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Serum Ferritin

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5661. Blood donations, iron stores, and risk of Parkinson's disease. (Abstract)

was inversely related to the ferritin levels in a subsample of the study population, no association was found between the number of blood donations and risk of PD (P for trend = 0.6). Unexpectedly, the risk of PD was higher among men who reported recent multiple blood donations (P for trend = 0.05). The results of this study do not support the hypothesis that reduced systemic iron stores lower the risk of PD. (...) Blood donations, iron stores, and risk of Parkinson's disease. Iron overload and systemic iron stores may be important in the pathogenesis of Parkinson's disease (PD). We therefore examined the association between blood donations, which reduce body iron stores, and risk of PD in the Health Professionals Follow-Up Study, a large cohort investigation of U.S. men. Our hypothesis was that blood donation reduces the risk of PD by lowering systemic iron stores. Although the number of blood donations

2006 Movement Disorders

5662. Cord blood and breast milk iron status in maternal anemia. Full Text available with Trip Pro

at term gestation. We measured hemoglobin, iron, and ferritin levels in paired maternal and cord blood and iron levels in early (day 3 +/- 1) and late (day 15 +/- 3) transitional milk. Maternal anthropometry, including weight, height, midarm circumference, triceps skinfold thickness, and placental weight, were recorded. The main outcome measure of the study was to find out the relationship of maternal hemoglobin, iron, ferritin, and anthropometry with hemoglobin, iron, and ferritin in cord blood (...) and iron levels in breast milk.Concentrations of hemoglobin, iron, and ferritin were significantly lower in the cord blood of anemic mothers and showed linear relationships with maternal hemoglobin and ferritin levels. Breast milk iron content was significantly reduced in severely anemic mothers but not in those with mild-to-moderate anemia. Breast milk iron level correlated with maternal hemoglobin and iron levels but not with ferritin levels. Maternal anthropometry had significant correlations

2008 Pediatrics

5663. Maternal peripheral blood level of IL-10 as a marker for inflammatory placental malaria. Full Text available with Trip Pro

of Tanzanian parturients, PM was determined by placental blood smears and placental inflammation was assessed by histology and TNF mRNA levels. Maternal peripheral blood levels of several immune mediators previously implicated in PM pathogenesis, as well as ferritin and leptin were measured. The relationship between the levels of these soluble factors to PM and placental inflammation was examined.Peripheral levels of TNF, TNF-RI, TNF-RII, IL-1, IL-10, and ferritin were elevated during PM, whereas levels (...) Maternal peripheral blood level of IL-10 as a marker for inflammatory placental malaria. Placental malaria (PM) is an important cause of maternal and foetal mortality in tropical areas, and severe sequelae and mortality are related to inflammation in the placenta. Diagnosis is difficult because PM is often asymptomatic, peripheral blood smear examination detects parasitemia as few as half of PM cases, and no peripheral markers have been validated for placental inflammation.In a cohort

2008 Malaria journal

5664. Red blood cell transfusions and iron overload in the treatment of patients with myelodysplastic syndromes. Full Text available with Trip Pro

recommend that the iron burden of transfused patients be monitored regularly and that iron chelation therapy be considered to maintain serum ferritin levels of <1000 ng/mL. (...) Red blood cell transfusions and iron overload in the treatment of patients with myelodysplastic syndromes. Approximately 15,000 new cases of myelodysplastic syndromes (MDS) are expected in the United States each year.The mainstay for the management of myelodysplastic syndromes (MDS) is supportive therapy with red blood cell (RBC) transfusions to improve the patient's quality of life. RBC transfusions enable adequate tissue oxygenation and increase hemoglobin levels, improve fatigue, and improve

2008 Cancer

5665. Insulin sensitivity, vascular function, and iron stores in voluntary blood donors. Full Text available with Trip Pro

blood donors (one to two donations in the last 2 years) aged 50-75 years. Serum markers of iron stores, whole-body insulin sensitivity index (WBISI) during oral glucose tolerance testing, and flow-mediated dilation in the brachial artery were determined in all subjects.Serum ferritin was decreased (median values 23 vs. 36 ng/ml, P < 0.05) and flow-mediated dilation in the brachial artery was increased (median values 5.9 vs. 5.3%, P < 0.05) in high-frequency donors compared with low-frequency donors (...) , respectively, but WBISI (median values 4.8 vs. 4.7) and related measures of glucose tolerance did not differ between groups. Flow-mediated dilation significantly decreased at 1 h after oral glucose loading in both groups, but the decrease in flow-mediated dilation at 1 h did not differ between high- and low-frequency donors.High-frequency blood donation reduced serum ferritin and increased flow-mediated dilation compared with low-frequency donation but did not improve insulin sensitivity or protect

2007 Diabetes Care

5666. Iron stores and vascular function in voluntary blood donors. Full Text available with Trip Pro

progression.Forty high-frequency voluntary blood donors (> or =8 donations in past 2 years) and 42 low-frequency blood donors (1 to 2 donations in past 2 years) aged 50 to 75 years were randomly selected from American Red Cross of Connecticut blood donor records. Flow-mediated dilation in the brachial artery, serum markers of iron stores, vascular inflammation and oxidative stress, and cardiac risk factors were assessed in all subjects. Serum ferritin was significantly decreased in high-frequency blood donors (...) when compared with low-frequency blood donors (median values 17 versus 52 ng/mL; P<0.001), but hematocrit did not differ between groups. Flow-mediated dilation in the brachial artery was significantly greater in high-frequency donors when compared with low-frequency donors in univariate analysis (5.5+/-2.6% versus 3.8+/-1.6%; P=0.0003) and in multivariate analysis adjusting for cardiac risk factors and other potential confounders. Serum biomarkers of vascular inflammation did not differ between

2005 Thrombosis and Vascular Biology

5667. Menstrual blood loss in women using the frameless FibroPlant LNG-IUS. (Abstract)

Menstrual blood loss in women using the frameless FibroPlant LNG-IUS. This study was conducted to report on a menstrual blood loss (MBL) study and iron stores in women with and without heavy menstrual bleeding using the frameless FibroPlant levonorgestrel-releasing intrauterine system (LNG-IUS) for contraception.An open, prospective, noncomparative MBL study, using FibroPlant releasing 14 mcg of LNG/day for contraception. MBL was assessed by the quantitative alkaline hematin (QAH) technique.The (...) MBL study was conducted in 40 heavy and normally menstruating Brazilian women seeking contraception. MBL was reduced from a mean baseline menstrual volume of 29.7 mL to a mean volume of 1.5 mL after 24 months, while ferritin values increased from a mean value of 31.1 ng/mL (at baseline) to a mean level of 72.5 ng/mL (after 24 months of use). Differences were highly significant (p<.0005). There were no significant differences between those who had normal menstrual bleeding and the heavy bleeders

2009 Contraception

5668. Safety of Frequent Venous Blood Sampling in a Pediatric Research Population. Full Text available with Trip Pro

Safety of Frequent Venous Blood Sampling in a Pediatric Research Population. To monitor hematological indices in otherwise healthy children with central precocious puberty who underwent frequent venous sampling as part of a longitudinal clinical research study.Thirty-four female subjects underwent frequent venous sampling (every 10-20 minutes for 8-16 hours) every 6 months for >or=3 years during and after their treatment with a gonadotropin-releasing hormone analogue. Hemoglobin (Hgb), mean (...) corpuscular volume, and ferritin levels were measured before and after each phlebotomy session.At baseline, the average Hgb level was 12.5+/-0.7 g/L. At the conclusion of the first sampling session, the Hgb level fell 1.2+/-0.1 g/L, remaining within the reference range for age. At the 3-month follow-up, there was complete recovery of Hgb (12.6+/-0.2 g/L). Longitudinal evaluation every 6 months for as long as 3 years showed no significant differences in Hgb, mean corpuscular volume, or ferritin levels from

2008 Journal of Pediatrics

5669. Blood donation, body iron status and carotid intima-media thickness. (Abstract)

Blood donation, body iron status and carotid intima-media thickness. Iron could promote free radical formation, which may lead to injury of the arterial wall and atherosclerosis. Blood donation may reduce cardiovascular risk by lowering body iron status. We collected data on blood donation history and intima-media thickness of the common carotid artery (CIMT) in 819 subjects (50-70 years), who were recruited from municipal and blood bank registries in The Netherlands. Serum iron parameters were (...) assessed, including non-transferrin bound iron (NTBI) that has recently been found in conditions of iron overload. Serum ferritin was lower in current donors (n=443; 44 microg/L) than in ex-donors (n=120; 114 microg/L) and never-donors (n=256; 124 microg/L, P for trend <0.001). For NTBI, values were 2.33, 2.54, and 2.51 micromol/L, respectively (P<0.05). CIMT was slightly reduced in frequent donors (i.e., > or =49 times during life or > or =2 times per year), although not statistically significant

2007 Atherosclerosis

5670. In vivo study of propolis supplementation effects on antioxidative status and red blood cells. (Abstract)

, uric acid, ferritin and transferrin, together with routine red blood cell parameters. The effect of daily propolis intake seems to be time and gender related. For the men test group after the initial 15 days of propolis treatment, 23.2% (p=0.005) decrease in concentration of malondialdehyde was observed. After 30 days of treatment, statistically significant (p=0.010) 20.9% increase in superoxide dismutase activity and change in some of the red blood cell parameters were detected. For the women test (...) In vivo study of propolis supplementation effects on antioxidative status and red blood cells. In vivo study has been conducted on 47 healthy women and men in order to investigate whether daily intake of powdered propolis extract during 30 days has any influence on the following blood parameters: activity of superoxide dismutase, glutathione peroxidase and catalase, concentration of plasma malondialdehyde, total cholesterol, low- and high-density lipoprotein cholesterol, triglycerides, glucose

2007 Journal of Ethnopharmacology

5671. Effect of sodium iron ethylenediaminetetra-acetate (NaFeEDTA) on haemoglobin and serum ferritin in iron-deficient populations: a systematic review and meta-analysis of randomised and quasi-randomised controlled trials

Effect of sodium iron ethylenediaminetetra-acetate (NaFeEDTA) on haemoglobin and serum ferritin in iron-deficient populations: a systematic review and meta-analysis of randomised and quasi-randomised controlled trials Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2008 DARE.

5672. Screening primary care patients for hereditary hemochromatosis with transferrin saturation and serum ferritin level: systematic review for the American College of Physicians

for practice or further research. Funding American College of Physicians. Bibliographic details Schmitt B, Golub R M, Green R. Screening primary care patients for hereditary hemochromatosis with transferrin saturation and serum ferritin level: systematic review for the American College of Physicians. Annals of Internal Medicine 2005; 143(7): 522-536 PubMedID Original Paper URL Indexing Status Subject indexing assigned by NLM MeSH Adult; Evidence-Based Medicine; Ferritins /blood; Genetic Testing (...) Screening primary care patients for hereditary hemochromatosis with transferrin saturation and serum ferritin level: systematic review for the American College of Physicians Screening primary care patients for hereditary hemochromatosis with transferrin saturation and serum ferritin level: systematic review for the American College of Physicians Screening primary care patients for hereditary hemochromatosis with transferrin saturation and serum ferritin level: systematic review for the American

2005 DARE.

5673. Peripheral Blood Film

-deficiency anaemia and thalassaemia. Abnormal Hb levels See also the separate , and articles. Anaemia with low MCV (microcytic): - look at serum ferritin level. . . Anaemia with normal MCV (normocytic): Recent bleeding. Anaemia of chronic disease (including renal disease). Combined iron and B12/folate deficiency. Most non-haematinic deficiency causes. Anaemia with high MCV (macrocytic): see the separate article. High Hb It is important first to ascertain the validity of this result if it does not tie (...) . They result in a raised platelet distribution width (the indicator of the range in platelet size in a blood sample) unlike the normal platelet distribution width seen in reactive thrombocytosis, where there is an increased platelet count but normal sized platelets. Satellitosis - describes platelets encircling a neutrophil. It occurs when a patient has a serum factor that reacts to the anticoagulant EDTA. Parasites in the blood film [ ] Blood films are useful for the diagnosis of: Babesiosis Malaria

2008 Mentor

5674. Full Blood Count

and thalassaemia. Abnormal Hb levels See also the separate , and articles. Anaemia with low MCV (microcytic): - look at serum ferritin level. . . Anaemia with normal MCV (normocytic): Recent bleeding. Anaemia of chronic disease (including renal disease). Combined iron and B12/folate deficiency. Most non-haematinic deficiency causes. Anaemia with high MCV (macrocytic): see the separate article. High Hb It is important first to ascertain the validity of this result if it does not tie in with known clinical (...) distribution width (the indicator of the range in platelet size in a blood sample) unlike the normal platelet distribution width seen in reactive thrombocytosis, where there is an increased platelet count but normal sized platelets. Satellitosis - describes platelets encircling a neutrophil. It occurs when a patient has a serum factor that reacts to the anticoagulant EDTA. Parasites in the blood film [ ] Blood films are useful for the diagnosis of: Babesiosis Malaria Microfilaria Trypanosomiasis Some

2008 Mentor

5675. Prevalence of HFE mutations and relation to serum iron status in patients with chronic hepatitis C and patients with nonalcoholic fatty liver disease in Taiwan Full Text available with Trip Pro

of HFE gene in 125 healthy subjects, 29 patients with CHC, and 33 patients with NAFLD. The serum iron markers, including ferritin, iron, and total iron binding capacity (TIBC), were assessed in all patients.All of the healthy subjects and patients were free from C282Y mutation. The prevalence of H63D heter-ozygosity was 4/125 (3.20%) in healthy subjects, 2/29 (6.90%) in CHC group, and 1/33 (3.03%) in NAFLD group. The healthy subjects showed no significant difference in the prevalence of H63D mutation (...) Prevalence of HFE mutations and relation to serum iron status in patients with chronic hepatitis C and patients with nonalcoholic fatty liver disease in Taiwan To assess the prevalence of the two mutations, C282Y and H63D of HFE gene, in healthy subjects, patients with chronic hepatitis C (CHC), and patients with nonalcoholic fatty liver disease (NAFLD) in Taiwan and to explore the contribution of the HFE mutation on serum iron stores in CHC and NAFLD groups.We examined C282Y and H63D mutations

2005 World journal of gastroenterology : WJG

5676. Reliability of Serum Assays of Iron Status in Postmenopausal Women Full Text available with Trip Pro

for ferritin (0.78; 95% confidence interval [CI], 0.67-0.86), soluble transferrin receptor (sTfR; 0.79; 95% CI, 0.69-0.87), sTfR/ferritin ratio (0.74; 95% CI, 0.62-0.83), and hepcidin (0.89; 95% CI, 0.84-0.94). In a subset of 30 women, lower reliability was observed for serum iron (0.50; 95% CI, 0.29-0.70), unsaturated iron-binding capacity (0.55; 95% CI, 0.34-0.73), total iron-binding capacity (0.60; 95% CI, 0.40-0.76), and serum transferrin saturation rate (0.44; 95% CI, 0.22-0.65). The reliability (...) Reliability of Serum Assays of Iron Status in Postmenopausal Women The aim of the study is to determine the reliability during a 2-year period of several newly developed iron-related assays to assess their potential for use in prospective epidemiologic studies.We assessed the temporal reliability of several iron-related assays by using three serum samples collected at yearly intervals from 50 postmenopausal participants in a large prospective study.We observed high reliability coefficients

2006 Annals of Epidemiology

5677. Relationship between serum leptin level and laboratory and anthropometric indices of malnutrition in patients on hemodialysis Full Text available with Trip Pro

of correlation coefficient between serum leptin and anthropometric parameters and most laboratory parameters was < 0.25 (except ferritin, iron, phosphorous in males and total protein, hemoglobin, urea, and creatinin in females which was between 0.25 and 0.50). Our results suggest that the increased serum leptin level does not have a major role in diagnosis of malnutrition in hemodialysis patients and there is a poor correlation between malnutrition parameters and serum leptin level. (...) Relationship between serum leptin level and laboratory and anthropometric indices of malnutrition in patients on hemodialysis Protein-energy malnutrition is a major problem and one of the risk factors for mortality in hemodialysis patients. There is no single index in evaluation of nutritional status in these patients, so leptin can be used as one of the parameters. In this study, the correlation between serum leptin with biochemical and anthropometric parameters of nutrition has been evaluated

2008 Indian Journal of Nephrology

5678. Impact of Providing High Protein Bar to Dialysis Patients With Low Serum Albumin

Impact of Providing High Protein Bar to Dialysis Patients With Low Serum Albumin Impact of Providing High Protein Bar to Dialysis Patients With Low Serum Albumin - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding (...) more. Impact of Providing High Protein Bar to Dialysis Patients With Low Serum Albumin The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00597025 Recruitment Status : Unknown Verified December 2007 by Satellite Healthcare. Recruitment status was: Recruiting First Posted : January 17, 2008 Last Update

2008 Clinical Trials

5679. Efficacy of SBR759 in Lowering Serum Phosphate Levels in Chronic Kidney Disease Patients on Hemodialysis

: All Accepts Healthy Volunteers: No Criteria Inclusion criteria Men or women of at least 18 years old. Stable maintenance of renal replacement therapy 3 times per week. Controlled Serum phosphate if under phosphate-binder therapy. Serum phosphate level ≥ 6.0 mg/dL (> 1.9 mmol/L) prior to study treatment initiation. Exclusion criteria Peritoneal dialysis. Parathyroidectomy or transplant scheduled during the study. Uncontrolled hyperparathyroidism History of hemochromatosis or ferritin > 1000 µg/L (...) Efficacy of SBR759 in Lowering Serum Phosphate Levels in Chronic Kidney Disease Patients on Hemodialysis Efficacy of SBR759 in Lowering Serum Phosphate Levels in Chronic Kidney Disease Patients on Hemodialysis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100

2008 Clinical Trials

5680. Optimal Titration Regimen for SBR759 in Lowering Serum Phosphate Levels in Asian Chronic Kidney Disease Patients on Hemodialysis

-binder therapy. Serum phosphate level > 6.0 mg/dL (> 1.9 mmol/L) prior to study treatment initiation. Exclusion criteria Peritoneal dialysis or a non-conventional hemodialysis technique . Parathyroidectomy or transplant scheduled during the study. Uncontrolled hyperparathyroidism History of hemochromatosis or ferritin > 800 µg/L. Clinically significant GI disorder Unstable medical condition other than Chronic Kidney Disease. Treated with sevelamer HCl monotherapy or SBR759. Treated with oral iron (...) Optimal Titration Regimen for SBR759 in Lowering Serum Phosphate Levels in Asian Chronic Kidney Disease Patients on Hemodialysis Optimal Titration Regimen for SBR759 in Lowering Serum Phosphate Levels in Asian Chronic Kidney Disease Patients on Hemodialysis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have

2008 Clinical Trials

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