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Serum Ferritin

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5581. Effect of sodium iron ethylenediaminetetra-acetate (NaFeEDTA) on haemoglobin and serum ferritin in iron-deficient populations: a systematic review and meta-analysis of randomised and quasi-randomised controlled trials

Effect of sodium iron ethylenediaminetetra-acetate (NaFeEDTA) on haemoglobin and serum ferritin in iron-deficient populations: a systematic review and meta-analysis of randomised and quasi-randomised controlled trials Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2008 DARE.

5582. Screening primary care patients for hereditary hemochromatosis with transferrin saturation and serum ferritin level: systematic review for the American College of Physicians

for practice or further research. Funding American College of Physicians. Bibliographic details Schmitt B, Golub R M, Green R. Screening primary care patients for hereditary hemochromatosis with transferrin saturation and serum ferritin level: systematic review for the American College of Physicians. Annals of Internal Medicine 2005; 143(7): 522-536 PubMedID Original Paper URL Indexing Status Subject indexing assigned by NLM MeSH Adult; Evidence-Based Medicine; Ferritins /blood; Genetic Testing (...) Screening primary care patients for hereditary hemochromatosis with transferrin saturation and serum ferritin level: systematic review for the American College of Physicians Screening primary care patients for hereditary hemochromatosis with transferrin saturation and serum ferritin level: systematic review for the American College of Physicians Screening primary care patients for hereditary hemochromatosis with transferrin saturation and serum ferritin level: systematic review for the American

2005 DARE.

5583. Serum Iron

the day and from day to day. For this reason, serum iron is almost always measured with other , including ferritin, transferrin, and calculated total iron-binding capacity (TIBC) and transferrin saturation. Serum iron tests may be ordered as follow-up tests when results from a show that a person's hemoglobin and hematocrit are low and their red blood cells are smaller and paler than normal ( and ), suggesting even though other clinical symptoms may not have developed yet. Testing may be ordered when (...) tries to compensate by producing more transferrin to increase iron transport. The serum iron level continues to decrease and transferrin and TIBC and UIBC increase. As this stage progresses, fewer and smaller red blood cells are produced, eventually resulting in . Iron overload If the iron level is high, the TIBC, UIBC and ferritin are normal and the person has a clinical history consistent with iron overdose, then it is likely that the person has iron poisoning. Iron poisoning occurs when a large

2004 Lab Tests Online USA

5584. Peripheral Blood Film

-deficiency anaemia and thalassaemia. Abnormal Hb levels See also the separate , and articles. Anaemia with low MCV (microcytic): - look at serum ferritin level. . . Anaemia with normal MCV (normocytic): Recent bleeding. Anaemia of chronic disease (including renal disease). Combined iron and B12/folate deficiency. Most non-haematinic deficiency causes. Anaemia with high MCV (macrocytic): see the separate article. High Hb It is important first to ascertain the validity of this result if it does not tie (...) . They result in a raised platelet distribution width (the indicator of the range in platelet size in a blood sample) unlike the normal platelet distribution width seen in reactive thrombocytosis, where there is an increased platelet count but normal sized platelets. Satellitosis - describes platelets encircling a neutrophil. It occurs when a patient has a serum factor that reacts to the anticoagulant EDTA. Parasites in the blood film [ ] Blood films are useful for the diagnosis of: Babesiosis Malaria

2008 Mentor

5585. Full Blood Count

and thalassaemia. Abnormal Hb levels See also the separate , and articles. Anaemia with low MCV (microcytic): - look at serum ferritin level. . . Anaemia with normal MCV (normocytic): Recent bleeding. Anaemia of chronic disease (including renal disease). Combined iron and B12/folate deficiency. Most non-haematinic deficiency causes. Anaemia with high MCV (macrocytic): see the separate article. High Hb It is important first to ascertain the validity of this result if it does not tie in with known clinical (...) distribution width (the indicator of the range in platelet size in a blood sample) unlike the normal platelet distribution width seen in reactive thrombocytosis, where there is an increased platelet count but normal sized platelets. Satellitosis - describes platelets encircling a neutrophil. It occurs when a patient has a serum factor that reacts to the anticoagulant EDTA. Parasites in the blood film [ ] Blood films are useful for the diagnosis of: Babesiosis Malaria Microfilaria Trypanosomiasis Some

2008 Mentor

5586. Impact of Providing High Protein Bar to Dialysis Patients With Low Serum Albumin

Impact of Providing High Protein Bar to Dialysis Patients With Low Serum Albumin Impact of Providing High Protein Bar to Dialysis Patients With Low Serum Albumin - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding (...) more. Impact of Providing High Protein Bar to Dialysis Patients With Low Serum Albumin The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00597025 Recruitment Status : Unknown Verified December 2007 by Satellite Healthcare. Recruitment status was: Recruiting First Posted : January 17, 2008 Last Update

2008 Clinical Trials

5587. Optimal Titration Regimen for SBR759 in Lowering Serum Phosphate Levels in Asian Chronic Kidney Disease Patients on Hemodialysis

-binder therapy. Serum phosphate level > 6.0 mg/dL (> 1.9 mmol/L) prior to study treatment initiation. Exclusion criteria Peritoneal dialysis or a non-conventional hemodialysis technique . Parathyroidectomy or transplant scheduled during the study. Uncontrolled hyperparathyroidism History of hemochromatosis or ferritin > 800 µg/L. Clinically significant GI disorder Unstable medical condition other than Chronic Kidney Disease. Treated with sevelamer HCl monotherapy or SBR759. Treated with oral iron (...) Optimal Titration Regimen for SBR759 in Lowering Serum Phosphate Levels in Asian Chronic Kidney Disease Patients on Hemodialysis Optimal Titration Regimen for SBR759 in Lowering Serum Phosphate Levels in Asian Chronic Kidney Disease Patients on Hemodialysis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have

2008 Clinical Trials

5588. Efficacy of SBR759 in Lowering Serum Phosphate Levels in Chronic Kidney Disease Patients on Hemodialysis

: All Accepts Healthy Volunteers: No Criteria Inclusion criteria Men or women of at least 18 years old. Stable maintenance of renal replacement therapy 3 times per week. Controlled Serum phosphate if under phosphate-binder therapy. Serum phosphate level ≥ 6.0 mg/dL (> 1.9 mmol/L) prior to study treatment initiation. Exclusion criteria Peritoneal dialysis. Parathyroidectomy or transplant scheduled during the study. Uncontrolled hyperparathyroidism History of hemochromatosis or ferritin > 1000 µg/L (...) Efficacy of SBR759 in Lowering Serum Phosphate Levels in Chronic Kidney Disease Patients on Hemodialysis Efficacy of SBR759 in Lowering Serum Phosphate Levels in Chronic Kidney Disease Patients on Hemodialysis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100

2008 Clinical Trials

5589. Prevalence of HFE mutations and relation to serum iron status in patients with chronic hepatitis C and patients with nonalcoholic fatty liver disease in Taiwan Full Text available with Trip Pro

of HFE gene in 125 healthy subjects, 29 patients with CHC, and 33 patients with NAFLD. The serum iron markers, including ferritin, iron, and total iron binding capacity (TIBC), were assessed in all patients.All of the healthy subjects and patients were free from C282Y mutation. The prevalence of H63D heter-ozygosity was 4/125 (3.20%) in healthy subjects, 2/29 (6.90%) in CHC group, and 1/33 (3.03%) in NAFLD group. The healthy subjects showed no significant difference in the prevalence of H63D mutation (...) Prevalence of HFE mutations and relation to serum iron status in patients with chronic hepatitis C and patients with nonalcoholic fatty liver disease in Taiwan To assess the prevalence of the two mutations, C282Y and H63D of HFE gene, in healthy subjects, patients with chronic hepatitis C (CHC), and patients with nonalcoholic fatty liver disease (NAFLD) in Taiwan and to explore the contribution of the HFE mutation on serum iron stores in CHC and NAFLD groups.We examined C282Y and H63D mutations

2005 World journal of gastroenterology : WJG

5590. Reliability of Serum Assays of Iron Status in Postmenopausal Women Full Text available with Trip Pro

for ferritin (0.78; 95% confidence interval [CI], 0.67-0.86), soluble transferrin receptor (sTfR; 0.79; 95% CI, 0.69-0.87), sTfR/ferritin ratio (0.74; 95% CI, 0.62-0.83), and hepcidin (0.89; 95% CI, 0.84-0.94). In a subset of 30 women, lower reliability was observed for serum iron (0.50; 95% CI, 0.29-0.70), unsaturated iron-binding capacity (0.55; 95% CI, 0.34-0.73), total iron-binding capacity (0.60; 95% CI, 0.40-0.76), and serum transferrin saturation rate (0.44; 95% CI, 0.22-0.65). The reliability (...) Reliability of Serum Assays of Iron Status in Postmenopausal Women The aim of the study is to determine the reliability during a 2-year period of several newly developed iron-related assays to assess their potential for use in prospective epidemiologic studies.We assessed the temporal reliability of several iron-related assays by using three serum samples collected at yearly intervals from 50 postmenopausal participants in a large prospective study.We observed high reliability coefficients

2006 Annals of Epidemiology

5591. Relationship between serum leptin level and laboratory and anthropometric indices of malnutrition in patients on hemodialysis Full Text available with Trip Pro

of correlation coefficient between serum leptin and anthropometric parameters and most laboratory parameters was < 0.25 (except ferritin, iron, phosphorous in males and total protein, hemoglobin, urea, and creatinin in females which was between 0.25 and 0.50). Our results suggest that the increased serum leptin level does not have a major role in diagnosis of malnutrition in hemodialysis patients and there is a poor correlation between malnutrition parameters and serum leptin level. (...) Relationship between serum leptin level and laboratory and anthropometric indices of malnutrition in patients on hemodialysis Protein-energy malnutrition is a major problem and one of the risk factors for mortality in hemodialysis patients. There is no single index in evaluation of nutritional status in these patients, so leptin can be used as one of the parameters. In this study, the correlation between serum leptin with biochemical and anthropometric parameters of nutrition has been evaluated

2008 Indian Journal of Nephrology

5592. Levels of serum transferrin receptor and its response to Fe-supplement in Fe-deficient children. (Abstract)

Levels of serum transferrin receptor and its response to Fe-supplement in Fe-deficient children. The object of the present study was to investigate the levels of serum transferrin receptor (sTfR) and its response to Fe supplementation in Fe-deficient children and the role of sTfR in detecting Fe deficiency and assessing the efficacy of Fe supplementation. According to the diagnostic standard, 1006 children, aged 6-14 years in Fangshan district, Beijing, Peoples Republic of China, were divided (...) into four groups: normal; Fe store depletion (IDs); Fe deficiency erythropoiesis (IDE); Fe deficiency anaemia (IDA). sTfR was determined and transferrin receptor-ferritin (TfR-F) index was calculated in 238 children, sixty-four normal and 174 Fe deficient. Children were administered a NaFeEDTA capsule containing 60 mg Fe once per week for the IDs and IDE groups and three times per week for the IDA group for nine consecutive weeks. The parameters reflecting Fe status and sTfR were determined before

2006 The British journal of nutrition Controlled trial quality: uncertain

5593. Serum prohepcidin concentration: no association with iron absorption in healthy men; and no relationship with iron status in men carrying HFE mutations, hereditary haemochromatosis patients undergoing phlebotomy treatment, or pregnant women. Full Text available with Trip Pro

Serum prohepcidin concentration: no association with iron absorption in healthy men; and no relationship with iron status in men carrying HFE mutations, hereditary haemochromatosis patients undergoing phlebotomy treatment, or pregnant women. Hepcidin plays a major role in iron homeostasis, but understanding its role has been hampered by the absence of analytical methods for quantification in blood. A commercial ELISA has been developed for serum prohepcidin, a hepcidin precursor (...) (ninety-one wild-type, forty-seven C282Y heterozygote), six hereditary haemochromatosis patients, and thirteen pregnant women. Mean serum prohepcidin concentrations were 214 (SD 118) ng/ml [208 (SD 122) ng/ml in wild-type and 225 (SD 109) ng/ml in C282Y heterozygotes] in healthy men, 177 (SD 36) ng/ml in haemochromatosis patients, and 159 (SD 59) ng/ml in pregnant women. There was no relationship between serum prohepcidin concentration and serum ferritin in any subject groups, nor was it associated

2007 The British journal of nutrition Controlled trial quality: uncertain

5594. Effects of bovine serum concentrate, with or without supplemental micronutrients, on the growth, morbidity, and micronutrient status of young children in a low-income, peri-urban Guatemalan community. Full Text available with Trip Pro

, peri-urban Guatemalan community.Children aged 6-7 months initially.Children received one of four maize-based dietary supplements daily for 8 months, containing: (1) BSC, (2) whey protein concentrate (WPC, control group), (3) WPC+MMN, or (4) BSC+MMN.There were no significant differences in growth or rates of morbidity by treatment group. Children who received MMN had lower rates of anemia and (in the group that received WPC+MMN) less of a decline in serum ferritin than those who did (...) Effects of bovine serum concentrate, with or without supplemental micronutrients, on the growth, morbidity, and micronutrient status of young children in a low-income, peri-urban Guatemalan community. To determine the effects of dietary supplements containing bovine serum concentrate (BSC, a source of immunoglobulins) and/or multiple micronutrients (MMN) on children's growth velocity, rates of common infections, and MN status.Randomized, controlled, community-based intervention trial.Low-income

2008 European journal of clinical nutrition Controlled trial quality: uncertain

5595. Diurnal normobaric moderate hypoxia raises serum erythropoietin concentration but does not stimulate accelerated erythrocyte production. (Abstract)

in hematocrit (4%), hemoglobin concentration (5%), red blood cell count (4%) on day 7 in the hypoxic group, these observations were likely due to dehydration or biological variation over time. There was no significant change in early erythropoietic markers (reticulocyte counts or serum ferritin concentration), which provided inconclusive evidence of accelerated erythroid differentiation and proliferation. The results suggest that the degree of hypoxia was sufficient to stimulate increased erythropoietin (...) of 81+/-2% on three consecutive days. The control group spent three consecutive 8-h days in modified tent systems that delivered normoxic air into the tent. Venous blood samples were collected before the exposure (days -5, 0), after each day of the exposure (days 1, 2, 3), and for 3 weeks after the exposure (days 7, 10, 13, 17, 24). Serum erythropoietin concentration significantly increased from 9.1+/-3.3 U.L(-1) to 30.7+/-8.6 U.L(-1) in the hypoxic group. Although there were significant increases

2006 European journal of applied physiology Controlled trial quality: uncertain

5596. Weekly iron supplementation does not block increases in serum zinc due to weekly zinc supplementation in Bangladeshi infants. Full Text available with Trip Pro

in Bangladeshi infants. In a double-blind, randomized, controlled community trial, 6-mo-old infants were assigned to receive weekly supplements of 1 mg riboflavin (control, n = 82) or 1 mg riboflavin + 20 mg iron (n = 83), 20 mg zinc (n = 83), or both (n = 85) for 6 mo. Hemoglobin, serum ferritin, transferrin receptor, zinc, and copper concentrations were measured at baseline and at the end of intervention. Serum Zn increased in both groups receiving zinc; the increase was greatest among children with low (...) Weekly iron supplementation does not block increases in serum zinc due to weekly zinc supplementation in Bangladeshi infants. Because infants and young children in many developing countries are deficient in both iron and zinc, and zinc can affect iron metabolism, evaluation of optimum strategies to simultaneously supplement iron and zinc is an important public health priority. This study evaluated the efficacy of weekly supplementation of iron or zinc or both on iron, zinc, and copper status

2005 The Journal of nutrition Controlled trial quality: uncertain

5597. Elevated serum ALT levels during pegylated interferon monotherapy may be caused by hepatic iron overload. (Abstract)

before and during therapy from 3 patients with elevated serum ALT levels.Serum ferritin levels were significantly increased after 24 weeks compared to baseline levels in group E (218 +/- 273 vs. 438 +/- 308 ng/ml; p < 0.0001) and group E- (146 +/- 152 vs. 410 +/- 291 ng/ml; p < 0.0001). Serum ALT and ferritin levels were significantly correlated after 24 weeks. The liver specimens revealed that TIS and fibrosis progressed during therapy.Our findings suggest that the elevation in serum ALT levels (...) Elevated serum ALT levels during pegylated interferon monotherapy may be caused by hepatic iron overload. Persistently elevated serum alanine aminotransferase (ALT) levels have been observed in chronic hepatitis C (CHC) patients during pegylated interferon (PEG-IFN) therapy. We investigated whether elevated serum ALT levels during PEG-IFN therapy are associated with iron overload.Sixty-three CHC patients treated with PEG-IFNalpha-2a monotherapy were evaluated. The associations between elevated

2008 Intervirology Controlled trial quality: uncertain

5598. Impact of daily consumption of iron fortified ready-to-eat cereal and pumpkin seed kernels (Cucurbita pepo) on serum iron in adult women. (Abstract)

. Eight healthy female, single or non pregnant subjects, aged 20-37 y consumed 30 g of iron fortified ready-to-eat cereal (providing 7.1 mg iron/day) plus 30 g of pumpkin seed kernels (providing 4.0 mg iron/day) for four weeks. Blood samples collected on the day 20 of menstrual cycles before and after consumption and indices of iron status such as reticulocyte count, hemoglobin (Hb), hematocrit (Ht), serum ferritin, iron, total iron-binding capacity (TIBC), transferrin and transferrin saturation (...) Impact of daily consumption of iron fortified ready-to-eat cereal and pumpkin seed kernels (Cucurbita pepo) on serum iron in adult women. Iron deficiency, anemia, is the most prevalent nutritional problem in the world today. The objective of this study was to consider the effectiveness of consumption of iron fortified ready-to-eat cereal and pumpkin seed kernels as two sources of dietary iron on status of iron nutrition and response of hematological characteristics of women at reproductive ages

2007 BioFactors (Oxford, England) Controlled trial quality: uncertain

5599. Effects of delayed sample processing and freezing on serum concentrations of selected nutritional indicators. Full Text available with Trip Pro

Effects of delayed sample processing and freezing on serum concentrations of selected nutritional indicators. Environmental conditions during sample processing, shipping, and storage are often suboptimal, particularly in less developed countries. We used samples from US volunteers to investigate the effects of delayed whole blood (WB) processing and delayed freezing of serum on selected nutritional indicators.WB tubes (n = 35) were either stored at 32 degrees C for up to 3 days before serum (...) did not unacceptably affect concentrations of carotenoids and vitamins B(12), D, and E; however, we obtained clinically unacceptable changes for ferritin (+9%), soluble transferrin receptor (sTfR) (+5%), and folate (-30%) after 1 day, and for vitamin A (-10%) after 3 days. Delayed freezing of serum did not affect concentrations of ferritin, sTfR, carotenoids, and vitamins A, B(12), and E; however, we obtained clinically unacceptable changes for vitamins C (-20%) and D (+7%) after 7 days

2008 Clinical Chemistry

5600. Association between serum bicarbonate and death in hemodialysis patients: is it better to be acidotic or alkalotic? Full Text available with Trip Pro

included dialysate HCO3(-) and Kt/V), and (3) adjusted for case mix and nine markers of MICS (body mass index; erythropoietin dose; protein intake; serum albumin; creatinine; phosphorus; calcium; ferritin and total iron binding capacity; and blood hemoglobin, WBC, and lymphocytes). There were significant inverse associations between serum HCO3(-) and serum phosphorus and estimated protein intake. The lowest unadjusted mortality was associated with predialysis HCO3(-) in the 17- to 23-mEq/L range (...) Association between serum bicarbonate and death in hemodialysis patients: is it better to be acidotic or alkalotic? The optimal acid-base status for survival in maintenance hemodialysis (MHD) patients remains controversial. According to recent reports, acidosis is associated with improved survival in MHD patients. It was hypothesized that this inverse association is due to a confounding effect of the malnutrition-inflammation complex syndrome (MICS). Associations between baseline (first 3 mo

2006 Clinical Journal of the American Society of Nephrology

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