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Serum Ferritin

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5741. Iron supplementation for menstruating female blood donors. (Abstract)

requested to donate every 8 weeks for at least 1 year. Blood samples were taken on each donation for measurements of hemoglobin, total iron binding capacity (TIBC), and ferritin. In the two groups taking iron supplements hemoglobin and ferritin increased from baseline values and the TIBC decreased. The vitamin C control group showed decreases from baseline for hemoglobin and ferritin and increases in TIBC. Differences between groups taking iron supplements and the group not taking supplements were (...) Iron supplementation for menstruating female blood donors. Depletion of body iron stores is a major factor limiting regular blood donations by menstruating females. To determine if regular iron supplementation would solve this problem, we conducted a double-blind study in which menstruating female donors were randomly placed into one of three groups: one taking 39 mg elemental iron, a second taking 39 mg of iron plus 75 mg vitamin C, and a third taking 100 mg vitamin C daily. The women were

1985 Transfusion Controlled trial quality: uncertain

5742. [The effect of vitamin, macro and microelement supplementation on markers of iron status in blood of pregnant women]. (Abstract)

. In serum of umbilical cord blood concentration of total iron, transferin and ferritin were similar in newborns of both groups of mothers. The above results suggested that vitamin, macro and microelement supplementation of pregnant women improved iron status in mothers and in their children. It seems that administration Vibovitmama formula can be recommended as a dietary supplement in pregnancy in order to prevent subclinical deficiency of iron. (...) trimester in comparison to the I trimester by 38% (p < 0.0001) and by 55% (p < 0.0001) respectively in non supplemented and supplemented groups were found. It was accompanied by significant increase of total iron-binding capacity (TIBC) (p < 0.0001). In both studied groups the level of ferritin was lower in the III than in the I trimester. In serum of women without supplementation, ferritin concentration decreased by 35% (p < 0.003); whereas in supplemented group it was statistically insignificant

2004 Przegla̧d lekarski Controlled trial quality: uncertain

5743. Protective effect of vitamin C on 8-hydroxy-2'-deoxyguanosine level in peripheral blood lymphocytes of chronic hemodialysis patients. Full Text available with Trip Pro

Protective effect of vitamin C on 8-hydroxy-2'-deoxyguanosine level in peripheral blood lymphocytes of chronic hemodialysis patients. This study focused on the effect of vitamin C on the 8-hydroxy-2'-deoxyguanosine (8-OHdG) level of cellular DNA, as well as 8-oxoguanine-DNA glycosylase 1 (hOGG1) and human MutT homologue (hMTH1) gene expression in peripheral blood lymphocytes of chronic hemodialysis patients.Sixty chronic hemodialysis patients (35 men and 25 women) were recruited to participate (...) in a randomized, placebo-controlled study. Treatment order is block-randomized with intravenous sodium ascorbate (vitamin C, 300 mg) or placebo (0.9% saline), administered postdialysis three times a week. We evaluated 8-OHdG level, intracellular reactive oxygen species (ROS) production, and gene expression of hOGG1 and hMTH1 in peripheral blood lymphocytes by using high-performance liquid chromatography (HPLC) electrochemical detection method, flow cytometric analysis, and reverse transcription-polymerase

2004 Kidney international Controlled trial quality: uncertain

5744. Gastrointestinal symptoms and blood indicators of copper load in apparently healthy adults undergoing controlled copper exposure. Full Text available with Trip Pro

corpuscular volume, serum ferritin, and liver enzyme activities were measured.The percentage of subjects reporting gastrointestinal symptoms was higher in the 6-mg Cu group than in the <0.01-mg Cu group (P < 0.02). One hundred ninety-five subjects fulfilled the inclusion criteria for the blood studies. Although a significant relation between copper intake and total gastrointestinal symptoms was observed, no relation was found between copper intake or reported symptoms and copper-load (...) healthy adults in whom acute gastrointestinal symptoms (nausea, vomiting, diarrhea, and abdominal pain) were assessed as responses to copper exposure (<0.01, 2, 4, or 6 mg/L water). Blood markers were measured in 240 participants at the end of the survey. Subjects with anemia, inflammation, or infection were excluded. Serum and erythrocyte copper, peripheral mononuclear cell copper, serum ceruloplasmin, the nonceruloplasmin bound copper fraction, superoxide dismutase activity, hemoglobin, mean

2003 The American journal of clinical nutrition Controlled trial quality: uncertain

5745. Antioxidant diet supplementation influences blood iron status in endurance athletes. (Abstract)

/d). The study was double blind. Hematological parameters, dietary intake, physical activity intensity, antioxidant status (GSH/GSSG ratio), and basal iron status (serum iron, transferrin, ferritin, and iron saturation index) were determined before and after the intervention trials.Exercise decreased antioxidant defenses in the placebo group but not in the antioxidant-supplemented group. No changes were found in the number of erythrocytes, hematocrit, or hemoglobin concentration, or in values (...) Antioxidant diet supplementation influences blood iron status in endurance athletes. The aim of this work was to check the effects of antioxidant supplementation (vitamins E and C, and beta-carotene) on the basal iron status of athletes prior to and following their training and competition season (3 months).Eighteen amateur trained male athletes were randomly distributed in 2 groups: placebo (lactose) and antioxidant supplemented (vitamin E, 500 mg/d; vitamin C, 1 g/d; and beta -carotene, 30 mg

2004 International journal of sport nutrition and exercise metabolism Controlled trial quality: uncertain

5746. Identification of blood erythroid markers useful in revealing erythropoietin abuse in athletes. (Abstract)

in the blood of 18 volunteers upon rEpo administration. Different rEpo regimens, iron, folic acid, and vitamin B12 administration did not significantly modify the percentage increase in hematocrit. However, a significant decrease in circulating ferritin (fr) and an increase in the soluble transferrin receptor (sTfr) were not found in athletes receiving low (30 IU/kg) doses of rEpo. Thus, an increase in the sTfr/fr ratio cannot be used as an indicator of rEpo abuse, at least when the hormone is administered (...) Identification of blood erythroid markers useful in revealing erythropoietin abuse in athletes. Recombinant human erythropoietin (rEpo) is being used with increasing frequency by endurance athletes to improve aerobic potential. Although rEpo administration has been banned by the International Olympic Committee, no methods are available to unequivocally detect its abuse in sports. Prompted by these considerations, we evaluated the main hematological and biochemical modifications measured

2001 Blood cells, molecules & diseases Controlled trial quality: uncertain

5747. Daily doses of 20 mg of elemental iron compensate for iron loss in regular blood donors: a randomized, double-blind, placebo-controlled study. (Abstract)

of elemental iron as ferrous gluconate for a period of 6 months, during which one unit of whole blood was collected on four occasions (males) or three occasions (females). Hemoglobin level, serum ferritin, and soluble transferrin receptor levels were measured before each donation.Daily doses of either 40 mg or 20 mg of elemental iron adequately compensated for iron loss in males, who gave blood at 2-month intervals, but did not result in a positive iron balance or an increase in storage iron as reflected (...) Daily doses of 20 mg of elemental iron compensate for iron loss in regular blood donors: a randomized, double-blind, placebo-controlled study. A considerable number of regular blood donors develops an iron deficiency, and the exact amount of iron required to compensate for the iron loss from whole-blood donation in males and females is still unknown.A total of 526 regular blood donors (289 male and 237 female) were randomly assigned to treatment with either 40 mg, 20 mg, or 0 mg per day

2004 Transfusion Controlled trial quality: uncertain

5748. Iron supplementation and 2-unit red blood cell apheresis: a randomized, double-blind, placebo-controlled study. (Abstract)

to receive 100 mg of iron(II) or placebo daily. Group A received iron capsules after the first three donations, and Group B after the second three donations, respectively. Hemoglobin, serum ferritin, and serum iron were measured before each donation.Mean serum ferritin concentration decreased after each donation in the placebo phase of both treatment groups, but it remained largely constant during the iron phase in Group A, and even increased during the iron phase in Group B.Regular iron supplementation (...) Iron supplementation and 2-unit red blood cell apheresis: a randomized, double-blind, placebo-controlled study. The benefits of 2-unit red blood cell (RBC) apheresis are evident, but iron depletion may be a limiting factor in using this technology. Regular iron supplementation may allow a better utilization of this technique.In this study, 260 regular blood donors donated 2-unit RBCs on each of a total of seven visits at intervals of 8 to 10 weeks. The volunteers were randomly assigned

2004 Transfusion Controlled trial quality: uncertain

5749. Assessment of menstrual blood loss in women with ideopathic menorrhagia using the frameless levonorgestrel-releasing intrauterine system. (Abstract)

Assessment of menstrual blood loss in women with ideopathic menorrhagia using the frameless levonorgestrel-releasing intrauterine system. This study was conducted to evaluate the effect of a "low-dose" levonorgestrel (LNG)-releasing intrauterine system (IUS) on the amount of menstrual blood loss (MBL) in women with ideopathic menorrhagia.Menstrual blood loss was assessed with the visual assessment technique in 12 Belgian FibroPlant-LNG users with menorrhagia. In addition, ferritin levels were (...) measured.The median MBL, evaluated by the visual scoring technique, decreased by more than 90%. The ferritin levels increased significantly during treatment with the levonorgestrel system.This study confirms previous MBL studies conducted with the FibroPlant-LNG IUS demonstrating the efficacy of the LNG-IUS to significantly reduce the amount of MBL in women with menorrhagia. The strong endometrial suppression is the principal mechanism explaining the effect on MBL. The therapeutic effect

2004 Contraception

5750. Assessment of menstrual blood loss in Brazilian users of the frameless copper-releasing IUD with copper surface area of 330 mm2 and the frameless levonorgestrel-releasing intrauterine system. (Abstract)

Assessment of menstrual blood loss in Brazilian users of the frameless copper-releasing IUD with copper surface area of 330 mm2 and the frameless levonorgestrel-releasing intrauterine system. This study was conducted to evaluate the effect of two types of IUDs on the amount of menstrual blood loss (MBL): the frameless copper-releasing intrauterine device (IUD) with copper surface area of 330 mm2 (GyneFix; Contrel Research, Ghent, Belgium) and the frameless levonorgestrel (LNG)-releasing (...) intrauterine system (IUS) releasing 14 microg per day (FibroPlant-LNG; Contrel Research). Heavy and abnormal MBL is the main reason for discontinuation of intrauterine devices.In 20 Brazilian women using GyneFix 330 and 32 using FibroPlant-LNG, respectively, MBL was measured by the quantitative alkaline hematin technique. In addition, ferritin levels were measured in GyneFix 330 and FibroPlant-LNG users.MBL with GyneFix 330, measured over a 24-month period, increased but was less when compared with TCu380A

2004 Contraception

5751. Menorrhagia I: measured blood loss, clinical features, and outcome in women with heavy periods: a survey with follow-up data. (Abstract)

heavy periods who also had consented to the measurement of their blood loss.Only 34% (95% CI, 28%-40%) of women had blood loss volume of >80 mL, but the volume was associated with subjective heaviness of period. Logistic regression with ferritin status, clots, and changing rate during full flow correctly predicts a loss of >80 mL for 76% of women (n=161 patients; sensitivity, 60%; specificity, 86%). Diagnosis and treatment of patients seem unrelated to the volume of blood loss.The subjective (...) Menorrhagia I: measured blood loss, clinical features, and outcome in women with heavy periods: a survey with follow-up data. Menorrhagia is defined as blood loss of >80 mL, but in routine clinical practice measurement is seldom undertaken. Our aim was to identify the features of the clinical history that best predict menorrhagic blood loss.A questionnaire survey of 952 menstrual complaint referrals at 3 hospital gynecology clinics in Glasgow and Edinburgh included 226 women with putatively

2004 American Journal of Obstetrics and Gynecology

5752. White blood cells as a novel mortality predictor in haemodialysis patients. (Abstract)

White blood cells as a novel mortality predictor in haemodialysis patients. Many conventional cardiovascular risk factors in the general population are not as predictive in end-stage renal disease (ESRD). As absolute neutrophil count and total white blood cell (WBC) count are associated with adverse cardiovascular outcomes and all-cause mortality, this analysis was undertaken to explore the associations of WBC variables with mortality risk in ESRD.Of a total study population of 44 114 ESRD (...) patients receiving haemodialysis during 1998 at facilities operated by Fresenius Medical Care, North America, 25 661 patients who underwent differential white cell count and had complete follow-up were included. Information on case mix (age, gender, race), clinical (diabetes, body mass index), and laboratory variables (haematocrit, albumin, creatinine, potassium, calcium, phosphorus, bicarbonate, ferritin, transferrin saturation and differential WBC count) was obtained. Associations between lymphocyte

2003 Transplantation

5753. Elevation of blood thioredoxin in hemodialysis patients with hepatitis C virus infection. Full Text available with Trip Pro

Elevation of blood thioredoxin in hemodialysis patients with hepatitis C virus infection. Thioredoxin (TRX) is a stress-inducible thiol-containing protein, which has been shown to be an indicator of oxidative stress in a variety of diseases. The association between oxidative stress and hepatitis C virus (HCV) infection, however, remains unknown in hemodialysis patients.We measured serum TRX levels in 85 hemodialysis patients positive for anti-HCV antibodies (age, 60 +/- 1 years old (...) correlated with time on hemodialysis (r = 0.27, P = 0.01) in HCV-positive patients, while it was associated with the patient's age in HCV-negative patients (r = 0.42, P < 0.01). Blood TRX was significantly correlated with asparate aminotransferase in patients with HCV infection (r = 0.34, P < 0.01) and without HCV infection (r = 0.46, P < 0.01). However, serum TRX was not associated with blood alanine aminotransferase, a relatively specific marker of hepatic cellular damage, in HCV-infected hemodialysis

2003 Kidney International

5754. Percentage of hypochromic red blood cells is an independent risk factor for mortality in kidney transplant recipients. Full Text available with Trip Pro

Percentage of hypochromic red blood cells is an independent risk factor for mortality in kidney transplant recipients. There are no published studies on the associations between anemia or iron status parameters and important long-term outcomes in kidney transplant recipients (KTR). We prospectively studied 438 KTR from a large transplant clinic for all-cause mortality and kidney allograft loss. Hemoglobin and iron status parameters (serum iron, transferrin, transferrin saturation, ferritin (...) , percentage of hypochromic red blood cells [%HRBC]) were assessed at baseline as were important demographic, clinical and laboratory characteristics. The Austrian Dialysis and Transplant Registry and the Eurotransplant database were used to ascertain immunological and transplantation-related parameters and to ascertain death and allograft rejection. Cox proportional hazard models were used for analyses. Over 7.8 years of follow-up, 129 deaths (29.5%) occurred and 208 grafts (47.5%) were lost. From

2004 American Journal of Transplantation

5755. Increase in total blood antioxidant status and selenium levels in black patients with active vitiligo. (Abstract)

been performed so far on patients with skin phototype VI (Fitzpatrick classification).To study the blood antioxidant status of black patients with active generalized vitiligo.Randox total antioxidant status, selenium, ferritin, transferrin, ceruloplasmin, tocopherol, and retinol levels were evaluated in blood samples obtained from 11 dark-skinned patients from the French West Indies (Isle of Martinique) with recent active lesions of vitiligo and from 11 age- and sex-matched healthy volunteers.Total (...) blood antioxidant status and selenium levels were significantly increased in vitiligo patients, compared to those in sex- and age-matched controls (P < 0.01 and P < 0.02, respectively). Blood levels of ferritin, transferrin, ceruloplasmin, retinol, and tocopherol were not significantly modified.This is the first report on the global blood antioxidant status in vitiligo. The increase in total blood antioxidant status observed in black patients was an unexpected result that needs to be confirmed

2002 International Journal of Dermatology

5756. Haemochromatosis-associated HFE genotypes in English blood donors: age-related frequency and biochemical expression. (Abstract)

Haemochromatosis-associated HFE genotypes in English blood donors: age-related frequency and biochemical expression. There are limited data on the frequency and biochemical expression of the haemochromatosis-associated mutations C282Y and H63D in healthy people.We genotyped (bi-directional PCR amplification of specific alleles method) and performed serum iron studies in randomly selected English male blood donors (<4 previous units donated) in four age bands <30, 30-40, 40-50 and >50 years.In (...) 6261 subjects, frequency of C282Y homozygosity (+/+) was 0.3%, C282Y/H63D compound heterozygosity (+/-) 2.0%, and H63D and C282Y heterozygosity +/-, 21.7 and 10.4%, respectively. Genotype distribution was within Hardy-Weinberg equilibrium in each age band. C282Y +/- frequency fell from 11.7% in subjects <30 years to 8.2% in subjects >50 (Chi2 7.19; P<0.005). No such trend was seen for C282Y +/+. In C282Y +/+ subjects, median serum ferritin was 247 (range 60-2449) microg/l and exceeded >500 microg/l

2003 Journal of Hepatology

5757. Population screening for hemochromatosis: a study in 5370 Spanish blood donors. (Abstract)

. Serum iron, serum ferritin and transferrin saturation were also measured.We have found eight (five men and three women) blood donors who are C282Y homozygotes (0.15%) and 74 C282Y/H63D compound heterozygotes (1.38%). Four out of the eight C282Y homozygotes, all men, had high serum ferritin and transferrin saturation values. No woman was detected with both iron parameters increased. Only one of the 74 C282Y/H63D compound heterozygotes showed elevated serum ferritin and transferrin saturation values (...) Population screening for hemochromatosis: a study in 5370 Spanish blood donors. Hereditary hemochromatosis is associated with homozygosity for C282Y mutation in the HFE gene, elevated serum transferrin saturation and excess iron deposits throughout the body. We conducted a population-based study in Spain to asses the prevalence of the HFE mutations and their effect on iron parameters.We screened 5370 blood donors for the C282Y and H63D HFE mutations by allele-specific polymerase chain reaction

2003 Journal of Hepatology

5758. Is blood donation induced low iron status associated with favourable levels of OxLDL, s-ICAM-1, sVCAM-1 and vWF-antigen in healthy men. (Abstract)

(circulating oxidised LDL, sICAM-1, sVCAM-1 and vWF-antigen) by comparing healthy male voluntary donors to non-donors, taking into account differences in baseline characteristics. Two fasting blood samples were collected within 1 week from 41 donors and 39 non-donors. The iron status was estimated by measuring the concentration of plasma iron, ferritin, haemoglobin and hematocrit. The markers of iron status were all significantly lower in donors compared to non-donors, especially for ferritin (...) concentrations. However, the lower iron status by blood donation was not reflected in the concentrations of OxLDL, sICAM-1, sVCAM-1 and vWF-antigen in men after adjustment for BMI and ratio total/HDL cholesterol. In order to avoid possible selection-bias related to donorship, we have additionally investigated the difference in marker concentrations within the non-donors, comparing low- and high-ferritin concentrations. This analysis suggests that ferritin concentration is not associated with in vivo LDL

2004 Atherosclerosis

5759. Serum Iron

the day and from day to day. For this reason, serum iron is almost always measured with other , including ferritin, transferrin, and calculated total iron-binding capacity (TIBC) and transferrin saturation. Serum iron tests may be ordered as follow-up tests when results from a show that a person's hemoglobin and hematocrit are low and their red blood cells are smaller and paler than normal ( and ), suggesting even though other clinical symptoms may not have developed yet. Testing may be ordered when (...) tries to compensate by producing more transferrin to increase iron transport. The serum iron level continues to decrease and transferrin and TIBC and UIBC increase. As this stage progresses, fewer and smaller red blood cells are produced, eventually resulting in . Iron overload If the iron level is high, the TIBC, UIBC and ferritin are normal and the person has a clinical history consistent with iron overdose, then it is likely that the person has iron poisoning. Iron poisoning occurs when a large

2004 Lab Tests Online USA

5760. Oral iron therapy reduced unexplained fatigue in non-anaemic women with serum ferritin concentrations 50 µg/l Full Text available with Trip Pro

Oral iron therapy reduced unexplained fatigue in non-anaemic women with serum ferritin concentrations 50 µg/l Oral iron therapy reduced unexplained fatigue in non-anaemic women with serum ferritin concentrations ⩽50 μg/l | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username (...) and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Oral iron therapy reduced unexplained fatigue in non-anaemic women with serum ferritin concentrations ⩽50 μg/l Article Text Therapeutics Oral iron therapy reduced

2005 Evidence-Based Medicine

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