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61. Risk of Hip Fracture in Older People Using Selective Serotonin Reuptake Inhibitors and Other Psychoactive Medicines Concurrently: A Matched Case–Control Study in Australia Full Text available with Trip Pro

Risk of Hip Fracture in Older People Using Selective Serotonin Reuptake Inhibitors and Other Psychoactive Medicines Concurrently: A Matched Case–Control Study in Australia Few studies have assessed the risk of hip fracture following concurrent use of psychoactive medicines, and none has investigated combinations with selective serotonin reuptake inhibitors.To assess the risk of hip fracture in older people as a result of concurrent use of selective serotonin reuptake inhibitors and other (...) differed from the sum of individual effects.There were 8828 cases and 35,310 controls. The median age of subjects was 88 years and 63% were women. The risk of hip fracture was elevated for all medicines assessed individually, most notably selective serotonin reuptake inhibitors (initiation: odds ratio [OR] = 2.7, 95% confidence interval [CI] 2.1, 3.6) and opioids (initiation: OR = 2.3, 95% CI 1.9, 2.9). Combinations associated with an increased odds of hip fracture included addition of benzodiazepines

2017 Drugs - real world outcomes

62. The Effects of Serotonin in Immune Cells Full Text available with Trip Pro

The Effects of Serotonin in Immune Cells Serotonin [5-hydroxytryptamine (5-HT)] plays an important role in many organs as a peripheral hormone. Most of the body's serotonin is circulating in the bloodstream, transported by blood platelets and is released upon activation. The functions of serotonin are mediated by members of the 7 known mammalian serotonin receptor subtype classes (15 known subtypes), the serotonin transporter (SERT), and by covalent binding of serotonin to different effector (...) proteins. Almost all immune cells express at least one serotonin component. In recent years, a number of immunoregulatory functions have been ascribed to serotonin. In monocytes/macrophages, for example, serotonin modulates cytokine secretion. Serotonin can also suppress the release of tumor necrosis factor-α and interleukin-1β by activating serotonin receptors. Furthermore, neutrophil recruitment and T-cell activation can both be mediated by serotonin. These are only a few of the known

2017 Frontiers in cardiovascular medicine

63. Negative self-referential processing is associated with genetic variation in the serotonin transporter-linked polymorphic region (5-HTTLPR): Evidence from two independent studies. Full Text available with Trip Pro

Negative self-referential processing is associated with genetic variation in the serotonin transporter-linked polymorphic region (5-HTTLPR): Evidence from two independent studies. The current research examined whether carriers of the short 5-HTTLPR allele (in SLC6A4), who have been shown to selectively attend to negative information, exhibit a bias towards negative self-referent processing. The self-referent encoding task (SRET) was used to measure self-referential processing of positive

2018 PLoS ONE

64. Serotonin and serotonin noradrenaline reuptake inhibitors for anxiety disorders in children and adolescents: a systematic review and meta-analysis

Serotonin and serotonin noradrenaline reuptake inhibitors for anxiety disorders in children and adolescents: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith

2018 PROSPERO

65. Selective serotonin reuptake inhibitors (SSRIs) for autism spectrum disorders (ASD). (Abstract)

Selective serotonin reuptake inhibitors (SSRIs) for autism spectrum disorders (ASD). Autism spectrum disorders (ASD) are characterised by abnormalities in social interaction and communication skills, as well as stereotypic behaviours and restricted activities and interests. Selective serotonin reuptake inhibitors (SSRIs) are prescribed for the treatment of conditions often comorbid with ASD such as depression, anxiety and obsessive-compulsive behaviours.To determine if treatment with an SSRI:1

2013 Cochrane

66. CPIC Guideline for Selective Serotonin Reuptake Inhibitors and CYP2D6 and CYP2C19

CPIC Guideline for Selective Serotonin Reuptake Inhibitors and CYP2D6 and CYP2C19 Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline forCYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors JKHicks 1 ,JRBishop 2 ,KSangkuhl 3 ,DJM€ uller 4 ,YJi 5 ,SGLeckband 6 ,JSLeeder 7 ,RLGraham 8 , DLChiulli 9 ,ALLerena 10 ,TCSkaar 11 ,SAScott 12 ,JCStingl 13 ,TEKlein 3 ,KECaudle 14 andAGaedigk 7 Selective serotonin reuptake inhibitors (SSRIs) are primary (...) with the selective serotonin reuptake inhibitors (SSRIs) are associated with CYP2D6 or CYP2C19 polymorphisms. 1 The purpose of this guideline is to provide information to allow the interpretation of existing CYP2D6 and/or CYP2C19 genotype tests to guide SSRI dosing, particu- larly focusing on ?uvoxamine, paroxetine, citalopram, escitalo- pram, and sertraline. Other clinical variables that may in?uence SSRI therapy as well as genotyping cost-effectiveness are beyond the scope of this article. CPIC guidelines

2015 Clinical Pharmacogenetics Implementation Consortium

67. Impact of serotonin transporter gene on rTMS augmentation of SSRIs for obsessive compulsive disorder. Full Text available with Trip Pro

Impact of serotonin transporter gene on rTMS augmentation of SSRIs for obsessive compulsive disorder. Repetitive transcranial magnetic stimulation (rTMS) is beneficial for treatment-resistant patients with obsessive-compulsive disorder (OCD). The serotonin transporter gene (SLC6A4) may be associated with OCD. We aimed to determine whether SLC6A4 impacts the beneficial effects of rTMS in patients with OCD treated with selective serotonin reuptake inhibitors (SSRIs).Fifty-seven untreated patients

2019 Neuropsychiatric disease and treatment Controlled trial quality: uncertain

68. Takotsubo cardiomyopathy associated with serotonin syndrome in a patient with stroke: A case report. Full Text available with Trip Pro

Takotsubo cardiomyopathy associated with serotonin syndrome in a patient with stroke: A case report. Takotsubo cardiomyopathy (TC) is characterized by transient left ventricular dysfunction. We describe a patient with stroke who presented with TC caused by serotonin syndrome (SS) following the administration of serotonergic and dopaminergic agents.A 55-year-old man with stroke was administered venlafaxine, tianeptine, ropinirole, carbidopa/levodopa, bromocriptine, and methylphenidate during

2019 Medicine

69. 5-HT1A receptor, 5-HT2A receptor and serotonin transporter binding in the human auditory cortex in depression Full Text available with Trip Pro

5-HT1A receptor, 5-HT2A receptor and serotonin transporter binding in the human auditory cortex in depression Serotonergic system abnormalities are implicated in many psychiatric disorders, including major depression. The temporal lobe receives a high density of serotonergic afferent projections, and responses in the primary auditory cortex to sound are modulated by serotonergic tone. However, the associations between changes in serotonergic tone, disease state and changes in auditory cortical (...) function remain to be clarified.We quantified serotonin 1A (5-HT1A) receptor binding, serotonin 2A (5-HT2A) receptor binding, and serotonin transporter (SERT) binding in Brodmann areas (BA) 41/42, 22, 9 and 4 from postmortem brain sections of 40 psychiatrically healthy controls and 39 individuals who had a history of a major depressive episode (MDE).There was 33% lower 5-HT2A receptor binding in BA 41/42 in individuals who had an MDE than in controls (p = 0.0069). Neither 5-HT1A nor SERT binding in BA

2019 Journal of Psychiatry & Neuroscience

70. Decreased plasma serotonin and other metabolite changes in healthy adults after consumption of wholegrain rye: an untargeted metabolomics study. (Abstract)

Decreased plasma serotonin and other metabolite changes in healthy adults after consumption of wholegrain rye: an untargeted metabolomics study. Wholegrain consumption has been associated with beneficial health effects including reduction of diabetes and cancer risk; however, the underlying mechanisms are not fully understood.The aim of this study was to characterize the effects of wholegrain rye intake on circulating metabolites in a human intervention study using untargeted metabolomics.The (...) serotonin is produced mainly in the gut, a hypothesis of its altered biosynthesis as a response to increased cereal fiber intake was tested by measuring intestinal serotonin of mice fed for 9 wk on a high-fat diet supplemented with different sources of fiber (rye bran flour, ground wheat aleurone, or powdered cellulose).Five endogenous metabolites and 15 rye phytochemicals associated with WGR intake were identified. Plasma concentrations of serotonin, taurine, and glycerophosphocholine were

2019 American Journal of Clinical Nutrition Controlled trial quality: uncertain

71. Citalopram overdose and severe serotonin syndrome in an intermediate metabolizing patient. (Abstract)

Citalopram overdose and severe serotonin syndrome in an intermediate metabolizing patient. Citalopram is a selective serotonin reuptake inhibitor used for treatment of depression. Metabolism is primarily through CYP3A4 and CYP2C19; activity of the latter can vary depending on genetics. Although rare after single agent exposure, large citalopram ingestions can lead to serotonin syndrome. We report a case of citalopram overdose in an intermediate CYP2C19 metabolizer complicated by severe (...) serotonin syndrome.A 25-year-old female presented after intentional citalopram overdose with seizures, tachycardia, persistent neuromuscular findings, and severe hyperthermia requiring aggressive sedation and cooling. Protracted symptoms required critical care services throughout a 14 day hospital stay despite traditional treatment of serotonin syndrome. Pharmacogenomic studies revealed intermediate CYP2C19 metabolism which reduces citalopram inactivation and may cause increased levels and toxicity.In

2019 American Journal of Emergency Medicine

72. Functional connectivity of the raphe nucleus as a predictor of the response to selective serotonin reuptake inhibitors in obsessive-compulsive disorder. (Abstract)

Functional connectivity of the raphe nucleus as a predictor of the response to selective serotonin reuptake inhibitors in obsessive-compulsive disorder. Selective serotonin reuptake inhibitors (SSRIs) are first-line pharmacological agents for treating obsessive-compulsive disorder (OCD). However, because nearly half of patients show insufficient SSRI responses, serotonergic dysfunction in heterogeneous OCD patients should be investigated for precision medicine. We aimed to determine whether

2019 Neuropsychopharmacology

73. Editorial: Cognitive-Behavior Therapy Versus Serotonin Reuptake Inhibitors for Pediatric Obsessive-Compulsive Disorder. (Abstract)

Editorial: Cognitive-Behavior Therapy Versus Serotonin Reuptake Inhibitors for Pediatric Obsessive-Compulsive Disorder. How should treatment be initiated for children with obsessive-compulsive disorder (OCD)? This editorial comments on an article by Melin and colleagues,1 published in this issue, from the NordLOTS study, which reports excellent outcomes from cognitive behavior therapy (CBT) for children with OCD. Children continued to improve after CBT was discontinued; at 3 year follow-up (...) , they enjoyed a 90% response rate. Such continuing improvement contrasts markedly with other studies finding, among patients treated with selective serotonin reuptake inhibitors (SSRIs), high relapse rates upon discontinuation. Evidence has accumulated that upon discontinuation of SSRIs, there is often not simply a return to baseline, but a withdrawal state for which opposites of the therapeutic effects can be prominent symptoms-these may include anxiety, dysphoria, irritability, and insomnia. The duration

2019 Journal of the American Academy of Child and Adolescent Psychiatry

74. Bioactivities of serotonin transporter mediate antidepressant effects of Acorus tatarinowii Schott. (Abstract)

Bioactivities of serotonin transporter mediate antidepressant effects of Acorus tatarinowii Schott. Acrorus tatarinowii Schott has been widely used in the treatments of neuropsychiatric and digestive disorders in clinical practices of traditional Chinese medicine for thousands of years. Both clinical and preclinical studies demonstrated antidepressant effects of A. tatarinowii. However, the possible action mechanisms of antidepressant effects of A. tatarinowii remain unraveled.The present study (...) aimed to investigate the roles of serotonin transporter (SERT) in antidepressant effects of A. tatarinowii.Antidepressant effects of water extract of A. tatarinowii were evaluated by forced swimming test (FST), tail suspension test (TST) and locomotor activity test. The water extract was analyzed by ultra high performance liquid chromatography (UPLC) method. Two major fractions of A. tatarinowii, petroleum ether extract and water extract after petroleum ether processed, were prepared and analyzed

2019 Journal of Ethnopharmacology

75. Illicit upregulation of serotonin signaling pathway in adrenals of patients with high plasma or intraadrenal ACTH levels. Full Text available with Trip Pro

Illicit upregulation of serotonin signaling pathway in adrenals of patients with high plasma or intraadrenal ACTH levels. In the human adrenal, serotonin (5-HT), released by mast cells stimulates corticosteroid secretion through activation of type 4 serotonin receptors (5-HT4R). In primary pigmented nodular adrenocortical disease (PPNAD) cells, activation of the cAMP/protein kinase A (PKA) pathway by PRKAR1A mutations triggers upregulation of the 5-HT synthesizing enzyme tryptophan hydroxylase

2019 Journal of Clinical Endocrinology and Metabolism

76. Emerging Roles for Serotonin in Regulating Metabolism: New Implications for an Ancient Molecule. Full Text available with Trip Pro

Emerging Roles for Serotonin in Regulating Metabolism: New Implications for an Ancient Molecule. Serotonin is a phylogenetically ancient biogenic amine that has played an integral role in maintaining energy homeostasis for billions of years. In mammals, serotonin produced within the central nervous system regulates behavior, suppresses appetite, and promotes energy expenditure by increasing sympathetic drive to brown adipose tissue. In addition to these central circuits, emerging evidence also (...) suggests an important role for peripheral serotonin as a factor that enhances nutrient absorption and storage. Specifically, glucose and fatty acids stimulate the release of serotonin from the duodenum, promoting gut peristalsis and nutrient absorption. Serotonin also enters the bloodstream and interacts with multiple organs, priming the body for energy storage by promoting insulin secretion and de novo lipogenesis in the liver and white adipose tissue, while reducing lipolysis and the metabolic

2019 Endocrine Reviews

77. Antidepressant Effect of <i>Tetragonia tetragonoides (Pall.) Kuntze</i> Extract on Serotonin Turnover. Full Text available with Trip Pro

Antidepressant Effect of Tetragonia tetragonoides (Pall.) Kuntze Extract on Serotonin Turnover. Tetragonia tetragonoides (Pall.) Kuntze (TTK) is a groundcover found along coastal areas of the Korean peninsula. TTK is traditionally used to improve women's health and treat gastrointestinal diseases. Use of herbal medicines in the treatment of mood disorders has recently been suggested as an alternative therapeutic strategy. In the present study, we determined that consumption of TTK (...) extract ameliorated progression of depressive-like symptoms in ovariectomized (OVX) rats and further examined the mechanisms involved, i.e., synthesis, release, and reuptake(s) of serotonin (also known as 5-HT). We assessed the mRNA expression levels of tryptophan hydroxylases (TPH-1 and TPH-2) and serotonin transporter (SERT) as well as the reuptake activity of serotonin in RBL-2H3 cells. We also determined whether or not TTK extract regulates the serum level of serotonin and improves depressive-like

2019 Evidence-based Complementary and Alternative Medicine (eCAM)

78. PLATELET SEROTONIN SIGNALING IN PATIENTS WITH CARDIOVASCULAR DISEASE AND COMORBID DEPRESSION. (Abstract)

PLATELET SEROTONIN SIGNALING IN PATIENTS WITH CARDIOVASCULAR DISEASE AND COMORBID DEPRESSION. Depression in patients with cardiovascular disease is associated with increased risk of adverse clinical outcomes. Investigators have searched for potential biobehavioral explanations for this increased risk. Platelet activation and response to serotonin is an attractive potential mechanism. Our objective was to examine platelet serotonin signaling in a group of patients with coronary artery disease (...) and comorbid depression to define the relationship between platelet serotonin signaling and cardiovascular complications.A total of 300 patients with CAD were enrolled (145 with acute coronary syndrome and 155 with stable coronary artery disease). Depression was assessed using the Structured Clinical Interview for DSM-IV as well as Beck depression inventory-II in a dichotomous and continuous manner. Platelet serotonin response was measured by serotonin augmented aggregation, direct platelet serotonin

2019 Psychosomatic Medicine

79. Correction: Psychedelic effects of psilocybin correlate with serotonin 2A receptor occupancy and plasma psilocin levels. Full Text available with Trip Pro

Correction: Psychedelic effects of psilocybin correlate with serotonin 2A receptor occupancy and plasma psilocin levels. The original version of this article contained an error in the labelling of Figures 2 and 3. While the captions and figures themselves are correct, in order to correspond with the in-text references, they have now been re-numbered in both the PDF and HTML versions of the article.

2019 Neuropsychopharmacology

80. Central serotonin prevents hypotension and hypothermia and reduces plasma and spleen cytokine levels during systemic inflammation. (Abstract)

Central serotonin prevents hypotension and hypothermia and reduces plasma and spleen cytokine levels during systemic inflammation. An exceptionally high mortality rate is observed in sepsis and septic shock. Systemic administration of lipopolysaccharide (LPS) has been used as an experimental model for sepsis resulting in an exacerbated immune response, brain neurochemistry adjustments, hypotension, and hypothermia followed by fever. Central serotonergic pathways not only modulate systemic (...) inflammation (SI) but also are affected by SI, including in the anteroventral region of the hypothalamus (AVPO), which is the hierarchically most important region for body temperature (Tb) control. In this study, we sought to determine if central serotonin (5-HT) plays a role in SI induced by intravenous administration of LPS (1.5 mg/kg) in male Wistar rats (280-350 g) by assessing 5-HT levels in the AVPO, mean arterial pressure, heart rate, and Tb up to 300 min after LPS administration, as well

2019 Brain, behavior, and immunity

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