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Serum Ferritin

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5741. The clinical relevance of ferritin concentration in the cerebrospinal fluid. Full Text available with Trip Pro

The clinical relevance of ferritin concentration in the cerebrospinal fluid. By means of a new technique (Particle Counting Immunoassay), we have determined the level of ferritin in 470 samples of cerebrospinal fluid of patients with various neurological disorders. The median value obtained in a control group was 2.3 ng/ml with an upper limit at 5.5 ng/ml. the concentrations in the serum and cerebrospinal fluid were independent, but that in cerebrospinal fluid correlated with its total protein (...) content. High values of ferritin were found in infectious meningo-encephalitis, in vascular diseases of the central nervous system, and, unexpectedly, in several cases of dementia without obvious vascular pathology.

1981 Journal of neurology, neurosurgery, and psychiatry

5742. A novel immunoradiometric assay for human liver ferritin. Full Text available with Trip Pro

A novel immunoradiometric assay for human liver ferritin. Rivanol, the cationic salt of an acridine base, has been used as a novel separation procedure in an immunoradiometric assay for human liver ferritin. The separation step is based on the differences in charge and molecular weight between the labelled antibody-ferritin complex and free labelled immunoglobulins. The resultant assay is simple, reproducible and sufficiently sensitive to determine serum concentrations of ferritin.

1983 Journal of Clinical Pathology

5743. Distribution of ferritin, transferrin and lactoferrin in breast carcinoma tissue. Full Text available with Trip Pro

. Transferrin was found inconsistently in myoepithelial cells surrounding normal ductules, or around neoplastic ducts of ductal in situ carcinoma. In eight carcinoma cases, transferrin staining was also positive in neoplastic cells. Lactoferrin was detected only in normal breast epithelial cells and in benign breast proliferative lesions. These immunohistochemical findings may suggest that raised serum ferritin concentrations in breast carcinoma patients might be attributed to stromal reaction rather than (...) Distribution of ferritin, transferrin and lactoferrin in breast carcinoma tissue. An immunoperoxidase staining technique was used for detecting three major iron binding proteins (ferritin, transferrin and lactoferrin) in 40 breast carcinoma cases and six benign breast proliferative lesions. Ferritin staining was detected mainly in connectival stroma and in histiocytes surrounding neoplastic cells. Few and faint ferritin positivities were also detected in neoplastic cells of 20 carcinoma cases

1984 Journal of Clinical Pathology

5744. Erythrocyte ferritin concentration in patients with myelodysplastic syndromes. Full Text available with Trip Pro

Erythrocyte ferritin concentration in patients with myelodysplastic syndromes. 3968206 1985 03 05 2018 11 13 0021-9746 38 1 1985 Jan Journal of clinical pathology J. Clin. Pathol. Erythrocyte ferritin concentration in patients with myelodysplastic syndromes. 113-4 Peters S W SW May S J SJ Jacobs A A eng Letter England J Clin Pathol 0376601 0021-9746 9007-73-2 Ferritins AIM IM Adult Aged Anemia, Aplastic blood Anemia, Sideroblastic blood Bone Marrow Diseases blood Erythrocytes metabolism (...) Ferritins blood Humans Middle Aged 1985 1 1 1985 1 1 0 1 1985 1 1 0 0 ppublish 3968206 PMC499085 Br J Haematol. 1983 Feb;53(2):211-6 6821650 Blood. 1984 Feb;63(2):314-8 6692037

1985 Journal of Clinical Pathology

5745. The lens in hereditary hyperferritinaemia cataract syndrome contains crystalline deposits of L-ferritin Full Text available with Trip Pro

The lens in hereditary hyperferritinaemia cataract syndrome contains crystalline deposits of L-ferritin Hereditary hyperferritinaemia cataract syndrome (HHCS) is an autosomal dominant disorder characterised by elevated serum L-ferritin and bilateral cataracts. The ocular manifestations of this disorder are poorly studied. This study therefore sought to determine the origin of cataracts in HHCS.L-ferritin ELISA, immunohistochemical and ultrastructural analysis of a lens nucleus from an HHCS (...) individual.The HHCS lens L-ferritin content was 147 microg/g dry weight of lens compared with <16 microg/g for a non-HHCS control cataract lens. The cataract comprised discrete crystalline inclusions with positive staining with anti-L-ferritin but not anti-H-ferritin.This unusual finding of crystalline opacities in the lens may be unique to HHCS and is likely to result from disturbed metabolism of L-ferritin within the lens or an abnormal interaction between L-ferritin and lens proteins.

2000 The British journal of ophthalmology

5746. Ferritin, finger clubbing, and lung disease. Full Text available with Trip Pro

Ferritin, finger clubbing, and lung disease. The serum ferritin concentration has been determined by an immunoradiometric assay in 90 subjects with a variety of pulmonary diseases. No association between ferritin concentrations and finger clubbing has been found in any of the diseases studied. Ferritin levels were significantly raised in the subjects with bronchial carcinoma, but were not useful in monitoring recurrence of the tumour. Pulmonary artery and pulmonary vein ferritin concentrations (...) were similar to systemic venous concentrations. It is therefore unlikely that the tumour releases ferritin into the pulmonary circulation. Ferritin levels were raised in patients with acute pneumonias but did not correlate with the total white cell count or erythrocyte sedimentation rate. Serum ferritin concentrations were also increased in a variety of chronic lung diseases but were normal in subjects with asbestosis.

1981 Thorax

5747. Synovial fluid ferritin in rheumatoid arthritis. Full Text available with Trip Pro

Synovial fluid ferritin in rheumatoid arthritis. 7427414 1981 01 29 2018 11 13 0007-1447 281 6242 1980 Sep 13 British medical journal Br Med J Synovial fluid ferritin in rheumatoid arthritis. 715-6 Blake D R DR Bacon P A PA Eastham E J EJ Brigham K K eng Journal Article England Br Med J 0372673 0007-1447 9007-73-2 Ferritins AIM IM Arthritis, Rheumatoid blood metabolism Ferritins metabolism Humans Osteoarthritis metabolism Synovial Fluid metabolism 1980 9 13 1980 9 13 0 1 1980 9 13 0 0 ppublish

1980 British medical journal

5748. Absorbed aluminium is found with two cytosolic protein fractions, other than ferritin, in the rat duodenum. Full Text available with Trip Pro

proteins. Both were heat stable at 60 degrees C and had molecular sizes of about 700 (kilo daltons) (kD) and 17 kD respectively. The larger molecule was distinct from ferritin. Neither molecule associated with 59Fe nor 45Ca. It is suggested that the aluminium peaks are relatively specific aluminium binding proteins that have a scavenging role, reducing entry of the metal from the intestinal contents into the portal blood. (...) Absorbed aluminium is found with two cytosolic protein fractions, other than ferritin, in the rat duodenum. After in vivo perfusion of the upper intestine of the rat with a range of concentrations of aluminium chloride, entry of the metal into the portal system was only detected when the perfusate exceeded 400 mumol/l, suggesting a mucosal block. Using gel filtration of a mucosal cytosol extract, two consistently appearing aluminium peaks were identified which may represent aluminium binding

1993 Gut

5749. Placental ferritin in coeliac disease: relation to clinical stage, origin, and possible role in the pathogenesis of malignancy. Full Text available with Trip Pro

Placental ferritin in coeliac disease: relation to clinical stage, origin, and possible role in the pathogenesis of malignancy. Placental ferritin is a tumour associated antigen present in the serum of patients with active Hodgkin's and non-Hodgkin's lymphoma, and the serum values fall during remission of the disease. There is no correlation between placental and total blood ferritin values. Because of the strong association between coeliac disease and lymphoma, 19 children with active and 25 (...) with inactive coeliac disease were screened for the presence of placental ferritin. Thirty two children with other intestinal disorders served as controls. Placental ferritin was identified by using a monoclonal antibody in an ELISA procedure. The mean (SEM) placental ferritin value in the control serum was 12.6 (2.4) while the values in serum of patients with active and inactive coeliac disease were 117 (22.8) and 43.8 (10.2) U/ml respectively. Patients with active coeliac disease differed significantly

1991 Gut

5750. Macromolecular charge and reticuloendothelial function: comparison between the kinetics of administered native and cationized ferritins and the corresponding immune complexes in the mouse. Full Text available with Trip Pro

hr whereas the latter persisted in the circulation at 24 hr. This was associated with a significant increase in the uptake of NF by the liver, spleen, and kidney. No differences were observed in blood cell-associated radioactivity. Immunohistochemical studies confirmed the presence of increased amounts of NF in Kupffer cells and splenic phagocytes. Thus, the uptake of ferritin by components of the RES is highly dependent upon its pI. The present data may be explained by differences (...) Macromolecular charge and reticuloendothelial function: comparison between the kinetics of administered native and cationized ferritins and the corresponding immune complexes in the mouse. In order to evaluate the role of macromolecular charge on uptake by the reticuloendothelial system (RES), kinetic studies were carried out following the intravenous administration of 125I-labelled native ferritin (NF, pI 4.5) or cationized ferritin (CF, pI 7) to Swiss-Webster female mice subsequently killed

1984 Immunology

5751. Pleural fluid ferritin concentrations in human disease. Full Text available with Trip Pro

Pleural fluid ferritin concentrations in human disease. The concentration of ferritin was measured in the pleural fluid of 108 patients with pleural effusions. In all groups of patients the ferritin concentration was higher in pleural fluid than in serum. The greatest differences, with up to 100 times more ferritin in the pleural fluid, were found for patients with rheumatoid pleurisy, malignant effusions, and empyema. In patients with non-malignant inflammatory pleural effusions (...) the concentration of ferritin in pleural fluid correlated significantly with other pleural fluid indices of inflammation: there was a positive correlation with lactate dehydrogenase activity and a negative correlation with concentrations of glucose and complement components C3 and C4. Ferritin was detected immunocytochemically only in the macrophages found among the pleural fluid cells. Our study shows that large amounts of ferritin accumulate locally in the pleural cavity in certain types of pleural

1985 Journal of Clinical Pathology

5752. Superoxide-dependent and -independent mechanisms of iron mobilization from ferritin by xanthine oxidase. Implications for oxygen-free-radical-induced tissue destruction during ischaemia and inflammation. Full Text available with Trip Pro

Superoxide-dependent and -independent mechanisms of iron mobilization from ferritin by xanthine oxidase. Implications for oxygen-free-radical-induced tissue destruction during ischaemia and inflammation. Xanthine oxidase is able to mobilize iron from ferritin. This mobilization can be blocked by 70% by superoxide dismutase, indicating that part of its action is mediated by superoxide (O2-). Uric acid induced the release of ferritin iron at concentrations normally found in serum. The O2 (...) (-)-independent mobilization of ferritin iron by xanthine oxidase cannot be attributed to uric acid, because uricase did not influence the O2(-)-independent part and acetaldehyde, a substrate for xanthine oxidase, also revealed an O2(-)-independent part, although no uric acid was produced. Presumably the amount of uric acid produced by xanthine oxidase and xanthine is insufficient to release a measurable amount of iron from ferritin. The liberation of iron from ferritin by xanthine oxidase has important

1986 Biochemical Journal

5753. Macrophage ferritin and iron deposition in the rat air pouch model of inflammatory synovitis. Full Text available with Trip Pro

challenge the (apo)ferritin containing macrophages are most numerous seven days after antigenic challenge when there is active connective tissue proliferation and a generalised mononuclear cell response in the pouch wall, suggesting that (apo)ferritin is produced in macrophages as part of the tissue inflammatory response. In contrast with control tissue, where there is a steady decrease in positive cells over the ensuing weeks, injection of blood into both single and double challenge air pouches (...) produces a significant (p less than 0.001) and continuing rise in the numbers of ferritin containing macrophages after day 7. Also, after 14 days Perls' positive ferric iron is detectable in increasing numbers of ferritin containing macrophages, a trend which is more marked in double challenge, blood injected air pouches. The histological data clearly show that there is a close relation between the presence of Perls' iron and proliferation of vascular and connective tissue elements in the pouch wall

1987 Annals of the Rheumatic Diseases

5754. Usefulness of erythrocyte ferritin analysis in hereditary hemochromatosis. Full Text available with Trip Pro

available from the literature were included. Likelihood analysis was used to evaluate the diagnostic value of erythrocyte ferritin analysis alone and in combination with serum ferritin testing. An erythrocyte ferritin value of 150 ag/cell or higher combined with a serum ferritin level above the 90th percentile indicated homozygosity, whereas a value of less than 150 ag/cell and a serum ferritin level at or below the 90th percentile indicated that homozygosity could be ruled out with a high degree (...) of confidence. The probability of heterozygosity rose to 92% when the erythrocyte ferritin value was between 29 and 149 ag/cell and to 98% when this result was combined with a serum ferritin level at or below the 90th percentile. Erythrocyte ferritin analysis in combination with serum ferritin testing is useful for identifying homozygotes and a proportion of heterozygotes in families affected with hemochromatosis.

1987 CMAJ: Canadian Medical Association Journal

5755. Association of increased levels of heavy-chain ferritin with increased CD4+ CD25+ regulatory T-cell levels in patients with melanoma. (Abstract)

Association of increased levels of heavy-chain ferritin with increased CD4+ CD25+ regulatory T-cell levels in patients with melanoma. We have shown previously that melanoma cells in culture release heavy-chain ferritin (H-Ferritin) into supernatants and that this is responsible for the suppression of responses of peripheral blood lymphocytes stimulated by anti-CD3. These effects were mediated by activation of regulatory T cells to produce interleukin (IL)-10. In the present study, we examined (...) whether a similar relation might exist between levels of H-Ferritin and activation of regulatory T cells in patients with melanoma. Ferritin levels were evaluated by ELISA and regulatory T-cell numbers were assessed by three-color flow cytometry to identify CD4(+) CD25(+) CD69(-) T cells. CD69 positive cells were excluded to avoid inclusion of normal activated CD4, CD25 expressing T cells. Measurements of H- and light-chain (L)-Ferritin by ELISA revealed that H- but not L-Ferritin was elevated

2003 Clinical Cancer Research

5756. A 13 year old patient has been told his father has haemachromatosis. Is this age too early to screen for the disease in my patient, using serum ferritin level and iron binding capacity?

storage status. Children ages 2-18 years should be monitored every 2-3 years with an iron profile if they have a diagnosed blood relative with hereditary hemochromatosis/iron overload….” [4] A search in the Medline databases found no information on the sensitivity and specificity of serum ferritin and iron binding capacity tests in children and adolescents for hereditary haemochromatosis. References 1. British Society for Haematology. Genetic haemochromatosis. February 2000. ( ) 2. Sfeir H (...) A 13 year old patient has been told his father has haemachromatosis. Is this age too early to screen for the disease in my patient, using serum ferritin level and iron binding capacity? A 13 year old patient has been told his father has haemachromatosis. Is this age too early to screen for the disease in my patient, using serum ferritin level and iron binding capacity? - Trip Database or use your Google+ account Turning Research Into Practice ALL of these words: Title only Anywhere

2007 TRIP Answers

5757. Often serum ferritin is normal but serum iron is low. How can we interpret this?

deficiency and iron deficient anaemia (IDA). These sources appear to suggest many of these tests, particularly if used alone, i.e. iron serum level, haemoglobin and serum ferritin level have diagnostic limitations. The PRODIGY guidance on iron deficient anaemia section on diagnosing IDA outlines appropriate investigations and their limitations: • “ Full blood count: o Low haemoglobin (Hb) concentration, less than 13 g/dl for men and less than 12 g/dl for women o Low MCV, MCH, and MCHC (mean cell volume (...) , mean cell Hb, mean cell Hb concentration) o Reticulocyte count low for the degree of anaemia o There may be a mild thrombocytosis (raised platelet concentration) • Blood film: microcytic hypochromic red cells, with occasional target cells and pencil-shaped poikilocytes. • Serum ferritin level: low (an indicator of reduced body-iron stores). However, as ferritin is an acute-phase protein, levels may be normal or elevated in infective, inflammatory or malignant disease despite iron deficiency. Serum

2006 TRIP Answers

5758. Serum ferritin is usually the preferred test when looking for the cause of anaemia when iron deficiency is suspected. Is there a circumstance where it is better to do serum iron and total iron binding

Serum ferritin is usually the preferred test when looking for the cause of anaemia when iron deficiency is suspected. Is there a circumstance where it is better to do serum iron and total iron binding Serum ferritin is usually the preferred test when looking for the cause of anaemia when iron deficiency is suspected. Is there a circumstance where it is better to do serum iron and total iron binding capacity?. - Trip Database or use your Google+ account Find evidence fast ALL of these words (...) @tripdatabase.com Serum ferritin is usually the preferred test when looking for the cause of anaemia when iron deficiency is suspected. Is there a circumstance where it is better to do serum iron and total iron binding capacity?. There is a consensus that serum ferritin should be used to confirm a diagnosis of iron deficiency anaemia (IDA) in patients without concomitant disease. However, we found little information on when it is preferable to do a serum iron and total iron binding capacity (TIBC) over a serum

2007 TRIP Answers

5759. Successful treatment with lamivudine may correlate with reduction of serum ferritin levels in the patients with chronic hepatitis and liver cirrhosis type B Full Text available with Trip Pro

Successful treatment with lamivudine may correlate with reduction of serum ferritin levels in the patients with chronic hepatitis and liver cirrhosis type B To study the changes in serum ferritin levels in lamivudine (LAM)-treated patients with chronic hepatitis and liver cirrhosis type B and determine whether successful treatment with LAM results in a reduction of serum ferritin levels.Thirty patients with chronic hepatitis B virus (HBV) infection were followed prospectively during (...) their treatment with LAM for 12 months. Serum HBV DNA, ferritin levels, and emergence of YMDD mutants were monitored. A case of severe liver cirrhosis with hepatic hemosiderosis that was treated successfully with LAM also is shown as a representative case.Serum alanine aminotransferase and ferritin levels decreased significantly more in the patients treated with LAM without YMDD mutants (n = 23) than those with mutants (n = 7). Hepatic hemosiderosis along with serum iron markers improved greatly

2008 Hepatology International

5760. Serum Ferritin and Metal Levels as Risk Factors for Amyotrophic Lateral Sclerosis Full Text available with Trip Pro

Serum Ferritin and Metal Levels as Risk Factors for Amyotrophic Lateral Sclerosis Metal toxicity has been identified as a possible risk factor for amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders. We conducted a retrospective chart review of urinary, hair and blood metal levels and serum ferritin in 321 people with ALS seen over a ten-year period at the Massachusetts General Hospital (MGH). We found that hair lead levels and serum ferritin levels were elevated in ALS (...) patients compared to published normal values. Metal levels of arsenic, lead, mercury, cadmium, thallium, cobalt and aluminum in 24-hour urine specimens and lead, mercury and arsenic in serum were within the normal range. We conclude that twenty-four hour urine or blood testing for metals is not warranted as part of the evaluation of ALS. Elevated levels of serum ferritin in ALS population could reflect an underlying perturbation in iron metabolism.

2008 The open neurology journal

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