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Serum Ferritin

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5761. Silybin treatment is associated with reduction in serum ferritin in patients with chronic hepatitis C. (Abstract)

Silybin treatment is associated with reduction in serum ferritin in patients with chronic hepatitis C. The goal of this study was to examine the effect of a standardized silybin and soy phosphatidylcholine complex (IdB 1016) on serum markers of iron status.Milk thistle and its components are widely used as an alternative therapy for liver disease because of purported antioxidant, anti-inflammatory, and iron chelating properties.Thirty-seven patients with chronic hepatitis C and Batts-Ludwig (...) fibrosis stage II, III, or IV were randomized to 1 of 3 doses of IdB 1016 for 12 weeks. Serum ferritin, serum iron, total iron binding capacity, and transferrin-iron saturation were measured at baseline, during treatment, and 4 weeks thereafter. Wilcoxon signed rank tests were used to compare baseline and posttreatment values.There was a significant decrease in serum ferritin from baseline to end of treatment (mean, 244 vs. 215 mug/L; median, 178 vs. 148 mug/L; P=0.0005); 78% of subjects had a decrease

2008 Journal of clinical gastroenterology Controlled trial quality: uncertain

5762. Body iron and individual iron prophylaxis in pregnancy--should the iron dose be adjusted according to serum ferritin? (Abstract)

Body iron and individual iron prophylaxis in pregnancy--should the iron dose be adjusted according to serum ferritin? This study aims to evaluate iron prophylaxis in pregnant women from the individual aspect, i.e. according to serum ferritin levels at the beginning of pregnancy, and to assess which dose of iron would be adequate to prevent iron deficiency (ID) and iron deficiency anaemia (IDA) during pregnancy and postpartum. A randomised, double-blind study comprising 301 healthy Danish (...) pregnant women allocated into four groups taking ferrous iron (as fumarate) in doses of 20 mg (n=74), 40 mg (n=76), 60 mg (n=77) and 80 mg (n=75) from 18 weeks gestation (inclusion) to 8 weeks postpartum. Iron status markers [serum ferritin, serum soluble transferrin receptor (sTfR), haemoglobin] were recorded at 18, 32 and 39 weeks gestation and 8 weeks postpartum. Body iron was calculated using the serum sTfR/serum ferritin ratio. ID was defined by serum ferritin <12 microg/l in pregnancy and <15

2006 Annals of hematology Controlled trial quality: uncertain

5763. Dietary iron intake and serum ferritin in relation to 7.5 years structure and function of large arteries in the SUVIMAX cohort. (Abstract)

Dietary iron intake and serum ferritin in relation to 7.5 years structure and function of large arteries in the SUVIMAX cohort. Few studies have investigated the relationship between iron stores and measures of atherosclerosis. Most of these studies were cross-sectional and yielded conflicting results. We aimed to assess the relationship between serum ferritin concentrations and dietary iron intake measured at baseline and 7.5 year pulse wave velocity (PWV), intima-media thickness (IMT (...) ) and plaques in a group of 824 men and women without known CVD, cancer or hemochromatosis.The SUVIMAX study is a randomized double-blind, placebo-controlled primary prevention trial designed to test the effect of antioxidant supplementation in reducing ischemic cardiovascular diseases and cancer.In multivariate analyses, no association was found between baseline serum ferritin levels and IMT 7 years later (beta (95% CI)=0.003 (-0.005;0.011) in men; -0.005 (-0.013;0.004) and -0.001 (-0.011;0.009) in women

2007 Diabetes & metabolism Controlled trial quality: predicted high

5764. Predictors of the response to treatment in anemic hemodialysis patients with high serum ferritin and low transferrin saturation. Full Text available with Trip Pro

Predictors of the response to treatment in anemic hemodialysis patients with high serum ferritin and low transferrin saturation. Treating hemodialysis patients to combat anemia corrects hemoglobin but exacerbates iron deficiency by utilizing iron stores. Patients needing iron should receive this by intravenous (i.v.) means. The Dialysis patients' Response to IV iron with Elevated ferritin (DRIVE) trial investigated the role of i.v. iron in anemic patients with high ferritin, low transferrin (...) saturation, and adequate epoetin doses. We examined whether baseline iron and inflammation markers predict the response of hemoglobin to treatment. Patients (134) were randomized to no added iron or to i.v. ferric gluconate for eight consecutive hemodialysis sessions spanning 6 weeks with epoetin increased by 25% in both groups. The patients started with hemoglobin less than or equal to 11 g/dl, ferritin between 500 and 1200 ng/ml, and transferrin saturation of less than 25%. Significantly, patients

2007 Kidney international Controlled trial quality: uncertain

5765. Adolescents eating diets rich in either lean beef or lean poultry and fish reduced fat and saturated fat intake and those eating beef maintained serum ferritin status. (Abstract)

Adolescents eating diets rich in either lean beef or lean poultry and fish reduced fat and saturated fat intake and those eating beef maintained serum ferritin status. Reducing red meat intake to lower serum cholesterol may also lower iron and zinc intake. Eighty-six seventh and eighth graders who enrolled in a study comparing serum ferritin, zinc, and cholesterol levels were randomized to a low-fat eating pattern emphasizing either lean beef or lean poultry and fish. Serum data and three 24 (...) -hour recalls were collected at baseline and 3 months. The lean beef group ate significantly more beef [26 (4, 37) g/d; P<.01] and both groups reduced total and saturated fat intake. Although serum ferritin level change between baseline and intervention was significantly different between the lean beef and lean poultry and fish groups (median [interquartile range] 0.7 [-6, 8] and -6.8 [-12, 2] microg/dL, respectively), the drop in the lean poultry and fish group was not clinically significant

2004 Journal of the American Dietetic Association Controlled trial quality: uncertain

5766. Relationship between serum ferritin, hepatic iron staining, diabetes mellitus and fibrosis progression in patients with chronic hepatitis C. Full Text available with Trip Pro

Relationship between serum ferritin, hepatic iron staining, diabetes mellitus and fibrosis progression in patients with chronic hepatitis C. Chronic infection with the hepatitis C virus affects over 170 million individuals worldwide and 20% of patients develop cirrhosis after 20 years. Increased iron stores and hepatic iron content have been suggested to be important in fibrosis progression. The increased prevalence of diabetes mellitus has been associated with increased iron deposits (...) in patients with chronic hepatitis C.To assess the potential relationship between serum ferritin and hepatic iron staining and liver fibrosis in patients with chronic hepatitis C virus infection and whether these factors are increased in diabetic patients with hepatitis C virus.This was a cross-sectional, multi-centre study involving hospitals in the north-east of London between 1992 and 2003. Chronic hepatitis C patients with a liver biopsy and data concerning age, sex, basal metabolic index, diabetes

2005 Alimentary Pharmacology & Therapeutics

5767. The diversity of liver diseases among outpatient referrals for elevated serum ferritin Full Text available with Trip Pro

The diversity of liver diseases among outpatient referrals for elevated serum ferritin The aim of the present study was to examine the diversity of liver diseases in outpatients referred because of elevated serum ferritin.A retrospective review was performed of outpatient referrals for serum ferritin elevations made to a tertiary care centre liver clinic between 1999 and 2005. Information regarding serum ferritin, transferrin saturation, liver biopsy, liver iron concentration and final (...) -C282Y homozygotes with an elevated serum ferritin concentration greater than 1000 microg/L, 64% did not have iron overload on liver biopsy.HFE-linked hemochromatosis accounted for less than one-half of the diagnoses in an outpatient population referred for elevated ferritin, suggesting a need to search further for an alternate cause.

2006 Canadian Journal of Gastroenterology

5768. Biological Signatures of Brain Damage Associated with High Serum Ferritin Levels in Patients with Acute Ischemic Stroke and Thrombolytic Treatment Full Text available with Trip Pro

Biological Signatures of Brain Damage Associated with High Serum Ferritin Levels in Patients with Acute Ischemic Stroke and Thrombolytic Treatment Increased body iron stores have been related to greater oxidative stress and brain injury in clinical and experimental cerebral ischemia and reperfusion. We aimed to investigate the biological signatures of excitotoxicity, inflammation and blood brain barrier disruption potentially associated with high serum ferritin levels-related damage in acute (...) stroke patients treated with i.v. t-PA.Serum levels of ferritin (as index of increased cellular iron stores), glutamate, interleukin-6, matrix metalloproteinase-9 and cellular fibronectin were determined in 134 patients treated with i.v. t-PA within 3 hours from stroke onset in blood samples obtained before t-PA treatment, at 24 and 72 hours.Serum ferritin levels before t-PA infusion correlated to glutamate (r = 0.59, p < 0.001) and interleukin-6 (r = 0.55, p < 0.001) levels at baseline

2008 Disease markers

5769. Response: Further analysis of the relationship between pretransplantation serum ferritin and transplantation outcome: cause-of-death analysis and impact of disease duration Full Text available with Trip Pro

Response: Further analysis of the relationship between pretransplantation serum ferritin and transplantation outcome: cause-of-death analysis and impact of disease duration 17916753 2007 11 28 2018 11 13 0006-4971 110 8 2007 Oct 15 Blood Blood Prognostic impact of elevated pretransplantation serum ferritin in patients undergoing myeloablative stem-cell transplantation. 3083; author reply 3083-4 Platzbecker Uwe U Ehninger Gerhard G Bornhäuser Martin M eng Comment Letter United States Blood (...) 7603509 0006-4971 9007-73-2 Ferritins AIM IM Blood. 2007 May 15;109(10):4586-8 17234738 Decision Support Techniques Ferritins blood Hematopoietic Stem Cell Transplantation Humans Myelodysplastic Syndromes blood complications therapy Myeloproliferative Disorders blood complications therapy Neutropenia etiology Opportunistic Infections complications epidemiology Prognosis 2007 10 6 9 0 2007 12 6 9 0 2007 10 6 9 0 ppublish 17916753 110/8/3083 10.1182/blood-2007-05-089839 PMC2018680 Blood. 2004 Jul 15;104

2007 Blood

5770. Serum ferritin levels correlate with haemoglobin concentration: a report on 589 outpatients from a single centre Full Text available with Trip Pro

Serum ferritin levels correlate with haemoglobin concentration: a report on 589 outpatients from a single centre 19204781 2010 06 10 2018 11 13 1723-2007 5 4 2007 Nov Blood transfusion = Trasfusione del sangue Blood Transfus Serum ferritin levels correlate with haemoglobin concentration: a report on 589 outpatients from a single centre. 244-5 10.2450/2007.0021-07 Franchini Massimo M Servizio di Immunoematologia e Trasfusione, Azienda Ospedaliera di Verona, Verona, Italy. mfranchini@univr.it (...) Salvagno Gian Luca GL Montagnana Martina M Lippi Giuseppe G eng Journal Article Italy Blood Transfus 101237479 1723-2007 2007 05 09 2007 06 21 2009 2 11 9 0 2007 11 1 0 0 2007 11 1 0 1 ppublish 19204781 10.2450/2007.0021-07 PMC2581914 Am J Hematol. 2006 Mar;81(3):202-9 16493621 Clin Chem. 1998 Dec;44(12):2429-32 9836708 Hematology Am Soc Hematol Educ Program. 2003;:40-61 14633776 Clin Chem. 2000 Feb;46(2):162-6 10657371 Br J Haematol. 2001 Aug;114(2):474-84 11529872 Clin Chem. 2001 Feb;47(2):202-8

2007 Blood Transfusion

5771. Serum ferritin and erythrocyte indices in iron overload Full Text available with Trip Pro

Serum ferritin and erythrocyte indices in iron overload 19204774 2010 06 10 2018 11 13 1723-2007 5 4 2007 Nov Blood transfusion = Trasfusione del sangue Blood Transfus Serum ferritin and erythrocyte indices in iron overload. 187-8 10.2450/2007.0036-07 Fiorelli Gemino G eng Editorial Italy Blood Transfus 101237479 1723-2007 2009 2 11 9 0 2007 11 1 0 0 2007 11 1 0 1 ppublish 19204774 10.2450/2007.0036-07 PMC2581906 Am J Gastroenterol. 2007 Jun;102(6):1251-8 17391316 Arch Intern Med. 2007 Apr

2007 Blood Transfusion

5772. Management of Elevated Serum Ferritin Levels Full Text available with Trip Pro

Management of Elevated Serum Ferritin Levels 21904507 2011 11 10 2018 11 13 1554-7914 4 5 2008 May Gastroenterology & hepatology Gastroenterol Hepatol (N Y) Management of elevated serum ferritin levels. 333-4 Adams Paul P Professor of Medicine Chief, Division of Gastroenterology University of Western Ontario, Canada. eng Journal Article United States Gastroenterol Hepatol (N Y) 101262648 1554-7914 2011 9 10 6 0 2008 5 1 0 0 2008 5 1 0 1 ppublish 21904507 PMC3093720 Lancet. 2002 Jan 19;359(9302 (...) ):211-8 11812557 Blood. 2005 Jan 15;105(2):855-61 15256427 N Engl J Med. 2005 Apr 28;352(17):1769-78 15858186 Clin Gastroenterol Hepatol. 2006 Jul;4(7):918-23; quiz 807 16797244 Arch Intern Med. 2007 Apr 9;167(7):722-6 17420432 J Fam Pract. 2007 Oct;56(10):829-34 17908514 Am J Med. 2007 Nov;120(11):999.e1-7 17976429 N Engl J Med. 2008 Jan 17;358(3):221-30 18199861 Can J Gastroenterol. 2006 Jul;20(7):467-70 16858498

2008 Gastroenterology & hepatology

5773. Fever of unknown origin: temporal arteritis presenting with persistent cough and elevated serum ferritin levels. (Abstract)

Fever of unknown origin: temporal arteritis presenting with persistent cough and elevated serum ferritin levels. Fever of unknown origin (FUO) at the present time is most frequently caused by neoplasm and less commonly by infection. Currently, collagen vascular diseases (CVDs) are an uncommon cause of FUO because most are readily diagnosable by serologic methods and do not remain undiagnosed for sufficient time to present as FUOs. CVDs presenting as FUOs not readily diagnosable with specific (...) % and are the presenting feature in 4%. Laboratory abnormalities associated with TA include a highly elevated erythrocyte sedimentation rate, anemia, and thrombocytosis, and mildly increased alkaline phosphatase/serum transaminases.We present a patient with FUO caused by TA whose predominant presenting symptom was persistent cough that overshadowed head and neck symptoms of TA. To the best of our knowledge, this is the first case of TA presenting as an FUO, with a highly elevated serum ferritin level.We conclude

2006 Heart & Lung

5774. Fever of unknown origin due to preleukemia/myelodysplastic syndrome: the diagnostic importance of monocytosis with elevated serum ferritin levels. (Abstract)

Fever of unknown origin due to preleukemia/myelodysplastic syndrome: the diagnostic importance of monocytosis with elevated serum ferritin levels. Fever of unknown origin (FUO) is a common clinical diagnostic dilemma. In the elderly, causes of FUO most commonly include malignancy or infection, and less commonly include collagen vascular diseases. Among the collagen vascular diseases causing FUO in the elderly, polymyalgia rheumatica/temporal arteritis, and adult Still's disease (adult juvenile (...) during hospital evaluation. These findings, in concert with the persistent monocytosis, highly elevated ferritin levels, polyclonal gammopathy on serum protein electrophoresis, and eventual presence of myelocytes/metamyelocytes on peripheral smear, prompted a bone marrow test that demonstrated blast cells confirming the diagnosis of preleukemia myelodysplastic syndrome as the cause of this patient's FUO.

2006 Heart & Lung

5775. Fever of unknown origin caused by adult juvenile rheumatoid arthritis: the diagnostic significance of double quotidian fevers and elevated serum ferritin levels. (Abstract)

Fever of unknown origin caused by adult juvenile rheumatoid arthritis: the diagnostic significance of double quotidian fevers and elevated serum ferritin levels. Fever of unknown origin (FUO) in adults is a commonly encountered clinical problem. Treatable causes of FUO in the adult should be the primary focus of the diagnostic workup. Neoplasms have replaced infectious diseases as being the most common cause of FUO in adults, and collagen vascular diseases are now relatively rare. The most (...) arthritis, ocular involvement, and evanescent salmon-colored truncal rash. An important diagnostic finding in adult JRA is the presence of a double quotidian fever, which occurs in few other disorders. Only visceral leishmaniasis and adult JRA are causes of FUO in adults associated with double quotidian fevers. Highly elevated serum ferritin levels are the most important nonspecific diagnostic finding associated with adult JRA. We present a case of FUO caused by adult JRA presenting with diffuse

2004 Heart & Lung

5776. Thyroid function and serum ferritin levels: the study of health in Pomerania. (Abstract)

Thyroid function and serum ferritin levels: the study of health in Pomerania. Serum ferritin levels are assumed to be an atherosclerotic risk factor. Ferritin production is increased in individuals with activated liver production, which has been shown in hyperthyroid conditions. An association between subclinical hyperthyroidism and serum ferritin levels would add an explanation to the relation between low serum thyrotropin levels and mortality. The aim of the present analysis (...) was to investigate an association between thyroid function and serum ferritin levels. We hypothesized low serum thyrotropin to be related to high serum ferritin levels.The Study of Health in Pomerania (SHIP) is a population-based study comprising male and female adults aged 20 to 79 years. Data of 4111 subjects (2071 females) were available for the present analysis. Serum ferritin levels were determined by an immunoturbidimetric assay. Multivariable analyses were performed to investigate an independent relation

2006 Thyroid

5777. Validation of serum ferritin values by magnetic susceptometry in predicting iron overload in dialysis patients. Full Text available with Trip Pro

Validation of serum ferritin values by magnetic susceptometry in predicting iron overload in dialysis patients. Guidelines for treating anemia in dialysis patients accept, as high-end range of serum ferritin useful to optimize erythropoietin therapy, values high as 500 to 900 microg/L, on the hypothesis that ferritin might be not representative of iron overload.A superconducting quantum interference device (SQUID) was used to make direct noninvasive magnetic measurements of nonheme hepatic iron (...) content in 40 dialysis patients treated with intravenous iron, and liver iron content was compared with biochemical markers of iron status.Only 12/40 (30%) patients showed normal hepatic iron content (SQUID <400 microg/g), while 32.5% had mild (400 to 1000 microg/g) and 37.5% severe (>1000 microg/g) iron overload, although 28/40 patients (70%) had serum ferritin below 500 microg/L. Among many parameters, hepatic iron content was only correlated with ferritin (r= 0.324, P= 0.04). The receiver operating

2004 Kidney International

5778. Serum ferritin levels are increased in patients with glomerular diseases and proteinuria. Full Text available with Trip Pro

Serum ferritin levels are increased in patients with glomerular diseases and proteinuria. Ferritin is a high molecular weight protein which reflects body iron stores, but may also rise in the case of an acute phase response. Recently, ferritin has been identified as a predictive factor in the development and progression of atherosclerosis. This is the first report on serum ferritin levels in patients with proteinuria.We have analysed the data of 142 male patients with a glomerular disease (...) , and proteinuria exceeding 1 g/day. In all patients, we measured various parameters related to proteinuria, serum ferritin and serum iron. Serum beta2-microglobulin and the Modification of Diet in Renal Disease (MDRD) equation were used as measures of the glomerular filtration rate (GFR).Mean age (+/-SD) was 46+/-15 years, MDRD-GFR 57+/-25 ml/min/1.73 m2 and median proteinuria 8.0 g/day [interquartile range (IQR) 3.6-13]. Serum albumin (29+/-9 g/l) and transferrin levels (1.7+/-0.5 g/l) were low

2004 Transplantation

5779. Association between serum ferritin and measures of inflammation, nutrition and iron in haemodialysis patients. (Abstract)

Association between serum ferritin and measures of inflammation, nutrition and iron in haemodialysis patients. Serum ferritin is a frequently used marker of iron status in dialysis patients. Iron administration is to be withheld for ferritin values >800 ng/ml according to K/DOQI guidelines. We hypothesized that such non-iron-related factors as elements of the malnutrition-inflammation complex syndrome (MICS) may increase serum ferritin concentration independently of iron status.We studied 82 (...) ferritin levels were increased across SGA categories: (ANOVA P-value 0.03). Both unadjusted and multivariate adjusted correlation coefficients (r) for serum ferritin and CRP vs pertinent values were statistically significant for DMS and MIS and some other measures of nutritional status and iron indices. After deleting 10 MHD patients with either iron deficiency (ferritin <200 ng/ml) or iron overload (ferritin >2000 ng/ml), in the remaining 72 MHD patients both bivariate and multivariate correlations

2004 Transplantation

5780. Assessing iron status: beyond serum ferritin and transferrin saturation. Full Text available with Trip Pro

Assessing iron status: beyond serum ferritin and transferrin saturation. The increasing prevalence of multiple comorbidities among anemic patients with chronic kidney disease has made the use of serum ferritin and transferrin saturation more challenging in diagnosing iron deficiency. Because serum ferritin is an acute-phase reactant and because the inflammatory state may inhibit the mobilization of iron from reticuloendothelial stores, the scenario of patients with serum ferritin >800 ng/ml (...) , suggesting iron overload, and transferrin saturation <20%, suggesting iron deficiency, has become more common. This article revisits the basis for the Kidney Disease Outcomes Quality Initiative recommendations regarding the use of serum ferritin and transferrin saturation in guiding iron therapy, then explores some of the newer alternative markers for iron status that may be useful when serum ferritin and transferrin saturation are insufficient. These newer tests include reticulocyte hemoglobin content

2006 Clinical Journal of the American Society of Nephrology

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