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Serum Ferritin

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5701. Blocking of the placental immune-modulatory ferritin activates Th1 type cytokines and affects placenta development, fetal growth and the pregnancy outcome. Full Text available with Trip Pro

Blocking of the placental immune-modulatory ferritin activates Th1 type cytokines and affects placenta development, fetal growth and the pregnancy outcome. Placenta immunomodulatory ferritin (PLIF) cDNA was recently cloned from the human placenta, where it is expressed in syncytiotrophoblast and decidual mononuclear cells. PLIF and its subcloned bioactive domain (C48), expressed in Escherichia coli, are immunosuppressive proteins and induce pronounced IL-10 production in vitro and in vivo.PLIF (...) serum level, measured by enzyme-linked immunosorbent assay, was elevated in pregnant mice throughout gestation and declined towards delivery. Blocking of PLIF activity by vaccination of mice with C48 prior to mating inhibited pregnancy development. Passive transfer of anti-C48 immunoglobulin (Ig) starting at 3.5-12.5 days post coitum (dpc) resulted in high rate of embryo resorption. Furthermore, treatment with anti-C48 Ig resulted in placental and embryonal growth restriction. At gestation day 13.5

2004 Human Reproduction

5702. Oxidative stress and ferritin expression in the skin of patients with rosacea. (Abstract)

Oxidative stress and ferritin expression in the skin of patients with rosacea. Rosacea is a common chronic light-sensitive inflammatory skin disease of unknown origin. The purpose of this work was to determine the parameters of oxidative stress, antioxidative capacity, and the pathophysiologic role of ferritin expression in skin cells of patients with rosacea.The investigation consisted of measurements of serum peroxide levels, serum total antioxidative potential levels, and immunohistochemical (...) analyses of ferritin in skin tissue samples.Serum peroxide levels were significantly higher and serum total antioxidative potential levels were significantly lower in patients with rosacea than in healthy control subjects (P < .05). Compared with control subjects, the number of ferritin-positive cells was significantly higher (P < .001) in skin samples from patients with rosacea, especially those with severe disease.Patients with rosacea in the study were aged 30 to 70 years (average age was 56 years

2008 Journal of American Academy of Dermatology

5703. Variability of ferritin measurements in chronic kidney disease; implications for iron management. Full Text available with Trip Pro

Variability of ferritin measurements in chronic kidney disease; implications for iron management. Serum ferritin levels are a proxy measure of iron stores; and existing guidelines for managing anemia in hemodialysis patients suggest that serum ferritin concentrations should be maintained at >200 ng/ml. The KDOQI recommendations further state there is insufficient evidence advocating routine intravenous iron when ferritin levels exceed 500 ng/ml. Here we determined the interassay differences (...) and short-term intraindividual variability of serum ferritin measurements in patients on chronic hemodialysis to illustrate how these variances may affect treatment decisions. Intermethod variations of up to 150 ng/ml were found comparing six commonly used ferritin assays that evaluated thirteen pools of serum from hemodialysis and nonhemodialysis patients. The intraindividual variability for ferritin in 60 stable hemodialysis patients ranged between 2-62% measured over an initial two-week period

2008 Kidney International

5704. Diabetes is the main factor accounting for the high ferritin levels detected in chronic hepatitis C virus infection. (Abstract)

Diabetes is the main factor accounting for the high ferritin levels detected in chronic hepatitis C virus infection. A high prevalence of diabetes has been reported in patients with hepatitis C virus (HCV) infection. Both diabetes and HCV infection are associated with high serum ferritin levels. Although HCV infection could be the main factor responsible for the high ferritin levels, it is also possible that diabetes rather than HCV infection might be a major contributor to the high ferritin (...) to those of group D. In multivariate analyses, diabetes but not HCV infection was independently related to serum ferritin concentrations.Diabetes rather than HCV infection itself is the main factor associated with the increased ferritin levels detected in patients with HCV infection. Therefore, the presence of diabetes should be taken into account when iron metabolism is evaluated in HCV-infected patients.

2004 Diabetes Care

5705. Soluble transferrin receptors and ferritin in Type 2 diabetic patients. (Abstract)

Soluble transferrin receptors and ferritin in Type 2 diabetic patients. To determine circulating transferrin receptor levels (sTfR) in Type 2 diabetic patients to evaluate whether serum ferritin reflects iron body stores or inflammation in diabetic population.A total of 84 consecutive Type 2 diabetic patients and 60 healthy subjects matched by age and gender were included in this case-control study. Ferritin concentration was measured by a turbidimetric method and sTfR concentration were (...) determined by nephelometry.Diabetic patients have higher serum ferritin levels than control subjects [114 ng/ml (12-831) vs. 74 ng/ml (11-697); P = 0.006]. However, no differences in sTfR concentrations were observed between both groups [1.27 mg/l (0.69-2.47) vs. 1.24 mg/l (0.77-2.80); P = NS]. A negative correlation between ferritin and sTfR concentration was detected in control subjects but not in diabetic patients.Serum ferritin levels are increased in Type 2 diabetic patients in the absence

2005 Diabetic Medicine

5706. Ferritin and transferrin are associated with metabolic syndrome abnormalities and their change over time in a general population: Data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR). Full Text available with Trip Pro

Data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) cohort, aged 30-65 years, were followed over 6 years.Higher concentrations of both ferritin and transferrin were associated with the International Diabetes Federation (IDF) and the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults Adult Treatment Panel III original and revised definitions of the metabolic syndrome at baseline: for the IDF (...) Ferritin and transferrin are associated with metabolic syndrome abnormalities and their change over time in a general population: Data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR). The aim of this work was to study cross-sectional and longitudinal relations between iron stocks (ferritin) and the iron transport protein (transferrin) with the metabolic syndrome and its abnormalities.A total of 469 men and 278 premenopausal and 197 postmenopausal women from the French

2007 Diabetes Care

5707. Usefulness of glycosylated ferritin in atypical presentations of adult onset Still's disease Full Text available with Trip Pro

and over Biomarkers blood Diagnosis, Differential Female Ferritins analogs & derivatives blood Humans Middle Aged Still's Disease, Adult-Onset diagnosis 2004 4 15 5 0 2004 6 21 10 0 2004 4 15 5 0 ppublish 15082500 10.1136/ard.2003.012484 63/5/605 PMC1754986 (...) Usefulness of glycosylated ferritin in atypical presentations of adult onset Still's disease 15082500 2004 06 07 2015 11 19 0003-4967 63 5 2004 May Annals of the rheumatic diseases Ann. Rheum. Dis. Usefulness of glycosylated ferritin in atypical presentations of adult onset Still's disease. 605 Hamidou M A MA Denis M M Barbarot S S Boutoille D D Belizna C C Le Moël G G eng Letter England Ann Rheum Dis 0372355 0003-4967 0 Biomarkers 0 glycosylated ferritin 9007-73-2 Ferritins IM Aged Aged, 80

2004 Annals of the Rheumatic Diseases

5708. DRIVE Trial (Dialysis Patients' Response to Intravenous [IV] Iron With Elevated Ferritin)

Elevated serum ferritin with low to normal transferrin saturation (TSAT) Moderate to severe anemia Receiving epoetin alfa treatment Exclusion Criteria: Known sensitivity to Ferrlecit® Medical conditions that would confound the efficacy evaluation Recent blood transfusion Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer (...) Pharmaceuticals Information provided by (Responsible Party): Watson Pharmaceuticals Study Details Study Description Go to Brief Summary: This study explores the safety and efficacy of intravenous iron therapy in anemic hemodialysis patients treated with epoetin alfa, who have higher serum ferritin levels, but low to normal transferrin saturation. Condition or disease Intervention/treatment Phase Anemia, Iron-Deficiency Kidney Failure, Chronic Hemodialysis Drug: Sodium ferric gluconate, Phase 4 Study Design Go

2005 Clinical Trials

5709. Biological variation of plasma ferritin in healthy adult males in south Indian population—A sample study Full Text available with Trip Pro

Biological variation of plasma ferritin in healthy adult males in south Indian population—A sample study A sample study of biological variation of plasma ferritin in healthy adult males 19-25 years of age (n=6) in the Indian population was determined. Venous blood was collected on 3 non-consecutive days during a 3 week period. Plasma ferritin was measured using enzyme linked immunoassay in an automated immunoassay system. Analytical and Biological variation was calculated. We found a mean

2006 Indian Journal of Clinical Biochemistry

5710. Investigating iron status in microcytic anaemia: General practitioners could test for ferritin, etc, before referral Full Text available with Trip Pro

Family Practice Ferritins blood Humans Referral and Consultation 2006 11 4 9 0 2006 11 15 9 0 2006 11 4 9 0 ppublish 17082563 333/7575/972 10.1136/bmj.333.7575.972 PMC1633804 BMJ. 2006 Oct 14;333(7572):791-3 17038737 (...) Investigating iron status in microcytic anaemia: General practitioners could test for ferritin, etc, before referral 17082563 2006 11 14 2018 11 13 1756-1833 333 7575 2006 Nov 04 BMJ (Clinical research ed.) BMJ Investigating iron status in microcytic anaemia: general practitioners could test for ferritin, etc, before referral. 972 Das Debasish D eng Comment Letter England BMJ 8900488 0959-8138 9007-73-2 Ferritins AIM IM BMJ. 2006 Oct 14;333(7572):791-3 17038737 Anemia, Iron-Deficiency diagnosis

2006 BMJ : British Medical Journal

5711. Case report: a subject with a mutation in the ATG start codon of L-ferritin has no haematological or neurological symptoms Full Text available with Trip Pro

Ferrari F F Fermo I I Foglieni B B Levi S S Bozzini C C Camparini M M Ferrari M M Arosio P P eng GP0075Y01 Telethon Italy Case Reports Journal Article Research Support, Non-U.S. Gov't England J Med Genet 2985087R 0022-2593 0 Codon, Initiator 9007-73-2 Ferritins 9013-31-4 Apoferritins IM Apoferritins Base Sequence Cataract blood genetics pathology Chromatography, High Pressure Liquid methods Codon, Initiator genetics DNA Mutational Analysis Ferritins blood genetics Hematologic Diseases genetics (...) Case report: a subject with a mutation in the ATG start codon of L-ferritin has no haematological or neurological symptoms 15173247 2004 09 27 2017 09 22 1468-6244 41 6 2004 Jun Journal of medical genetics J. Med. Genet. Case report: a subject with a mutation in the ATG start codon of L-ferritin has no haematological or neurological symptoms. e81 Cremonesi L L Genomics for the Diagnosis of Human Pathologies Unit, IRCCS H. San Raffaele, Via Olgettina 58, 20132 Milan, Italy. Cozzi A A Girelli D D

2004 Journal of Medical Genetics

5712. To exclude haemachromatosis developing I understand it is useful to check ferritin levels, but how often should a patient with a family history of haemochromatosis have a ferritin level checked?

haemachromatosis developing I understand it is useful to check ferritin levels, but how often should a patient with a family history of haemochromatosis have a ferritin level checked? Although we found a number of guidelines supporting the testing of relatives of patients with hereditary haemochromatosis, none specified how often transferrin saturation and serum ferritin tests should be performed on an individual in whom initial normal levels were confirmed. However, the American Haemochromatosis Society web (...) To exclude haemachromatosis developing I understand it is useful to check ferritin levels, but how often should a patient with a family history of haemochromatosis have a ferritin level checked? To exclude haemachromatosis developing I understand it is useful to check ferritin levels, but how often should a patient with a family history of haemochromatosis have a ferritin level checked? - Trip Database or use your Google+ account Liberating the literature ALL of these words: Title only Anywhere

2006 TRIP Answers

5713. Can you tell me what a low ferritin and low blood count indicates?

pathological approach. Thus, the NLH Q & A Service would recommend discussing this issue with an haematologist who will be able to advise on the likely cause and offer a possible diagnosis given these parameters. We did, however, locate a PRODIGY guideline on iron deficiency anaemia containing a section on diagnostic investigations describing low blood counts and low serum ferritin levels. • “ Full blood count: o Low haemoglobin (Hb) concentration, less than 13 g/dl for men and less than 12 g/dl for women (...) o Low MCV, MCH, and MCHC (mean cell volume, mean cell Hb, mean cell Hb concentration) o Reticulocyte count low for the degree of anaemia o There may be a mild thrombocytosis (raised platelet concentration) • Blood film: microcytic hypochromic red cells, with occasional target cells and pencil-shaped poikilocytes. • Serum ferritin level: low (an indicator of reduced body-iron stores). However, as ferritin is an acute-phase protein, levels may be normal or elevated in infective, inflammatory

2006 TRIP Answers

5714. Female (mid 40s) with occasional PR bleed. She's had blood tests (high MCV, low B12, low folate, high ferritin and normal HB. What other investigations might be useful in arriving at a diagnosis?

Female (mid 40s) with occasional PR bleed. She's had blood tests (high MCV, low B12, low folate, high ferritin and normal HB. What other investigations might be useful in arriving at a diagnosis? Female (mid 40s) with occasional PR bleed. She's had blood tests (high MCV, low B12, low folate, high ferritin and normal HB. What other investigations might be useful in arriving at a diagnosis? - Trip Database or use your Google+ account Liberating the literature ALL of these words: Title only (...) Female (mid 40s) with occasional PR bleed. She's had blood tests (high MCV, low B12, low folate, high ferritin and normal HB. What other investigations might be useful in arriving at a diagnosis? We were unable to trace clinical guidelines (in English, 1) on management of patients presenting with rectal bleeding without other symptoms. The guidance on referral for suspected cancer considers rectal bleeding of significance when coupled with ‘change in bowel habits’ (2). GP notebook has a section

2006 TRIP Answers

5715. In an elderly patient with CCF has a microcytic hypochromic blood picture with Hb 9.1 but ferritin is in the normal range (28 units). Can the anaemia still be accounted for by iron deficiency?

In an elderly patient with CCF has a microcytic hypochromic blood picture with Hb 9.1 but ferritin is in the normal range (28 units). Can the anaemia still be accounted for by iron deficiency? In an elderly patient with CCF has a microcytic hypochromic blood picture with Hb 9.1 but ferritin is in the normal range (28 units). Can the anaemia still be accounted for by iron deficiency? - Trip Database or use your Google+ account Liberating the literature ALL of these words: Title only Anywhere (...) patient with CCF has a microcytic hypochromic blood picture with Hb 9.1 but ferritin is in the normal range (28 units). Can the anaemia still be accounted for by iron deficiency? The CKS guideline on iron deficiency anaemia discusses how the full blood count should be interpreted and notes: “ People who are not pregnant: • Haemoglobin level: o The World Health Organization defines anaemia as [WHO et al, 2001]: ? In men over 15 years of age: haemoglobin (Hb) below 13 g/dL. ? In non-pregnant women over

2008 TRIP Answers

5716. [Ferritin level in newborn infants after prepartal iron medication]. (Abstract)

ferritin levels in the 30th week of pregnancy (p less than 0.048), higher levels measured in the cord blood at birth (p less than 0.001), and also the newborn of this group had statistically significant higher serum ferritin levels than the newborn of the control group (p less than 0.001). Our conclusion is that prepartal iron medication leads to increased iron stores in the newborn. (...) [Ferritin level in newborn infants after prepartal iron medication]. Aim of the study was to find out the influence of iron medication of pregnant women on the iron levels of their newborn. In a prospective randomised study the iron-substituted group (n = 57) was treated with 2 x 1 Aktiferrin comp. Kps. (Merckle) during pregnancy, starting from the 22nd week. The control group (n = 46) had no medication during pregnancy. The substituted group had statistically significantly higher serum

1991 Geburtshilfe und Frauenheilkunde Controlled trial quality: uncertain

5717. Decreased ferritin levels, despite iron supplementation, during erythropoietin therapy in anaemia of prematurity. (Abstract)

Decreased ferritin levels, despite iron supplementation, during erythropoietin therapy in anaemia of prematurity. Erythropoietin (rHuEPO) therapy has been shown to be beneficial in preventing and treating anaemia of prematurity and to decrease the need for blood transfusions. There is, however, only scanty data on the effect of rHuEPO therapy on iron metabolism. We studied 29 preterm infants (age 34 +/- 14 days) who were randomly assigned to receive either rHuEPO 900 U kg-1 week-1 with 6 mg kg (...) -1 day-1 of iron for 4 weeks (n = 15) or no therapy. The following parameters were evaluated and compared between and within groups at the beginning, during and at the end of the study: Haematocrit (SI), reticulocytes (10(9) micrograms l-1), serum ferritin (microgram 1-1) and iron (mumol l-1). The results were as follows. At the baseline, erythropoietin levels were similar in both groups: 7.2 +/- 5.6 versus 6.2 +/- 3.2 mU ml-1 (NS). In the treated infants the haematocrit remained stable during

1996 Acta paediatrica (Oslo, Norway : 1992) Controlled trial quality: uncertain

5718. Calcium supplementation and plasma ferritin concentrations in premenopausal women. (Abstract)

intake (r = 0.21, P = 0.04), serum iron concentration (r = 0.19, P = 0.04), transferrin saturation (r = 0.31, P = 0.001), and hemoglobin concentration (r = 0.22, P = 0.02), and negatively correlated with total iron-binding capacity (TIBC, r = -0.42, P < 0.001). No significant differences in absolute or percent changes in plasma ferritin concentrations, serum iron concentrations, TIBC, transferrin saturation, hemoglobin concentrations, or hematocrit were observed between the treatment and control (...) Calcium supplementation and plasma ferritin concentrations in premenopausal women. The effect of calcium supplement use on iron stores was examined in a randomized controlled study in free-living, healthy, premenopausal women. Of 109 women who completed the study, 52 were in the control group and 57 took two tablets containing 250 mg Ca as the carbonate with each of two meals daily for 12 wk. In all subjects at baseline, plasma ferritin concentrations were positively correlated with heme-iron

1992 The American journal of clinical nutrition Controlled trial quality: uncertain

5719. Targeting higher ferritin concentrations with intravenous iron dextran lowers erythropoietin requirement in hemodialysis patients. (Abstract)

factors including functional iron deficiency. Since the optimal prescription for iron replacement is not yet known, we evaluated the effect of intravenous iron dextran (IVFe) infusion on serum ferritin (SFer) concentration and rHuEPO dose. Our objective was to raise and maintain serum ferritin concentrations to 2 different levels above the National Kidney Foundation Dialysis Outcome Quality Initiative standard of 100 ng/ml to determine whether, and by what degree rHuEPO dose could be lowered.HD (...) ng/ml. The mean decrease in rHuEPO dose for Group 1 was 31 U/kg body weight/week (250 - 219 U/kg bw/wk) while in Group 2 it was 154 U/kg body weight/week (312 - 158 U/kg bw/wk) (p < 0.001). There was no difference in HCT between groups. Our results suggest that higher target serum ferritin concentrations can be well tolerated and lower rHuEPO requirements.

2003 Clinical nephrology Controlled trial quality: uncertain

5720. Longitudinal changes in ferritin during chronic transfusion: a report from the Stroke Prevention Trial in Sickle Cell Anemia (STOP). (Abstract)

chronic transfusion in a clinical trial of stroke prevention. A serum ferritin level of less than 500 ng/mL was required for study entry. Ferritin levels were obtained quarterly. Fifty patients who had four or more ferritin measurements were included in this analysis. Transfusions were administered as exchange or simple, with washed, reconstituted, or packed red blood cells, at the discretion of the site investigator.Serum ferritin levels increased linearly with cumulative transfusion volume during (...) Longitudinal changes in ferritin during chronic transfusion: a report from the Stroke Prevention Trial in Sickle Cell Anemia (STOP). Chronic red cell transfusion has been used for prevention of recurrent stroke in patients with sickle cell disease for three decades, and its effectiveness in primary prevention was recently shown. Iron overload, the inevitable result of chronic transfusion, is commonly monitored with serum ferritin concentration.Sixty-one patients at high risk for stroke received

2002 Journal of pediatric hematology/oncology Controlled trial quality: uncertain

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