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Serum Ferritin

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4601. Dietary iron intake and serum ferritin in relation to 7.5 years structure and function of large arteries in the SUVIMAX cohort. (PubMed)

Dietary iron intake and serum ferritin in relation to 7.5 years structure and function of large arteries in the SUVIMAX cohort. Few studies have investigated the relationship between iron stores and measures of atherosclerosis. Most of these studies were cross-sectional and yielded conflicting results. We aimed to assess the relationship between serum ferritin concentrations and dietary iron intake measured at baseline and 7.5 year pulse wave velocity (PWV), intima-media thickness (IMT (...) ) and plaques in a group of 824 men and women without known CVD, cancer or hemochromatosis.The SUVIMAX study is a randomized double-blind, placebo-controlled primary prevention trial designed to test the effect of antioxidant supplementation in reducing ischemic cardiovascular diseases and cancer.In multivariate analyses, no association was found between baseline serum ferritin levels and IMT 7 years later (beta (95% CI)=0.003 (-0.005;0.011) in men; -0.005 (-0.013;0.004) and -0.001 (-0.011;0.009) in women

2007 Diabetes & metabolism Controlled trial quality: predicted high

4602. Siderosomal ferritin. The missing link between ferritin and haemosiderin? (PubMed)

. On subcellular fractionation the electrophoretically fast ferritin was enriched in pellet fractions and was the sole soluble ferritin isolated from iron-laden secondary lysosomes (siderosomes). The amount and relative proportion of the electrophoretically fast species increased with iron loading. Haemosiderin isolated from siderosomes was found to contain a peptide reactive to anti-ferritin serum and corresponding to the 17.3 kDa peptide of the electrophoretically fast ferritin species. Unlike (...) Siderosomal ferritin. The missing link between ferritin and haemosiderin? A minor electrophoretically fast component was found in ferritin from iron-loaded rat liver in addition to a major electrophoretically slow ferritin similar to that observed in control rats. The electrophoretically fast ferritin showed immunological identity with the slow component, but on electrophoresis in SDS it gave a peptide of 17.3 kDa, in contrast with the electrophoretically slow ferritin, which gave a major band

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1987 Biochemical Journal

4603. Ferric gluconate is highly efficacious in anemic hemodialysis patients with high serum ferritin and low transferrin saturation: results of the Dialysis Patients' Response to IV Iron with Elevated Ferritin (DRIVE) Study. (PubMed)

Ferric gluconate is highly efficacious in anemic hemodialysis patients with high serum ferritin and low transferrin saturation: results of the Dialysis Patients' Response to IV Iron with Elevated Ferritin (DRIVE) Study. Few data exist to guide treatment of anemic hemodialysis patients with high ferritin and low transferrin saturation (TSAT). The Dialysis Patients' Response to IV Iron with Elevated Ferritin (DRIVE) trial was designed to evaluate the efficacy of intravenous ferric gluconate (...) in such patients. Inclusion criteria were hemoglobin ferritin 500 to 1200 ng/ml, TSAT or=225 IU/kg per wk or >or=22,500 IU/wk. Patients with known infections or recent significant blood loss were excluded. Participants (n=134) were randomly assigned to no iron (control) or to ferric gluconate 125 mg intravenously with eight consecutive hemodialysis sessions (intravenous iron). At randomization, epoetin was increased 25% in both groups; further dosage changes were

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2007 Journal of the American Society of Nephrology : JASN Controlled trial quality: uncertain

4604. Lack of correlation between free erythrocyte porphyrin and serum ferritin values at birth and at 2 months of life in low birthweight infants. (PubMed)

Lack of correlation between free erythrocyte porphyrin and serum ferritin values at birth and at 2 months of life in low birthweight infants. Red cell free erythrocyte porphyrin and serum ferritin determinations were performed on capillary blood specimens from 63 healthy infants weighing 2500 g or less at birth, during the first week of life, and, from 44 of them, again at 8-10 weeks. Free erythrocyte porphyrin values were high both at 3-7 days (mean 156 microgram/100 ml RBC) and at 8-10 weeks (...) (mean 128 microgram/100 ml RBC). The respective serum ferritin values were also high (mean 226 and 107 ng/ml), excluding a depletion in iron stores. In addition, no correlation was found between free erythrocyte porphyrin and serum ferritin values either at birth or at age 2 months. These findings are consistent with an earlier hypothesis that in the presence of iron stores, the rate of iron release from the stores in low birthweight infants may not be sufficient to maintain optimal erythropoiesis

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1983 Archives of Disease in Childhood

4605. Binding of serum ferritin to concanavalin A in patients with iron overload and with chronic liver disease. (PubMed)

Binding of serum ferritin to concanavalin A in patients with iron overload and with chronic liver disease. Total serum ferritin and the proportion of serum ferritin binding to concanavalin A (glycosylated ferritin) was measured in 18 healthy volunteers and in 84 patients, eight with primary haemochromatosis, 43 with beta-thalassaemia major and secondary iron overload and 33 with chronic liver diseases without iron overload. The total serum ferritin was either equally or even more closely (...) related than either the non-binding or the concanavalin A binding ferritin, to the liver iron concentration in all patients with iron overload, and with the units of blood transfused in non-chelated thalassaemic patients. The total serum ferritin showed a significant correlation with serum aminotransferase for the group of 84 patients. In the thalassaemic patients the ferritin binding to concanavalin A also correlated with aminotransferase. However, in the other groups it was the ferritin not binding

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1982 Journal of Clinical Pathology

4606. Effect of ascorbic acid deficiency on serum ferritin concentration in patients with beta-thalassaemia major and iron overload. (PubMed)

Effect of ascorbic acid deficiency on serum ferritin concentration in patients with beta-thalassaemia major and iron overload. The incidence of ascorbic acid (AA) deficiency and its effect on serum ferritin concentration relative to body iron stores was studied in 61 unchelated patients with beta-thalassaemia major. Thirty-nine (64%) of patients had subnormal leucocyte ascorbate concentrations without clinical evidence of scurvy. The lowest leucocyte ascorbate concentrations tended to occur (...) in the most transfused patients. No correlation was found between the units transfused and serum ferritin concentration in the AA-deficient patients but a close correlation (r = +0.82; p less than 0.005) existed for the AA-replete group. Similarly a close correlation (r = +0.77; p less than 0.005) was obtained between liver iron concentration and serum ferritin in AA-replete patients but only a weak correlation (r = +0.385; p less than 0.025) existed for the AA-deficient group. When AA-deficient patients

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1982 Journal of Clinical Pathology

4607. Serum ferritin, liver iron stores, and liver histology in children with thalassaemia. (PubMed)

Serum ferritin, liver iron stores, and liver histology in children with thalassaemia. Serum ferritin, liver iron stores, and liver histology were studied in 38 children with thalassaemia major who were being treated by regular blood transfusions. There was no correlation between serum ferritin levels and either the number of transfusions or the amount of iron deposited in the liver. However, for a given level of iron stores, ferritin levels were higher in patients with chronic hepatitis (...) (including chronic aggressive and chronic persistent forms) than in those with hepatic siderosis only. We conclude that serum ferritin reflects tissue iron deposits in regularly transfused thalassaemic patients, only in the absence of hepatitis.

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1980 Archives of Disease in Childhood

4608. EDTA plasma rather than serum for B12, folate and ferritin estimations? (PubMed)

EDTA plasma rather than serum for B12, folate and ferritin estimations? 4056074 1985 12 03 2018 11 13 0021-9746 38 10 1985 Oct Journal of clinical pathology J. Clin. Pathol. EDTA plasma rather than serum for B12, folate and ferritin estimations? 1197 Sviland L L Rodger R S RS Fail J B JB Hamilton P J PJ eng Letter England J Clin Pathol 0376601 0021-9746 9007-73-2 Ferritins 935E97BOY8 Folic Acid P6YC3EG204 Vitamin B 12 AIM IM Ferritins blood Folic Acid blood Humans Plasma Vitamin B 12 blood 1985

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1985 Journal of Clinical Pathology

4609. Serum ferritin concentration in sickle cell crisis. (PubMed)

Serum ferritin concentration in sickle cell crisis. Serum ferritin, aspartate aminotransferase (AST), alkaline phosphatase and hydroxybutyrate dehydrogenase (HBD) were studied during 21 vaso-occlusive crises in 12 adults with sickle cell disease (11 SS, 1 S beta degrees). The patients comprised three groups: those who had been untransfused (4), those who had received occasional exchange transfusion in crisis (3), and those who had been multiply transfused (5). Serum ferritin concentrations (...) in crisis were compared with those of the steady state value. Rises in serum ferritin concentrations occurred in all crises in all groups. Although AST, alkaline phosphatase, and HBD rose, there was no correlation between these and log ferritin concentrations. The clinical impression was that the degree of rise in ferritin related to the severity of the particular crisis, and the above results showed that haemolysis and liver damage were not causally related to this rise. An estimate of serum ferritin

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1986 Journal of Clinical Pathology

4610. IgA mesangial deposits in C3H/HeJ mice after oral immunization with ferritin or bovine serum albumin. (PubMed)

IgA mesangial deposits in C3H/HeJ mice after oral immunization with ferritin or bovine serum albumin. In order to study an experimental model of IgA nephropathy, C3H/HeJ mice which are high IgA responders were strongly immunized orally with ferritin and compared to syngeneic C3H/eB. C3H/HeJ exhibited a significant increase of total IgA level in the serum and of IgA deposits in the mesangium. However the low level of IgA antibody to ferritin detected in the serum and the unsuccessful search (...) for ferritin and antibody to ferritin in the glomeruli suggest that strong oral immunization of C3H/HeJ mice leads to high level of non specific IgA in the serum and deposition of IgA in the kidney.

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1986 Clinical and experimental immunology

4611. Serum ferritin as indicator of iron responsive anaemia in patients with rheumatoid arthritis. (PubMed)

Serum ferritin as indicator of iron responsive anaemia in patients with rheumatoid arthritis. In order to test the hypothesis that serum ferritin below 60 micrograms/l is a good indicator of iron deficiency in patients with rheumatoid arthritis peroral iron was given to 67 patients with active rheumatoid arthritis over a three month period. A rise in haemoglobin concentration was taken as evidence of iron responsive anaemia. In anaemic patients serum ferritin below 60 micrograms/l was a good (...) indicator of iron responsive anaemia, with a predictive value of 83%. Although high plasma transferrin and low mean cell volume showed similar predictive values, more patients with iron deficiency anaemia could be diagnosed by serum ferritin measurements than by other conventional blood tests. In contrast, the predictive value of serum ferritin above 60 micrograms/l was low (50%). The test was of no predictive value in non-anaemic patients. In patients with anaemia and active rheumatoid arthritis serum

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1986 Annals of the Rheumatic Diseases

4612. Serum ferritin: an indicator of iron responsive anaemia in patients with RA? (PubMed)

Serum ferritin: an indicator of iron responsive anaemia in patients with RA? 3592795 1987 07 16 2018 11 13 0003-4967 46 4 1987 Apr Annals of the rheumatic diseases Ann. Rheum. Dis. Serum ferritin: an indicator of iron responsive anaemia in patients with RA? 349-50 Cavill I I Radford M M eng Letter England Ann Rheum Dis 0372355 0003-4967 9007-73-2 Ferritins IM Anemia blood Arthritis, Rheumatoid blood Ferritins blood Humans 1987 4 1 1987 4 1 0 1 1987 4 1 0 0 ppublish 3592795 PMC1002135 Clin

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1987 Annals of the Rheumatic Diseases

4613. Evaluation of serum ferritin as a marker for adult Still's disease activity. (PubMed)

Evaluation of serum ferritin as a marker for adult Still's disease activity. Extremely high serum ferritin values (greater than 10,000 micrograms/l) were detected in two patients with adult Still's disease. The ferritin concentrations decreased to normal after adequate treatment. During a one year follow up ferritin concentration was helpful in monitoring disease activity and guiding decisions about treatment. Raised concentrations of soluble interleukin 2 receptors (sCD25) were also found (...) . Detection of ferritin values above 3000 micrograms/l should lead to the consideration of Still's disease when there is an acute febrile illness without evidence for bacterial or viral infections, serum ferritin being suitable for monitoring treatment.

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1992 Annals of the Rheumatic Diseases

4614. Logarithmic quantitation model using serum ferritin to estimate iron overload in secondary haemochromatosis. (PubMed)

Logarithmic quantitation model using serum ferritin to estimate iron overload in secondary haemochromatosis. Nineteen children and adolescents receiving repeated transfusions and subcutaneous desferrioxamine treatment were investigated in an attempt to quantitate iron overload non-invasively. Before patients were started on desferrioxamine individual relationships were correlated for 12 to 36 months between transfused iron, absorbed iron estimated gastrointestinally, and increasing serum (...) ferritin concentrations. Patients with inflammation, increased liver enzymes, or haemolysis were excluded from analysis. The relationship between the variables could be described by a logarithmic regression curve (y = transfused iron [plus eventually gastrointestinally absorbed iron] = iron overload = a+b log [x = serum ferritin]) for each individual patient. All patients showed close correlation (R2) between x and y (median R2 of 0.909, 0.98, and 0.92 in thalassaemia, aplastic anaemia, and sickle cell

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1996 Archives of Disease in Childhood

4615. Serum ferritin levels after multivitamin iron ingestion during teenage pregnancy. (PubMed)

Serum ferritin levels after multivitamin iron ingestion during teenage pregnancy. The postabsorptive serum ferritin levels following normal dosages of prenatal multivitamin/multimineral supplements were studied in 17 pregnant teenagers, whose fetuses were between 16 and 20 weeks gestational age. The purpose of the study was to determine the effect of a single oral dose of differing prenatal multivitamin/multimineral tablets containing 60 or 65 mg of elemental iron on the postabsorptive serum (...) ferritin levels. Each woman was randomly tested following the ingestion of one of three different tablets, both in a fed and a fasting state. Blood samples were obtained for ferritin measurement immediately prior to ingestion of the prenatal tablet, with or without a standard meal, and at 1, 3, 6, and 8 hours postabsorption. The group mean serum ferritin levels increased dramatically during the fasting state following ingestion of the Stuart Prenatal tablet and decreased when the Stuartnatal 1 + 1

1989 Clinical therapeutics

4616. Percentage of glycosylated serum ferritin remains low throughout the course of adult onset Still's disease (PubMed)

Percentage of glycosylated serum ferritin remains low throughout the course of adult onset Still's disease To determine the evolution of levels of total serum ferritin and percentage of the glycosylated form in patients with adult onset Still's disease (AOSD) at the time of diagnosis and during follow up.All patients with AOSD were tested at the time of diagnosis and during follow up. Total serum ferritin levels were analysed by immunoassay, and the percentage of glycosylated ferritin (...) was determined by methods using Sepharose-Con A.14 patients (eight women, six men) with AOSD were enrolled. At the time of diagnosis, mean (SD) age was 36 (16) years. Mean initial total serum ferritin was 6350 (1300) microg/l (normal <250 microg/l). The mean initial percentage of glycosylated ferritin was 14.7 (13)% (normal >50%). Mean follow up time was 37 (35) months. At the time of the last examination all patients were in remission except one, who presented a chronic articular form. Total serum ferritin

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2000 Annals of the Rheumatic Diseases

4617. Iron status in young Danes. Evaluation by serum ferritin and haemoglobin in a population survey of 634 individuals aged 14-23 yr. (PubMed)

Iron status in young Danes. Evaluation by serum ferritin and haemoglobin in a population survey of 634 individuals aged 14-23 yr. Iron status was assessed by serum ferritin and haemoglobin in a population survey comprising 634 randomly selected urban Danes (312 males, 322 females) 14-23 yr old. At all ages, males had significantly higher serum ferritin and haemoglobin values than females. Males: median serum ferritin displayed a steady increase with age from 33 to 109 micrograms/l (rs = 0.53, p (...) < 0.0001). The prevalence of absent mobilizable body iron stores (serum ferritin < 13 micrograms/l) was 3.5% at 16-17 yr of age, gradually declining to 0% at 22-23 yr. None of the males had iron deficiency anaemia (serum ferritin < 13 micrograms/l and haemoglobin < 129 g/l). Females: median ferritin values displayed a slight increase with age from 28 to 39 micrograms/l (rs = 0.19, p < 0.001). The prevalence of absent iron stores was 12.5% at 16-17 yr of age, declining to 6.6% at 22-23 yr

1997 European journal of haematology

4618. There is no clear association between low serum ferritin and chronic diffuse telogen hair loss. (PubMed)

There is no clear association between low serum ferritin and chronic diffuse telogen hair loss. Low iron stores are considered a possible cause of chronic diffuse telogen hair loss in women. Estimation of serum ferritin is recommended as part of the initial assessment when women present with chronic diffuse telogen hair loss, and iron supplementation therapy is commonly recommended for those found to have low iron stores.To evaluate the relationship between low serum ferritin (serum ferritin and had two 4-mm punch biopsies taken from the vertex of the scalp. One biopsy was sectioned horizontally and the other vertically.Twelve women were found to have a serum ferritin of 20 micro g L-1 or less (6.2%). Androgenetic

2002 British Journal of Dermatology

4619. Relationship of serum ferritin with cardiovascular risk factors and inflammation in young men and women. (PubMed)

Relationship of serum ferritin with cardiovascular risk factors and inflammation in young men and women. Elevated ferritin levels have been reported as a risk factor for coronary heart disease in Finnish and Italian studies. Studies in other populations have found no association between ferritin and cardiovascular disease raising the possibility of confounding with other cardiovascular risk factors. We determined ferritin levels, metabolic cardiovascular risk factors, C-reactive protein (CRP (...) ), anthropometric measurements and blood pressure in 815 men and women aged 26 years. In women serum ferritin correlated with CRP, waist measurement, body mass index (BMI), and triglycerides. In multiple regression analysis CRP alone was independently associated with serum ferritin. Serum ferritin in men correlated with waist measurement, BMI, triglycerides and high-density lipoprotein (HDL) cholesterol. After adjustment for the other variables, waist measurement was the only independent predictor of ferritin

2002 Atherosclerosis

4620. Serum ferritin as a marker of potential biochemical iron overload in athletes. (PubMed)

Serum ferritin as a marker of potential biochemical iron overload in athletes. Beyond hematological manipulation, iron supplementation therapy is commonplace in athletes to counterbalance physiological or pathologic anemia and to prevent physiologic dysfunction. However, misuse of iron therapy, occasionally resulting in iron overload, is not free from metabolic risks.We planned to measure baseline serum ferritin concentration in sedentary individual and athletes.The Institute of Clinical (...) Biochemistry of the Verona University. PARTICIPANTS Serum ferritin was measured in 60 male healthy sedentary controls, 80 amateur road cyclists, 42 male professional cross-country skiers, and 88 professional male road cyclists.The biochemical iron overload was ascertained by measuring baseline serum ferritin concentration as a reliable approach that mirrors the total body iron content.The concentration of serum ferritin in healthy controls was 112 +/- 78 ng/mL, whereas that of amateur cyclists

2005 Clinical Journal of Sport Medicine

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