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Serum Aldolase

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1. Serum Aldolase

Serum Aldolase Serum Aldolase Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Serum Aldolase Serum Aldolase Aka: Serum Aldolase II (...) . Interpretation: Normal Aldolase < 6 U/L III. Interpretation: Increased Aldolase or Trichinosis and other liver disease Hemorrhagic Gangrene IV. Interpretation: Decreased Aldolase Loss of muscle mass Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Serum Aldolase." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Ontology: Aldolase measurement (C0201839) Definition

2018 FP Notebook

2. Serum aldolase and phosphocreatine kinase in umbilical cord blood Full Text available with Trip Pro

Serum aldolase and phosphocreatine kinase in umbilical cord blood Aldolase was estimated in the cord blood of 81 newborn infants and phosphocreatine kinase in 87 infants. There is a wide range in the results, with some values falling in the range reported in children with muscular dystrophy or of carriers of the disease. There is no correlation of the serum enzyme levels with the infant's birth weight. High levels of phosphocreatine kinase were found in infants of mothers with pre-eclamptic (...) toxaemia. A single estimation of cord phosphocreatine kinase and aldolase is of little help in determining whether or not an infant has muscular dystrophy.

1966 Journal of Clinical Pathology

3. TRThe Expression of Aldolase B in Islets is Negatively Associated with Insulin Secretion in Humans. Full Text available with Trip Pro

TRThe Expression of Aldolase B in Islets is Negatively Associated with Insulin Secretion in Humans. Reduced β-cell mass, impaired islet function, and dedifferentiation are considered causal to development of hyperglycemia and type 2 diabetes. In human cohort studies, changes of islet cell-specific expression patterns have been associated with diabetes but not directly with in vivo insulin secretion.This study investigates alterations of islet gene expression and corresponding gene variants (...) in the context of in vivo glycemic traits from the same patients.Fasting blood was collected before surgery, and pancreatic tissue was frozen after resection from 18 patients undergoing pancreatectomy. Islet tissue was isolated by laser capture microdissection. Islet transcriptome was analyzed using microarray and quantitative RT-PCR. Proteins were examined by immunohistochemistry and western blotting. The association of gene variants with insulin secretion was investigated with oral glucose tolerance test

2018 Journal of Clinical Endocrinology and Metabolism

4. Serum Aldolase

Serum Aldolase Serum Aldolase Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Serum Aldolase Serum Aldolase Aka: Serum Aldolase II (...) . Interpretation: Normal Aldolase < 6 U/L III. Interpretation: Increased Aldolase or Trichinosis and other liver disease Hemorrhagic Gangrene IV. Interpretation: Decreased Aldolase Loss of muscle mass Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Serum Aldolase." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Ontology: Aldolase measurement (C0201839) Definition

2015 FP Notebook

5. Identification of aldolase A as a potential diagnostic biomarker for colorectal cancer based on proteomic analysis using formalin-fixed paraffin-embedded tissue Full Text available with Trip Pro

(FFPE) CRC tissue. We identified 84 candidate proteins whose expression levels were differentially expressed in cancer and non-cancer regions. A label-free semiquantitative method based on spectral counting and gene ontology (GO) analysis led to a total of 21 candidate proteins that could potentially be detected in blood. Validation studies revealed cyclophilin A, annexin A2, and aldolase A mRNA and protein expression levels were significantly higher in cancer regions than in non-cancer regions (...) . Moreover, an in vitro study showed that secretion of aldolase A into the culture medium was clearly suppressed in CRC cells compared to normal colon epithelium. These findings suggest that decreased aldolase A in blood may be a novel biomarker for the early detection of CRC.

2016 Tumour Biology

6. Analysis of Paracoccidioides secreted proteins reveals fructose 1,6-bisphosphate aldolase as a plasminogen-binding protein Full Text available with Trip Pro

Analysis of Paracoccidioides secreted proteins reveals fructose 1,6-bisphosphate aldolase as a plasminogen-binding protein Despite being important thermal dimorphic fungi causing Paracoccidioidomycosis, the pathogenic mechanisms that underlie the genus Paracoccidioides remain largely unknown. Microbial pathogens express molecules that can interact with human plasminogen, a protein from blood plasma, which presents fibrinolytic activity when activated into plasmin. Additionally, plasmin exhibits (...) study, we employed proteomic analysis of the secretome, in order to identify plasminogen-binding proteins of Paracoccidioides, Pb01. Fifteen proteins were present in the fungal secretome, presenting the ability to bind to plasminogen. Those proteins are probable targets of the fungus interaction with the host; thus, they could contribute to the invasiveness of the fungus. For validation tests, we selected the protein fructose 1,6-bisphosphate aldolase (FBA), described in other pathogens

2015 BMC microbiology

7. Aldolase Activity in the Plasma or Serum of Normal Children and Families with Muscular Dystrophy Full Text available with Trip Pro

Aldolase Activity in the Plasma or Serum of Normal Children and Families with Muscular Dystrophy 14021638 1998 11 01 2018 12 01 0003-9888 38 1963 Jun Archives of disease in childhood Arch. Dis. Child. Aldolase activity in the plasma or serum of normal children and families with muscular dystrophy. 208-14 CLAYTON B E BE WILSON K M KM CARTER C O CO eng Journal Article England Arch Dis Child 0372434 0003-9888 EC 4.1.2.13 Fructose-Bisphosphate Aldolase OM Child Fructose-Bisphosphate Aldolase Humans (...) Muscular Dystrophies ALDOLASE MUSCULAR DYSTROPHY 1963 6 1 1963 6 1 0 1 1963 6 1 0 0 ppublish 14021638 PMC2019036 Ann Hum Genet. 1961 May;25:41-9 13761775 Am J Phys Med. 1955 Feb;34(1):313-9 14361709 Dtsch Z Nervenheilkd. 1955;173(5-6):482-98 13305346 Proc Staff Meet Mayo Clin. 1954 Nov 10;29(23):591-603 13215569 Ann Hum Genet. 1959 Apr;23(2):127-63 13637556 Brain. 1957 Dec;80(4):557-70 13499760 J Lab Clin Med. 1958 May;51(5):745-52 13539491 Am J Hum Genet. 1960 Mar;12:52-66 13810211 J Pediatr. 1959 Jan

1963 Archives of Disease in Childhood

8. Methylation of protein aspartates and deamidated asparagines as a function of blood bank storage and oxidative stress in human red blood cells. Full Text available with Trip Pro

Methylation of protein aspartates and deamidated asparagines as a function of blood bank storage and oxidative stress in human red blood cells. Being devoid of de novo protein synthesis capacity, red blood cells (RBCs) have evolved to recycle oxidatively damaged proteins via mechanisms that involve methylation of dehydrated and deamidated aspartate and asparagine residues. Here we hypothesize that such mechanisms are relevant to routine storage in the blood bank.Within the framework of the REDS (...) -III RBC-Omics (Recipient Epidemiology Donor Evaluation Study III Red Blood Cell-Omics) study, packed RBC units (n = 599) were stored under blood bank conditions for 10, 23, and 42 days and profiled for oxidative hemolysis and time-dependent metabolic dysregulation of the trans-sulfuration pathway.In these units, methionine consumption positively correlated with storage age and oxidative hemolysis. Mechanistic studies show that this phenomenon is favored by oxidative stress or hyperoxic storage

2018 Transfusion

9. Comparative performance of aldolase and lactate dehydrogenase rapid diagnostic tests in Plasmodium vivax detection. Full Text available with Trip Pro

detection kits (One Step Malaria P.f/P.v, ParaHit Total ver. 1.0, SD Bioline Malaria) and an anti-P. vivax aldolase-specific monoclonal antibody (mAb) pair 1C3-12 F10 were evaluated with P. vivax positive as well as non-P. vivax samples and healthy samples using blood smear examination as standard. Each test was read according to the manufacturer's instructions.MAb 1C3-12 F10 pair targeting P. vivax-specific aldolase exhibited very good specificity and sensitivity of 100 and 97.4%, respectively (...) Comparative performance of aldolase and lactate dehydrogenase rapid diagnostic tests in Plasmodium vivax detection. Misdiagnosis of malaria by commercial rapid diagnostic tests (RDTs) is a major cause of concern in the diagnosis of malaria. This retrospective study was aimed at assessing the relative performance of four RDTs with emphasis on the detection of two Plasmodium vivax antigens: aldolase and lactate dehydrogenase (LDH).Three commercially available Plasmodium LDH or aldolase antigen

2014 Malaria journal

10. Dataset on the comparative proteomic profiling of mouse saliva and serum from wild type versus the dystrophic mdx-4cv mouse model of dystrophinopathy Full Text available with Trip Pro

Dataset on the comparative proteomic profiling of mouse saliva and serum from wild type versus the dystrophic mdx-4cv mouse model of dystrophinopathy The comparative proteomic data presented in this article provide supporting information to the related research article "Proteomic identification of elevated saliva kallikrein levels in the mdx-4cv mouse model of Duchenne muscular dystrophy " (Murphy et al., 2018). Here we provide additional datasets on the comparative proteomic analysis of saliva (...) and serum proteins and the mass spectrometric identification of kallikrein isoform Klk-1 in wild type versus mdx-4cv saliva specimens. The data article presents the systematic identification of the assessable saliva proteome and the differential presence of proteins in saliva versus serum samples. Representative mass spectrometric scans of unique peptides that were employed to identify the kallikrein isoform Klk-1 in wild type versus mdx-4cv saliva specimens are provided. The dataset contains typical

2018 Data in brief

11. Fructose 1-Phosphate Aldolase Deficiency (Fructose Intolerance) (Overview)

Fructose 1-Phosphate Aldolase Deficiency (Fructose Intolerance) (Overview) Hereditary Fructose Intolerance (HFI) (Fructose 1-Phosphate Aldolase Deficiency): Background, Pathophysiology, Epidemiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2FydGljbGUvOTQ0NTQ4LW92ZXJ2aWV3 processing > Hereditary Fructose Intolerance (HFI) (Fructose 1-Phosphate Aldolase Deficiency) Updated: Aug 10, 2017 Author: Karl S Roth, MD; Chief Editor: Maria Descartes, MD Share Email Print Feedback Close Sections Sections Hereditary Fructose Intolerance (HFI) (Fructose 1-Phosphate Aldolase Deficiency) Overview Background Clinical intolerance to fructose was initially described in 1956. The following year, researchers reported a familial incidence of the disorder in several family members

2014 eMedicine Pediatrics

12. Fructose 1-Phosphate Aldolase Deficiency (Fructose Intolerance) (Diagnosis)

Fructose 1-Phosphate Aldolase Deficiency (Fructose Intolerance) (Diagnosis) Hereditary Fructose Intolerance (HFI) (Fructose 1-Phosphate Aldolase Deficiency): Background, Pathophysiology, Epidemiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2FydGljbGUvOTQ0NTQ4LW92ZXJ2aWV3 processing > Hereditary Fructose Intolerance (HFI) (Fructose 1-Phosphate Aldolase Deficiency) Updated: Aug 10, 2017 Author: Karl S Roth, MD; Chief Editor: Maria Descartes, MD Share Email Print Feedback Close Sections Sections Hereditary Fructose Intolerance (HFI) (Fructose 1-Phosphate Aldolase Deficiency) Overview Background Clinical intolerance to fructose was initially described in 1956. The following year, researchers reported a familial incidence of the disorder in several family members

2014 eMedicine Pediatrics

13. Plasmodium vivax aldolase-specific monoclonal antibodies and its application in clinical diagnosis of malaria infections in China. Full Text available with Trip Pro

Plasmodium vivax aldolase-specific monoclonal antibodies and its application in clinical diagnosis of malaria infections in China. Most rapid diagnostic tests (RDTs) currently used for malaria diagnosis cannot distinguish the various Plasmodium infections. The development of a Plasmodium vivax specific RDTs with high sensitivity to sufficiently differentiate the two most common Plasmodium infections would be very crucial for disease treatment and control.Plasmodium vivax aldolase gene (PvALDO (...) ) was amplified from the extracted genomic DNA and constructed into pET30a vector. Plasmodium vivax aldolase protein was successfully expressed in Escherichia coli in soluble form and the overall purity was over 95% after one-step affinity chromatography purification. The purified products were used for the immunization of mice and rabbits. Rabbit polyclonal antibodies generated were deployed to develop a novel antibody-capture ELISA for hybridoma screening.Three PvALDO specific mAbs (14C7, 15F1 and 5H7

2013 Malaria journal

14. Diagnostic value of immunoglobulin G antibodies against Candida enolase and fructose-bisphosphate aldolase for candidemia. Full Text available with Trip Pro

%. The tests were specific to the Candida genus and antibody titers were higher for candidemia patients than for controls. Positive antibody tests were obtained before blood culture results for 42.2% of patients for anti-Eno and 51.1% for anti-Fba1.These data suggest that tests that detect IgG antibodies against Candida enolase and fructose-bisphosphate aldolase, especially when used in combination, could be a powerful tool for diagnosing IC. (...) Diagnostic value of immunoglobulin G antibodies against Candida enolase and fructose-bisphosphate aldolase for candidemia. The yeast Candida is one of the most frequent pathogens isolated from bloodstream infections and is associated with significant morbidity and mortality. Problems with clinical and microbiological diagnosis of invasive candidiasis (IC) have prompted the development of non-culture-based laboratory methods. Previous reports suggest that serological detection of antibodies

2013 BMC Infectious Diseases

15. Polymyositis with elevated serum IgG4 levels and abundant IgG4+ plasma cell infiltration: A case report and literature review. Full Text available with Trip Pro

differential diagnosis. Herein, we report the first case of PM with elevated serum IgG4 levels and IgG4 plasma cells in the muscles, mimicking IgG4-RD.A 73-year-old woman visited our hospital because of proximal muscle weakness of both thighs. Her blood test showed high levels of serum creatinine kinase, aldolase, and IgG4. Magnetic resonance imaging of the thighs showed muscle edema. Needle electromyography showed findings typical of myositis. Histological analysis of her left quadriceps revealed (...) Polymyositis with elevated serum IgG4 levels and abundant IgG4+ plasma cell infiltration: A case report and literature review. Polymyositis (PM) is a type of autoimmune, inflammatory myopathy. IgG4-related disease (IgG4-RD) is a recently recognized disease entity characterized by elevated serum IgG4 levels and IgG4 plasma-cell infiltration of various organs. However, several reports have described cases of other diseases that present with those features, suggesting the importance of careful

2017 Medicine

16. Discovery and Validation of a Six-Marker Serum Protein Signature for the Diagnosis of Active Pulmonary Tuberculosis Full Text available with Trip Pro

confirmed or ruled out for TB by culture and clinical follow-up. HIV coinfection was present in 34% of samples, and 25% were sputum smear negative. Serum protein biomarkers were identified by stability selection using L1-regularized logistic regression and by Kolmogorov-Smirnov (KS) statistics. A naive Bayes classifier using six host response markers (HR6 model), including SYWC, kallistatin, complement C9, gelsolin, testican-2, and aldolase C, performed well in a training set (area under the sensitivity (...) Discovery and Validation of a Six-Marker Serum Protein Signature for the Diagnosis of Active Pulmonary Tuberculosis New non-sputum biomarker tests for active tuberculosis (TB) diagnostics are of the highest priority for global TB control. We performed in-depth proteomic analysis using the 4,000-plex SOMAscan assay on 1,470 serum samples from seven countries where TB is endemic. All samples were from patients with symptoms and signs suggestive of active pulmonary TB that were systematically

2017 Journal of clinical microbiology

17. Genetic variation of aldolase from Korean isolates of Plasmodium vivax and its usefulness in serodiagnosis. Full Text available with Trip Pro

Genetic variation of aldolase from Korean isolates of Plasmodium vivax and its usefulness in serodiagnosis. The malaria aldolase is widely used as rapid diagnostic test (RDT), but the efficacy in aspect of its serological effectiveness in diagnosis is not known. The genetic variation of Korean isolates was analysed and recombinant aldolase was evaluated as a serological antigen in Plasmodium vivax malaria.Genomic DNA was purified and the aldolase gene of P. vivax from 25 patients' blood samples (...) was amplified. The samples came from 5 epidemic areas; Bucheon-si, Gimpo-si, Paju-si of Gyeonggido, Gangwha-gun of Incheon metropolitan city, and Cheorwon of Gangwon-do, South Korea. The antigenicity of the recombinant aldolase was tested by western blot and enzyme-linked immunosorbent assay (ELISA).Sequence analysis of 25 Korean isolates of P. vivax showed that the open reading frame (ORF) of 1,110 nucleotides encoded a deduced protein of 369 amino acids (aa). This ORF showed 100% homology with the P

2012 Malaria journal

18. Specific changes in the messenger ribonucleic acid content of the rat ventral prostate gland after androgenic stimulation. Evidence from the synthesis of aldolase messenger ribonucleic acid Full Text available with Trip Pro

a maximum after 8h of androgenic treatment and then declined. 4. The androgenic control of aldolase mRNA synthesis was also investigated in vivo. After treatment of castrated animals with various steroids in vivo [(35)S]methionine was injected directly into the prostate gland, and labelled aldolase was selectively precipitated from isolated polyribosomes with anti-aldolase serum. The regulation of aldolase mRNA synthesis in the prostate gland was stringently steroid-specific and could only be evoked (...) Specific changes in the messenger ribonucleic acid content of the rat ventral prostate gland after androgenic stimulation. Evidence from the synthesis of aldolase messenger ribonucleic acid 1. Aldolase was selected as a suitable marker for following the androgenic regulation of mRNA synthesis in the prostate gland. 2. Antibodies raised in rabbits against crystalline prostate aldolase were used to monitor the synthesis of this androgen-induced enzyme after hormonal stimulation of castrated

1974 Biochemical Journal

19. Up-regulation of Aldolase B and Overproduction of Methylglyoxal in Vascular Tissues from Rats with Metabolic Syndrome. Full Text available with Trip Pro

, i.e. chronically fructose-fed hypertensive Sprague-Dawley rats, spontaneously hypertensive rats, obese non-diabetic Zucker rats, and diabetic Zucker rats, serum and aortic MG and fructose levels were increased, and the expression of GLUT5 (transporting fructose) and aldolase B (converting fructose to MG) in aorta were up-regulated. Aortic expressions of aldolase A, semicarbazide-sensitive amine oxidase (SSAO), and cytochrome P450 2E1 (CYP 2E1), accounting for MG formation during glycolysis (...) Up-regulation of Aldolase B and Overproduction of Methylglyoxal in Vascular Tissues from Rats with Metabolic Syndrome. Methylglyoxal (MG) overproduction has been reported in metabolic syndrome with hyperglycaemia (diabetes) or without hyperglycaemia (hypertension), and the underlying mechanism was investigated.Contributions of different pathways or enzymes to MG formation were evaluated in aorta or cultured vascular smooth muscle cells (VSMCs). In all four animal models of metabolic syndrome

2011 Cardiovascular Research

20. Safety and possible effects of low-intensity resistance training associated with partial blood flow restriction in polymyositis and dermatomyositis Full Text available with Trip Pro

and aldolase) were also unchanged (P >0.05) after the intervention.We demonstrated that a 12-week supervised low-intensity resistance training program associated with partial blood flow restriction may be safe and effective in improving muscle strength and function as well as muscle mass and health-related quality of life in patients with PM and DM.Clinicaltrials.gov NCT01501019. Registered November 29, 2011. (...) Safety and possible effects of low-intensity resistance training associated with partial blood flow restriction in polymyositis and dermatomyositis Our aim was to evaluate the safety and efficacy of a low-intensity resistance training program combined with partial blow flow restriction (BFR training) in a cohort of patients with polymyositis (PM) and dermatomyositis (DM).In total, 13 patients with PM and DM completed a 12-week twice a week low-intensity (that is, 30% one-repetition-maximum (1RM

2014 Arthritis research & therapy Controlled trial quality: uncertain

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