deficiencies including haemoglobin, B12, folate, iron, serum (...) Do patients with coeliacs need blind supplementation ie calcium/folic acid or is it enough to check yearly calcium/fbc/folate/b12 and ferritin? Do patients with coeliacs need blind supplementation ie calcium/folic acid or is it enough to check yearly calcium/fbc/folate/b12 and ferritin? - Trip Database or use your Google+ account Find evidence fast ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only

2007 TRIP Answers

5790. A 64 year old female vegetarian has a low normal hb of 11.4 and a low ferritin of 17(nr 20-3000). Is it safe to assume this is diet related and just treat, or at what stage is it mandatory to endoscop

A 64 year old female vegetarian has a low normal hb of 11.4 and a low ferritin of 17(nr 20-3000). Is it safe to assume this is diet related and just treat, or at what stage is it mandatory to endoscop A 64 year old female vegetarian has a low normal hb of 11.4 and a low ferritin of 17(nr 20-3000). Is it safe to assume this is diet related and just treat, or at what stage is it mandatory to endoscope and colonoscope? - Trip Database or use your Google+ account Liberating the literature ALL (...) @tripdatabase.com A 64 year old female vegetarian has a low normal hb of 11.4 and a low ferritin of 17(nr 20-3000). Is it safe to assume this is diet related and just treat, or at what stage is it mandatory to endoscope and colonoscope? The NLH Q&A Service is unable to comment on any assumptions regarding the cause of this females low hb, we can simply report on the literature we find. PRODIGY has a guideline on iron-deficiency anaemia [1] which we recommend you read (see reference section for URL). With regard

2006 TRIP Answers

5791. Somebody c/o tiredness and with a suspicion of anaemia has hb=13.4, slightly low MCV and MCH and ferritin =10(borderline normal). Should this person be treated with iron supplements? Note all other b

in the diagnosis of anaemia: “ Full blood count: • Low haemoglobin (Hb) concentration, less than 13 g/dl for men and less than 12 g/dl for women • Low MCV, MCH, and MCHC (mean cell volume, mean cell Hb, mean cell Hb concentration) • Reticulocyte count low for the degree of anaemia • There may be a mild thrombocytosis (raised platelet concentration) • Serum ferritin level: low (an indicator of reduced body-iron stores). However, as ferritin is an acute-phase protein, levels may be normal or elevated (...) in infective, inflammatory or malignant disease despite iron deficiency. Serum ferritin level is also increased by excessive alcohol consumption. The clinical scenario “Iron deficiency anaemia excluding pregnancy” notes: • A reason for iron deficiency should always be sought. • Consider gastrointestinal blood loss, excessive menstrual loss, malabsorption, or nutritional deficiency. • Dietary deficiency, by itself, is rarely a cause of iron deficiency anaemia in developed countries unless

2006 TRIP Answers

5792. Effects of recombinant human erythropoietin on cerebral and cutaneous blood flow and on blood coagulability. (Abstract)

of five according to their serum ferritin concentration: group A. less than 800 microgram/liter, and group B. greater than 800 micrograms/liter. After a month of placebo administration, recombinant human erythropoietin was given (150 U/kg intravenously thrice weekly) for four months and then stopped for one month. Hematocrit values were maintained at 0.33 +/- 0.02 (mean +/- SD) by dose adjustment in group A and at 0.26 +/- 0.02 by thrice weekly phlebotomies in group B, who received a constant dose (...) Effects of recombinant human erythropoietin on cerebral and cutaneous blood flow and on blood coagulability. Seizures, hypertensive encephalopathy, transient ischemic attacks, and thrombosis of hemodialysis accesses occurred in early clinical trials with recombinant human erythropoietin. To determine if these events may be caused by the increased hematocrit value or some direct effect of the recombinant human hormone, 10 transfusion-dependent hemodialysis patients were divided into two groups

1990 Kidney international

5793. Biological variation of plasma ferritin in healthy adult males in south Indian population—A sample study Full Text available with Trip Pro

Biological variation of plasma ferritin in healthy adult males in south Indian population—A sample study A sample study of biological variation of plasma ferritin in healthy adult males 19-25 years of age (n=6) in the Indian population was determined. Venous blood was collected on 3 non-consecutive days during a 3 week period. Plasma ferritin was measured using enzyme linked immunoassay in an automated immunoassay system. Analytical and Biological variation was calculated. We found a mean

2006 Indian Journal of Clinical Biochemistry

5794. Investigating iron status in microcytic anaemia: General practitioners could test for ferritin, etc, before referral Full Text available with Trip Pro

Family Practice Ferritins blood Humans Referral and Consultation 2006 11 4 9 0 2006 11 15 9 0 2006 11 4 9 0 ppublish 17082563 333/7575/972 10.1136/bmj.333.7575.972 PMC1633804 BMJ. 2006 Oct 14;333(7572):791-3 17038737 (...) Investigating iron status in microcytic anaemia: General practitioners could test for ferritin, etc, before referral 17082563 2006 11 14 2018 11 13 1756-1833 333 7575 2006 Nov 04 BMJ (Clinical research ed.) BMJ Investigating iron status in microcytic anaemia: general practitioners could test for ferritin, etc, before referral. 972 Das Debasish D eng Comment Letter England BMJ 8900488 0959-8138 9007-73-2 Ferritins AIM IM BMJ. 2006 Oct 14;333(7572):791-3 17038737 Anemia, Iron-Deficiency diagnosis

2006 BMJ : British Medical Journal

5795. DRIVE Trial (Dialysis Patients' Response to Intravenous [IV] Iron With Elevated Ferritin)

Elevated serum ferritin with low to normal transferrin saturation (TSAT) Moderate to severe anemia Receiving epoetin alfa treatment Exclusion Criteria: Known sensitivity to Ferrlecit® Medical conditions that would confound the efficacy evaluation Recent blood transfusion Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer (...) Pharmaceuticals Information provided by (Responsible Party): Watson Pharmaceuticals Study Details Study Description Go to Brief Summary: This study explores the safety and efficacy of intravenous iron therapy in anemic hemodialysis patients treated with epoetin alfa, who have higher serum ferritin levels, but low to normal transferrin saturation. Condition or disease Intervention/treatment Phase Anemia, Iron-Deficiency Kidney Failure, Chronic Hemodialysis Drug: Sodium ferric gluconate, Phase 4 Study Design Go

2005 Clinical Trials

5796. Ferric gluconate reduces epoetin requirements in hemodialysis patients with elevated ferritin. Full Text available with Trip Pro

+/- 19,987 IU/wk, P = 0.809). Mean hemoglobin, TSAT, and serum ferritin levels remained higher in the ferric gluconate group than in the control group (P = 0.062, P < 0.001, and P = 0.014, respectively). Over the entire 12-wk study period (DRIVE plus DRIVE-II), the control group experienced significantly more serious adverse events than the ferric gluconate group (incidence rate ratio = 1.73, P = 0.041). In conclusion, ferric gluconate maintains hemoglobin and allows lower epoetin doses in anemic (...) Ferric gluconate reduces epoetin requirements in hemodialysis patients with elevated ferritin. The Dialysis Patients Response to IV Iron with Elevated Ferritin (DRIVE) study demonstrated the efficacy of intravenous ferric gluconate to improve hemoglobin levels in anemic hemodialysis patients who were receiving adequate epoetin doses and who had ferritin levels between 500 and 1200 ng/ml and transferrin saturation (TSAT) < or = 25%. The DRIVE-II study reported here was a 6-wk observational

2008 Journal of the American Society of Nephrology : JASN Controlled trial quality: uncertain

5797. Efficacy of oral iron in patients with restless legs syndrome and a low-normal ferritin: A randomized, double-blind, placebo-controlled study. (Abstract)

Efficacy of oral iron in patients with restless legs syndrome and a low-normal ferritin: A randomized, double-blind, placebo-controlled study. Restless Legs Syndrome (RLS) is a primary disorder of sensation that affects sleep and has been associated with iron deficiency. The purpose of this study was to determine if symptomatic RLS patients with low-normal serum ferritin levels benefit from oral iron replacement.This was a randomized, placebo-controlled, double-blinded study. Eligible patients (...) were randomized to oral iron therapy vs. appearance-matched placebo and followed over a 12 week period.Baseline International Restless Leg Scale (IRLS) scores for the treatment (24.8+/-5.72) and placebo (23.0+/-5.03) groups were similar. Baseline ferritin levels for the treatment (40.6+/-15.3ng/ml) and placebo (36.7+/-20.8ng/ml) groups were also similar. After 12 weeks, IRLS scores decreased more in the treatment arm (10.3+/-7.40) than in the placebo arm (1.14+/-5.64), (p=0.01). Ferritin levels

2009 Sleep medicine Controlled trial quality: predicted high

5798. Iron absorption from soybean ferritin in nonanemic women. Full Text available with Trip Pro

. After 28 d, whole-body 59Fe and 59Fe in red blood cells were measured before and after dosing.There was no significant difference in whole-body iron absorption from soybean ferritin (29.9 +/- 19.8%) and that from FeSO4 (34.3 +/- 23.6%) or in iron absorption calculated from red blood cell incorporation (33.0 +/- 20.1% for soybean ferritin and 35.3 +/- 23.4% for FeSO4), which confirmed previous results with animal ferritin that was mineralized and labeled similarly. An inverse relation was observed (...) between serum ferritin and iron absorption from both ferritin and FeSO4, which suggested that sensors regulating iron absorption respond similarly to iron provided as ferrous salts or as ferritin mineral.Iron from soybean ferritin is well absorbed and may provide a model for novel, utilizable, plant-based forms of iron for populations with a low iron status.

2006 The American journal of clinical nutrition Controlled trial quality: uncertain

5799. Fever of unknown origin (FUO) due to a solitary cavitary lung lesion: The deadly ferritin-laced doughnut. (Abstract)

diagnosis included bronchogenic carcinoma, lymphoma, and metastatic carcinoma. Her nonspecific laboratory tests indicated a highly elevated erythrocyte sedimentation rate (ESR) >100 mm/hour, chronic thrombocytosis, relative lymphopenia, and highly elevated serum ferritin levels. Excluding highly elevated serum ferritin levels, the differential diagnosis of her FUO with a solitary, thick-walled cavitary lesion was lung abscess vs tuberculosis. However, her highly elevated serum ferritin levels proved (...) to be the critical diagnostic clue in predicting the diagnosis of squamous-cell carcinoma. We conclude that serum ferritin levels are an important part of the laboratory workup. As with other nonspecific laboratory tests, the diagnostic significance of highly elevated ferritin levels depends associated clinical features in the clinical presentation.

2009 Heart & Lung

5800. [Effectiveness of different iron supplementation strategies on hemoglobin and ferritin levels among schoolchildren in Teresina, Piauí State, Brazil]. (Abstract)

[Effectiveness of different iron supplementation strategies on hemoglobin and ferritin levels among schoolchildren in Teresina, Piauí State, Brazil]. This study evaluated the effectiveness of supplementation with ferrous sulfate and iron bis-glycinate chelate on hemoglobin and serum ferritin levels among schoolchildren (7-11 years) of both sexes. A randomized community-based trial including 138 anemic children (hemoglobin < 11.5 g/dL) was conducted in Teresina, Piauí State, Brazil. Children (...) > 0.05). No effect was observed on body iron for either intervention (p > 0.05). Children with depleted iron stores (< 15 ng/mL) at the beginning of interventions showed increased serum ferritin concentrations after 8 weeks (p < 0.01), although no difference between treatments (p > 0.05) was observed. The results confirm the effectiveness of the iron supplementation interventions and corroborate the use of iron salts or ferrous bisglycinate chelate on a weekly basis to overcome iron deficiency

2007 Cadernos de Saúde Pública / Ministério da Saúde Controlled trial quality: uncertain

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