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Serum Ferritin

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5521. Duodenal expression of iron transport molecules in untreated haemochromatosis subjects. Full Text available with Trip Pro

in haemochromatosis patients and iron replete subjects but in haemochromatosis patients with elevated serum ferritin concentrations, both DMT1 (IRE) and Ireg1 expression were inappropriately increased relative to serum ferritin concentration. Hephaestin and Dcytb levels were not upregulated in haemochromatosis. DMT1 (IRE) and Ireg1 levels showed significant inverse correlations with serum ferritin concentration in each group of patients.These findings are consistent with DMT1 (IRE) and Ireg1 playing primary roles (...) in the adaptive response to iron deficiency. Untreated haemochromatosis patients showed inappropriate increases in DMT1 (IRE) and Ireg1 expression for a given level of serum ferritin concentration, although the actual level of expression of these iron transport genes was not significantly different from that of normal subjects.

2003 Gut

5522. Patient compliance with phlebotomy therapy for iron overload associated with hemochromatosis. (Abstract)

to achieve iron depletion; and 3) participation in therapy to maintain serum ferritin serum ferritin concentration, HFE genotype, units of blood removed to achieve iron depletion, and presence or absence of cirrhosis at diagnosis.A total of 118 patients were evaluable for iron depletion and 142 for maintenance therapy; 96.6% achieved iron (...) Patient compliance with phlebotomy therapy for iron overload associated with hemochromatosis. The aim of this study was to evaluate patient compliance with phlebotomy therapy of hemochromatosis-associated iron overload.We reviewed medical records of white adults with hemochromatosis and iron overload diagnosed during medical care. We defined three elements of compliance: 1) achieving iron depletion (serum ferritin

2003 American Journal of Gastroenterology

5523. Racial differences in the relationship between hepatitis C infection and iron stores. Full Text available with Trip Pro

determined the risk of having increased iron stores, defined as elevation of both serum ferritin and transferrin-iron saturation (TS), in HCV-RNA-positive blacks (n = 100) and nonblacks (n = 126) relative to HCV-RNA-negative blacks (n = 4,002) and nonblacks (n = 10,943). HCV-positive blacks were 5.4 times (95% CI, 1.2 to 24) more likely to have increased iron stores than HCV-positive nonblacks. The proportion of HCV-positive blacks who had increased iron stores was 16.4% among those with abnormal liver

2003 Hepatology

5524. Noninvasive prediction of cirrhosis in C282Y-linked hemochromatosis. Full Text available with Trip Pro

. Prediction of cirrhosis was assessed first by univariate regression analysis. Variables significantly related to cirrhosis were then evaluated by stepwise linear multivariate regression. Receiver operating characteristic curve analysis of the most informative variables from multivariate analysis was then used to devise a clinically applicable index for the noninvasive prediction of cirrhosis. This index was then validated in 162 C282Y homozygous patients in France. Ferritin, blood platelets (...) , and aspartate transaminase (AST) level were selected for the clinical index. The combination of ferritin levels of 1,000 microg/L or greater, platelet levels of 200 x 10(9)/L or less, and AST levels above the upper limit of normal led to a correct diagnosis of cirrhosis in 77% of Canadian patients. In the French patients, this led to a correct diagnosis of cirrhosis in 90%. In conclusion, in C282Y homozygous patients, a combination of easily measured laboratory variables (ferritin, platelets, AST) can

2002 Hepatology

5525. Mild iron overload in patients carrying the HFE S65C gene mutation: a retrospective study in patients with suspected iron overload and healthy controls. Full Text available with Trip Pro

and HFE mutation analysis (for the C282Y, H63D, and S65C mutations) were analysed in 250 healthy control subjects and collected retrospectively in 296 patients with suspected iron overload (elevated serum ferritin and/or transferrin saturation). The frequency of patients having at least mild iron overload, and mean serum ferritin and transferrin saturation values were calculated for each HFE genotype. For patients carrying the S65C mutation, clinical data, liver biopsy results, and amount of blood (...) removed at phlebotomy were determined.The HFE S65C mutation was found in 14 patients and eight controls. In controls, the S65C allele frequency was 1.6%. The S65C allele frequency was enriched in non-C282Y non-H63D chromosomes from patients (4.9%) compared with controls (1.9%) (p<0.05). Serum ferritin was significantly increased in controls carrying the S65C mutation compared with those without HFE mutations. Fifty per cent of controls and relatives having the S65C mutation had elevated serum ferritin

2002 Gut

5526. Respiratory function in patients with thalassaemia major: relation with iron overload. Full Text available with Trip Pro

resonance imaging measurements of the liver. Serum ferritin was measured. The signal intensity ratio of liver to that of paraspinal muscle (T1 weighted sequence) and serum ferritin were used as surrogate index of body iron content.Sixteen boys and 13 girls (median age 14.2 years) were studied. None had clinical evidence of congestive heart failure. Sixteen had normal lung function. Impairment of diffusion capacity (median DL(co) 83.5% predicted) was the most common abnormality, being observed in 34

2002 Archives of Disease in Childhood

5527. Hemochromatosis (HFE) gene mutations and response to chloroquine in porphyria cutanea tarda. (Abstract)

therapy was accompanied by clinical remission and reduced urinary porphyrin excretion (P<.001) in the 24 patients (39%) with HFE wild type as well as in 35 HFE heterozygous patients with PCT (56%). Decreases of serum iron markers following chloroquine therapy were limited to patients with PCT and HFE wild type. All patients homozygous for the C282Y mutation (3 [5%] of 62) had high serum iron, ferritin, and transferrin saturation and failed to respond to chloroquine treatment.The therapeutic response (...) response, urinary porphyrin excretion, liver enzyme activities, and serum iron markers. Serum samples and corresponding complete sets of data before and after therapy were available in 62 of 207 patients with PCT who were treated exclusively with chloroquine.Academic teaching hospital.For treatment, low-dose chloroquine diphosphate, 125 to 250 mg twice weekly, was used during a median time of 16 months (range, 12-26 months).Of the 62 German patients with PCT, 37 (60%) carries HFE mutations. Chloroquine

2003 Archives of Dermatology

5528. Infectious and inflammatory stimuli decrease endothelial nitric oxide synthase activity in vitro. (Abstract)

Infectious and inflammatory stimuli decrease endothelial nitric oxide synthase activity in vitro. Perturbation of iron metabolism, especially the increase of serum ferritin levels, is often associated with both inflammation and hypertension. Changes in iron availability can affect an important regulator of vascular tone, the endothelial nitric oxide synthase (eNOS), activated by a heme-dependent dimerization.To study the regulation of the anti-hypertensive eNOS in human endothelial cells (...) , in correlation with iron metabolism alterations and stimuli triggering them in vivo, such as inflammation or infection.Cells were treated with stimuli mimicking infection or inflammation [lipopolysaccharide (LPS) and/or tumor necrosis factor alpha (TNFalpha)]. and iron shortage (succinylacetone and desferrioxamine). The effect on eNOS expression and activation was evaluated, as well as ferritin content.eNOS protein expression was evaluated by separating the monomeric from the active dimeric form by low

2003 Journal of Hypertension

5529. Left ventricular remodelling, and systolic and diastolic function in young adults with beta thalassaemia major: a Doppler echocardiographic assessment and correlation with haematological data. Full Text available with Trip Pro

data, only serum ferritin showed a weak negative correlation with left ventricular ejection fraction. The patients with the highest serum ferritin (> 2500 ng/ml) had the lowest ejection fraction.Patients with beta thalassaemia on an adequate transfusion and chelation treatment regimen show abnormal left ventricular remodelling with increased volumes, mass, and mass/volume ratio. Systolic chamber function and contractile state are reduced, with a slightly increased afterload. These findings seem (...) mainly to be related to the increased cardiac output caused by chronic anaemia. Left ventricular performance is better preserved when chelation treatment is adjusted to maintain the serum ferritin concentration at < 1000 ng/ml.

2003 Heart

5530. Iron withdrawal strategies fail to prevent the growth of SiHa-induced tumors in mice. (Abstract)

continued for 5 weeks after injection of the tumor cells. Treatment with the maximum tolerated doses of DFO, L1, or starch-DFO conjugate induced no significant iron deprivation in non-iron-overloaded mice, while an iron-poor diet led to a dramatic decrease in serum iron, transferrin iron saturation, and ferritin levels. However, neither iron chelators nor an iron-poor diet could significantly inhibit tumor growth.Despite a potent antitumor effect in vitro, iron chelators fail to prevent the growth

2003 Gynecologic Oncology

5531. Response predicting factors to recombinant human erythropoietin in cancer patients undergoing platinum-based chemotherapy. Full Text available with Trip Pro

-alpha was administered subcutaneously three times a week at a dose of 150 IU/kg. Ninety patients were examined.Response was defined as an increase in Hb of at least 2 g/dL during the treatment period. The response rate was 63.3%. The following data were compared between responders and nonresponders at the onset of treatment and after 2 and 4 weeks of epoetin therapy: Hb, reticulocytes, serum iron, ferritin, transferrin, transferrin saturation index, and endogenous erythropoietin levels. At baseline

2002 Cancer

5532. Changes in haematological parameters and iron metabolism associated with a 1600 kilometre ultramarathon Full Text available with Trip Pro

, total red cell count, mean red cell volume, mean red cell haemoglobin, total white cell count and differential, platelets, reticulocytes, iron, ferritin, total iron binding capacity, percentage transferrin saturation, haptoglobin, and bilirubin and corrected for changes in plasma volume.The following variables decreased during the event (p < 0.05): haemoglobin, packed cell volume, mean red cell volume, percentage lymphocytes, percentage monocytes, serum iron, total iron binding capacity (...) Changes in haematological parameters and iron metabolism associated with a 1600 kilometre ultramarathon To investigate haematological variations and iron related changes in the serum of participants in a 1600 kilometre ultramarathon run.Seven male and two female participants in a 1600 km foot race.Blood samples were obtained from the participants before, after four and 11 days of running, and at the end of the event. Samples were analysed by standard methods for haemoglobin, packed cell volume

1999 British Journal of Sports Medicine

5533. The acute phase response and exercise: court and field sports Full Text available with Trip Pro

The acute phase response and exercise: court and field sports To determine the presence or absence of an acute phase response after training for court and field sports.All members of the Australian women's soccer team (n = 18) and all members of the Australian Institute of Sport netball team (n = 14).Twelve acute phase reactants (white blood cell count, neutrophil count, platelet count, serum iron, ferritin, and transferrin, percentage transferrin saturation, alpha(1) antitrypsin

2001 British Journal of Sports Medicine

5534. Evaluation of iron metabolism indices and their relation with physical work capacity in athletes. Full Text available with Trip Pro

Evaluation of iron metabolism indices and their relation with physical work capacity in athletes. To evaluate the relation between iron status and physical working capacity, and to assess the effect of oral iron treatment on these variables, in athletes with borderline iron status.Blood haemoglobin (Hb), packed cell volume (PCV), red blood cell count (RBC), serum iron, total iron binding capacity (TIBC), and ferritin determinations were compared in 71 male and 18 female athletes participating (...) in various sports and in matched male (n = 11) and female (n = 8) controls. The first aim was to assess the relations between these variables and performance in a physical work capacity test (PWC170). Oral iron treatment (175-350 mg ferrous fumarate daily) was provided for three weeks to six male and five female athletes with borderline Hb concentrations, to determine the effects of such treatment on both iron status and performance.Among females, handball players had the lowest serum ferritin

1996 British Journal of Sports Medicine

5535. Effects of exercise on soluble transferrin receptor and other variables of the iron status Full Text available with Trip Pro

Effects of exercise on soluble transferrin receptor and other variables of the iron status Soluble transferrin receptor (sTfr) is a new marker of iron status and erythropoietic activity. It has been included in multivariable blood testing models for the detection of performance enhancing erythropoietin misuse in sport.To evaluate the effect of different types and volumes of physical activity on sTfr concentration, variables of iron status (ferritin, transferrin, iron, and protein (...) volume were analysed in venous blood samples before and after exercise. Changes in blood and plasma volume were estimated.sTfr levels were slightly increased in trained and untrained subjects immediately after test A. Test B and aerobic exercise had no significant effect on sTfr. Ferritin levels were increased after the laboratory tests for trained and untrained subjects and after prolonged aerobic exercise in male cyclists. Transferrin was increased significantly in trained and untrained subjects

2002 British Journal of Sports Medicine

5536. The response of trained athletes to six weeks of endurance training in hypoxia or normoxia. (Abstract)

%) and in maximal blood lactate concentration (from 7.0 to 9.1 mM) in HG only. Ferritin levels were decreased from 67.4 +/- 16.3 to 42.2 +/- 9.5 microg/l (p < 0.05) in the HG and from 54.3 +/- 6.9 to 31.4+/- 8.0 microg/l (p = 0.17) in the NG. Reticulocytes were significantly increased in both groups by a factor of two. In conclusion, the integration of six weeks of high intensity endurance training did not lead to improved performance in endurance trained athletes whether this training was carried out

2003 International Journal of Sports Medicine Controlled trial quality: uncertain

5537. Iron deficiency in adolescent female dancers. Full Text available with Trip Pro

Iron deficiency in adolescent female dancers. The iron balance of 25 adolescent dancers and 23 control females of the same age were studied. The concentrations of fasting blood haemoglobin, serum iron, serum transferrin and serum ferritin were determined. Iron supplementation (ferrous sulphate corresponding to 100 mg of elemental iron per day) was instigated if body iron stores were low (serum ferritin less than 30 micrograms.l-1). Blood samples were drawn again after ten weeks. Low haemoglobin (...) concentration (blood haemoglobin less than 125 g.l-1) was more prevalent among dancers than among control subjects. Reduced iron stores as well as completely absent iron stores (serum ferritin concentration less than 12 micrograms.l-1) were equally common in both groups (25% of the subjects). Iron supplementation reduced the number of anaemic girls from 16 to 4 and the highly significant difference in haemoglobin level between the treated and untreated groups disappeared. Ten weeks of iron therapy

1988 British Journal of Sports Medicine

5538. ferritin

ferritin ferritin - General Practice Notebook This site is intended for healthcare professionals General Practice Notebook | Medical search ferritin Ferritin is an iron-protein complex found in most tissues, but particularly the bone marrow and reticuloendothelial system. Clinically, its importance is: as an acute phase protein as a non-specific index of liver disease its close relationship to body stores of iron. Thus a low serum ferritin implies iron deficiency. Conversely, high ferritin can (...) imply iron overload states. However, given the first two points in the list, ferritin levels must be interpreted in the light of ongoing inflammation and liver disease. Notes (1): whilst low serum ferritin (SF) is a sensitive and specific indicator of low total body iron stores, elevated SF is sensitive but very nonspecific for iron overload a normal SF rules out iron overload raised SF only 10% of cases of elevated SF are due to iron overload - chronic alcohol consumption, metabolic syndrome

2010 GP Notebook

5539. serum ferritin

serum ferritin serum ferritin - General Practice Notebook This site is intended for healthcare professionals General Practice Notebook | Medical search serum ferritin Ferritin is an iron-protein complex found in most tissues, but particularly the bone marrow and reticuloendothelial system. Clinically, its importance is: as an acute phase protein as a non-specific index of liver disease its close relationship to body stores of iron. Thus a low serum ferritin implies iron deficiency. Conversely (...) , high ferritin can imply iron overload states. However, given the first two points in the list, ferritin levels must be interpreted in the light of ongoing inflammation and liver disease. Notes (1): whilst low serum ferritin (SF) is a sensitive and specific indicator of low total body iron stores, elevated SF is sensitive but very nonspecific for iron overload a normal SF rules out iron overload raised SF only 10% of cases of elevated SF are due to iron overload - chronic alcohol consumption

2010 GP Notebook

5540. Cost-effectiveness impact of iron dextran on hemodialysis patients' use of epoetin alfa and blood

, and transferrin saturation greater than 20%, initiate iron dextran protocol; for hematocrit below 30%, ferritin concentration over 100ng/mL, and transferrin saturation above 20%, increase dosage by 50% to a maximum of 10,000 units three times a week. Before the initiation of the iron dextran protocol at the end of the six-month baseline period, iron dextran was administered randomly at doses ranging from a total of 100 to 500mg. Blood prescribing was at the nephrologists' discretion throughout the study (...) . Analysis of effectiveness The principle used in the analysis of effectiveness appears to have been treatment completers only. The primary outcome measure was success rate. Successful treatment was defined as a hematocrit of 33-36%, a transferrin saturation above 10%, a ferritin concentration of more than 100ng/mL, and no blood use except for acute blood loss. The following clinical variables were also reported: ferritin level, transferrin saturation, hematocrit, number of units of blood, epoetin alfa

1998 NHS Economic Evaluation Database.

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