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Serum Ferritin

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5701. Development of a type 2 diabetes risk model from a panel of serum biomarkers from the Inter99 cohort. Full Text available with Trip Pro

a validated bootstrap bias-correction procedure.A model using six biomarkers (adiponectin, C-reactive protein, ferritin, interleukin-2 receptor A, glucose, and insulin) was developed for assessing an individual's 5-year risk of developing type 2 diabetes. This model has a bootstrap-estimated area under the curve of 0.76, which is greater than that for A1C, fasting plasma glucose, fasting serum insulin, BMI, sex-adjusted waist circumference, a model using fasting glucose and insulin, and a noninvasive (...) Development of a type 2 diabetes risk model from a panel of serum biomarkers from the Inter99 cohort. The purpose of this study was to develop a model for assessing the 5-year risk of developing type 2 diabetes from a panel of 64 circulating candidate biomarkers.Subjects were selected from the Inter99 cohort, a longitudinal population-based study of approximately 6,600 Danes in a nested case-control design with the primary outcome of 5-year conversion to type 2 diabetes. Nondiabetic subjects

2009 Diabetes Care

5702. Effects of delayed sample processing and freezing on serum concentrations of selected nutritional indicators. Full Text available with Trip Pro

Effects of delayed sample processing and freezing on serum concentrations of selected nutritional indicators. Environmental conditions during sample processing, shipping, and storage are often suboptimal, particularly in less developed countries. We used samples from US volunteers to investigate the effects of delayed whole blood (WB) processing and delayed freezing of serum on selected nutritional indicators.WB tubes (n = 35) were either stored at 32 degrees C for up to 3 days before serum (...) did not unacceptably affect concentrations of carotenoids and vitamins B(12), D, and E; however, we obtained clinically unacceptable changes for ferritin (+9%), soluble transferrin receptor (sTfR) (+5%), and folate (-30%) after 1 day, and for vitamin A (-10%) after 3 days. Delayed freezing of serum did not affect concentrations of ferritin, sTfR, carotenoids, and vitamins A, B(12), and E; however, we obtained clinically unacceptable changes for vitamins C (-20%) and D (+7%) after 7 days

2008 Clinical Chemistry

5703. HbA1C, but not serum glycated albumin, is elevated in late pregnancy due to iron deficiency. Full Text available with Trip Pro

(MCH), serum transferrin saturation, and serum ferritin were lower in groups III and IV. A1C levels were negatively correlated with MCH, serum transferrin saturation, and serum ferritin. In study 2, A1C levels were significantly increased at gestational weeks 32-33 from those at weeks 20-23, whereas serum glycated albumin levels did not differ between the two gestational periods. MCH, serum transferrin saturation, and serum ferritin were decreased at gestational weeks 32-33. A1C levels showed (...) HbA1C, but not serum glycated albumin, is elevated in late pregnancy due to iron deficiency. A1C levels have been shown to be elevated in relation to glycemia in late pregnancy, although the precise mechanisms remain undetermined. We hypothesized that iron deficiency is involved in the A1C increase in late pregnancy.In study 1, A1C, serum glycated albumin, erythrocyte indexes, and iron metabolism indexes were determined in 47 nondiabetic pregnant women not receiving iron supplementation who

2008 Diabetes Care

5704. Body fat mass and serum leptin levels influence epoetin sensitivity in patients with ESRD. (Abstract)

Body fat mass and serum leptin levels influence epoetin sensitivity in patients with ESRD. Dose requirements of epoetin vary considerably among patients with end-stage renal disease (ESRD), whereas determinants of epoetin sensitivity are poorly understood. Fat mass is an important source of adipokines, including interleukin 6 (IL-6), which is associated with decreased epoetin sensitivity. Furthermore, the adipokine leptin stimulates human erythroid development in vitro. In the present study, we (...) investigate the impact of fat mass and leptin level on epoetin sensitivity in patients with ESRD.One hundred sixty-six patients with ESRD (107 men; 64%) with a mean age of 56.9 +/- 0.9 years were studied in a post hoc cross-sectional analysis. Body composition was analyzed by dual-energy X-ray absorptiometry and correlated with serum markers of inflammation and leptin (analyzed by enzyme-linked immunosorbent assays), as well as with epoetin dose, in international units administered per week (IU/wk

2005 American Journal of Kidney Diseases

5705. Association of hepatitis C virus infection with serum iron status: analysis of data from the third National Health and Nutrition Examination Survey. Full Text available with Trip Pro

status was assessed in the US population.We analyzed data from a total of 14,462 participants in the Third National Health and Nutrition Examination Survey. We excluded subjects who were aged <12 years, subjects for whom measurements of serum levels of iron or ferritin or the results of liver function tests were missing, and subjects who had a serum transferrin saturation of > or =50% (to help exclude subjects with hemochromatosis).Mean serum levels of ferritin and iron (+/- standard error) were (...) significantly higher among subjects with HCV infection (100+/-3 ng/mL and 229+/-17 microg/dL, respectively) than among subjects without liver disease (83+/-0.3 ng/mL and 101+/-2.1 microg/dL, respectively) (P<.0001). Serum levels of ferritin were directly and significantly correlated with serum levels of alanine aminotransferase, aspartate aminotransferase, and gamma-glutamyl transpeptidase (r=0.25, r=0.24, and r=0.28, respectively; P<.0001), whereas platelet counts were inversely correlated with serum

2005 Clinical Infectious Diseases

5706. Macrophage serum markers in pneumococcal bacteremia: Prediction of survival by soluble CD163. (Abstract)

Macrophage serum markers in pneumococcal bacteremia: Prediction of survival by soluble CD163. Soluble CD163 (sCD163) is a new macrophage-specific serum marker. This study investigated sCD163 and other markers of macrophage activation (neopterin, ferritin, transcobalamin, and soluble urokinase plasminogen activator receptor [suPAR]) as prognostic factors in patients with pneumococcal bacteremia.Observational cohort study.Five university hospitals in Denmark.A total of 133 patients (...) with Streptococcus pneumoniae bacteremia (positive blood culture) and 133 age- and gender-matched controls.Samples were collected for biochemical analyses at the time of first positive blood culture.sCD163 was highly correlated with other macrophage markers and was significantly elevated (median [25-75 percentiles], 4.6 mg/L [2.8-8.9]) compared with healthy controls (2.7 mg/L [2.1-3.3], p < .0001). Increased levels were observed in patients who needed intensive care (hemodialysis, p = .0011; hypotension, p

2006 Critical Care Medicine

5707. Serum iron and matrix metalloproteinase-9 variations in limbs affected by chronic venous disease and venous leg ulcers. (Abstract)

the following in the serum of the arm and ankle veins of 30 patients (C4-6) with CVD and 14 normal subjects: ferritin, transferrin, iron, percentage of transferrin iron binding capacity (%TIBC), and MMP-9. Optical microscopy examinations with Perls' staining of chronic wounds were also performed.Histology consistently revealed iron deposits. Serum ferritin, iron, and %TIBC were significantly increased in the legs affected by severe CVD compared with the arm of the same subjects or the controls. In addition (...) Serum iron and matrix metalloproteinase-9 variations in limbs affected by chronic venous disease and venous leg ulcers. Severe chronic venous disease (CVD) is characterized by both dermal hemosiderin accumulation and matrix metalloproteinase (MMP) hyperactivation. The iron-driven pathway is one of the recognized mechanisms of MMP hyperactivation.To investigate the potential consequences of leg hemosiderin deposits on both iron metabolism and activation of MMPs.We contemporaneously assessed

2005 Dermatologic Surgery

5708. HFE Mutations Modulate the Effect of Iron on Serum Hepcidin-25 in Chronic Hemodialysis Patients. Full Text available with Trip Pro

correlated positively with ferritin and C reactive protein, and negatively with serum iron after adjustment for confounders. Hepcidin/ferritin ratio was lower in patients with (n = 25) than in those without (n = 40) HFE mutations. At multivariate analysis, hepcidin-25 was independently associated with ferritin and HFE status. In a subgroup of 22 "stable" patients, i.e., with Hb levels on target, normal CRP levels, and absence of complications for at least 1 yr, hepcidin-25 was negatively correlated (...) HFE Mutations Modulate the Effect of Iron on Serum Hepcidin-25 in Chronic Hemodialysis Patients. Increased serum hepcidin has been reported in patients receiving chronic hemodialysis, and hypothesized to contribute to the alterations of iron metabolism of end-stage renal disease. However, no quantitative assessment is available to date; the clinical determinants are still under definition; and the role of genetic factors, namely HFE mutations, has not yet been evaluated. The aim of this study

2009 Clinical Journal of the American Society of Nephrology

5709. A follow-up study to determine the value of liver biopsy and need for antiviral therapy for hepatitis C virus carriers with persistently normal serum aminotransferase. (Abstract)

/microl were entered and 69 were followed for over 5 years. Thirty-five patients underwent serial liver biopsies. Serum ferritin and thioredoxin levels were also determined.Seventeen patients had normal liver histology, 10 had moderate chronic hepatitis and the remainder 102 had mild hepatitis. Serum ferritin and thioredoxin levels were normal. The mean follow-up period for the 69 patients was 8.5 years. Of these 69 patients, 10 had persistently normal ALT levels (group A), 39 had transient elevation (...) A follow-up study to determine the value of liver biopsy and need for antiviral therapy for hepatitis C virus carriers with persistently normal serum aminotransferase. Long-term follow-up study was performed to identify the candidates for antiviral therapy for hepatitis C virus (HCV) infection among carriers with persistently normal aminotransferase (ALT< or = 30 U/L) levels (PNAL).One hundred and twenty-nine HCV carriers with PNAL who underwent liver biopsy and had platelet count over 150,000

2005 Journal of Hepatology

5710. Variants in TF and HFE Explain approximately 40% of Genetic Variation in Serum-Transferrin Levels. Full Text available with Trip Pro

Variants in TF and HFE Explain approximately 40% of Genetic Variation in Serum-Transferrin Levels. Only a small proportion of genetic variation in complex traits has been explained by SNPs from genome-wide association studies (GWASs). We report the results from two GWASs for serum markers of iron status (serum iron, serum transferrin, transferrin saturation with iron, and serum ferritin), which are important in iron overload (e.g., hemochromatosis) and deficiency (e.g., anemia) conditions. We (...) performed two GWASs on samples of Australians of European descent. In the first GWAS, 411 adolescent twins and their siblings were genotyped with 100K SNPs. rs1830084, 10.8 kb 3' of TF, was significantly associated with serum transferrin (p total association test = 1.0 x 10(-9); p within-family test = 2.2 x 10(-5)). In the second GWAS on an independent sample of 459 female monozygotic (MZ) twin pairs genotyped with 300K SNPs, we found rs3811647 (within intron 11 of TF, HapMap CEU r(2) with rs1830084

2008 American Journal of Human Genetics

5711. Ascorbic acid supplementation: its effects on body iron stores and white blood cells. (Abstract)

Ascorbic acid supplementation: its effects on body iron stores and white blood cells. 3519526 1986 07 17 2018 11 13 0021-1265 155 3 1986 Mar Irish journal of medical science Ir J Med Sci Ascorbic acid supplementation: its effects on body iron stores and white blood cells. 74-9 Malone H E HE Kevany J P JP Scott J M JM O'Broin S D SD O'Connor G G eng Clinical Trial Journal Article Randomized Controlled Trial Ireland Ir J Med Sci 7806864 0021-1265 9007-73-2 Ferritins E1UOL152H7 Iron PQ6CK8PD0R (...) Ascorbic Acid IM Adolescent Adult Ascorbic Acid administration & dosage Clinical Trials as Topic Diet Double-Blind Method Female Ferritins blood Humans Iron metabolism Leukocytes drug effects Random Allocation 1986 3 1 1986 3 1 0 1 1986 3 1 0 0 ppublish 3519526 Am J Clin Nutr. 1976 Aug;29(8):859-67 941868 Br J Nutr. 1974 May;31(3):367-75 4835790 Am J Clin Nutr. 1974 Feb;27(2):152-62 4812931 Blood. 1984 Sep;64(3):721-6 6466873 Am J Clin Nutr. 1979 Oct;32(10):2115-9 484529 Ir J Med Sci. 1985 Feb;154(2

1986 Irish journal of medical science Controlled trial quality: uncertain

5712. Cord blood transferrin receptors to assess fetal iron status Full Text available with Trip Pro

Cord blood transferrin receptors to assess fetal iron status To study iron status at different gestational ages using cord blood serum transferrin receptors (STfRs).STfRs, iron, ferritin, total iron binding capacity, haemoglobin, and reticulocytes were measured in 144 cord blood samples. The babies were divided into three groups according to gestation (26 very preterm (24-29 weeks); 50 preterm (30-36 weeks); 68 term (37-41 weeks)).Serum iron, ferritin, and total iron binding capacity were (...) highest at term, whereas reticulocytes were highest in the very preterm. STfR levels were not influenced by gestation. Haemoglobin (r = 0.46; p < 0.0001) and reticulocytes (r = 0.42; p < 0.0001) were the only indices that independently correlated with STfR levels.STfR levels in cord blood are not directly influenced by gestation and probably reflect the iron requirements of the fetus for erythropoiesis.

2001 Archives of Disease in Childhood. Fetal and Neonatal Edition

5713. Recombinant human erythropoietin as adjuvant treatment for autologous blood donation. Full Text available with Trip Pro

-26-7 Erythropoietin 9007-73-2 Ferritins AIM IM Blood Specimen Collection Blood Transfusion, Autologous Erythropoiesis drug effects Erythropoietin pharmacology Female Ferritins analysis Hemoglobins analysis Hip Prosthesis Humans Male Recombinant Proteins pharmacology Stimulation, Chemical 1990 6 23 1990 6 23 0 1 1990 6 23 0 0 ppublish 2372643 PMC1663274 N Engl J Med. 1989 Oct 26;321(17):1163-8 2677725 J Bone Joint Surg Am. 1987 Mar;69(3):320-4 3818697 (...) Recombinant human erythropoietin as adjuvant treatment for autologous blood donation. 2372643 1990 08 24 2018 11 13 0959-8138 300 6740 1990 Jun 23 BMJ (Clinical research ed.) BMJ Recombinant human erythropoietin as adjuvant treatment for autologous blood donation. 1627-8 Graf H H 2nd Department of Medicine, University of Vienna, Austria. Watzinger U U Ludvik B B Wagner A A Höcker P P Zweymüller K K KK eng Journal Article England BMJ 8900488 0959-8138 0 Hemoglobins 0 Recombinant Proteins 11096

1990 BMJ : British Medical Journal

5714. Screening for genetic haemochromatosis in blood samples with raised alanine aminotransferase Full Text available with Trip Pro

Screening for genetic haemochromatosis in blood samples with raised alanine aminotransferase In the UK approximately 1 in 140 people are homozygous for the C282Y mutation of the HFE gene and are at risk from iron overload caused by genetic haemochromatosis (GH). Early detection can prevent organ damage secondary to iron deposition and increase life expectancy.To screen for GH in all blood samples sent to the laboratory for routine liver function tests in which raised serum alanine (...) aminotransferase (ALT) activity was detected.ALT was measured in sera sent to the laboratory for routine liver function tests. In those samples found to have raised activity, transferrin saturation and ferritin were measured followed by genetic testing when transferrin saturation was increased.Of the 35 069 serum samples assayed for routine liver function tests, 1490 (4.2%) had raised ALT levels (>50 u/l). Transferrin saturation and serum ferritin concentrations were measured in these patient samples

2000 Gut

5715. Cognitive deficits associated with blood lead concentrations <10 microg/dL in US children and adolescents. Full Text available with Trip Pro

%) had blood lead concentrations > or =10 microg/dL. After adjustment for gender, race/ethnicity, poverty, region of the country, parent or caregiver's educational level, parent or caregiver's marital status parent, serum ferritin level, and serum cotinine level, the data showed an inverse relationship between blood lead concentration and scores on four measures of cognitive functioning. For every 1 microg/dL increase in blood lead concentration, there was a 0.7-point decrement in mean arithmetic (...) Cognitive deficits associated with blood lead concentrations <10 microg/dL in US children and adolescents. Lead is a confirmed neurotoxicant, but the lowest blood lead concentration associated with deficits in cognitive functioning and academic achievement is poorly defined. The purpose of the present study was to examine the relationship of relatively low blood lead concentrations-especially concentrations <10 micrograms per deciliter (microg/dL)--with performance on tests of cognitive

2000 Public Health Reports

5716. Study of maternal influences on fetal iron status at term using cord blood transferrin receptors Full Text available with Trip Pro

Study of maternal influences on fetal iron status at term using cord blood transferrin receptors To determine effects of maternal iron depletion and smoking on iron status of term babies using serum transferrin receptors (STfR) and their ratio to ferritin (TfR-F index) in cord blood.Iron, ferritin, STfR, and haemoglobin (Hb) concentration were measured and TfR-F index calculated in 67 cord /maternal blood pairs. Twenty six mothers were iron depleted (ferritin <10 microg/l) and 28 were (...) smokers.Maternal iron depletion was associated with decreased cord ferritin (113 v 171 microg/l) and Hb (156 v 168 g/l) but no change in STfR or TfR-F index. Smoking was associated with increased cord Hb (168 v 157 g/l) and TfR-F index (4.1 v 3.4), and decreased ferritin (123 v 190 microg/l). Cord TfR-F index and Hb were positively correlated (r = 0.48).Maternal iron depletion is associated with reduced fetal iron stores but no change in free iron availability. Smoking is associated with increased fetal iron

2001 Archives of Disease in Childhood. Fetal and Neonatal Edition

5717. Hepatic iron storage in very low birthweight infants after multiple blood transfusions Full Text available with Trip Pro

Hepatic iron storage in very low birthweight infants after multiple blood transfusions To investigate the effect of multiple blood transfusions on hepatic iron storage in preterm, very low birthweight (VLBW) infants.Seventeen VLBW infants who died within the first six months of life and underwent postmortem examination were studied. Serum ferritin, iron, and total iron binding capacity were measured within the week before the infants' death. Liver iron concentration was quantitatively (...) further subjected to multivariate stepwise regression analysis.Infants in group B had significantly higher serum iron (p < 0.01), serum ferritin (p < 0.01), and liver iron concentration (p < 0.01) than those in group A. The total and net volume of blood transfused were significantly associated with liver iron concentration (p < 0.001, r = 0.86; p < 0.001, r = 0.71 respectively), semiquantitative histochemical liver iron grading (p < 0.001, r = 0.80; p < 0.005, r = 0.71 respectively), and serum

2001 Archives of Disease in Childhood. Fetal and Neonatal Edition

5718. Consequences of uterine blood loss caused by various intrauterine contraceptive devices in South American women. World Health Organization Special Programme of Research, Development and Research Training in Human Reproduction. (Abstract)

received the Copper-7 or ProgestasertR devices and in Juiz de Fora, the TCu 200 and the T-Chloroquin IUDs were also tested. MBL and haemoglobin (HGB) were measured for 3 menstrual cycles before insertion, and following insertion, at one, two, four, six, nine, twelve, eighteen and twenty-four months in the majority of cases. Serum ferritin was measured before insertion and at intervals of six months. Mean values of MBL prior to IUD insertion in both centres varied from 21-30 ml. As with previous (...) publications, the use of the Lippes Loop was associated with the greatest increase in MBL which was sustained throughout the 24 months of observation. Women who had one of the two types of Multiload devices inserted also had increased MBL and reduced ferritin for at least 12 months of use. TCu 200 and Copper-7 IUD users had an initial increase in MBL of 1 to 17 ml in the first six months of observation returning to normal levels beyond six months. Serum ferritin levels were lower for one year

1988 Contraception Controlled trial quality: uncertain

5719. Treatment of iron deficiency conditions in blood donors: controlled study of iron sulphate versus iron protein succinylate. (Abstract)

Treatment of iron deficiency conditions in blood donors: controlled study of iron sulphate versus iron protein succinylate. Iron protein succinylate is a new iron preparation for oral administration. In a controlled study versus iron sulphate in 40 blood donors with low levels of stored iron, treatment for 30 days with iron protein succinylate resulted in greater iron absorption compared to the reference drug. Serum iron concentration significantly increased compared with baseline values only (...) in patients given iron protein succinylate. The amount of stored iron, evaluated by serum ferritin levels, significantly increased in both treatment groups.

1988 The Journal of international medical research Controlled trial quality: uncertain

5720. Carbonyl iron for short-term supplementation in female blood donors. (Abstract)

less than 0.001), and in the placebo group (n = 19) there were decreases in mean MCV (p less than 0.01), serum ferritin (p less than 0.001), and percent saturation (p = 0.027) with an increase in mean TIBC (p = 0.004). Carbonyl iron seems to be effective for short-term iron replacement in repeat blood donors and may have the advantage of decreased or absent risk of poisoning if accidentally ingested by children. (...) initially and 56 days later were tested for hemoglobin, mean corpuscular volume (MCV), free erythrocyte protoporphyrin, serum ferritin, serum iron, total iron binding capacity (TIBC), and percent saturation of TIBC. The prevalence of gastrointestinal side effects was similar in both groups taking iron. At the end of the study there was no laboratory evidence of change in iron status in women who received carbonyl iron (n = 15). In those treated with ferrous sulfate (n = 17) the mean TIBC increased (p

1987 Transfusion Controlled trial quality: predicted high

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