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Serotonin

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121. Serotonin and Motherhood: From Molecules to Mood. Full Text available with Trip Pro

Serotonin and Motherhood: From Molecules to Mood. Emerging research points to a valuable role of the monoamine neurotransmitter, serotonin, in the display of maternal behaviors and reproduction-associated plasticity in the maternal brain. Serotonin is also implicated in the pathophysiology of numerous affective disorders and likely plays an important role in the pathophysiology of maternal mental illness. Therefore, the main goals of this review are to detail: (1) how the serotonin system (...) of the female brain changes across pregnancy and postpartum; (2) the role of the central serotonergic system in maternal caregiving and maternal aggression; and (3) how the serotonin system and selective serotonin reuptake inhibitor medications (SSRIs) are involved in the treatment of maternal mental illness. Although there is much work to be done, studying the central serotonin system's multifaceted role in the maternal brain is vital to our understanding of the processes governing matrescence

2019 Frontiers in Neuroendocrinology

122. Fenfluramine, a serotonin-releasing drug, prevents seizure-induced respiratory arrest and is anticonvulsant in the DBA/1 mouse model of SUDEP. (Abstract)

Fenfluramine, a serotonin-releasing drug, prevents seizure-induced respiratory arrest and is anticonvulsant in the DBA/1 mouse model of SUDEP. Prevention of sudden unexpected death in epilepsy (SUDEP) is a critical goal for epilepsy therapy. The DBA/1 mouse model of SUDEP exhibits an elevated susceptibility to seizure-induced death in response to electroconvulsive shock, hyperthermia, convulsant drug, and acoustic stimulation. The serotonin hypothesis of SUDEP is based on findings (...) that treatments which modify serotonergic function significantly alter susceptibility to seizure-induced sudden death in several epilepsy models, including DBA/1 mice. Serotonergic abnormalities have also recently been observed in human SUDEP. Fenfluramine is a drug that enhances serotonin release in the brain. Recent studies have found that the addition of fenfluramine improved seizure control in patients with Dravet syndrome, which has a high incidence of SUDEP. Therefore, we investigated the effects

2019 Epilepsia

123. Peripheral serotonin causes dengue-induced thrombocytopenia through 5HT<sub>2</sub> receptors. Full Text available with Trip Pro

Peripheral serotonin causes dengue-induced thrombocytopenia through 5HT2 receptors. Dengue virus (DENV) is the most prevalent vector-borne viral pathogen, infecting millions of patients annually. Thrombocytopenia, a reduction in circulating platelet counts, is the most consistent sign of DENV-induced disease, independent of disease severity. However, the mechanisms leading to DENV-induced thrombocytopenia are unknown. Here, we show that thrombocytopenia is caused by serotonin (...) , derived from mast cells (MCs), which are immune cells that are present in the perivascular space and a major peripheral source of serotonin. We show that during DENV infection, MCs release serotonin, which prompts platelet activation, aggregation and enhanced phagocytosis, dependent on 5HT2A receptors. MC-deficiency in mice or pharmacological inhibition of MCs reversed thrombocytopenia. Furthermore, reconstitution of MC-deficient mice with wild-type MCs, but not MCs lacking serotonin synthesis due

2019 Blood

124. The effects of serotonin modulation on medial prefrontal connectivity strength and stability: A pharmacological fMRI study with citalopram. Full Text available with Trip Pro

The effects of serotonin modulation on medial prefrontal connectivity strength and stability: A pharmacological fMRI study with citalopram. Static and dynamic functional connectivity are being increasingly used to measure the effects of disease and a range of different interventions on brain networks. While preliminary evidence suggests that static connectivity can be modulated by chronic antidepressants administration in healthy individuals and in major depression, much less is known about (...) the acute effects of antidepressants especially on dynamic functional connectivity changes. Here we examine acute effects of antidepressants on dynamic functional connectivity within the default mode network. The default mode network is a well described network with many functions in which the role of serotonin is not clear.In this work we measured acute pharmacological effects of an infusion of the selective serotonin reuptake inhibitor (SSRI) citalopram (10 mg) in a sample of thirteen healthy

2019 Progress in neuro-psychopharmacology & biological psychiatry Controlled trial quality: uncertain

125. Traditional Tibetan medicine Anzhijinhua San attenuates Ovalbumin-induced diarrhea by regulating serotonin signaling system in mice. (Abstract)

Traditional Tibetan medicine Anzhijinhua San attenuates Ovalbumin-induced diarrhea by regulating serotonin signaling system in mice. Tibetan medicine has a history of 3800 years. Anzhijinhua San (AZJHS) which is a traditional Tibetan medicine was effective in the treatment of indigestion, anorexia and cold diarrhea etc. However, the effects of AZJHS on allergic diarrhea have not been reported.The aim of present study is to elucidate the effect of AZJHS on the preventive effect of experimental (...) . Immunohistochemical and histopathology were performed in gastrointestinal tract tissues. 5-HT-related gene expression was assayed in colon.Severe symptoms of allergic diarrhea were observed in the model group. AZJHS (46.7, 467.0mg/kg) ameliorated diarrhea and reduced anaphylaxis in mice. There was a very significant hyperplasia (P<0.05) in serotonin (5-HT)-related cells after the 10th challenged with OVA, and AZJHS (46.7, 467.0mg/kg) significant suppressed the increases of 5-HT-related cells. The nuclei of EC

2019 Journal of Ethnopharmacology

126. Psychedelic effects of psilocybin correlate with serotonin 2A receptor occupancy and plasma psilocin levels. Full Text available with Trip Pro

Psychedelic effects of psilocybin correlate with serotonin 2A receptor occupancy and plasma psilocin levels. The main psychedelic component of magic mushrooms is psilocybin, which shows promise as a treatment for depression and other mental disorders. Psychedelic effects are believed to emerge through stimulation of serotonin 2A receptors (5-HT2ARs) by psilocybin's active metabolite, psilocin. We here report for the first time the relationship between intensity of psychedelic effects, cerebral

2019 Neuropsychopharmacology

127. Persistence with selective serotonin (norepinephrine) reuptake inhibitors in Germany-A retrospective database analysis. (Abstract)

Persistence with selective serotonin (norepinephrine) reuptake inhibitors in Germany-A retrospective database analysis. Selective serotonin (norepinephrine) reuptake inhibitors (SS(N)RIs) are used in the treatment of depression. The aim of this study was to assess the persistence with SS(N)RIs in outpatients treated by general practitioners (GP) or psychiatrists (PSY) in Germany, and to investigate the association between persistence and the following factors: age, gender, specialty

2019 Journal of Affective Disorders

128. Impact of serotonin transporter gene on rTMS augmentation of SSRIs for obsessive compulsive disorder. Full Text available with Trip Pro

Impact of serotonin transporter gene on rTMS augmentation of SSRIs for obsessive compulsive disorder. Repetitive transcranial magnetic stimulation (rTMS) is beneficial for treatment-resistant patients with obsessive-compulsive disorder (OCD). The serotonin transporter gene (SLC6A4) may be associated with OCD. We aimed to determine whether SLC6A4 impacts the beneficial effects of rTMS in patients with OCD treated with selective serotonin reuptake inhibitors (SSRIs).Fifty-seven untreated patients

2019 Neuropsychiatric disease and treatment Controlled trial quality: uncertain

129. Unified protocol for the discontinuation of long-term serotonin reuptake inhibitors in obsessive compulsive disorder: Study protocol and methods. Full Text available with Trip Pro

Unified protocol for the discontinuation of long-term serotonin reuptake inhibitors in obsessive compulsive disorder: Study protocol and methods. Obsessive-compulsive disorder (OCD) is chronic psychiatric disorder associated with high rates of functional impairment and decreased quality of life. Although serotonin reuptake inhibitors have demonstrated efficacy in the treatment of OCD, little data is available to guide clinicians on how to manage these medications long-term. Cognitive-behavioral

2019 Contemporary clinical trials Controlled trial quality: uncertain

130. Modeling the acute pharmacological response to selective serotonin reuptake inhibitors in human brain using simultaneous PET/MR imaging. (Abstract)

Modeling the acute pharmacological response to selective serotonin reuptake inhibitors in human brain using simultaneous PET/MR imaging. Pharmacological imaging of the effects of selective serotonin reuptake inhibitors (SSRI) may aid the clarification of their mechanism of action and influence treatment of highly prevalent neuropsychiatric conditions if the detected effects could be related to patient outcomes. In a randomized double-blind design, 38 healthy participants received a constant (...) infusion of 8 mg citalopram or saline during either their first or second of two PET/MR scans. Resting-state functional MRI (fMRI) was acquired simultaneously with PET data on the binding of serotonin transporters (5-HTT) using [11C]DASB. Three different approaches for modeling of pharmacological fMRI response were tested separately. These relied on the use of regressors corresponding to (1) the drug infusion paradigm, (2) time courses of citalopram plasma concentrations and (3) changes in 5-HTT

2019 European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology Controlled trial quality: uncertain

131. Hypophagia induced by hindbrain serotonin is mediated through central GLP-1 signaling and involves 5-HT2C and 5-HT3 receptor activation. Full Text available with Trip Pro

Hypophagia induced by hindbrain serotonin is mediated through central GLP-1 signaling and involves 5-HT2C and 5-HT3 receptor activation. The overlap in neurobiological circuitry mediating the physiological and behavioral response to satiation and noxious/stressful stimuli are not well understood. The interaction between serotonin (5-HT) and glucagon-like peptide-1 (GLP-1) could play a role as upstream effectors involved in mediating associations between anorectic and noxious/stressful stimuli

2019 Neuropsychopharmacology

132. Selective serotonin reuptake inhibitors during pregnancy do not increase the risk of Hirschsprung's disease. (Abstract)

Selective serotonin reuptake inhibitors during pregnancy do not increase the risk of Hirschsprung's disease. Hirschsprung disease (HSCR) is a multifactorial disease. Maternal intake of selective serotonin reuptake inhibitors (SSRI) during early pregnancy has previously been associated with increased risk for HSCR. The aim of this study was to assess the risk for HSCR in newborns after maternal intake of SSRI in a population-based Swedish cohort.This was a Swedish nationwide, population-based

2019 Journal of Pediatric Surgery

133. PLATELET SEROTONIN SIGNALING IN PATIENTS WITH CARDIOVASCULAR DISEASE AND COMORBID DEPRESSION. Full Text available with Trip Pro

PLATELET SEROTONIN SIGNALING IN PATIENTS WITH CARDIOVASCULAR DISEASE AND COMORBID DEPRESSION. Depression in patients with cardiovascular disease is associated with increased risk of adverse clinical outcomes. Investigators have searched for potential biobehavioral explanations for this increased risk. Platelet activation and response to serotonin is an attractive potential mechanism. Our objective was to examine platelet serotonin signaling in a group of patients with coronary artery disease (...) and comorbid depression to define the relationship between platelet serotonin signaling and cardiovascular complications.A total of 300 patients with CAD were enrolled (145 with acute coronary syndrome and 155 with stable coronary artery disease). Depression was assessed using the Structured Clinical Interview for DSM-IV as well as Beck depression inventory-II in a dichotomous and continuous manner. Platelet serotonin response was measured by serotonin augmented aggregation, direct platelet serotonin

2019 Psychosomatic Medicine

134. Antidepressant Effect of <i>Tetragonia tetragonoides (Pall.) Kuntze</i> Extract on Serotonin Turnover. Full Text available with Trip Pro

Antidepressant Effect of Tetragonia tetragonoides (Pall.) Kuntze Extract on Serotonin Turnover. Tetragonia tetragonoides (Pall.) Kuntze (TTK) is a groundcover found along coastal areas of the Korean peninsula. TTK is traditionally used to improve women's health and treat gastrointestinal diseases. Use of herbal medicines in the treatment of mood disorders has recently been suggested as an alternative therapeutic strategy. In the present study, we determined that consumption of TTK (...) extract ameliorated progression of depressive-like symptoms in ovariectomized (OVX) rats and further examined the mechanisms involved, i.e., synthesis, release, and reuptake(s) of serotonin (also known as 5-HT). We assessed the mRNA expression levels of tryptophan hydroxylases (TPH-1 and TPH-2) and serotonin transporter (SERT) as well as the reuptake activity of serotonin in RBL-2H3 cells. We also determined whether or not TTK extract regulates the serum level of serotonin and improves depressive-like

2019 Evidence-based Complementary and Alternative Medicine (eCAM)

135. Correction: Psychedelic effects of psilocybin correlate with serotonin 2A receptor occupancy and plasma psilocin levels. Full Text available with Trip Pro

Correction: Psychedelic effects of psilocybin correlate with serotonin 2A receptor occupancy and plasma psilocin levels. The original version of this article contained an error in the labelling of Figures 2 and 3. While the captions and figures themselves are correct, in order to correspond with the in-text references, they have now been re-numbered in both the PDF and HTML versions of the article.

2019 Neuropsychopharmacology

136. Risks of hospitalization for upper gastrointestinal bleeding in selective serotonin reuptake inhibitors users after Helicobacter pylori eradication therapy: a propensity score matching analysis. Full Text available with Trip Pro

Risks of hospitalization for upper gastrointestinal bleeding in selective serotonin reuptake inhibitors users after Helicobacter pylori eradication therapy: a propensity score matching analysis. Selective serotonin reuptake inhibitors (SSRIs) are the first-line treatment for depression but there is a concern about the risk of upper gastrointestinal bleeding (UGIB). Past studies, however, are largely confounded by the presence of Helicobacter pylori (HP).To evaluate the UGIB risk of SSRI users

2019 Alimentary Pharmacology & Therapeutics

137. Abnormalities of mucosal serotonin metabolism and 5-HT<sub>3</sub> receptor subunit 3C polymorphism in irritable bowel syndrome with diarrhoea predict responsiveness to ondansetron. Full Text available with Trip Pro

Abnormalities of mucosal serotonin metabolism and 5-HT3 receptor subunit 3C polymorphism in irritable bowel syndrome with diarrhoea predict responsiveness to ondansetron. Irritable bowel syndrome with diarrhoea (IBS-D) is a common condition, greatly reducing the quality of life with few effective treatment options available.To report the beneficial response shown in our trial with the 5-hydroyxtryptamine (5-HT) receptor 3 antagonist, ondansetron in IBS-D METHODS: A randomised (...) , placebo-controlled, cross-over trial of 5 weeks of ondansetron versus placebo in 125 patients meeting modified Rome III criteria for IBS-D as previously described. Patients were compared to 21 healthy controls. 5-HT and 5-HIAA were measured in rectal biopsies. Whole gut transit time was assessed using a radio-opaque marker technique. Whole blood DNA was genotyped for an insertion polymorphism in the promoter region of the serotonin transporter gene SLC6A4, as well as single nucleotide polymorphisms

2019 Alimentary Pharmacology & Therapeutics Controlled trial quality: uncertain

138. Brain serotonin transporter binding, plasma arachidonic acid and depression severity: A positron emission tomography study of major depression. Full Text available with Trip Pro

Brain serotonin transporter binding, plasma arachidonic acid and depression severity: A positron emission tomography study of major depression. Serotonin transporter (5-HTT) binding and polyunsaturated fatty acids (PUFAs) are implicated in major depressive disorder (MDD). Links between the two systems in animal models have not been investigated in humans.Using positron emission tomography (PET) and [11C]DASB, we studied relationships between 5-HTT binding potential and plasma levels of PUFAs (...) curve. 5-HTT binding potential mediated the relationship between AA and depression severity.Given the small sample and multiple comparisons, results require replication.Our findings suggest that AA status may impact depression pathophysiology through effects on serotonin transport. Future studies should examine whether these relationships explain therapeutic effects of PUFAs in the treatment of MDD.Copyright © 2019. Published by Elsevier B.V.

2019 Journal of Affective Disorders

139. Takotsubo cardiomyopathy associated with serotonin syndrome in a patient with stroke: A case report. Full Text available with Trip Pro

Takotsubo cardiomyopathy associated with serotonin syndrome in a patient with stroke: A case report. Takotsubo cardiomyopathy (TC) is characterized by transient left ventricular dysfunction. We describe a patient with stroke who presented with TC caused by serotonin syndrome (SS) following the administration of serotonergic and dopaminergic agents.A 55-year-old man with stroke was administered venlafaxine, tianeptine, ropinirole, carbidopa/levodopa, bromocriptine, and methylphenidate during

2019 Medicine

140. Serotonin Transporter Binding in the Human Brain After Pharmacological Challenge Measured Using PET and PET/MR. Full Text available with Trip Pro

Serotonin Transporter Binding in the Human Brain After Pharmacological Challenge Measured Using PET and PET/MR. Introduction:In-vivo quantification of the serotonin transporter (SERT) guided our understanding of many neuropsychiatric disorders. A recently introduced bolus plus constant infusion protocol has been shown to allow the reliable determination of SERT binding with reduced scan time. In this work, the outcomes of two methods, a bolus injection paradigm on a GE PET camera, and a bolus

2019 Frontiers in molecular neuroscience Controlled trial quality: uncertain

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