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Serum Ferritin

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5681. A lady with terrible restless legs and a low ferritin of 7.5 (ref range 12-230) but a normal Hb. is it worth putting her on iron?

.” The review also discussed ferritin, including the statement: “The possibility that RLS might be associated with iron metabolism has quite a long history. For instance, the observation that serum ferritin was lower in patients with RLS than in those without RLS suggested some link, albeit that the study had only 18 elderly patients. The inverse correlation of severity of RLS with serum ferritin levels, and improved symptoms after two months of treatment with oral iron salts helped to underline any (...) A lady with terrible restless legs and a low ferritin of 7.5 (ref range 12-230) but a normal Hb. is it worth putting her on iron? A lady with terrible restless legs and a low ferritin of 7.5 (ref range 12-230) but a normal Hb. is it worth putting her on iron? - Trip Database or use your Google+ account Turning Research Into Practice ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere

2006 TRIP Answers

5682. A 64 year old female vegetarian has a low normal hb of 11.4 and a low ferritin of 17(nr 20-3000). Is it safe to assume this is diet related and just treat, or at what stage is it mandatory to endoscop

A 64 year old female vegetarian has a low normal hb of 11.4 and a low ferritin of 17(nr 20-3000). Is it safe to assume this is diet related and just treat, or at what stage is it mandatory to endoscop A 64 year old female vegetarian has a low normal hb of 11.4 and a low ferritin of 17(nr 20-3000). Is it safe to assume this is diet related and just treat, or at what stage is it mandatory to endoscope and colonoscope? - Trip Database or use your Google+ account Liberating the literature ALL (...) @tripdatabase.com A 64 year old female vegetarian has a low normal hb of 11.4 and a low ferritin of 17(nr 20-3000). Is it safe to assume this is diet related and just treat, or at what stage is it mandatory to endoscope and colonoscope? The NLH Q&A Service is unable to comment on any assumptions regarding the cause of this females low hb, we can simply report on the literature we find. PRODIGY has a guideline on iron-deficiency anaemia [1] which we recommend you read (see reference section for URL). With regard

2006 TRIP Answers

5683. Effects of recombinant human erythropoietin on cerebral and cutaneous blood flow and on blood coagulability. (Abstract)

of five according to their serum ferritin concentration: group A. less than 800 microgram/liter, and group B. greater than 800 micrograms/liter. After a month of placebo administration, recombinant human erythropoietin was given (150 U/kg intravenously thrice weekly) for four months and then stopped for one month. Hematocrit values were maintained at 0.33 +/- 0.02 (mean +/- SD) by dose adjustment in group A and at 0.26 +/- 0.02 by thrice weekly phlebotomies in group B, who received a constant dose (...) Effects of recombinant human erythropoietin on cerebral and cutaneous blood flow and on blood coagulability. Seizures, hypertensive encephalopathy, transient ischemic attacks, and thrombosis of hemodialysis accesses occurred in early clinical trials with recombinant human erythropoietin. To determine if these events may be caused by the increased hematocrit value or some direct effect of the recombinant human hormone, 10 transfusion-dependent hemodialysis patients were divided into two groups

1990 Kidney international

5684. Ferritin

Ferritin Ferritin Produced by In partnership with User Top Links Menu Search User Top Links Search Ferritin Test Also Known As Serum ferritin Formal Name Ferritin, serum This article was last reviewed on 12 January 2017. This article was last modified on 27 July 2018. At a Glance Why Get Tested? To help assess the levels of iron stored in your body When To Get Tested? When your doctor suspects that you have either too little or too much iron in your system Sample Required? A blood sample taken (...) . Accordion Title Common Questions The ferritin blood test is requested to see how much iron your body has stored for future use. It is the most useful indicator of iron deficiency, as the ferritin stores can be significantly decreased before any fall in serum iron occurs. If iron excess is suspected, ferritin may be requested in combination with an and either , , or transferrin saturation (TSAT). An elevated ferritin in combination with a high iron level and either a low TIBC, low UIBC or an elevated

2004 Lab Tests Online UK

5685. Ferritin

. As iron deficiency continues, all of the stored iron is used and the body tries to compensate by producing more transferrin to increase iron transport. The serum iron level continues to decrease and transferrin and TIBC and UIBC increase. As this stage progresses, fewer and smaller red blood cells are produced, eventually resulting in . Transferrin saturation is decreased with iron deficiency. Iron overload If the iron level and transferrin saturation are high, the TIBC, UIBC and ferritin are normal (...) Ferritin Ferritin - Understand the Test User Top Links Menu Search User Top Links Search Ferritin Also Known As Serum Ferritin Formal Name Ferritin, serum This article was last reviewed on March 28, 2018. This article was last modified on December 19, 2018. At a Glance Why Get Tested? To determine your body's total iron storage capacity; to help diagnose iron deficiency or iron overload When To Get Tested? When you have low hemoglobin and hematocrit on a ; when your healthcare practitioner

2004 Lab Tests Online USA

5686. DRIVE Trial (Dialysis Patients' Response to Intravenous [IV] Iron With Elevated Ferritin)

Elevated serum ferritin with low to normal transferrin saturation (TSAT) Moderate to severe anemia Receiving epoetin alfa treatment Exclusion Criteria: Known sensitivity to Ferrlecit® Medical conditions that would confound the efficacy evaluation Recent blood transfusion Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer (...) Pharmaceuticals Information provided by (Responsible Party): Watson Pharmaceuticals Study Details Study Description Go to Brief Summary: This study explores the safety and efficacy of intravenous iron therapy in anemic hemodialysis patients treated with epoetin alfa, who have higher serum ferritin levels, but low to normal transferrin saturation. Condition or disease Intervention/treatment Phase Anemia, Iron-Deficiency Kidney Failure, Chronic Hemodialysis Drug: Sodium ferric gluconate, Phase 4 Study Design Go

2005 Clinical Trials

5687. Usefulness of glycosylated ferritin in atypical presentations of adult onset Still's disease Full Text available with Trip Pro

and over Biomarkers blood Diagnosis, Differential Female Ferritins analogs & derivatives blood Humans Middle Aged Still's Disease, Adult-Onset diagnosis 2004 4 15 5 0 2004 6 21 10 0 2004 4 15 5 0 ppublish 15082500 10.1136/ard.2003.012484 63/5/605 PMC1754986 (...) Usefulness of glycosylated ferritin in atypical presentations of adult onset Still's disease 15082500 2004 06 07 2015 11 19 0003-4967 63 5 2004 May Annals of the rheumatic diseases Ann. Rheum. Dis. Usefulness of glycosylated ferritin in atypical presentations of adult onset Still's disease. 605 Hamidou M A MA Denis M M Barbarot S S Boutoille D D Belizna C C Le Moël G G eng Letter England Ann Rheum Dis 0372355 0003-4967 0 Biomarkers 0 glycosylated ferritin 9007-73-2 Ferritins IM Aged Aged, 80

2004 Annals of the Rheumatic Diseases

5688. Case report: a subject with a mutation in the ATG start codon of L-ferritin has no haematological or neurological symptoms Full Text available with Trip Pro

Ferrari F F Fermo I I Foglieni B B Levi S S Bozzini C C Camparini M M Ferrari M M Arosio P P eng GP0075Y01 Telethon Italy Case Reports Journal Article Research Support, Non-U.S. Gov't England J Med Genet 2985087R 0022-2593 0 Codon, Initiator 9007-73-2 Ferritins 9013-31-4 Apoferritins IM Apoferritins Base Sequence Cataract blood genetics pathology Chromatography, High Pressure Liquid methods Codon, Initiator genetics DNA Mutational Analysis Ferritins blood genetics Hematologic Diseases genetics (...) Case report: a subject with a mutation in the ATG start codon of L-ferritin has no haematological or neurological symptoms 15173247 2004 09 27 2017 09 22 1468-6244 41 6 2004 Jun Journal of medical genetics J. Med. Genet. Case report: a subject with a mutation in the ATG start codon of L-ferritin has no haematological or neurological symptoms. e81 Cremonesi L L Genomics for the Diagnosis of Human Pathologies Unit, IRCCS H. San Raffaele, Via Olgettina 58, 20132 Milan, Italy. Cozzi A A Girelli D D

2004 Journal of Medical Genetics

5689. Investigating iron status in microcytic anaemia: General practitioners could test for ferritin, etc, before referral Full Text available with Trip Pro

Family Practice Ferritins blood Humans Referral and Consultation 2006 11 4 9 0 2006 11 15 9 0 2006 11 4 9 0 ppublish 17082563 333/7575/972 10.1136/bmj.333.7575.972 PMC1633804 BMJ. 2006 Oct 14;333(7572):791-3 17038737 (...) Investigating iron status in microcytic anaemia: General practitioners could test for ferritin, etc, before referral 17082563 2006 11 14 2018 11 13 1756-1833 333 7575 2006 Nov 04 BMJ (Clinical research ed.) BMJ Investigating iron status in microcytic anaemia: general practitioners could test for ferritin, etc, before referral. 972 Das Debasish D eng Comment Letter England BMJ 8900488 0959-8138 9007-73-2 Ferritins AIM IM BMJ. 2006 Oct 14;333(7572):791-3 17038737 Anemia, Iron-Deficiency diagnosis

2006 BMJ : British Medical Journal

5690. Biological variation of plasma ferritin in healthy adult males in south Indian population—A sample study Full Text available with Trip Pro

Biological variation of plasma ferritin in healthy adult males in south Indian population—A sample study A sample study of biological variation of plasma ferritin in healthy adult males 19-25 years of age (n=6) in the Indian population was determined. Venous blood was collected on 3 non-consecutive days during a 3 week period. Plasma ferritin was measured using enzyme linked immunoassay in an automated immunoassay system. Analytical and Biological variation was calculated. We found a mean

2006 Indian Journal of Clinical Biochemistry

5691. Iron absorption from soybean ferritin in nonanemic women. Full Text available with Trip Pro

. After 28 d, whole-body 59Fe and 59Fe in red blood cells were measured before and after dosing.There was no significant difference in whole-body iron absorption from soybean ferritin (29.9 +/- 19.8%) and that from FeSO4 (34.3 +/- 23.6%) or in iron absorption calculated from red blood cell incorporation (33.0 +/- 20.1% for soybean ferritin and 35.3 +/- 23.4% for FeSO4), which confirmed previous results with animal ferritin that was mineralized and labeled similarly. An inverse relation was observed (...) between serum ferritin and iron absorption from both ferritin and FeSO4, which suggested that sensors regulating iron absorption respond similarly to iron provided as ferrous salts or as ferritin mineral.Iron from soybean ferritin is well absorbed and may provide a model for novel, utilizable, plant-based forms of iron for populations with a low iron status.

2006 The American journal of clinical nutrition Controlled trial quality: uncertain

5692. [Effectiveness of different iron supplementation strategies on hemoglobin and ferritin levels among schoolchildren in Teresina, Piauí State, Brazil]. (Abstract)

[Effectiveness of different iron supplementation strategies on hemoglobin and ferritin levels among schoolchildren in Teresina, Piauí State, Brazil]. This study evaluated the effectiveness of supplementation with ferrous sulfate and iron bis-glycinate chelate on hemoglobin and serum ferritin levels among schoolchildren (7-11 years) of both sexes. A randomized community-based trial including 138 anemic children (hemoglobin < 11.5 g/dL) was conducted in Teresina, Piauí State, Brazil. Children (...) > 0.05). No effect was observed on body iron for either intervention (p > 0.05). Children with depleted iron stores (< 15 ng/mL) at the beginning of interventions showed increased serum ferritin concentrations after 8 weeks (p < 0.01), although no difference between treatments (p > 0.05) was observed. The results confirm the effectiveness of the iron supplementation interventions and corroborate the use of iron salts or ferrous bisglycinate chelate on a weekly basis to overcome iron deficiency

2007 Cadernos de Saúde Pública / Ministério da Saúde Controlled trial quality: uncertain

5693. Factors accounting for high ferritin levels in obesity. Full Text available with Trip Pro

Factors accounting for high ferritin levels in obesity. Ferritin is a widely used marker of iron status. A relationship between iron stores, obesity and metabolic syndrome (METs) has been proposed.To compare serum ferritin between obese women with and without METs, and to evaluate the main factors accounting for ferritin levels.Prospective study.A total of 239 consecutive postmenopausal women with body mass index (BMI) > or =30 kg/m(2) were included. Exclusion criteria were conditions (...) that could influence body iron stores. In addition to ferritin, serum iron, transferrin, transferrin saturation index and the soluble transferrin receptor were measured. METs was defined according to the International Diabetes Federation guidelines. Multiple regression analyses were performed taking into account ferritin as the dependent variable.Serum ferritin levels were significantly higher in obese women with METs (n=169) in comparison with obese women without METs (n=70): 81.00 (17-648) vs 48.50 (11

2008 International Journal of Obesity

5694. The fascinating but deceptive ferritin: to measure it or not to measure it in chronic kidney disease? Full Text available with Trip Pro

associations of Fe with infection and oxidative stress have fueled the "iron apprehension." To date, no reliable marker of Fe stores in CKD has been agreed on. Serum ferritin continues to be the focus of attention. Almost half of all maintenance hemodialysis patients have a serum ferritin >500 ng/ml. In this ferritin range, Fe supplementation currently is not encouraged, although most reported hemochromatosis cases had a serum ferritin >2000 ng/ml. The moderate-range hyperferritinemia (500 to 2000 ng/ml (...) ) seems to be due mostly to non-Fe-related conditions, including inflammation, malnutrition, liver disease, infection, and malignancy. Recent epidemiologic studies have shown that a low, rather than a high, serum Fe is associated with a poor survival in maintenance hemodialysis patients. In multivariate adjusted models that mitigate the confounding effect of malnutrition-inflammation, serum ferritin <1200 ng/ml and Fe saturation ratio in 30 to 50% range are associated with the greatest survival

2006 Clinical Journal of the American Society of Nephrology

5695. The long-term impact of ferritin level on treatment and complications of type 2 diabetes. (Abstract)

triglyceride, blood pressure and liver enzyme levels at the end of follow up. However, ferritin level had no impact on the initial or final requirements for diabetic medication and the development of diabetic complications.Although elevated serum ferritin is a marker of insulin resistance and chronic inflammation, it is not necessarily a bad prognostic indicator that should affect the clinician's approach to management. (...) The long-term impact of ferritin level on treatment and complications of type 2 diabetes. To investigate if high-serum ferritin has long-term impact on response to treatment and the development of diabetic complications in patients with type 2 diabetes.We analysed the record of 90 consecutive type 2 diabetic subjects who had serum ferritin level determined soon after diagnosis of diabetes and who also had long-term follow-up data.Patients with higher serum ferritin level had slightly worse

2008 obesity & metabolism

5696. Iron in ferritin or in salts (ferrous sulfate) is equally bioavailable in nonanemic women. Full Text available with Trip Pro

and 28 d and by red blood cell incorporation after 28 d.There was no significant difference in iron absorption between ferritin and ferrous sulfate: low-phosphate iron mineral ferritin (x +/- SD: 21.4 +/- 14.7%) compared with ferrous sulfate (21.9 +/- 14.6%), or high-phosphate iron mineral ferritin (22.2 +/- 19.2%) compared with ferrous sulfate (16.7 +/- 7.1%). Results obtained by using whole-body retention of iron and red blood cell incorporation differed with the type of iron, which suggests (...) Iron in ferritin or in salts (ferrous sulfate) is equally bioavailable in nonanemic women. Recent studies in humans suggest that ferritin iron in soybeans has high bioavailability. However, direct evidence for this is lacking because the soybeans were intrinsically labeled; thus, iron bound to other ligands, such as phytate, was also labeled.The objectives of the study were to evaluate the absorption of iron from extrinsically labeled, purified ferritin (horse spleen) reconstituted with either

2004 The American journal of clinical nutrition Controlled trial quality: uncertain

5697. Augmentation in restless legs syndrome is associated with low ferritin. (Abstract)

to patients who did not experience augmentation.Augmentation symptoms causing premature discontinuation from the study or which were tolerated (n=36, ferritin: 85+59 ng/ml) were associated with lower levels of serum ferritin compared to patients without augmentation (n=302, ferritin: 118+108 ng/ml, p=0.0062).Ferritin as a marker of iron storage may play an important role in the pathophysiology of RLS and may prove to be a biomarker for the development of augmentation under dopaminergic therapy. (...) Augmentation in restless legs syndrome is associated with low ferritin. Augmentation is a major problem with dopaminergic therapy for restless legs syndrome (RLS), and predictors of augmentation have not yet been identified. We aimed to analyze the relationship between baseline ferritin level and occurrence of augmentation in a retrospective analysis of a prospective double-blind trial of cabergoline versus levodopa on augmentation in RLS.Patients who experienced augmentation were compared

2008 Sleep medicine Controlled trial quality: uncertain

5698. Ferric gluconate reduces epoetin requirements in hemodialysis patients with elevated ferritin. Full Text available with Trip Pro

+/- 19,987 IU/wk, P = 0.809). Mean hemoglobin, TSAT, and serum ferritin levels remained higher in the ferric gluconate group than in the control group (P = 0.062, P < 0.001, and P = 0.014, respectively). Over the entire 12-wk study period (DRIVE plus DRIVE-II), the control group experienced significantly more serious adverse events than the ferric gluconate group (incidence rate ratio = 1.73, P = 0.041). In conclusion, ferric gluconate maintains hemoglobin and allows lower epoetin doses in anemic (...) Ferric gluconate reduces epoetin requirements in hemodialysis patients with elevated ferritin. The Dialysis Patients Response to IV Iron with Elevated Ferritin (DRIVE) study demonstrated the efficacy of intravenous ferric gluconate to improve hemoglobin levels in anemic hemodialysis patients who were receiving adequate epoetin doses and who had ferritin levels between 500 and 1200 ng/ml and transferrin saturation (TSAT) < or = 25%. The DRIVE-II study reported here was a 6-wk observational

2008 Journal of the American Society of Nephrology : JASN Controlled trial quality: uncertain

5699. A novel ferritin light chain gene mutation in a Japanese family with neuroferritinopathy: Description of clinical features and implications for genotype-phenotype correlations. (Abstract)

with insertions in the 3' portion of exon 4 develop early-onset tremor, suggesting genotype-phenotype correlations. In this family, male predominance and normal serum ferritin levels are characteristic.(c) 2008 Movement Disorder Society. (...) A novel ferritin light chain gene mutation in a Japanese family with neuroferritinopathy: Description of clinical features and implications for genotype-phenotype correlations. Neuroferritinopathy is a hereditary neurodegenerative disorder caused by mutations in the ferritin light chain gene (FTL1). The cardinal features are progressive movement disturbance, hypoferritinemia, and iron deposition in the brain. To date, five mutations have been described in Caucasian and Japanese families

2008 Movement Disorders

5700. Low glycosylated ferritin, a good marker for the diagnosis of hemophagocytic syndrome. (Abstract)

Low glycosylated ferritin, a good marker for the diagnosis of hemophagocytic syndrome. A very low percentage of glycosylated ferritin (<20%) has only been reported in association with adult-onset Still's disease (AOSD), a disease classically associated with hemophagocytic syndrome. We undertook this study to determine whether hemophagocytic syndrome outside the context of AOSD is also associated with a very low percentage of glycosylated ferritin.From October 2006 to September 2007, the serum (...) (14 with confirmed hemophagocytic syndrome, 7 with suspected but unconfirmed hemophagocytic syndrome, and 21 controls). The median level (interquartile range [IQR]) of total serum ferritin was significantly higher in patients with confirmed hemophagocytic syndrome (3,344 microg/liter [2,074-7,334]) than in patients with suspected but unconfirmed hemophagocytic syndrome (555 microg/liter [464-1,420]) (P = 0.02) or in controls (451 microg/liter [126-929]) (P < 0.001). The median (IQR) percentage

2008 Arthritis and Rheumatism

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