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Serum Ferritin

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5721. Can you tell me what a low ferritin and low blood count indicates?

pathological approach. Thus, the NLH Q & A Service would recommend discussing this issue with an haematologist who will be able to advise on the likely cause and offer a possible diagnosis given these parameters. We did, however, locate a PRODIGY guideline on iron deficiency anaemia containing a section on diagnostic investigations describing low blood counts and low serum ferritin levels. • “ Full blood count: o Low haemoglobin (Hb) concentration, less than 13 g/dl for men and less than 12 g/dl for women (...) o Low MCV, MCH, and MCHC (mean cell volume, mean cell Hb, mean cell Hb concentration) o Reticulocyte count low for the degree of anaemia o There may be a mild thrombocytosis (raised platelet concentration) • Blood film: microcytic hypochromic red cells, with occasional target cells and pencil-shaped poikilocytes. • Serum ferritin level: low (an indicator of reduced body-iron stores). However, as ferritin is an acute-phase protein, levels may be normal or elevated in infective, inflammatory

2006 TRIP Answers

5722. Female (mid 40s) with occasional PR bleed. She's had blood tests (high MCV, low B12, low folate, high ferritin and normal HB. What other investigations might be useful in arriving at a diagnosis?

Female (mid 40s) with occasional PR bleed. She's had blood tests (high MCV, low B12, low folate, high ferritin and normal HB. What other investigations might be useful in arriving at a diagnosis? Female (mid 40s) with occasional PR bleed. She's had blood tests (high MCV, low B12, low folate, high ferritin and normal HB. What other investigations might be useful in arriving at a diagnosis? - Trip Database or use your Google+ account Liberating the literature ALL of these words: Title only (...) Female (mid 40s) with occasional PR bleed. She's had blood tests (high MCV, low B12, low folate, high ferritin and normal HB. What other investigations might be useful in arriving at a diagnosis? We were unable to trace clinical guidelines (in English, 1) on management of patients presenting with rectal bleeding without other symptoms. The guidance on referral for suspected cancer considers rectal bleeding of significance when coupled with ‘change in bowel habits’ (2). GP notebook has a section

2006 TRIP Answers

5723. In an elderly patient with CCF has a microcytic hypochromic blood picture with Hb 9.1 but ferritin is in the normal range (28 units). Can the anaemia still be accounted for by iron deficiency?

In an elderly patient with CCF has a microcytic hypochromic blood picture with Hb 9.1 but ferritin is in the normal range (28 units). Can the anaemia still be accounted for by iron deficiency? In an elderly patient with CCF has a microcytic hypochromic blood picture with Hb 9.1 but ferritin is in the normal range (28 units). Can the anaemia still be accounted for by iron deficiency? - Trip Database or use your Google+ account Liberating the literature ALL of these words: Title only Anywhere (...) patient with CCF has a microcytic hypochromic blood picture with Hb 9.1 but ferritin is in the normal range (28 units). Can the anaemia still be accounted for by iron deficiency? The CKS guideline on iron deficiency anaemia discusses how the full blood count should be interpreted and notes: “ People who are not pregnant: • Haemoglobin level: o The World Health Organization defines anaemia as [WHO et al, 2001]: ? In men over 15 years of age: haemoglobin (Hb) below 13 g/dL. ? In non-pregnant women over

2008 TRIP Answers

5724. Effect of smoking on plasma ferritin concentrations in pregnant women. (Abstract)

Trial Journal Article Randomized Controlled Trial Research Support, U.S. Gov't, P.H.S. United States Clin Chem 9421549 0009-9147 9007-73-2 Ferritins J41CSQ7QDS Zinc IM Female Ferritins blood Humans Pregnancy Smoking blood Zinc administration & dosage 1995 8 1 1995 8 1 0 1 1995 8 1 0 0 ppublish 7628097 (...) Effect of smoking on plasma ferritin concentrations in pregnant women. 7628097 1995 09 07 2013 11 21 0009-9147 41 8 Pt 1 1995 Aug Clinical chemistry Clin. Chem. Effect of smoking on plasma ferritin concentrations in pregnant women. 1190-1 Tamura T T Dept. of Nutrition Sci, Univ. of Alabama at Birmingham 35294, USA. Goldenberg R L RL Johnston K E KE DuBard M B MB eng HD27289 HD NICHD NIH HHS United States HD28119 HD NICHD NIH HHS United States HD32901 HD NICHD NIH HHS United States Clinical

1995 Clinical Chemistry Controlled trial quality: uncertain

5725. Haemoglobin and ferritin concentrations in children aged 12 and 18 months Full Text available with Trip Pro

Haemoglobin and ferritin concentrations in children aged 12 and 18 months To define the normal ranges and investigate associated factors for haemoglobin and ferritin in British children at 12 and 18 months of age, and to estimate correlations between both haemoglobin and ferritin concentrations at 8, 12, and 18 months of age.Subjects were part of the "children in focus" sample, randomly selected from the Avon longitudinal study of pregnancy and childhood. Capillary blood samples were taken from (...) 940 children at 12 months and 827 children at 18 months of age.Haemoglobin was distributed normally and ferritin was distributed log normally at 12 and 18 months of age. Ninety five per cent reference ranges were established from empirical centiles of haemoglobin and ferritin. Haemoglobin concentrations at 18 months were associated with sex and maternal education. Concentrations of ferritin at 12 and 18 months of age were associated with birth weight and current weight. Girls at 12 months

1999 Archives of Disease in Childhood

5726. Why should women have lower reference limits for haemoglobin and ferritin concentrations than men? Full Text available with Trip Pro

eng Journal Article England BMJ 8900488 0959-8138 0 Hemoglobins 9007-73-2 Ferritins AIM IM BMJ. 2001 Oct 6;323(7316):807-8 11669080 BMJ. 2001 Oct 6;323(7316):806-7; author reply 807-8 11669079 Anemia, Iron-Deficiency blood Animals Erythrocyte Count Female Ferritins blood Hemoglobins analysis Humans Male Menstruation blood Primates blood Reference Values Sex Characteristics 2001 6 2 10 0 2001 6 29 10 1 2001 6 2 10 0 ppublish 11387188 PMC1120434 Annu Rev Nutr. 1986;6:13-40 3524613 Lancet. 1996 Oct (...) Why should women have lower reference limits for haemoglobin and ferritin concentrations than men? 11387188 2001 06 28 2018 11 13 0959-8138 322 7298 2001 Jun 02 BMJ (Clinical research ed.) BMJ Why should women have lower reference limits for haemoglobin and ferritin concentrations than men? 1355-7 Rushton D H DH School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DT, UK. rushton@btinternet.com Dover R R Sainsbury A W AW Norris M J MJ Gilkes J J JJ Ramsay I D ID

2001 BMJ : British Medical Journal

5727. Reference limits for haemoglobin and ferritin : If it's not broken, don't fix it Full Text available with Trip Pro

Ferritins blood Hemoglobins analysis Humans Reference Values 2001 10 24 10 0 2001 11 3 10 1 2001 10 24 10 0 ppublish 11669079 PMC1121347 J Am Coll Nutr. 2001 Oct;20(5):477-84 11601562 N Z Med J. 2001 Mar 23;114(1128):134-8 11346162 BMJ. 2001 Jun 2;322(7298):1355-7 11387188 Br J Haematol. 2001 Aug;114(2):474-84 11529872 Am J Clin Nutr. 1998 Feb;67(2):271-5 9459375 Annu Rev Nutr. 1986;6:13-40 3524613 Pediatr Res. 1993 Nov;34(5):680-7 8284110 JAMA. 1997 Mar 26;277(12):973-6 9091669 Am J Clin Nutr. 1997 Aug (...) Reference limits for haemoglobin and ferritin : If it's not broken, don't fix it 11669079 2001 11 01 2018 11 13 0959-8138 323 7316 2001 Oct 06 BMJ (Clinical research ed.) BMJ Reference limits for haemoglobin and ferritin. If it's not broken, don't fix it. 806-7; author reply 807-8 Heath A L AL Fairweather-Tait S S Worwood M M eng Comment Letter England BMJ 8900488 0959-8138 0 Biomarkers 0 Hemoglobins 9007-73-2 Ferritins AIM IM BMJ. 2001 Jun 2;322(7298):1355-7 11387188 Biomarkers analysis

2001 BMJ : British Medical Journal

5728. Is increased tissue ferritin a risk factor for atherosclerosis and ischaemic heart disease? Full Text available with Trip Pro

9007-73-2 Ferritins E1UOL152H7 Iron AIM IM Age Factors Arteriosclerosis etiology Diet Female Ferritins metabolism Humans Iron blood Male Myocardial Infarction blood Myocardial Ischemia etiology Myocardial Reperfusion Injury metabolism Risk Factors Sex Factors 1995 3 1 1995 3 1 0 1 1995 3 1 0 0 ppublish 7727177 PMC483799 Circulation. 1994 Jan;89(1):102-8 8281634 Circulation. 1994 Mar;89(3):969-74 8124837 Circulation. 1988 Aug;78(2):442-9 3396180 Circulation. 1991 Mar;83(3):1006-14 1847847 Clin Chim (...) Is increased tissue ferritin a risk factor for atherosclerosis and ischaemic heart disease? 7727177 1995 06 01 2018 11 13 0007-0769 73 3 1995 Mar British heart journal Br Heart J Is increased tissue ferritin a risk factor for atherosclerosis and ischaemic heart disease? 208 Koster J F JF Department of Biochemistry, Erasmus University (Rotterdam), (COEUR), Faculty of Medicine and Health Sciences, Rotterdam, The Netherlands. Sluiter W W eng Journal Article England Br Heart J 0370634 0007-0769

1995 British Heart Journal

5729. The immunosuppressive human placental ferritin subunit p43 is produced by activated CD4+ lymphocytes. Full Text available with Trip Pro

The immunosuppressive human placental ferritin subunit p43 is produced by activated CD4+ lymphocytes. Human placental ferritin is an immunosuppressive protein composed of a 43-kDa subunit (p43) and ferritin light chains. Its physiological action seems to be downregulation of the immune response of the mother against her embryo. Elevated levels of p43 in serum are associated with pregnancy, lymphomas, breast cancer, and AIDS. Although it is known that p43 is produced by activated T lymphocytes (...) , the specific T-lymphocyte subset involved is unknown. p43 is measured by enzyme-linked immunosorbent assays with CM-H-9 monoclonal antibody specific for p43. We studied the de novo biosynthesis of p43 by isolated activated CD4+ and CD8+ T lymphocytes in a normal donor and in a patient with elevated levels of p43 in serum. The results indicated that p43 was synthesized by activated CD4+ lymphocytes from the normal donor (0.45% of the total de novo proteins) but that its biosynthesis by CD8+ lymphocytes

1995 Clinical and Diagnostic Laboratory Immunology

5730. Zinc protoporphyrin/haem ratio and plasma ferritin in preterm infants Full Text available with Trip Pro

changes in plasma ferritin. Subjects with higher ZPP/H ratios tended to have lower ferritins, but changes in ZPP/H in a given subject were poorly reflected by changes in plasma ferritin. Between 6 and 9 months of age, ZPP/H correlated with other measures of iron status, but serum ferritin concentration did not.Use of the ZPP/H ratio as a measure of iron status during the first year of life appears to be confounded by the developmental changes in ZPP/H, but in the later half of this period it may (...) be a better measure of iron status than serum ferritin.

2002 Archives of disease in childhood Fetal and neonatal edition

5731. Haemoglobin and ferritin concentrations in men and women: cross sectional study Full Text available with Trip Pro

NIDDK NIH HHS United States DK 07022-20 DK NIDDK NIH HHS United States RR00833 RR NCRR NIH HHS United States T32 DK007022 DK NIDDK NIH HHS United States R01 DK053505 DK NIDDK NIH HHS United States Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. England BMJ 8900488 0959-8138 0 Hemoglobins 9007-73-2 Ferritins AIM IM BMJ. 2002 Nov 16;325(7373):1176 12433777 Adult Aged Aged, 80 and over Aging blood Cross-Sectional Studies Female Ferritins blood Hemoglobins analysis (...) Haemoglobin and ferritin concentrations in men and women: cross sectional study 12130609 2002 08 05 2018 11 13 1756-1833 325 7356 2002 Jul 20 BMJ (Clinical research ed.) BMJ Haemoglobin and ferritin concentrations in men and women: cross sectional study. 137 Waalen Jill J Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA. jwaalen@scripps.edu Felitti Vincent V Beutler Ernest E eng M01 RR000833 RR NCRR NIH HHS United States DK53505-04 DK

2002 BMJ : British Medical Journal

5732. Cerebrospinal fluid ferritin in HIV infected patients with acute neurological episodes. Full Text available with Trip Pro

Cerebrospinal fluid ferritin in HIV infected patients with acute neurological episodes. To measure cerebrospinal fluid (CSF) ferritin in HIV infected patients with acute neurological episodes and to correlate the findings with the type and severity of neurological disease.CSF ferritin and the ratio of CSF to serum albumin (QAlb) were prospectively measured in 27 consecutive HIV infected patients admitted to a specialist unit for investigation of acute neurological episodes; the results were (...) had normal QAlb values, implying an intact CSF-blood barrier, and thus that local synthesis of ferritin had occurred. Elevated ferritin levels were not associated with particular neurological diagnoses. In those with HIV associated dementia complex there was no correlation between CSF ferritin levels and the severity of clinical cognitive deficit or the extent of magnetic resonance imaging abnormalities.An elevated CSF ferritin level is a non-specific finding in HIV infected patients presenting

1997 Genitourinary Medicine

5733. The effects of oral iron supplementation on ferritin levels in pregnant Burmese women. (Abstract)

The effects of oral iron supplementation on ferritin levels in pregnant Burmese women. The usefulness of serum ferritin levels in assessing iron stores in pregnant women before and after supplementation with iron was studied. One hundred thirty-five healthy pregnant women between 22 to 28 wk were randomly allotted to daily dose regimes of 60, 120, or 240 mg of ferrous sulphate. The tablets were given after meals under strict personal supervision. Before supplementation, iron deficiency (...) (ferritin level less than 10 micrograms/L) was present in 54.8% of the pregnant women, compared to an incidence of 17.8% when assessed by serum iron concentration of less than 50 micrograms/dl. The mean ferritin level of pregnant women was 14.15 micrograms/L and was less than one-half that of healthy single women and one-sixth of that of healthy males. Supplementation with oral iron for 12 wk produced an increase in ferritin levels in all the groups, but significant increases were seen only in women

1982 The American journal of clinical nutrition Controlled trial quality: uncertain

5734. Decreased ferritin levels, despite iron supplementation, during erythropoietin therapy in anaemia of prematurity. (Abstract)

Decreased ferritin levels, despite iron supplementation, during erythropoietin therapy in anaemia of prematurity. Erythropoietin (rHuEPO) therapy has been shown to be beneficial in preventing and treating anaemia of prematurity and to decrease the need for blood transfusions. There is, however, only scanty data on the effect of rHuEPO therapy on iron metabolism. We studied 29 preterm infants (age 34 +/- 14 days) who were randomly assigned to receive either rHuEPO 900 U kg-1 week-1 with 6 mg kg (...) -1 day-1 of iron for 4 weeks (n = 15) or no therapy. The following parameters were evaluated and compared between and within groups at the beginning, during and at the end of the study: Haematocrit (SI), reticulocytes (10(9) micrograms l-1), serum ferritin (microgram 1-1) and iron (mumol l-1). The results were as follows. At the baseline, erythropoietin levels were similar in both groups: 7.2 +/- 5.6 versus 6.2 +/- 3.2 mU ml-1 (NS). In the treated infants the haematocrit remained stable during

1996 Acta paediatrica (Oslo, Norway : 1992) Controlled trial quality: uncertain

5735. [Ferritin level in newborn infants after prepartal iron medication]. (Abstract)

ferritin levels in the 30th week of pregnancy (p less than 0.048), higher levels measured in the cord blood at birth (p less than 0.001), and also the newborn of this group had statistically significant higher serum ferritin levels than the newborn of the control group (p less than 0.001). Our conclusion is that prepartal iron medication leads to increased iron stores in the newborn. (...) [Ferritin level in newborn infants after prepartal iron medication]. Aim of the study was to find out the influence of iron medication of pregnant women on the iron levels of their newborn. In a prospective randomised study the iron-substituted group (n = 57) was treated with 2 x 1 Aktiferrin comp. Kps. (Merckle) during pregnancy, starting from the 22nd week. The control group (n = 46) had no medication during pregnancy. The substituted group had statistically significantly higher serum

1991 Geburtshilfe und Frauenheilkunde Controlled trial quality: uncertain

5736. Calcium supplementation and plasma ferritin concentrations in premenopausal women. (Abstract)

intake (r = 0.21, P = 0.04), serum iron concentration (r = 0.19, P = 0.04), transferrin saturation (r = 0.31, P = 0.001), and hemoglobin concentration (r = 0.22, P = 0.02), and negatively correlated with total iron-binding capacity (TIBC, r = -0.42, P < 0.001). No significant differences in absolute or percent changes in plasma ferritin concentrations, serum iron concentrations, TIBC, transferrin saturation, hemoglobin concentrations, or hematocrit were observed between the treatment and control (...) Calcium supplementation and plasma ferritin concentrations in premenopausal women. The effect of calcium supplement use on iron stores was examined in a randomized controlled study in free-living, healthy, premenopausal women. Of 109 women who completed the study, 52 were in the control group and 57 took two tablets containing 250 mg Ca as the carbonate with each of two meals daily for 12 wk. In all subjects at baseline, plasma ferritin concentrations were positively correlated with heme-iron

1992 The American journal of clinical nutrition Controlled trial quality: uncertain

5737. Longitudinal changes in ferritin during chronic transfusion: a report from the Stroke Prevention Trial in Sickle Cell Anemia (STOP). (Abstract)

chronic transfusion in a clinical trial of stroke prevention. A serum ferritin level of less than 500 ng/mL was required for study entry. Ferritin levels were obtained quarterly. Fifty patients who had four or more ferritin measurements were included in this analysis. Transfusions were administered as exchange or simple, with washed, reconstituted, or packed red blood cells, at the discretion of the site investigator.Serum ferritin levels increased linearly with cumulative transfusion volume during (...) Longitudinal changes in ferritin during chronic transfusion: a report from the Stroke Prevention Trial in Sickle Cell Anemia (STOP). Chronic red cell transfusion has been used for prevention of recurrent stroke in patients with sickle cell disease for three decades, and its effectiveness in primary prevention was recently shown. Iron overload, the inevitable result of chronic transfusion, is commonly monitored with serum ferritin concentration.Sixty-one patients at high risk for stroke received

2002 Journal of pediatric hematology/oncology Controlled trial quality: uncertain

5738. Targeting higher ferritin concentrations with intravenous iron dextran lowers erythropoietin requirement in hemodialysis patients. (Abstract)

factors including functional iron deficiency. Since the optimal prescription for iron replacement is not yet known, we evaluated the effect of intravenous iron dextran (IVFe) infusion on serum ferritin (SFer) concentration and rHuEPO dose. Our objective was to raise and maintain serum ferritin concentrations to 2 different levels above the National Kidney Foundation Dialysis Outcome Quality Initiative standard of 100 ng/ml to determine whether, and by what degree rHuEPO dose could be lowered.HD (...) ng/ml. The mean decrease in rHuEPO dose for Group 1 was 31 U/kg body weight/week (250 - 219 U/kg bw/wk) while in Group 2 it was 154 U/kg body weight/week (312 - 158 U/kg bw/wk) (p < 0.001). There was no difference in HCT between groups. Our results suggest that higher target serum ferritin concentrations can be well tolerated and lower rHuEPO requirements.

2003 Clinical nephrology Controlled trial quality: uncertain

5739. Protective effect of tissue ferritins in experimental Escherichia coli infection of mice in vivo. Full Text available with Trip Pro

mouse, the maximum survival rates were 86% (FH), 81% (FM) and 79% (FB), while only 5% of the control mice survived up to the 30th day. The survival rates of animals injected with bovine serum albumin (BSA) and heat-inactivated FB were 8 and 25%, respectively. Intraperitoneal injection of FB was as effective as intravenous in enhancing the resistance of mice against bacteria. These data provide evidence for the beneficial role of tissue ferritins in nonspecific antibacterial resistance. (...) Protective effect of tissue ferritins in experimental Escherichia coli infection of mice in vivo. The effect of ferritins from horse (FH) and bovine (FB) spleen and murine liver (FM) on the survival rate of CFW mice lethally infected with Escherichia coli (strain 8440-78 K 80/B) was evaluated. Ferritins given intravenously 24 h before intravenous inoculation of bacteria, protected mice most effectively from death due to infection. The effect was dose dependent. At 500 micrograms of ferritin per

1991 International journal of experimental pathology

5740. Hepatic molecular conversion and detoxification of ferritin iron in adult lampreys (Geotria australis), following natural and induced iron loading. Full Text available with Trip Pro

Hepatic molecular conversion and detoxification of ferritin iron in adult lampreys (Geotria australis), following natural and induced iron loading. Weekly intramuscular injections of 3 mg of iron as horse spleen ferritin into adult Geotria australis over 10 weeks, resulted in a progressive increase in that form of iron in the serum. However, as with control animals, the ferritin in the liver of injected lampreys consisted of one subunit type, whose M(r) (20,300) differed from those of the two (...) subunit types of horse spleen ferritin. Thus, lampreys had converted horse spleen ferritin iron into endogenous ferritin iron, presumably in their liver. Marked rises in hepatic non-haem iron during the first 2 weeks and between weeks 8 and 10 of iron injections were accompanied by pronounced increases in superoxide dismutase (SOD) activity. This rise, which parallels the rise in SOD activity that occurs as iron increases during the very protracted upstream migration of G. australis, is consistent

1995 Biochemical Journal

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