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Serotonin

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81. Correction: Selective serotonin reuptake inhibitors and venlafaxine in pregnancy: Changes in drug disposition. Full Text available with Trip Pro

Correction: Selective serotonin reuptake inhibitors and venlafaxine in pregnancy: Changes in drug disposition. [This corrects the article DOI: 10.1371/journal.pone.0181082.].

2018 PLoS ONE

82. Biophysical validation of serotonin 5-HT2A and 5-HT2C receptor interaction. Full Text available with Trip Pro

Biophysical validation of serotonin 5-HT2A and 5-HT2C receptor interaction. The serotonin (5-HT) 5-HT2A receptor (5-HT2AR) and 5-HT2C receptor (5-HT2CR) in the central nervous system are implicated in a range of normal behaviors (e.g., appetite, sleep) and physiological functions (e.g., endocrine secretion) while dysfunctional 5-HT2AR and/or 5-HT2CR are implicated in neuropsychiatric disorders (e.g., addiction, obesity, schizophrenia). Preclinical studies suggest that the 5-HT2AR and 5-HT2CR

2018 PLoS ONE

83. The Effects of Serotonin in Immune Cells Full Text available with Trip Pro

The Effects of Serotonin in Immune Cells Serotonin [5-hydroxytryptamine (5-HT)] plays an important role in many organs as a peripheral hormone. Most of the body's serotonin is circulating in the bloodstream, transported by blood platelets and is released upon activation. The functions of serotonin are mediated by members of the 7 known mammalian serotonin receptor subtype classes (15 known subtypes), the serotonin transporter (SERT), and by covalent binding of serotonin to different effector (...) proteins. Almost all immune cells express at least one serotonin component. In recent years, a number of immunoregulatory functions have been ascribed to serotonin. In monocytes/macrophages, for example, serotonin modulates cytokine secretion. Serotonin can also suppress the release of tumor necrosis factor-α and interleukin-1β by activating serotonin receptors. Furthermore, neutrophil recruitment and T-cell activation can both be mediated by serotonin. These are only a few of the known

2017 Frontiers in cardiovascular medicine

84. Risk of Hip Fracture in Older People Using Selective Serotonin Reuptake Inhibitors and Other Psychoactive Medicines Concurrently: A Matched Case–Control Study in Australia Full Text available with Trip Pro

Risk of Hip Fracture in Older People Using Selective Serotonin Reuptake Inhibitors and Other Psychoactive Medicines Concurrently: A Matched Case–Control Study in Australia Few studies have assessed the risk of hip fracture following concurrent use of psychoactive medicines, and none has investigated combinations with selective serotonin reuptake inhibitors.To assess the risk of hip fracture in older people as a result of concurrent use of selective serotonin reuptake inhibitors and other (...) differed from the sum of individual effects.There were 8828 cases and 35,310 controls. The median age of subjects was 88 years and 63% were women. The risk of hip fracture was elevated for all medicines assessed individually, most notably selective serotonin reuptake inhibitors (initiation: odds ratio [OR] = 2.7, 95% confidence interval [CI] 2.1, 3.6) and opioids (initiation: OR = 2.3, 95% CI 1.9, 2.9). Combinations associated with an increased odds of hip fracture included addition of benzodiazepines

2017 Drugs - real world outcomes

85. Negative self-referential processing is associated with genetic variation in the serotonin transporter-linked polymorphic region (5-HTTLPR): Evidence from two independent studies. Full Text available with Trip Pro

Negative self-referential processing is associated with genetic variation in the serotonin transporter-linked polymorphic region (5-HTTLPR): Evidence from two independent studies. The current research examined whether carriers of the short 5-HTTLPR allele (in SLC6A4), who have been shown to selectively attend to negative information, exhibit a bias towards negative self-referent processing. The self-referent encoding task (SRET) was used to measure self-referential processing of positive

2018 PLoS ONE

86. Correction: Anatomical relationships between serotonin 5-HT2A and dopamine D2 receptors in living human brain. Full Text available with Trip Pro

Correction: Anatomical relationships between serotonin 5-HT2A and dopamine D2 receptors in living human brain. [This corrects the article DOI: 10.1371/journal.pone.0189318.].

2018 PLoS ONE

87. Harman and norharman, metabolites of entomopathogenic fungus Conidiobolus coronatus (Entomopthorales), disorganize development of Galleria mellonella (Lepidoptera) and affect serotonin-regulating enzymes. Full Text available with Trip Pro

Harman and norharman, metabolites of entomopathogenic fungus Conidiobolus coronatus (Entomopthorales), disorganize development of Galleria mellonella (Lepidoptera) and affect serotonin-regulating enzymes. Naturally occurring entomopathogenic fungi such as Conidiobolus coronatus are important regulatory factors of insect populations. GC-MS analysis of fungal cell-free filtrates showed that C. coronatus synthesizes two β- carboline alkaloids: harman and norharman. Significantly higher levels (...) delayed pupation and adult eclosion, and inhibit total monoamine oxidase activity. In addition, they increased the serotonin concentration and decreased the monoamine oxidase A level in the heads of the moths. It is likely that the alkaloids were metabolized by the insects, as their effect wore off 24 hours after topical application. This is the first study to show that C. coronatus produces alkaloids. Its aim was to identify the actions of β-carboline alkaloids on insect development and serotonin

2018 PLoS ONE

88. An amine oxidase gene from mud crab, Scylla paramamosain, regulates the neurotransmitters serotonin and dopamine in vitro. Full Text available with Trip Pro

An amine oxidase gene from mud crab, Scylla paramamosain, regulates the neurotransmitters serotonin and dopamine in vitro. Amine oxidase, which participates in the metabolic processing of biogenic amines, is widely found in organisms, including higher organisms and various microorganisms. In this study, the full-length cDNA of a novel amine oxidase gene was cloned from the mud crab, Scylla paramamosain, and termed SpAMO. The cDNA sequence was 2,599 bp in length, including an open reading frame (...) with 50 mg/kg/d quercetin, the expression of SpAMO declined rapidly and remained low in the brain and haemolymph. These results indicated that quercetin could inhibit the transcription of SpAMO, and the high dose (50 mg/kg/d) had a relatively significant inhibitory effect. SpAMO showed the highest catalytic activity on serotonin, followed by dopamine, β-phenylethylamine, and spermine, suggesting that the specific substrates of SpAMO are serotonin and dopamine. A bioinformatics analysis of SpAMO showed

2018 PLoS ONE

89. Serotonin and serotonin noradrenaline reuptake inhibitors for anxiety disorders in children and adolescents: a systematic review and meta-analysis

Serotonin and serotonin noradrenaline reuptake inhibitors for anxiety disorders in children and adolescents: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith

2018 PROSPERO

90. Selective serotonin reuptake inhibitors (SSRIs) for autism spectrum disorders (ASD). (Abstract)

Selective serotonin reuptake inhibitors (SSRIs) for autism spectrum disorders (ASD). Autism spectrum disorders (ASD) are characterised by abnormalities in social interaction and communication skills, as well as stereotypic behaviours and restricted activities and interests. Selective serotonin reuptake inhibitors (SSRIs) are prescribed for the treatment of conditions often comorbid with ASD such as depression, anxiety and obsessive-compulsive behaviours.To determine if treatment with an SSRI:1

2013 Cochrane

91. CPIC Guideline for Selective Serotonin Reuptake Inhibitors and CYP2D6 and CYP2C19

CPIC Guideline for Selective Serotonin Reuptake Inhibitors and CYP2D6 and CYP2C19 Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline forCYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors JKHicks 1 ,JRBishop 2 ,KSangkuhl 3 ,DJM€ uller 4 ,YJi 5 ,SGLeckband 6 ,JSLeeder 7 ,RLGraham 8 , DLChiulli 9 ,ALLerena 10 ,TCSkaar 11 ,SAScott 12 ,JCStingl 13 ,TEKlein 3 ,KECaudle 14 andAGaedigk 7 Selective serotonin reuptake inhibitors (SSRIs) are primary (...) with the selective serotonin reuptake inhibitors (SSRIs) are associated with CYP2D6 or CYP2C19 polymorphisms. 1 The purpose of this guideline is to provide information to allow the interpretation of existing CYP2D6 and/or CYP2C19 genotype tests to guide SSRI dosing, particu- larly focusing on ?uvoxamine, paroxetine, citalopram, escitalo- pram, and sertraline. Other clinical variables that may in?uence SSRI therapy as well as genotyping cost-effectiveness are beyond the scope of this article. CPIC guidelines

2015 Clinical Pharmacogenetics Implementation Consortium

92. Selective Serotonin Reuptake Inhibitor Monotherapy for Anxiety Disorders in Children and Adolescents with Autism Spectrum Disorder: A Chart Review. (Abstract)

Selective Serotonin Reuptake Inhibitor Monotherapy for Anxiety Disorders in Children and Adolescents with Autism Spectrum Disorder: A Chart Review. Objective: Anxiety disorders are one of the most commonly co-occurring psychiatric diagnoses in youth with autism spectrum disorder (ASD), with a frequency ranging from 22% to 84%. Methods: We conducted a chart review of 29 children and adolescents with ASD who had been treated with selective serotonin reuptake inhibitor (SSRI) monotherapy

2019 Journal of Child and Adolescent Psychopharmacology

93. Degree of serotonin reuptake inhibition of antidepressants and ischemic risk: A cohort study. Full Text available with Trip Pro

Degree of serotonin reuptake inhibition of antidepressants and ischemic risk: A cohort study. To assess whether use of antidepressants with strong inhibition of serotonin reuptake is associated with a decreased incidence of ischemic stroke and myocardial infarction (MI).We conducted a cohort study using the UK Clinical Practice Research Datalink and considering new users of selective serotonin reuptake inhibitors (SSRIs) or third-generation antidepressants who were ≥18 years of age between 1995 (...) and 2014. Using a nested case-control approach, we matched each case of a first ischemic stroke or MI identified during follow-up with up to 30 controls on age, sex, calendar time, and duration of follow-up. We estimated incidence rate ratios (RRs) and 95% confidence intervals (CIs) of each outcome associated with current use of strong compared with weak inhibitors of serotonin reuptake using conditional logistic regression.The cohort included 938,388 incident users of SSRIs (n = 868,755) or third

2019 Neurology

94. Postictal serotonin levels are associated with peri-ictal apnea. Full Text available with Trip Pro

Postictal serotonin levels are associated with peri-ictal apnea. To determine the relationship between serum serotonin (5-HT) levels, ictal central apnea (ICA), and postconvulsive central apnea (PCCA) in epileptic seizures.We prospectively evaluated video EEG, plethysmography, capillary oxygen saturation (SpO2), and ECG for 49 patients (49 seizures) enrolled in a multicenter study of sudden unexpected death in epilepsy (SUDEP). Postictal and interictal venous blood samples were collected after

2019 Neurology

95. Perioperative Selective Serotonin Reuptake Inhibitor Use Is Associated With an Increased Risk of Transfusion in Total Hip and Knee Arthroplasty. (Abstract)

Perioperative Selective Serotonin Reuptake Inhibitor Use Is Associated With an Increased Risk of Transfusion in Total Hip and Knee Arthroplasty. Selective serotonin reuptake inhibitors (SSRIs) have been shown in both orthopedic and general surgery literature to be associated with an increased risk of blood loss, and this is thought to occur via diminished platelet serotonin reuptake and subsequent decline in platelet aggregation potential. In this study, we aim at quantifying the effect

2019 Journal of Arthroplasty

96. Selective Serotonin Reuptake Inhibitor Use and Hip Fracture Risk Among Patients on Hemodialysis. Full Text available with Trip Pro

Selective Serotonin Reuptake Inhibitor Use and Hip Fracture Risk Among Patients on Hemodialysis. Use of selective serotonin reuptake inhibitors (SSRIs) has been associated with hip fracture risk in the general population. This study examined this relationship among patients with kidney failure treated by hemodialysis, a unique high-risk subpopulation, within which the impact of SSRIs on hip fracture risk remains unexplored.Case-control study.Eligible cases of hip fracture among maintenance

2019 American Journal of Kidney Diseases

97. Another Step Toward Clarifying the Benefits and Burdens of Selective Serotonin Reuptake Inhibitors. (Abstract)

Another Step Toward Clarifying the Benefits and Burdens of Selective Serotonin Reuptake Inhibitors. Selective serotonin reuptake inhibitors (SSRIs) have substantial beneficial effects for the treatment of major depressive mood disorders and other conditions but can also result in unwanted clinical outcomes. One of the reported disadvantages of SSRIs, based on cross-sectional studies, is their adverse effects on glycemic control. However, in this issue of Psychosomatic Medicine, Tharmaraja et al

2019 Psychosomatic Medicine

98. Serotonin system genes and obsessive-compulsive trait dimensions in a population-based, pediatric sample: a genetic association study. (Abstract)

Serotonin system genes and obsessive-compulsive trait dimensions in a population-based, pediatric sample: a genetic association study. Serotonin system genes are commonly studied in obsessive-compulsive disorder (OCD), but genetic studies to date have produced inconsistent results, possibly because phenotypic heterogeneity has not been adequately accounted for. In this paper, we studied candidate serotonergic genes and homogenous phenotypic subgroups as presented through obsessive-compulsive (...) genotyped candidate serotonin genes (directly genotyping the 5-HTTLPR polymorphism in SLC6A4 for 2018 individuals and using single nucleotide polymorphism (SNP) array data for genes SLC6A4, HTR2A, and HTR1B for 4711 individuals). We assessed the association between variants across these genes and each of the OC trait dimensions, within males and females separately. We analyzed OC traits as both (a) dichotomized based on a threshold value and (b) quantitative scores.The [LG + S] variant in 5-HTTLPR

2019 Journal of Child Psychology and Psychiatry

99. The Effect of Vitamin D3 Supplementation on Serum BDNF, Dopamine, and Serotonin in Children with Attention-Deficit/Hyperactivity Disorder. (Abstract)

The Effect of Vitamin D3 Supplementation on Serum BDNF, Dopamine, and Serotonin in Children with Attention-Deficit/Hyperactivity Disorder. Attention-Deficit/Hyperactivity Disorder (ADHD) is one of the most common psychiatric disorders in childhood. The exact etiology of this disease is unknown, but it is believed to be related to the disorder of catecholaminergic and serotonergic systems. Also, serum vitamin D levels in patients with ADHD is lower. Several studies have also shown the effect (...) of vitamin D on the synthesis pathways of dopamine, serotonin, and a number of neurotrophic factors. Therefore, this study aimed to investigate the effect of vitamin D3 supplementation on serum levels of Brain-Derived Neurotrophic Factor (BDNF), dopamine, and serotonin in school-aged children with ADHD.Eighty-six children with ADHD were divided into two groups, based on randomized permuted blocks. Patients received 2000 IU vitamin D/day or a placebo for 12 weeks. Serum levels of BDNF, dopamine, serotonin

2019 CNS & neurological disorders drug targets Controlled trial quality: uncertain

100. Decreased plasma serotonin and other metabolite changes in healthy adults after consumption of wholegrain rye: an untargeted metabolomics study. (Abstract)

Decreased plasma serotonin and other metabolite changes in healthy adults after consumption of wholegrain rye: an untargeted metabolomics study. Wholegrain consumption has been associated with beneficial health effects including reduction of diabetes and cancer risk; however, the underlying mechanisms are not fully understood.The aim of this study was to characterize the effects of wholegrain rye intake on circulating metabolites in a human intervention study using untargeted metabolomics.The (...) serotonin is produced mainly in the gut, a hypothesis of its altered biosynthesis as a response to increased cereal fiber intake was tested by measuring intestinal serotonin of mice fed for 9 wk on a high-fat diet supplemented with different sources of fiber (rye bran flour, ground wheat aleurone, or powdered cellulose).Five endogenous metabolites and 15 rye phytochemicals associated with WGR intake were identified. Plasma concentrations of serotonin, taurine, and glycerophosphocholine were

2019 American Journal of Clinical Nutrition Controlled trial quality: uncertain

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