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Serum Ferritin

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5661. Iron status markers and serum erythropoietin in 120 mothers and newborn infants. Effect of iron supplementation in normal pregnancy. (Abstract)

Iron status markers and serum erythropoietin in 120 mothers and newborn infants. Effect of iron supplementation in normal pregnancy. In a randomized, double-blind, placebo controlled study of the effect of iron supplementation during pregnancy, iron status (hemoglobin (Hb), serum (S-)transferrin saturation, S-ferritin) and S-erythropoietin (EPO) were assessed in 120 healthy pregnant women at 14-16 weeks of gestation, and just before delivery; 63 women were treated with 66 mg iron daily, and 57 (...) with placebo. There were no differences in baseline values in the two groups. At term, the iron treated group had significantly higher Hb, transferrin saturation, S-ferritin (median 22 micrograms/l vs. 14 micrograms/l, (p < 0.0001) and lower S-EPO compared to the placebo treated group. In the iron group, 30.2% had exhausted iron stores (i.e. S-ferritin < 20 micrograms/l), 6.3% latent iron deficiency (S-ferritin < 20 micrograms/l and transferrin saturation < 15%), and no patients had iron deficiency anemia

1994 Acta Obstetricia et Gynecologica Scandinavica Controlled trial quality: predicted high

5662. Response of serum transferrin receptor to iron supplementation in iron-depleted, nonanemic women. Full Text available with Trip Pro

Response of serum transferrin receptor to iron supplementation in iron-depleted, nonanemic women. Serum transferrin receptor (sTfR) concentration has been recognized recently as a reliable indicator of functional iron deficiency, but its response to iron supplementation has not been investigated in marginally iron-deficient women. In this randomized, double-blinded trial, 37 female subjects aged 19-35 y with iron depletion without anemia (hemoglobin > 120 g/L and serum ferritin < 16 microg/L (...) ) received an iron supplement or placebo for 8 wk. Iron status was measured before treatment, after 4 wk of treatment, and posttreatment (ie, after 8 wk of treatment). Iron supplementation of these iron-depleted, nonanemic women resulted in a progressive and significant decrease in sTfR and a significant increase in serum ferritin, and prevented a fall in hemoglobin. The responsiveness of sTfR to iron treatment indicated that sTfR is a sensitive indicator of marginal iron deficiency in iron-depleted

1998 The American journal of clinical nutrition Controlled trial quality: uncertain

5663. Serum erythropoietin during normal pregnancy: relationship to hemoglobin and iron status markers and impact of iron supplementation in a longitudinal, placebo-controlled study on 118 women. (Abstract)

took placebo. Blood samples were obtained at 4-week intervals until delivery as well as post-partum. In the placebo-treated women, median serum EPO rose from 22.5 U/l at inclusion to 35.0 U/l at delivery (P = 0.0001). In the iron-treated women, median serum EPO rose from 23.9 to 29.9 U/l (P = 0.0001). Serum EPO showed a steeper increase in the placebo-treated women than in the iron-treated women (P < 0.05). After delivery, serum EPO became normal in both groups (P = 0.0001). Median Hb was lower (...) in placebo-treated (iron depleted) than in iron-treated (iron repleted) women (P < 0.05). In the placebo-treated women there was a negative correlation and in the iron-treated women a positive correlation between serum EPO and Hb. In the placebo-treated women, inverse correlations existed between serum EPO and serum transferrin saturation and serum ferritin, reflecting the consequences of iron deficiency, whereas the iron-treated women displayed no correlation. A physiological, nonhypoxia-induced

1997 International journal of hematology Controlled trial quality: uncertain

5664. Tardive dyskinesia and serum iron indices. (Abstract)

Tardive dyskinesia and serum iron indices. This study was undertaken to evaluate whether peripheral (serum) markers of iron status are associated with severity of the choreoathetoid movements seen in tardive dyskinesia (TD).Serum iron indices (ferritin, iron, and total iron binding capacity) and fluphenazine levels were measured in a group of 30 male DSM-III diagnosed schizophrenic patients chronically treated with fluphenazine decanoate. The severity of choreoathetoid movements was assessed (...) with the Abnormal Involuntary Movement Scale (AIMS), and akathisia was assessed with the Barnes scale.A significant positive correlation was observed between AIMS scores and serum ferritin. This relationship remained significant after controlling for age and plasma fluphenazine levels. No significant correlations were observed between serum iron or total iron binding capacity and choreoathetoid movement ratings. There were no significant associations between serum iron indices and akathisia ratings.The data

1998 Biological psychiatry Controlled trial quality: uncertain

5665. Effects of weaning cereals with different phytate contents on hemoglobin, iron stores, and serum zinc: a randomized intervention in infants from 6 to 12 mo of age. Full Text available with Trip Pro

remained in the analysis.Hemoglobin concentrations of < 110 g/L, serum ferritin concentrations of < 12 microg/L, and serum zinc concentrations of < 10.7 micromol/L had overall prevalences at baseline and 12 mo of 28% and 15%, 9% and 18%, and 22% and 27%, respectively. After the intervention, there were no significant differences in any measure of iron or zinc status between the CC and the PR groups. However, hemoglobin was significantly higher (120 g/L compared with 117 g/L; P = 0.012 (...) Effects of weaning cereals with different phytate contents on hemoglobin, iron stores, and serum zinc: a randomized intervention in infants from 6 to 12 mo of age. Weaning foods frequently contain phytate, an inhibitor of iron and zinc absorption, which may contribute to the high prevalence of iron and zinc deficiency seen in infancy.The objective was to investigate whether either an extensive reduction in the phytate content of infant cereals or the use of milk-based, iron-fortified infant

2003 The American journal of clinical nutrition Controlled trial quality: uncertain

5666. Serum transferrin receptor in children with respiratory infections. Full Text available with Trip Pro

and 94 children hospitalized for acute pneumonia constituted the experimental group. Hemoglobin (Hb), sTfR and serum ferritin were estimated in all the children at the time of diagnosis and again on the 15th and 30th days after the infection in those who were available for follow-up.Mean (95% CI) sTfR was 6.08 (5.1-7.1) mg/l in healthy non-anemic children. Upper respiratory infection had no impact on Hb or sTfR but it significantly elevated serum ferritin levels. Eighty-three percent of the children (...) with pneumonia had Hb less than 110 g/l at the time of diagnosis and had elevated mean sTfR, 18.0 (15.7-20.3) mg/l. There was a decline in mean sTfR by the 15th day of infection to 14.3 (11.3-17.4) mg/l with further rise to 22.9 (13.0-31.9) mg/l by 30 days. Serum ferritin was significantly elevated at the time of diagnosis (85.9; 71.1-100.8 micro g/l) as well as at 15 days (89.1; 68-110.1 micro g/l) with a decline by 30 days.Severe lower respiratory infection exaggerates iron-deficient erythropoiesis

2003 European journal of clinical nutrition Controlled trial quality: uncertain

5667. Effect of rhEPO administration on serum levels of sTfR and cycling performance. (Abstract)

Effect of rhEPO administration on serum levels of sTfR and cycling performance. We assessed the possibility of using soluble transferrin receptor (sTfR) as an indicator of doping with recombinant erythropoietin (rhEPO).A double-blind, placebo-controlled study was conducted with the administration of 5,000 U of rhEPO (N = 10) or placebo (N = 10) three times weekly (181-232 U x kg(-1) x wk-1) for 4 wk to male athletes. We measured hematocrit and the concentration of hemoglobin, sTfR, ferritin (...) , EPO, and quantified the effects on performance by measuring time to exhaustion and maximal oxygen uptake (VO2max) on a cycle ergometer.Hematocrit increased from 42.7 +/- 1.6% to 50.8 +/- 2.0% in the EPO group, and peaked 1 d after treatment was stopped. In the EPO group, there was an increase in sTfR (from 3.1 +/- 0.9 to 6.3 +/- 2.3 mg x L(-1) , P < 0.001) and in the ratio between sTfR and ferritin (sTfR-ferritin(-1)) (from 3.2 +/- 1.6 to 11.8 +/- 5.1, P < 0.001). The sTfR increase was significant

2000 Medicine and science in sports and exercise Controlled trial quality: predicted high

5668. Hepatocellular fat accumulation and low serum cholesterol in patients infected with HCV-3a. (Abstract)

< 0.01). Steatosis in HCV-3a-infected patients did not correlate with the body mass index, hepatic iron content, ferritin, or transferrin saturation. At baseline, serum cholesterol was lower in patients infected with HCV-3a (147 +/- 42 mg/dl; p < 0.01) compared with HCV-1 (188 +/- 36) or HCV-4 (172 +/- 35). In contrast to HCV-1- or HCV-4-infected patients, serum cholesterol increased in HCV-3a virological responders at the end of treatment and 6 months after therapy (baseline 146 +/- 38, end (...) Hepatocellular fat accumulation and low serum cholesterol in patients infected with HCV-3a. The aim of this study was to prospectively investigate the prevalence of hepatic steatosis in chronic hepatitis C patients with respect to viral genotype, hepatic iron concentration, total body iron, body mass index, and serum lipid parameters. Furthermore, the effect of hepatitis C virus (HCV) eradication by antiviral therapy on serum cholesterol levels was studied.Hepatocellular fat and hepatic iron

2002 American Journal of Gastroenterology

5669. Serum thioredoxin levels as a predictor of steatohepatitis in patients with nonalcoholic fatty liver disease. (Abstract)

TRX levels (medians and (ranges), ng/ml) were significantly elevated in patients with NASH (60.3 (17.6-104.7)), compared to those in patients with simple steatosis (24.6 (16.6-69.7), P=0.0009) and in healthy controls (23.5 (1.3-50.7), P<0.0001). Serum ferritin levels in patients with NASH were also significantly higher than the levels in patients with simple steatosis. The receiver operating characteristic curve confirmed that serum TRX and ferritin levels were predictors for distinguishing NASH (...) Serum thioredoxin levels as a predictor of steatohepatitis in patients with nonalcoholic fatty liver disease. Thioredoxin (TRX) is a stress-inducible thiol-containing protein. The aim of this study was to evaluate the clinical significance of serum TRX in patients with nonalcoholic steatohepatitis (NASH) or simple steatosis.Serum TRX levels were determined using an enzyme-linked immunosorbent assay kit in 25 patients with NASH, 15 patients with simple steatosis, and 17 healthy volunteers.Serum

2003 Journal of Hepatology

5670. Serum cytokine profiles in patients with adult onset Still's disease. (Abstract)

-2R levels tended to be higher in the active state than in healthy controls, but there was no statistically significant difference between the 2 groups. Serum sIL-2R levels decreased significantly with antiinflammatory therapy (p < 0.05). Serum IL-18 and sIL-2R levels correlated significantly with serum ferritin levels in the active AOSD group (p < 0.05).Overproduction of IL-18 may contribute to the pathogenic mechanism of AOSD, and serum sIL-2R levels may be used as a marker for monitoring (...) Serum cytokine profiles in patients with adult onset Still's disease. Adult onset Still's disease (AOSD) is a systemic inflammatory disorder characterized by fever, arthritis, and rash. Although the pathogenesis is not known, immunologically mediated inflammation occurs in active AOSD. To evaluate the pathogenesis and disease activity of AOSD, we measured serial serum concentrations of several cytokines in patients with active and inactive disease.Seventeen patients diagnosed as having AOSD

2003 Journal of Rheumatology

5671. Iron overload in children who are treated for acute lymphoblastic leukemia estimated by liver siderosis and serum iron parameters. (Abstract)

correlated most significantly positively with serum ferritin (r(S) = 0.899), transferrin iron saturation (r(S) = 0.764), and the amount of transfused red blood cells (r(S) = 0.783). Serum iron parameters normalized in most patients during the follow-up. In 3 (14%) of 22 patients, serum ferritin level remained high (>1000 microg/L).Long-term iron overload is detected in at least 14% of children after therapy for acute lymphoblastic leukemia. Serum sTfR is an inappropriate marker for liver iron overload (...) of therapy using total iron score (TIS). Serum iron parameters and sTfR were measured at the same time and in 22 patients 1 to 3 years after therapy.In 19 (63%) of 30 patients, liver TIS was >15, indicating at least moderate iron overload. Serum ferritin, iron, and transferrin iron saturation levels were highest and transferrin level lowest in the patients with the highest liver iron content. Serum sTfR levels did not differ significantly between the patients with varying amounts of liver iron. TIS

2003 Pediatrics

5672. Serum transferrin receptors in rheumatoid arthritis. Full Text available with Trip Pro

Serum transferrin receptors in rheumatoid arthritis. Serum transferrin receptors (sTfR) were determined in patients affected by rheumatoid arthritis (RA) to verify a possible relationship with the degree of anaemia and with the severity of the inflammatory disease.sTfR, IL1-b, TNF-a and common parameters of iron metabolism were studied in 72 patients with active RA. Anaemia (Hb < 12 g/dl) was present in 51 patients. Twenty normal healthy subjects and 40 iron-deficient anaemic patients without (...) chronic inflammatory, infective or malignant diseases were studied as controls.In patients with RA sTfR levels were significantly higher than in the normal group but lower than in iron-deficient anaemic patients and correlated positively with ESR and IL1-b and negatively with Hb. Anaemic patients with RA were divided into two groups. Group A (56%) showed a possible iron deficiency (TSI < 16 and ferritin < 50 ng/ml); group B did not show iron deficiency (TSI > 16 and ferritin > 50 ng/ml

1994 Annals of the Rheumatic Diseases

5673. Chromogranin A in children with neuroblastoma. Serum concentration parallels disease stage and predicts survival. Full Text available with Trip Pro

as a useful diagnostic tool for neuroblastoma, comparable to or better than other measurements such as neuron-specific enolase, ferritin, or dopamine-beta-hydroxylase. Mean serum chromogranin A correlated with disease stage (r = 0.76, P less than 0.01). The relationship of prognosis (progression-free survival) to baseline serum chromogranin A, age, and disease stage was determined in 34 patients at risk for relapse, with a median followup period of 18 mo (range, 1-48 mo). The survival rate for patients (...) Chromogranin A in children with neuroblastoma. Serum concentration parallels disease stage and predicts survival. Chromogranin A is an acidic protein costored and coreleased with catecholamines from storage vesicles. Its serum concentration is elevated in patients with peptide-producing endocrine neoplasia. We measured serum chromogranin A at the time of diagnosis in 34 children with all stages of neuroblastoma. With a sensitivity of 91% and specificity of 100%, serum chromogranin A emerged

1990 Journal of Clinical Investigation

5674. Anaemia of rheumatoid arthritis: serum erythropoietin concentrations and red cell distribution width in relation to iron status. Full Text available with Trip Pro

Anaemia of rheumatoid arthritis: serum erythropoietin concentrations and red cell distribution width in relation to iron status. Immunoreactive serum erythropoietin concentrations were measured in 35 patients with anaemia associated with active rheumatoid arthritis. Based on an evaluation of stainable iron in the bone marrow (marrow iron grade 0-4) and serum ferritin concentrations (concentrations less than or equal to 60 micrograms/l compatible with iron deficiency) the anaemia was found (...) to be complicated by iron deficiency in 19/35 (54%) of the patients. The mean serum erythropoietin level (57.6 (SD) 27.3) U/l) was sufficiently raised for the degree of anaemia irrespective of the size of the marrow iron stores. Thus the data do not support the contention that suppressed secretion of erythropoietin is involved in the pathogenesis of anaemia of chronic disorders. There was a significant inverse correlation between the haemoglobin concentration and log serum erythropoietin in the patients

1990 Annals of the Rheumatic Diseases

5675. Association of rheumatic fever with serum albumin concentration and body iron stores in Bangladeshi children: case-control study Full Text available with Trip Pro

, Japan. mzaman@bangla.net Yoshiike N N Rouf M A MA Haque S S Chowdhury A H AH Nakayama T T Tanaka H H eng Journal Article Research Support, Non-U.S. Gov't England BMJ 8900488 0959-8138 0 Biomarkers 0 Serum Albumin 9007-73-2 Ferritins E1UOL152H7 Iron AIM IM Adolescent Adult Bangladesh epidemiology Biomarkers blood Case-Control Studies Child Child, Preschool Ferritins blood Humans Iron blood deficiency Rheumatic Fever blood epidemiology etiology Risk Factors Serum Albumin analysis 1998 11 7 1998 11 7 0 (...) Association of rheumatic fever with serum albumin concentration and body iron stores in Bangladeshi children: case-control study 9804715 1998 12 14 2018 11 13 0959-8138 317 7168 1998 Nov 07 BMJ (Clinical research ed.) BMJ Association of rheumatic fever with serum albumin concentration and body iron stores in Bangladeshi children: case-control study. 1287-8 Zaman M M MM Department of Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, 2-3-10 Kandasurugadai, Tokyo 101

1998 BMJ : British Medical Journal

5676. Serum iron concentrations following administration of two different iron preparations. (Abstract)

Serum iron concentrations following administration of two different iron preparations. Serum iron curves were determined in two groups of iron deficient patients after oral administration of iron protein succinylate or ferritin. The two preparations induced a significant increase of serum iron from 30 min after administration of a dose corresponding to 80 mg Fe3+. The increase induced by iron protein succinylate was more prolonged than that of ferritin.

1988 The Journal of international medical research Controlled trial quality: uncertain

5677. A 64 year old female vegetarian has a low normal hb of 11.4 and a low ferritin of 17(nr 20-3000). Is it safe to assume this is diet related and just treat, or at what stage is it mandatory to endoscop

A 64 year old female vegetarian has a low normal hb of 11.4 and a low ferritin of 17(nr 20-3000). Is it safe to assume this is diet related and just treat, or at what stage is it mandatory to endoscop A 64 year old female vegetarian has a low normal hb of 11.4 and a low ferritin of 17(nr 20-3000). Is it safe to assume this is diet related and just treat, or at what stage is it mandatory to endoscope and colonoscope? - Trip Database or use your Google+ account Liberating the literature ALL (...) @tripdatabase.com A 64 year old female vegetarian has a low normal hb of 11.4 and a low ferritin of 17(nr 20-3000). Is it safe to assume this is diet related and just treat, or at what stage is it mandatory to endoscope and colonoscope? The NLH Q&A Service is unable to comment on any assumptions regarding the cause of this females low hb, we can simply report on the literature we find. PRODIGY has a guideline on iron-deficiency anaemia [1] which we recommend you read (see reference section for URL). With regard

2006 TRIP Answers

5678. A lady with terrible restless legs and a low ferritin of 7.5 (ref range 12-230) but a normal Hb. is it worth putting her on iron?

.” The review also discussed ferritin, including the statement: “The possibility that RLS might be associated with iron metabolism has quite a long history. For instance, the observation that serum ferritin was lower in patients with RLS than in those without RLS suggested some link, albeit that the study had only 18 elderly patients. The inverse correlation of severity of RLS with serum ferritin levels, and improved symptoms after two months of treatment with oral iron salts helped to underline any (...) A lady with terrible restless legs and a low ferritin of 7.5 (ref range 12-230) but a normal Hb. is it worth putting her on iron? A lady with terrible restless legs and a low ferritin of 7.5 (ref range 12-230) but a normal Hb. is it worth putting her on iron? - Trip Database or use your Google+ account Turning Research Into Practice ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere

2006 TRIP Answers

5679. In a patient with an asymptomatic mild normocytic normochromic anaemia, (Hb 11.5 in a male aged 65), when iron levels are low, but ferritin levels are normal, is it safe to monitor without investigati

be normal or elevated in infective, inflammatory or malignant disease despite iron deficiency. Serum ferritin level is also increased by excessive alcohol consumption.” It later says: “A reason for iron deficiency should always be sought. History-taking should attempt to determine whether gastrointestinal (GI) blood loss, menstrual loss, malabsorption, or nutritional deficiency is likely. Drug history of nonsteroidal anti-inflammatory use is particularly important, as this might point to possible GI (...) summary of the guidelines says: “Background: Colonic cancer, gastric cancer and coeliac disease are the most important gastrointestinal causes of iron deficiency anaemia. Definitions: The lower limit of the normal range should be used to define anaemia. Iron deficiency should be confirmed by a low serum ferritin, red cell microcytosis or hypochromia in the absence of chronic disease or haemoglobinopathies. Any level of iron deficiency anaemia should be investigated. Investigations: Rectal examination

2006 TRIP Answers

5680. Somebody c/o tiredness and with a suspicion of anaemia has hb=13.4, slightly low MCV and MCH and ferritin =10(borderline normal). Should this person be treated with iron supplements? Note all other b

in the diagnosis of anaemia: “ Full blood count: • Low haemoglobin (Hb) concentration, less than 13 g/dl for men and less than 12 g/dl for women • Low MCV, MCH, and MCHC (mean cell volume, mean cell Hb, mean cell Hb concentration) • Reticulocyte count low for the degree of anaemia • There may be a mild thrombocytosis (raised platelet concentration) • Serum ferritin level: low (an indicator of reduced body-iron stores). However, as ferritin is an acute-phase protein, levels may be normal or elevated (...) in infective, inflammatory or malignant disease despite iron deficiency. Serum ferritin level is also increased by excessive alcohol consumption. The clinical scenario “Iron deficiency anaemia excluding pregnancy” notes: • A reason for iron deficiency should always be sought. • Consider gastrointestinal blood loss, excessive menstrual loss, malabsorption, or nutritional deficiency. • Dietary deficiency, by itself, is rarely a cause of iron deficiency anaemia in developed countries unless

2006 TRIP Answers

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