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Serum Ferritin

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5541. Should patients with Anemia and a Normal Ferritin Undergo Colonoscopy?

any other indications for colonoscopy including positive fecal occult blood testing, change in bowel habits, personal or family history of colon cancer, FAP, HNPCC, or IBD. For inclusion, a ferritin level must have been checked in the eight weeks preceding colonoscopy. Four-hundred and twenty four patients were included and were divided into three groups based on ferritin levels: 1) <50ng/dL (iron-deficient, N=254), 2) 51-100ng/dL (low normal, N=55), and 3) >100ng/dL (normal, N=115). The primary (...) Should patients with Anemia and a Normal Ferritin Undergo Colonoscopy? Should patients with Anemia and a Normal Ferritin Undergo Colonoscopy? – Clinical Correlations Search Should patients with Anemia and a Normal Ferritin Undergo Colonoscopy? February 16, 2007 3 min read Commentary By: Joshua Olstein PGY-3 Second only to lung cancer, colon cancer claimed an estimated 55,000 lives in the United States in 2006. In an effort to reduce colon cancer morbidity and mortality, multiple screening tests

2007 Clinical Correlations

5542. I have a patient (80 yr female) who has a serum ferrritin of 262 (nr 13-150) what investigations are needed?

on ‘Interpretation of an elevated serum ferritin’ [1]. This articles starts with the statement: “The interpretation of an elevated serum ferritin requires consideration of several separate disease categories. These come under the broad headings of: - Iron overload - Acute inflammatory conditions - Liver disease - Alcohol excess” This further expands the potential causes of: “ Causes of iron overload Primary -Hereditary haemochromatosis -Hereditary aceruloplasminemia (Wilson’s disease) Secondary -Transfusion (...) overload -Excess dietary iron -Porphyria cutanea tarda -Ineffective erythropoiesis (Sideroblastic anaemia, Thalassemia) Causes of high serum ferritin without iron overload -Liver disease – non-alcoholic hepatitic steatosis (NASH)* or viral hepatitis (B/C?G) -Alcohol excess -Chronic inflammatory conditions – Rheumatoid arthritis, inflammatory bowel disease – Bacterial infections -Malignancy especially haematological -Thyrotoxicosis -Familial hyperferritinemia and cataract syndrome” The document

2006 TRIP Answers

5543. Description of Iron Status in Blood Donors

100 mg A: 100 mg pr day in 8 days Outcome Measures Go to Primary Outcome Measures : Iron status [ Time Frame: april 2008 ] Secondary Outcome Measures : Hemoglobin and serum ferritin [ Time Frame: april 2008 ] Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact (...) Description of Iron Status in Blood Donors Description of Iron Status in Blood Donors - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Description of Iron Status in Blood Donors The safety and scientific

2008 Clinical Trials

5544. Expanded Access of Deferasirox to Patients With Congenital Disorders of Red Blood Cells and Chronic Iron Overload

, unacceptable toxicities and/or documented poor response to locally approved iron chelators despite proper compliance History of at least 20 blood transfusions (equivalent to 100 mL/kg of packed red blood cells (PRBC]) Serum ferritin value greater than or equal to 1000 µg/L Ability to comply with all study-related procedures, medications, and evaluations Exclusion Criteria: Ongoing treatment with another iron chelator (Any other iron chelation therapy must be discontinued at least 24 hours prior to study (...) ) leading to study drug interruption or discontinuation. Note: only treatment emergent AEs are summarized. Secondary Outcome Measures : The Change in Serum Ferritin Values From Baseline Through Completion of the Study [ Time Frame: Baseline to end of study (Median exposure time to drug was approximately 30 weeks; Maximum exposure was 104 weeks) ] The number of participants with Improvement, No Change or Worsening in Serum ferritin category levels at the end of the study compared to baseline. Serum

2005 Clinical Trials

5545. MRI Screening for Patients With Myelodysplastic Syndrome (MDS), Who Have Received Multiple Red Blood Cell Transfusions

patients with MDS who have received at least 50 units of Red Blood Cell Transfusions. Serum ferritin > 1,000 Written informed consent by the patient. Exclusion Criteria: Contraindication to MRI, including cardiac pacemaker, brain aneurysm clip, implanted neurostimulator, insulin pump, cochlear implant, metal slivers in the eyes, intrauterine device or any other MRI incompatible metal implants or intractable claustrophobia. Contacts and Locations Go to Information from the National Library of Medicine (...) MRI Screening for Patients With Myelodysplastic Syndrome (MDS), Who Have Received Multiple Red Blood Cell Transfusions MRI Screening for Patients With Myelodysplastic Syndrome (MDS), Who Have Received Multiple Red Blood Cell Transfusions - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum

2008 Clinical Trials

5546. MRI Evaluation of Iron Overload in the Heart, Liver and Pancreas in Patients Receiving Multiple Blood Transfusions.

MRI Evaluation of Iron Overload in the Heart, Liver and Pancreas in Patients Receiving Multiple Blood Transfusions. MRI Evaluation of Iron Overload in the Heart, Liver and Pancreas in Patients Receiving Multiple Blood Transfusions. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number (...) of saved studies (100). Please remove one or more studies before adding more. MRI Evaluation of Iron Overload in the Heart, Liver and Pancreas in Patients Receiving Multiple Blood Transfusions. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00629291 Recruitment Status : Completed First Posted : March 5

2008 Clinical Trials

5547. Clinical Evaluation of Iron Treatment Efficiency Among Non-anemic But Iron-deficient Female Blood Donors

Posted : February 15, 2013 Last Update Posted : February 15, 2013 Sponsor: University of Lausanne Collaborator: Pierre Fabre Laboratories Information provided by (Responsible Party): Bernard Favrat, University of Lausanne Study Details Study Description Go to Brief Summary: The purpose of this study is to determine the subjective response of iron substitution (Tardyferon®) on fatigue in women blood donors with a mean serum ferritin < 30ng/ml and to assess variation of ferritin and hemoglobin after (...) the subjective response of iron substitution (Tardyferon®) on fatigue in women blood donors with a mean serum ferritin < 30ng/ml and to assess variation of ferritin and hemoglobin after a blood donation. We will measure blood count, ferritin level and C-reactive protein at the time of the blood donation and then after a week, a month and 3 months. A week after the blood donation, donors with a ferritin level <30 ng/ml and hemoglobin > 120g/l (non anaemic) will be included in the study and randomised. A one

2008 Clinical Trials

5548. Iron Replacement in Blood Donors

Update Posted: July 2, 2017 Last Verified: March 1, 2012 Keywords provided by National Institutes of Health Clinical Center (CC): Hemoglobin Iron Supplementation Donor Retention Iron Stores Ferritin Transferrin Saturation Healthy Volunteer HV Blood Donors Additional relevant MeSH terms: Layout table for MeSH terms Anemia, Iron-Deficiency Anemia, Hypochromic Anemia Hematologic Diseases Iron Metabolism Disorders Metabolic Diseases Iron Trace Elements Micronutrients Nutrients Growth Substances (...) Iron Replacement in Blood Donors Iron Replacement in Blood Donors - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Iron Replacement in Blood Donors The safety and scientific validity of this study

2006 Clinical Trials

5549. Study in Women With Idiopathic Menorrhagia to Determine the Reduction in Menstrual Blood Loss (MBL) After Treatment With the Levonorgestrel-releasing Intrauterine System (IUS)

days. In the MPA group, each menstrual cycle starts on the 1st bleeding day (withdrawal bleeding) and lasts until the last non-bleeding day before next withdrawal bleeding starts. Percent Change in Hemoglobin [ Time Frame: Baseline and up to 6 months ] Percent Change in Hematocrit [ Time Frame: Baseline and up to 6 months ] Percent Change in Serum Ferritin [ Time Frame: Baseline and up to 6 months ] Percentage of Patients With Improvement in the Investigator Global Assessment Scale [ Time Frame: Up (...) Study in Women With Idiopathic Menorrhagia to Determine the Reduction in Menstrual Blood Loss (MBL) After Treatment With the Levonorgestrel-releasing Intrauterine System (IUS) Study in Women With Idiopathic Menorrhagia to Determine the Reduction in Menstrual Blood Loss (MBL) After Treatment With the Levonorgestrel-releasing Intrauterine System (IUS) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information

2006 Clinical Trials

5550. Efficacy and Safety Study of Magnesium Iron Hydroxycarbonate for the Reduction of High Blood Phosphate in Hemodialysis Patients

, megacolon, or mechanical obstruction. A significant illness in the 4 weeks before screening. Taking medication prescribed for seizures. A history of haemochromatosis. A history of high serum ferritin concentration of ≥ 1000ng/ml (excluding transient, treatment-induced ferritin elevation). A history of dysphagia or swallowing disorders that might limit the subject's ability to swallow study medication in the opinion of the investigator. Female subjects who are lactating or pregnant. Women of childbearing (...) Efficacy and Safety Study of Magnesium Iron Hydroxycarbonate for the Reduction of High Blood Phosphate in Hemodialysis Patients Efficacy and Safety Study of Magnesium Iron Hydroxycarbonate for the Reduction of High Blood Phosphate in Hemodialysis Patients - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached

2006 Clinical Trials

5551. Oral supplementation with NaFeEDTA reduces blood lead in postmenopausal but not premenopausal Korean women with anemia. (Abstract)

group. When age and baseline Hb levels were adjusted for, PbB concentrations decreased by 0.10 and 0.31 microg/dL in the PRE-M and POST-M groups, respectively, and the results were significant using a multivariate model (P = 0.016). Iron status determined by zinc protoporphyrin, transferrin saturation, and Hb improved significantly in both groups, but serum ferritin decreased significantly in the POST-M women (P < 0.001), with no change in the PRE-M group.After 6 mo of supplementation (...) Oral supplementation with NaFeEDTA reduces blood lead in postmenopausal but not premenopausal Korean women with anemia. The objective was to evaluate the effect of iron supplementation for 6 mo on blood lead (PbB) concentration in populations of premenopausal (PRE-M) and postmenopausal (POST-M) Korean women.We conducted a community intervention trial in Asan, Republic of Korea. Of the 137 enrolled women with hemoglobin (Hb) levels lower than 12 g/dL, 37 were PRE-M and 100 were POST-M. Each

2008 Nutrition (Burbank, Los Angeles County, Calif.)

5552. Iron status of regular voluntary blood donors Full Text available with Trip Pro

automatic haematology analyzer, serum iron and total iron-binding capacity (TIBC) by biochemical methods, ferritin using ELISA kits and transferrin using immunoturbidometry kits. Iron/TIBC ratio x 100 gave percentage of transferrin saturation value.Statistical evaluation was done by mean, standard deviation, pair t-test, chi(2) and anova (F-test).Preliminary analysis revealed that there was no significant difference in the iron profile of vegetarian and non-vegetarian subjects or controls and the donors (...) Iron status of regular voluntary blood donors Our blood bank is a regional blood transfusion centre, which accepts blood only from voluntary donors.The aim is to study iron status of regular voluntary donors who donated their blood at least twice in a year.Prior to blood donation, blood samples of 220 male and 30 female voluntary donors were collected. Control included 100 each male and female healthy individuals in the 18- to 60-year age group, who never donated blood and did not have any

2008 Asian journal of transfusion science

5553. [The effect of vitamin, macro and microelement supplementation on markers of iron status in blood of pregnant women]. (Abstract)

. In serum of umbilical cord blood concentration of total iron, transferin and ferritin were similar in newborns of both groups of mothers. The above results suggested that vitamin, macro and microelement supplementation of pregnant women improved iron status in mothers and in their children. It seems that administration Vibovitmama formula can be recommended as a dietary supplement in pregnancy in order to prevent subclinical deficiency of iron. (...) trimester in comparison to the I trimester by 38% (p < 0.0001) and by 55% (p < 0.0001) respectively in non supplemented and supplemented groups were found. It was accompanied by significant increase of total iron-binding capacity (TIBC) (p < 0.0001). In both studied groups the level of ferritin was lower in the III than in the I trimester. In serum of women without supplementation, ferritin concentration decreased by 35% (p < 0.003); whereas in supplemented group it was statistically insignificant

2004 Przegla̧d lekarski Controlled trial quality: uncertain

5554. Iron fortification reduces blood lead levels in children in Bangalore, India. (Abstract)

and compliance monitored.Hemoglobin, serum ferritin, C-reactive protein, transferrin receptor, zinc protoporphyrin, and blood lead concentrations were measured.The prevalence of iron deficiency was significantly reduced in the iron group (from 70% to 28%) compared with the control group (76% to 55%). There was a significant decrease in median blood lead concentration in the iron group compared with the control group. The prevalence of blood lead levels > or =10 microg/dL was significantly reduced in the iron (...) Iron fortification reduces blood lead levels in children in Bangalore, India. Chronic lead poisoning and iron deficiency are concentrated in urban children from lower socioeconomic strata, and both impair neurocognitive development. Our study objective was to determine if iron fortification reduces blood lead levels in urban, lead-exposed, iron-deficient children in Bangalore, India.A randomized, double-blind, controlled school-based feeding trial was done in 5- to 13-year-old iron-deficient

2006 Pediatrics Controlled trial quality: predicted high

5555. Pre-operative oral iron supplementation reduces blood transfusion in colorectal surgery - a prospective, randomised, controlled trial. Full Text available with Trip Pro

at pound1500). At admission, ferritin in the iron-treated group had risen significantly from 40 microg/l (range, 15-222 microg/l) to 73 microg/l (range, 27-386 microg/l; P = 0.0036; 95% CI 46.53-10.57).Oral ferrous sulphate given pre-operatively in patients undergoing colorectal surgery offers a simple, inexpensive method of reducing blood transfusions. (...) Pre-operative oral iron supplementation reduces blood transfusion in colorectal surgery - a prospective, randomised, controlled trial. Allogeneic blood transfusion confers a risk to the recipient. Recent trials in colorectal surgery have shown that the most significant factors predicting blood transfusion are pre-operative haemoglobin, operative blood loss and presence of a transfusion protocol. We report a randomised, controlled trial of oral ferrous sulphate 200 mg TDS for 2 weeks' pre

2007 Annals of the Royal College of Surgeons of England Controlled trial quality: uncertain

5556. Short-term ferrous sulfate supplementation in female blood donors. (Abstract)

for possible repeat donation. Each volunteer was given 21 tablets of 150 mg of ferrous sulfate or placebo to be taken three times daily for 1 week after each blood donation. Their hemoglobin (Hb) concentration, hematocrit (Hct), serum ferritin, total iron-binding capacity (TIBC), and percent saturation of the TIBC were tested throughout the course of the study.The group taking ferrous sulfate showed no significant difference between the mean initial and final result for any of the values other than Hb (...) values, whereas there was a significant decline in mean Hb, Hct, serum iron, serum ferritin, and percent saturation in the group taking placebo. Hb concentrations declined significantly in both groups; however, it was more severe in the placebo group when compared to the ferrous sulfate group. The relative risk of iron deficiency in placebo group was 3.6 (95% confidence interval = 1.73-7.74).The results indicate that supplementation therapy can be considered as one of the strategies to promote safe

2008 Transfusion Controlled trial quality: uncertain

5557. Red blood cell metallothionein as an indicator of zinc status during pregnancy. Full Text available with Trip Pro

(86 who received daily supplements containing 60 mg of iron and 250 microg of folic acid and 72 whose supplements also contained 25 mg of zinc). In addition, we measured plasma and urinary zinc concentrations, hemoglobin and serum ferritin, and, on a limited sample, RBC zinc and placental MT.RBCMT increased during pregnancy, and levels in the cord blood approximated maternal values at 36 wk. Only RBC zinc at 36 wk differed by supplement type (P < 0.05). Increases in RBCMT over pregnancy were (...) Red blood cell metallothionein as an indicator of zinc status during pregnancy. We describe the levels and patterns of change in red blood cell (RBC) metallothionein (MT) during pregnancy and the neonate and relate RBCMT to other indicators of zinc and iron status.As part of a double-masked controlled trial of prenatal zinc supplementation among 242 Peruvian pregnant women, we determined RBCMT at enrollment (10-16 wk), at 28 and 36 wk of gestation, and in the cord blood at delivery in 158 women

2008 Nutrition (Burbank, Los Angeles County, Calif.) Controlled trial quality: uncertain

5558. Intravenous iron exacerbates oxidative DNA damage in peripheral blood lymphocytes in chronic hemodialysis patients. Full Text available with Trip Pro

/reduced glutathione ratio (P < 0.05). In summary, intravenous iron sucrose provokes oxidative damage to peripheral blood lymphocyte DNA in hemodialysis patients, especially among those with high levels of ferritin. (...) Intravenous iron exacerbates oxidative DNA damage in peripheral blood lymphocytes in chronic hemodialysis patients. Patients undergoing maintenance hemodialysis have elevated markers of oxidative stress, but the reasons for this are not fully understood. Intravenous administration of iron, which many of these patients receive, may provoke the generation of bioactive iron, which enhances oxidative stress and lipid peroxidation. In this study, 110 hemodialysis patients were randomly assigned

2008 Journal of the American Society of Nephrology : JASN Controlled trial quality: uncertain

5559. Iron stores, blood donation, and insulin sensitivity and secretion. Full Text available with Trip Pro

], decreased insulin secretion [186 (82) vs 401.7 (254) mIU/L x min; P <0.0001], and significantly lower iron stores [serum ferritin, 101.5 (74) vs 162 (100) microg/L; P = 0.017] than nondonors, but the 2 groups had similar blood hematocrits and blood hemoglobin concentrations.Blood donation is simultaneously associated with increased insulin sensitivity and decreased iron stores. Stored iron seems to impact negatively on insulin action even in healthy people, and not just in classic pathologic conditions (...) Iron stores, blood donation, and insulin sensitivity and secretion. Epidemiologists have observed that blood donation is associated with decreased risk of type 2 diabetes and cardiovascular disease.We investigated the relationship between iron stores and insulin sensitivity, after controlling for known confounding factors, and compared insulin sensitivity between blood donors and individuals who had never donated blood (nondonors). In 181 men, insulin sensitivity and insulin secretion were

2005 Clinical Chemistry

5560. Antioxidant diet supplementation influences blood iron status in endurance athletes. (Abstract)

/d). The study was double blind. Hematological parameters, dietary intake, physical activity intensity, antioxidant status (GSH/GSSG ratio), and basal iron status (serum iron, transferrin, ferritin, and iron saturation index) were determined before and after the intervention trials.Exercise decreased antioxidant defenses in the placebo group but not in the antioxidant-supplemented group. No changes were found in the number of erythrocytes, hematocrit, or hemoglobin concentration, or in values (...) Antioxidant diet supplementation influences blood iron status in endurance athletes. The aim of this work was to check the effects of antioxidant supplementation (vitamins E and C, and beta-carotene) on the basal iron status of athletes prior to and following their training and competition season (3 months).Eighteen amateur trained male athletes were randomly distributed in 2 groups: placebo (lactose) and antioxidant supplemented (vitamin E, 500 mg/d; vitamin C, 1 g/d; and beta -carotene, 30 mg

2004 International journal of sport nutrition and exercise metabolism Controlled trial quality: uncertain

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