How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

5,854 results for

Serum Ferritin

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

5601. [Does long-term erythropoietin therapy influence the prevalence of serum markers of hepatitis B and C in haemodialysed uraemic patients?]. (Abstract)

of 15 haemodialysed patients treated with rHuEPO, the second group composed of 17 occasionally treated with blood transfusions (No-EPO group). In patients of both groups the following parameters were examined before (0) and after 3, 6, 9, 12 months of monitoring number of units blood transfused, hemoglobin concentration, serum levels of ferritin. Before the study (0) and after 6 and 12 months presence of antigen HBs (AgHBs), antibodies anti-HBc, anti-HBs, anti-HCV, DNA HBV and RNA HCV were examined (...) [Does long-term erythropoietin therapy influence the prevalence of serum markers of hepatitis B and C in haemodialysed uraemic patients?]. Haemodialysed patients are highly exposed to different virus infections namely hepatitis B (HBV) and C (HCV). Recently it was shown, that the use of recombinant human erythropoietin (rHuEPO) in haemodialysed patients with chronic renal failure (CRF) stimulates not only erythropoesis but also increases--in an indirect or direct manner--the humoral and cell

2004 Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego Controlled trial quality: uncertain

5602. Effect of intravenous ascorbic acid medication on serum levels of soluble transferrin receptor in hemodialysis patients. Full Text available with Trip Pro

TfR in HD patients who are on maintenance rHuEPO treatment. Second, 36 HD patients were recruited in a randomized, controlled study to receive IVAA (total dose of 2000 mg) or normal saline (placebo) medication. Serum levels of TfR, EPO, and ferritin and TSAT were measured at baseline and within 7 d after starting IVAA or placebo. There were no significant changes in serum EPO and ferritin levels in patients who received either IVAA (n = 18) or placebo (n = 18). Serum TfR levels (P < 0.001 (...) ) significantly declined with a parallel rise in TSAT (P < 0.05) as compared with presupplemental values within 7 d in IVAA patients before any apparent alteration in hematocrit values, but the changes were not observed in the placebo group. The trend of decreased serum TfR and increased TSAT was similar in IVAA patients with ferritin of <500 microg/L or >500 microg/L. It is concluded that ascorbic acid status can significantly decrease serum TfR concentrations and increase percentage of TSAT, probably

2004 Journal of the American Society of Nephrology : JASN Controlled trial quality: uncertain

5603. The effect of 4 wk of oral echinacea supplementation on serum erythropoietin and indices of erythropoietic status. (Abstract)

) or placebo (PLA) in 5 x 400 mg x 4 times/d for 28 d. Blood samples were collected and analyzed for red blood cells (RBCs), hematocrit (Hct), hemoglobin (Hb), mean corpuscular volume, mean corpuscular hemoglobin content, prostaglandin E2, ferritin, erythropoietin (EPO), interleukin 3 (IL-3), and granulocyte-macrophage-colony-stimulating factor using automated flow cytometry and ELISA. ANOVA was used to determine significant differences (P ? 0.05). EPO was greater (P < 0.001) in ECH at Days 7, 14, and 21 (...) The effect of 4 wk of oral echinacea supplementation on serum erythropoietin and indices of erythropoietic status. The purpose of this investigation was to determine whether echinacea supplementation results in alterations of erythroid growth factors and erythropoietic status. Twenty-four men age 24.9 +/- 4.2 y, height 1.7 +/- 0.8 m, weight 87.9 +/- 14.6 kg, and 19.3% +/- 6.5% body fat were grouped using a double-blind design and self- administered an 8000-mg/d dose of either echinacea (ECH

2007 International journal of sport nutrition and exercise metabolism Controlled trial quality: uncertain

5604. The effects of iron supplementation on serum copper and zinc levels in pregnant women with high-normal hemoglobin. (Abstract)

containing 50 mg elemental iron daily, while the control group received placebo. Hemoglobin, ferritin, copper, and zinc levels at 24-28 and 32-36 weeks of pregnancy were measured and compared.In the case group, serum copper levels in the second and third trimester were significantly lower than the control group (P<0.01 and P<0.001, respectively). Serum zinc levels in the case group in the second and third trimester were also significantly lower than the control group (P<0.001).Iron supplementation (...) The effects of iron supplementation on serum copper and zinc levels in pregnant women with high-normal hemoglobin. To evaluate the effect of iron supplementation on serum copper and zinc levels.In a randomized, double-blind, placebo-controlled trial, 66 pregnant women with hemoglobin 13.2 g/dL or greater between the 13th and 18th week of pregnancy were randomized into case and control groups. From the 20th week until the end of pregnancy the case group received one ferrous sulfate tablet

2008 International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics Controlled trial quality: predicted high

5605. Variants in TF and HFE Explain approximately 40% of Genetic Variation in Serum-Transferrin Levels. Full Text available with Trip Pro

Variants in TF and HFE Explain approximately 40% of Genetic Variation in Serum-Transferrin Levels. Only a small proportion of genetic variation in complex traits has been explained by SNPs from genome-wide association studies (GWASs). We report the results from two GWASs for serum markers of iron status (serum iron, serum transferrin, transferrin saturation with iron, and serum ferritin), which are important in iron overload (e.g., hemochromatosis) and deficiency (e.g., anemia) conditions. We (...) performed two GWASs on samples of Australians of European descent. In the first GWAS, 411 adolescent twins and their siblings were genotyped with 100K SNPs. rs1830084, 10.8 kb 3' of TF, was significantly associated with serum transferrin (p total association test = 1.0 x 10(-9); p within-family test = 2.2 x 10(-5)). In the second GWAS on an independent sample of 459 female monozygotic (MZ) twin pairs genotyped with 300K SNPs, we found rs3811647 (within intron 11 of TF, HapMap CEU r(2) with rs1830084

2008 American Journal of Human Genetics

5606. Macrophage serum markers in pneumococcal bacteremia: Prediction of survival by soluble CD163. (Abstract)

Macrophage serum markers in pneumococcal bacteremia: Prediction of survival by soluble CD163. Soluble CD163 (sCD163) is a new macrophage-specific serum marker. This study investigated sCD163 and other markers of macrophage activation (neopterin, ferritin, transcobalamin, and soluble urokinase plasminogen activator receptor [suPAR]) as prognostic factors in patients with pneumococcal bacteremia.Observational cohort study.Five university hospitals in Denmark.A total of 133 patients (...) with Streptococcus pneumoniae bacteremia (positive blood culture) and 133 age- and gender-matched controls.Samples were collected for biochemical analyses at the time of first positive blood culture.sCD163 was highly correlated with other macrophage markers and was significantly elevated (median [25-75 percentiles], 4.6 mg/L [2.8-8.9]) compared with healthy controls (2.7 mg/L [2.1-3.3], p < .0001). Increased levels were observed in patients who needed intensive care (hemodialysis, p = .0011; hypotension, p

2006 Critical Care Medicine

5607. Body fat mass and serum leptin levels influence epoetin sensitivity in patients with ESRD. (Abstract)

Body fat mass and serum leptin levels influence epoetin sensitivity in patients with ESRD. Dose requirements of epoetin vary considerably among patients with end-stage renal disease (ESRD), whereas determinants of epoetin sensitivity are poorly understood. Fat mass is an important source of adipokines, including interleukin 6 (IL-6), which is associated with decreased epoetin sensitivity. Furthermore, the adipokine leptin stimulates human erythroid development in vitro. In the present study, we (...) investigate the impact of fat mass and leptin level on epoetin sensitivity in patients with ESRD.One hundred sixty-six patients with ESRD (107 men; 64%) with a mean age of 56.9 +/- 0.9 years were studied in a post hoc cross-sectional analysis. Body composition was analyzed by dual-energy X-ray absorptiometry and correlated with serum markers of inflammation and leptin (analyzed by enzyme-linked immunosorbent assays), as well as with epoetin dose, in international units administered per week (IU/wk

2005 American Journal of Kidney Diseases

5608. A low serum iron level is a predictor of poor outcome in hemodialysis patients. (Abstract)

Poisson and Cox models adjusted for demographic features, dialysis dose and vintage, serum albumin and ferritin and blood hemoglobin concentrations, and administered EPO and iron doses showed that both serum iron level and iron saturation ratio had significant, but inverse, associations with prospective mortality and hospitalization. There was a statistically significant trend toward greater rates of mortality and hospitalization with lower serum iron levels. This reverse association remained (...) A low serum iron level is a predictor of poor outcome in hemodialysis patients. Iron administration has been implicated as a cause of poor clinical outcome in maintenance hemodialysis (MHD) patients. However, the role of low iron levels in the clinical outcome of MHD patients is not clear.We examined the predicting value of baseline serum iron level on prospective mortality and hospitalization in a cohort of all 1,283 MHD patients from 10 DaVita dialysis facilities in Los Angeles County

2004 American Journal of Kidney Diseases

5609. Association of hepatitis C virus infection with serum iron status: analysis of data from the third National Health and Nutrition Examination Survey. Full Text available with Trip Pro

status was assessed in the US population.We analyzed data from a total of 14,462 participants in the Third National Health and Nutrition Examination Survey. We excluded subjects who were aged <12 years, subjects for whom measurements of serum levels of iron or ferritin or the results of liver function tests were missing, and subjects who had a serum transferrin saturation of > or =50% (to help exclude subjects with hemochromatosis).Mean serum levels of ferritin and iron (+/- standard error) were (...) significantly higher among subjects with HCV infection (100+/-3 ng/mL and 229+/-17 microg/dL, respectively) than among subjects without liver disease (83+/-0.3 ng/mL and 101+/-2.1 microg/dL, respectively) (P<.0001). Serum levels of ferritin were directly and significantly correlated with serum levels of alanine aminotransferase, aspartate aminotransferase, and gamma-glutamyl transpeptidase (r=0.25, r=0.24, and r=0.28, respectively; P<.0001), whereas platelet counts were inversely correlated with serum

2005 Clinical Infectious Diseases

5610. Clinical significance of hepatic iron deposition and serum iron values in patients with chronic hepatitis C infection. (Abstract)

Clinical significance of hepatic iron deposition and serum iron values in patients with chronic hepatitis C infection. To assess the potential association between hepatic iron deposition or serum iron values and hepatic fibrosis and inflammatory activity in patients with chronic hepatitis C virus infection.In 100 consecutive patients with hepatitis C virus infection, tissue iron deposition was assessed by quantifying iron stain on liver biopsy specimens. Serum iron, ferritin, and transferrin (...) between the iron concentration or the hepatic iron index in patients with stage III or IV fibrosis compared with patients with stage I or II fibrosis. At least 1 of 3 serum iron values assessed was abnormal in 55 patients. In univariate analysis, elevated serum iron (p = 0.01), serum ferritin (p < 0.001), and transferrin saturation (p = 0.002) were associated with stage III or IV fibrosis. In multivariate analysis, the only independent predictive factor of severe hepatic fibrosis was serum ferritin (p

2004 American Journal of Gastroenterology

5611. A follow-up study to determine the value of liver biopsy and need for antiviral therapy for hepatitis C virus carriers with persistently normal serum aminotransferase. (Abstract)

/microl were entered and 69 were followed for over 5 years. Thirty-five patients underwent serial liver biopsies. Serum ferritin and thioredoxin levels were also determined.Seventeen patients had normal liver histology, 10 had moderate chronic hepatitis and the remainder 102 had mild hepatitis. Serum ferritin and thioredoxin levels were normal. The mean follow-up period for the 69 patients was 8.5 years. Of these 69 patients, 10 had persistently normal ALT levels (group A), 39 had transient elevation (...) A follow-up study to determine the value of liver biopsy and need for antiviral therapy for hepatitis C virus carriers with persistently normal serum aminotransferase. Long-term follow-up study was performed to identify the candidates for antiviral therapy for hepatitis C virus (HCV) infection among carriers with persistently normal aminotransferase (ALT< or = 30 U/L) levels (PNAL).One hundred and twenty-nine HCV carriers with PNAL who underwent liver biopsy and had platelet count over 150,000

2005 Journal of Hepatology

5612. Low-dose continuous iron therapy leads to a positive iron balance and decreased serum transferrin levels in chronic haemodialysis patients. Full Text available with Trip Pro

Low-dose continuous iron therapy leads to a positive iron balance and decreased serum transferrin levels in chronic haemodialysis patients. Iron balance is critical for adequate erythropoiesis, but its optimal therapeutic regimen remains to be defined. Continuous maintenance therapy with iron has been proposed for dialysis patients on recombinant human erythropoietin (rHuEpo) in the hope that the regimen is adequate and safe.We determined serum ferritin, transferrin, transferrin saturation (...) maintenance iron therapy (i.v. iron gluconate 31.25 mg/week) for another 9 months (Period 3 or re-challenge phase).A significant increase in serum ferritin and TSAT was observed, with values exceeding 500 ng/ml and 50% in 10/30 (33%) and 7/30 (23%) of subjects, respectively, in Period 1, and in 11 and 5% in Period 3. A significant decrease in serum transferrin was documented during Period 1, followed by an increase in Period 2 and a decrease in Period 3. Serum albumin remained stable. Serum transferrin

2004 Transplantation

5613. HbA1C, but not serum glycated albumin, is elevated in late pregnancy due to iron deficiency. Full Text available with Trip Pro

(MCH), serum transferrin saturation, and serum ferritin were lower in groups III and IV. A1C levels were negatively correlated with MCH, serum transferrin saturation, and serum ferritin. In study 2, A1C levels were significantly increased at gestational weeks 32-33 from those at weeks 20-23, whereas serum glycated albumin levels did not differ between the two gestational periods. MCH, serum transferrin saturation, and serum ferritin were decreased at gestational weeks 32-33. A1C levels showed (...) HbA1C, but not serum glycated albumin, is elevated in late pregnancy due to iron deficiency. A1C levels have been shown to be elevated in relation to glycemia in late pregnancy, although the precise mechanisms remain undetermined. We hypothesized that iron deficiency is involved in the A1C increase in late pregnancy.In study 1, A1C, serum glycated albumin, erythrocyte indexes, and iron metabolism indexes were determined in 47 nondiabetic pregnant women not receiving iron supplementation who

2008 Diabetes Care

5614. Serum iron and matrix metalloproteinase-9 variations in limbs affected by chronic venous disease and venous leg ulcers. (Abstract)

the following in the serum of the arm and ankle veins of 30 patients (C4-6) with CVD and 14 normal subjects: ferritin, transferrin, iron, percentage of transferrin iron binding capacity (%TIBC), and MMP-9. Optical microscopy examinations with Perls' staining of chronic wounds were also performed.Histology consistently revealed iron deposits. Serum ferritin, iron, and %TIBC were significantly increased in the legs affected by severe CVD compared with the arm of the same subjects or the controls. In addition (...) Serum iron and matrix metalloproteinase-9 variations in limbs affected by chronic venous disease and venous leg ulcers. Severe chronic venous disease (CVD) is characterized by both dermal hemosiderin accumulation and matrix metalloproteinase (MMP) hyperactivation. The iron-driven pathway is one of the recognized mechanisms of MMP hyperactivation.To investigate the potential consequences of leg hemosiderin deposits on both iron metabolism and activation of MMPs.We contemporaneously assessed

2005 Dermatologic Surgery

5615. Ascorbic acid supplementation: its effects on body iron stores and white blood cells. (Abstract)

Ascorbic acid supplementation: its effects on body iron stores and white blood cells. 3519526 1986 07 17 2018 11 13 0021-1265 155 3 1986 Mar Irish journal of medical science Ir J Med Sci Ascorbic acid supplementation: its effects on body iron stores and white blood cells. 74-9 Malone H E HE Kevany J P JP Scott J M JM O'Broin S D SD O'Connor G G eng Clinical Trial Journal Article Randomized Controlled Trial Ireland Ir J Med Sci 7806864 0021-1265 9007-73-2 Ferritins E1UOL152H7 Iron PQ6CK8PD0R (...) Ascorbic Acid IM Adolescent Adult Ascorbic Acid administration & dosage Clinical Trials as Topic Diet Double-Blind Method Female Ferritins blood Humans Iron metabolism Leukocytes drug effects Random Allocation 1986 3 1 1986 3 1 0 1 1986 3 1 0 0 ppublish 3519526 Am J Clin Nutr. 1976 Aug;29(8):859-67 941868 Br J Nutr. 1974 May;31(3):367-75 4835790 Am J Clin Nutr. 1974 Feb;27(2):152-62 4812931 Blood. 1984 Sep;64(3):721-6 6466873 Am J Clin Nutr. 1979 Oct;32(10):2115-9 484529 Ir J Med Sci. 1985 Feb;154(2

1986 Irish journal of medical science Controlled trial quality: uncertain

5616. Cord blood transferrin receptors to assess fetal iron status Full Text available with Trip Pro

Cord blood transferrin receptors to assess fetal iron status To study iron status at different gestational ages using cord blood serum transferrin receptors (STfRs).STfRs, iron, ferritin, total iron binding capacity, haemoglobin, and reticulocytes were measured in 144 cord blood samples. The babies were divided into three groups according to gestation (26 very preterm (24-29 weeks); 50 preterm (30-36 weeks); 68 term (37-41 weeks)).Serum iron, ferritin, and total iron binding capacity were (...) highest at term, whereas reticulocytes were highest in the very preterm. STfR levels were not influenced by gestation. Haemoglobin (r = 0.46; p < 0.0001) and reticulocytes (r = 0.42; p < 0.0001) were the only indices that independently correlated with STfR levels.STfR levels in cord blood are not directly influenced by gestation and probably reflect the iron requirements of the fetus for erythropoiesis.

2001 Archives of Disease in Childhood. Fetal and Neonatal Edition

5617. Comparison of Asymptomatic Carotid Atherosclerosis Between Frequent and Infrequent Blood Donors

: March 4, 2008 Last Verified: May 2002 Keywords provided by National Institutes of Health Clinical Center (CC): Ferritin Atherosclerosis Myocardial Infarction Blood Donors Low Density Lipoprotein Asymptomatic Carotid Atherosclerosis Additional relevant MeSH terms: Layout table for MeSH terms Infarction Myocardial Infarction Atherosclerosis Carotid Artery Diseases Ischemia Pathologic Processes Necrosis Myocardial Ischemia Heart Diseases Cardiovascular Diseases Vascular Diseases Arteriosclerosis (...) Comparison of Asymptomatic Carotid Atherosclerosis Between Frequent and Infrequent Blood Donors Comparison of Asymptomatic Carotid Atherosclerosis Between Frequent and Infrequent Blood Donors - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one

1999 Clinical Trials

5618. Autologous Peripheral Blood Stem Cell Transplantation in Patients With Life Threatening Autoimmune Diseases

decreased marrow erythroid precursors Positive marrow coculture with serum or cells or response to immunosuppression No evidence for PNH Negative Ham's test and sucrose hemolysis Severe disease: Chronic (i.e., greater than 1 year) Transfusion dependent or untransfused hemoglobin less than 8.0 g/dL Ferritin greater than 2,000 or evidence of organ dysfunction due to iron overload Refractory to conventional therapy after all 3 of the following: High dose steroids (at least 1 mg/kg) for at least 21 days (...) Autologous Peripheral Blood Stem Cell Transplantation in Patients With Life Threatening Autoimmune Diseases Autologous Peripheral Blood Stem Cell Transplantation in Patients With Life Threatening Autoimmune Diseases - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies

2000 Clinical Trials

5619. Safety of ICL670 vs. Deferoxamine in Sickle Cell Disease Patients With Iron Overload Due to Blood Transfusions

, Layout table for eligibility information Ages Eligible for Study: 2 Years and older (Child, Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Age greater than or equal to 2 years Sickle cell disease patients already treated with or suitable for treatment with deferoxamine 20 to 40 mg/kg/day Serum ferritin greater than 1000 mg/ml Liver iron content greater than 2 mg iron/g dw assessed by means of superconducting quantum interference device (...) Safety of ICL670 vs. Deferoxamine in Sickle Cell Disease Patients With Iron Overload Due to Blood Transfusions Safety of ICL670 vs. Deferoxamine in Sickle Cell Disease Patients With Iron Overload Due to Blood Transfusions - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved

2003 Clinical Trials

5620. Iron supplementation for menstruating female blood donors. (Abstract)

requested to donate every 8 weeks for at least 1 year. Blood samples were taken on each donation for measurements of hemoglobin, total iron binding capacity (TIBC), and ferritin. In the two groups taking iron supplements hemoglobin and ferritin increased from baseline values and the TIBC decreased. The vitamin C control group showed decreases from baseline for hemoglobin and ferritin and increases in TIBC. Differences between groups taking iron supplements and the group not taking supplements were (...) Iron supplementation for menstruating female blood donors. Depletion of body iron stores is a major factor limiting regular blood donations by menstruating females. To determine if regular iron supplementation would solve this problem, we conducted a double-blind study in which menstruating female donors were randomly placed into one of three groups: one taking 39 mg elemental iron, a second taking 39 mg of iron plus 75 mg vitamin C, and a third taking 100 mg vitamin C daily. The women were

1985 Transfusion Controlled trial quality: uncertain

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>