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Serum Ferritin

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5721. Protective effect of tissue ferritins in experimental Escherichia coli infection of mice in vivo. Full Text available with Trip Pro

mouse, the maximum survival rates were 86% (FH), 81% (FM) and 79% (FB), while only 5% of the control mice survived up to the 30th day. The survival rates of animals injected with bovine serum albumin (BSA) and heat-inactivated FB were 8 and 25%, respectively. Intraperitoneal injection of FB was as effective as intravenous in enhancing the resistance of mice against bacteria. These data provide evidence for the beneficial role of tissue ferritins in nonspecific antibacterial resistance. (...) Protective effect of tissue ferritins in experimental Escherichia coli infection of mice in vivo. The effect of ferritins from horse (FH) and bovine (FB) spleen and murine liver (FM) on the survival rate of CFW mice lethally infected with Escherichia coli (strain 8440-78 K 80/B) was evaluated. Ferritins given intravenously 24 h before intravenous inoculation of bacteria, protected mice most effectively from death due to infection. The effect was dose dependent. At 500 micrograms of ferritin per

1991 International journal of experimental pathology

5722. The effects of oral iron supplementation on ferritin levels in pregnant Burmese women. (Abstract)

The effects of oral iron supplementation on ferritin levels in pregnant Burmese women. The usefulness of serum ferritin levels in assessing iron stores in pregnant women before and after supplementation with iron was studied. One hundred thirty-five healthy pregnant women between 22 to 28 wk were randomly allotted to daily dose regimes of 60, 120, or 240 mg of ferrous sulphate. The tablets were given after meals under strict personal supervision. Before supplementation, iron deficiency (...) (ferritin level less than 10 micrograms/L) was present in 54.8% of the pregnant women, compared to an incidence of 17.8% when assessed by serum iron concentration of less than 50 micrograms/dl. The mean ferritin level of pregnant women was 14.15 micrograms/L and was less than one-half that of healthy single women and one-sixth of that of healthy males. Supplementation with oral iron for 12 wk produced an increase in ferritin levels in all the groups, but significant increases were seen only in women

1982 The American journal of clinical nutrition Controlled trial quality: uncertain

5723. [Ferritin level in newborn infants after prepartal iron medication]. (Abstract)

ferritin levels in the 30th week of pregnancy (p less than 0.048), higher levels measured in the cord blood at birth (p less than 0.001), and also the newborn of this group had statistically significant higher serum ferritin levels than the newborn of the control group (p less than 0.001). Our conclusion is that prepartal iron medication leads to increased iron stores in the newborn. (...) [Ferritin level in newborn infants after prepartal iron medication]. Aim of the study was to find out the influence of iron medication of pregnant women on the iron levels of their newborn. In a prospective randomised study the iron-substituted group (n = 57) was treated with 2 x 1 Aktiferrin comp. Kps. (Merckle) during pregnancy, starting from the 22nd week. The control group (n = 46) had no medication during pregnancy. The substituted group had statistically significantly higher serum

1991 Geburtshilfe und Frauenheilkunde Controlled trial quality: uncertain

5724. Decreased ferritin levels, despite iron supplementation, during erythropoietin therapy in anaemia of prematurity. (Abstract)

Decreased ferritin levels, despite iron supplementation, during erythropoietin therapy in anaemia of prematurity. Erythropoietin (rHuEPO) therapy has been shown to be beneficial in preventing and treating anaemia of prematurity and to decrease the need for blood transfusions. There is, however, only scanty data on the effect of rHuEPO therapy on iron metabolism. We studied 29 preterm infants (age 34 +/- 14 days) who were randomly assigned to receive either rHuEPO 900 U kg-1 week-1 with 6 mg kg (...) -1 day-1 of iron for 4 weeks (n = 15) or no therapy. The following parameters were evaluated and compared between and within groups at the beginning, during and at the end of the study: Haematocrit (SI), reticulocytes (10(9) micrograms l-1), serum ferritin (microgram 1-1) and iron (mumol l-1). The results were as follows. At the baseline, erythropoietin levels were similar in both groups: 7.2 +/- 5.6 versus 6.2 +/- 3.2 mU ml-1 (NS). In the treated infants the haematocrit remained stable during

1996 Acta paediatrica (Oslo, Norway : 1992) Controlled trial quality: uncertain

5725. Absorbed aluminium is found with two cytosolic protein fractions, other than ferritin, in the rat duodenum. Full Text available with Trip Pro

proteins. Both were heat stable at 60 degrees C and had molecular sizes of about 700 (kilo daltons) (kD) and 17 kD respectively. The larger molecule was distinct from ferritin. Neither molecule associated with 59Fe nor 45Ca. It is suggested that the aluminium peaks are relatively specific aluminium binding proteins that have a scavenging role, reducing entry of the metal from the intestinal contents into the portal blood. (...) Absorbed aluminium is found with two cytosolic protein fractions, other than ferritin, in the rat duodenum. After in vivo perfusion of the upper intestine of the rat with a range of concentrations of aluminium chloride, entry of the metal into the portal system was only detected when the perfusate exceeded 400 mumol/l, suggesting a mucosal block. Using gel filtration of a mucosal cytosol extract, two consistently appearing aluminium peaks were identified which may represent aluminium binding

1993 Gut

5726. Placental ferritin in coeliac disease: relation to clinical stage, origin, and possible role in the pathogenesis of malignancy. Full Text available with Trip Pro

Placental ferritin in coeliac disease: relation to clinical stage, origin, and possible role in the pathogenesis of malignancy. Placental ferritin is a tumour associated antigen present in the serum of patients with active Hodgkin's and non-Hodgkin's lymphoma, and the serum values fall during remission of the disease. There is no correlation between placental and total blood ferritin values. Because of the strong association between coeliac disease and lymphoma, 19 children with active and 25 (...) with inactive coeliac disease were screened for the presence of placental ferritin. Thirty two children with other intestinal disorders served as controls. Placental ferritin was identified by using a monoclonal antibody in an ELISA procedure. The mean (SEM) placental ferritin value in the control serum was 12.6 (2.4) while the values in serum of patients with active and inactive coeliac disease were 117 (22.8) and 43.8 (10.2) U/ml respectively. Patients with active coeliac disease differed significantly

1991 Gut

5727. The immunosuppressive human placental ferritin subunit p43 is produced by activated CD4+ lymphocytes. Full Text available with Trip Pro

The immunosuppressive human placental ferritin subunit p43 is produced by activated CD4+ lymphocytes. Human placental ferritin is an immunosuppressive protein composed of a 43-kDa subunit (p43) and ferritin light chains. Its physiological action seems to be downregulation of the immune response of the mother against her embryo. Elevated levels of p43 in serum are associated with pregnancy, lymphomas, breast cancer, and AIDS. Although it is known that p43 is produced by activated T lymphocytes (...) , the specific T-lymphocyte subset involved is unknown. p43 is measured by enzyme-linked immunosorbent assays with CM-H-9 monoclonal antibody specific for p43. We studied the de novo biosynthesis of p43 by isolated activated CD4+ and CD8+ T lymphocytes in a normal donor and in a patient with elevated levels of p43 in serum. The results indicated that p43 was synthesized by activated CD4+ lymphocytes from the normal donor (0.45% of the total de novo proteins) but that its biosynthesis by CD8+ lymphocytes

1995 Clinical and Diagnostic Laboratory Immunology

5728. Is increased tissue ferritin a risk factor for atherosclerosis and ischaemic heart disease? Full Text available with Trip Pro

9007-73-2 Ferritins E1UOL152H7 Iron AIM IM Age Factors Arteriosclerosis etiology Diet Female Ferritins metabolism Humans Iron blood Male Myocardial Infarction blood Myocardial Ischemia etiology Myocardial Reperfusion Injury metabolism Risk Factors Sex Factors 1995 3 1 1995 3 1 0 1 1995 3 1 0 0 ppublish 7727177 PMC483799 Circulation. 1994 Jan;89(1):102-8 8281634 Circulation. 1994 Mar;89(3):969-74 8124837 Circulation. 1988 Aug;78(2):442-9 3396180 Circulation. 1991 Mar;83(3):1006-14 1847847 Clin Chim (...) Is increased tissue ferritin a risk factor for atherosclerosis and ischaemic heart disease? 7727177 1995 06 01 2018 11 13 0007-0769 73 3 1995 Mar British heart journal Br Heart J Is increased tissue ferritin a risk factor for atherosclerosis and ischaemic heart disease? 208 Koster J F JF Department of Biochemistry, Erasmus University (Rotterdam), (COEUR), Faculty of Medicine and Health Sciences, Rotterdam, The Netherlands. Sluiter W W eng Journal Article England Br Heart J 0370634 0007-0769

1995 British Heart Journal

5729. Pleural fluid ferritin concentrations in human disease. Full Text available with Trip Pro

Pleural fluid ferritin concentrations in human disease. The concentration of ferritin was measured in the pleural fluid of 108 patients with pleural effusions. In all groups of patients the ferritin concentration was higher in pleural fluid than in serum. The greatest differences, with up to 100 times more ferritin in the pleural fluid, were found for patients with rheumatoid pleurisy, malignant effusions, and empyema. In patients with non-malignant inflammatory pleural effusions (...) the concentration of ferritin in pleural fluid correlated significantly with other pleural fluid indices of inflammation: there was a positive correlation with lactate dehydrogenase activity and a negative correlation with concentrations of glucose and complement components C3 and C4. Ferritin was detected immunocytochemically only in the macrophages found among the pleural fluid cells. Our study shows that large amounts of ferritin accumulate locally in the pleural cavity in certain types of pleural

1985 Journal of Clinical Pathology

5730. Macromolecular charge and reticuloendothelial function: comparison between the kinetics of administered native and cationized ferritins and the corresponding immune complexes in the mouse. Full Text available with Trip Pro

hr whereas the latter persisted in the circulation at 24 hr. This was associated with a significant increase in the uptake of NF by the liver, spleen, and kidney. No differences were observed in blood cell-associated radioactivity. Immunohistochemical studies confirmed the presence of increased amounts of NF in Kupffer cells and splenic phagocytes. Thus, the uptake of ferritin by components of the RES is highly dependent upon its pI. The present data may be explained by differences (...) Macromolecular charge and reticuloendothelial function: comparison between the kinetics of administered native and cationized ferritins and the corresponding immune complexes in the mouse. In order to evaluate the role of macromolecular charge on uptake by the reticuloendothelial system (RES), kinetic studies were carried out following the intravenous administration of 125I-labelled native ferritin (NF, pI 4.5) or cationized ferritin (CF, pI 7) to Swiss-Webster female mice subsequently killed

1984 Immunology

5731. Usefulness of erythrocyte ferritin analysis in hereditary hemochromatosis. Full Text available with Trip Pro

available from the literature were included. Likelihood analysis was used to evaluate the diagnostic value of erythrocyte ferritin analysis alone and in combination with serum ferritin testing. An erythrocyte ferritin value of 150 ag/cell or higher combined with a serum ferritin level above the 90th percentile indicated homozygosity, whereas a value of less than 150 ag/cell and a serum ferritin level at or below the 90th percentile indicated that homozygosity could be ruled out with a high degree (...) of confidence. The probability of heterozygosity rose to 92% when the erythrocyte ferritin value was between 29 and 149 ag/cell and to 98% when this result was combined with a serum ferritin level at or below the 90th percentile. Erythrocyte ferritin analysis in combination with serum ferritin testing is useful for identifying homozygotes and a proportion of heterozygotes in families affected with hemochromatosis.

1987 CMAJ: Canadian Medical Association Journal

5732. Macrophage ferritin and iron deposition in the rat air pouch model of inflammatory synovitis. Full Text available with Trip Pro

challenge the (apo)ferritin containing macrophages are most numerous seven days after antigenic challenge when there is active connective tissue proliferation and a generalised mononuclear cell response in the pouch wall, suggesting that (apo)ferritin is produced in macrophages as part of the tissue inflammatory response. In contrast with control tissue, where there is a steady decrease in positive cells over the ensuing weeks, injection of blood into both single and double challenge air pouches (...) produces a significant (p less than 0.001) and continuing rise in the numbers of ferritin containing macrophages after day 7. Also, after 14 days Perls' positive ferric iron is detectable in increasing numbers of ferritin containing macrophages, a trend which is more marked in double challenge, blood injected air pouches. The histological data clearly show that there is a close relation between the presence of Perls' iron and proliferation of vascular and connective tissue elements in the pouch wall

1987 Annals of the Rheumatic Diseases

5733. Synovial fluid ferritin in rheumatoid arthritis. Full Text available with Trip Pro

Synovial fluid ferritin in rheumatoid arthritis. 7427414 1981 01 29 2018 11 13 0007-1447 281 6242 1980 Sep 13 British medical journal Br Med J Synovial fluid ferritin in rheumatoid arthritis. 715-6 Blake D R DR Bacon P A PA Eastham E J EJ Brigham K K eng Journal Article England Br Med J 0372673 0007-1447 9007-73-2 Ferritins AIM IM Arthritis, Rheumatoid blood metabolism Ferritins metabolism Humans Osteoarthritis metabolism Synovial Fluid metabolism 1980 9 13 1980 9 13 0 1 1980 9 13 0 0 ppublish

1980 British medical journal

5734. Ferritin, finger clubbing, and lung disease. Full Text available with Trip Pro

Ferritin, finger clubbing, and lung disease. The serum ferritin concentration has been determined by an immunoradiometric assay in 90 subjects with a variety of pulmonary diseases. No association between ferritin concentrations and finger clubbing has been found in any of the diseases studied. Ferritin levels were significantly raised in the subjects with bronchial carcinoma, but were not useful in monitoring recurrence of the tumour. Pulmonary artery and pulmonary vein ferritin concentrations (...) were similar to systemic venous concentrations. It is therefore unlikely that the tumour releases ferritin into the pulmonary circulation. Ferritin levels were raised in patients with acute pneumonias but did not correlate with the total white cell count or erythrocyte sedimentation rate. Serum ferritin concentrations were also increased in a variety of chronic lung diseases but were normal in subjects with asbestosis.

1981 Thorax

5735. Superoxide-dependent and -independent mechanisms of iron mobilization from ferritin by xanthine oxidase. Implications for oxygen-free-radical-induced tissue destruction during ischaemia and inflammation. Full Text available with Trip Pro

Superoxide-dependent and -independent mechanisms of iron mobilization from ferritin by xanthine oxidase. Implications for oxygen-free-radical-induced tissue destruction during ischaemia and inflammation. Xanthine oxidase is able to mobilize iron from ferritin. This mobilization can be blocked by 70% by superoxide dismutase, indicating that part of its action is mediated by superoxide (O2-). Uric acid induced the release of ferritin iron at concentrations normally found in serum. The O2 (...) (-)-independent mobilization of ferritin iron by xanthine oxidase cannot be attributed to uric acid, because uricase did not influence the O2(-)-independent part and acetaldehyde, a substrate for xanthine oxidase, also revealed an O2(-)-independent part, although no uric acid was produced. Presumably the amount of uric acid produced by xanthine oxidase and xanthine is insufficient to release a measurable amount of iron from ferritin. The liberation of iron from ferritin by xanthine oxidase has important

1986 Biochemical Journal

5736. Haemoglobin and ferritin concentrations in children aged 12 and 18 months Full Text available with Trip Pro

Haemoglobin and ferritin concentrations in children aged 12 and 18 months To define the normal ranges and investigate associated factors for haemoglobin and ferritin in British children at 12 and 18 months of age, and to estimate correlations between both haemoglobin and ferritin concentrations at 8, 12, and 18 months of age.Subjects were part of the "children in focus" sample, randomly selected from the Avon longitudinal study of pregnancy and childhood. Capillary blood samples were taken from (...) 940 children at 12 months and 827 children at 18 months of age.Haemoglobin was distributed normally and ferritin was distributed log normally at 12 and 18 months of age. Ninety five per cent reference ranges were established from empirical centiles of haemoglobin and ferritin. Haemoglobin concentrations at 18 months were associated with sex and maternal education. Concentrations of ferritin at 12 and 18 months of age were associated with birth weight and current weight. Girls at 12 months

1999 Archives of Disease in Childhood

5737. Reference limits for haemoglobin and ferritin : If it's not broken, don't fix it Full Text available with Trip Pro

Ferritins blood Hemoglobins analysis Humans Reference Values 2001 10 24 10 0 2001 11 3 10 1 2001 10 24 10 0 ppublish 11669079 PMC1121347 J Am Coll Nutr. 2001 Oct;20(5):477-84 11601562 N Z Med J. 2001 Mar 23;114(1128):134-8 11346162 BMJ. 2001 Jun 2;322(7298):1355-7 11387188 Br J Haematol. 2001 Aug;114(2):474-84 11529872 Am J Clin Nutr. 1998 Feb;67(2):271-5 9459375 Annu Rev Nutr. 1986;6:13-40 3524613 Pediatr Res. 1993 Nov;34(5):680-7 8284110 JAMA. 1997 Mar 26;277(12):973-6 9091669 Am J Clin Nutr. 1997 Aug (...) Reference limits for haemoglobin and ferritin : If it's not broken, don't fix it 11669079 2001 11 01 2018 11 13 0959-8138 323 7316 2001 Oct 06 BMJ (Clinical research ed.) BMJ Reference limits for haemoglobin and ferritin. If it's not broken, don't fix it. 806-7; author reply 807-8 Heath A L AL Fairweather-Tait S S Worwood M M eng Comment Letter England BMJ 8900488 0959-8138 0 Biomarkers 0 Hemoglobins 9007-73-2 Ferritins AIM IM BMJ. 2001 Jun 2;322(7298):1355-7 11387188 Biomarkers analysis

2001 BMJ : British Medical Journal

5738. Why should women have lower reference limits for haemoglobin and ferritin concentrations than men? Full Text available with Trip Pro

eng Journal Article England BMJ 8900488 0959-8138 0 Hemoglobins 9007-73-2 Ferritins AIM IM BMJ. 2001 Oct 6;323(7316):807-8 11669080 BMJ. 2001 Oct 6;323(7316):806-7; author reply 807-8 11669079 Anemia, Iron-Deficiency blood Animals Erythrocyte Count Female Ferritins blood Hemoglobins analysis Humans Male Menstruation blood Primates blood Reference Values Sex Characteristics 2001 6 2 10 0 2001 6 29 10 1 2001 6 2 10 0 ppublish 11387188 PMC1120434 Annu Rev Nutr. 1986;6:13-40 3524613 Lancet. 1996 Oct (...) Why should women have lower reference limits for haemoglobin and ferritin concentrations than men? 11387188 2001 06 28 2018 11 13 0959-8138 322 7298 2001 Jun 02 BMJ (Clinical research ed.) BMJ Why should women have lower reference limits for haemoglobin and ferritin concentrations than men? 1355-7 Rushton D H DH School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DT, UK. rushton@btinternet.com Dover R R Sainsbury A W AW Norris M J MJ Gilkes J J JJ Ramsay I D ID

2001 BMJ : British Medical Journal

5739. Zinc protoporphyrin/haem ratio and plasma ferritin in preterm infants Full Text available with Trip Pro

changes in plasma ferritin. Subjects with higher ZPP/H ratios tended to have lower ferritins, but changes in ZPP/H in a given subject were poorly reflected by changes in plasma ferritin. Between 6 and 9 months of age, ZPP/H correlated with other measures of iron status, but serum ferritin concentration did not.Use of the ZPP/H ratio as a measure of iron status during the first year of life appears to be confounded by the developmental changes in ZPP/H, but in the later half of this period it may (...) be a better measure of iron status than serum ferritin.

2002 Archives of disease in childhood Fetal and neonatal edition

5740. Haemoglobin and ferritin concentrations in men and women: cross sectional study Full Text available with Trip Pro

NIDDK NIH HHS United States DK 07022-20 DK NIDDK NIH HHS United States RR00833 RR NCRR NIH HHS United States T32 DK007022 DK NIDDK NIH HHS United States R01 DK053505 DK NIDDK NIH HHS United States Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. England BMJ 8900488 0959-8138 0 Hemoglobins 9007-73-2 Ferritins AIM IM BMJ. 2002 Nov 16;325(7373):1176 12433777 Adult Aged Aged, 80 and over Aging blood Cross-Sectional Studies Female Ferritins blood Hemoglobins analysis (...) Haemoglobin and ferritin concentrations in men and women: cross sectional study 12130609 2002 08 05 2018 11 13 1756-1833 325 7356 2002 Jul 20 BMJ (Clinical research ed.) BMJ Haemoglobin and ferritin concentrations in men and women: cross sectional study. 137 Waalen Jill J Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA. jwaalen@scripps.edu Felitti Vincent V Beutler Ernest E eng M01 RR000833 RR NCRR NIH HHS United States DK53505-04 DK

2002 BMJ : British Medical Journal

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