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Sentinel Node Breast Biopsy

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101. Excision of both pretreatment marked positive nodes and sentinel nodes improves axillary staging after neoadjuvant systemic therapy in breast cancer. Full Text available with Trip Pro

Excision of both pretreatment marked positive nodes and sentinel nodes improves axillary staging after neoadjuvant systemic therapy in breast cancer. Marking the axilla with radioactive iodine seed and sentinel lymph node (SLN) biopsy have been proposed for axillary staging after neoadjuvant systemic therapy in clinically node-positive breast cancer. This study evaluated the identification rate and detection of residual disease with combined excision of pretreatment-positive marked lymph nodes (...) (MLNs) together with SLNs.This was a multicentre retrospective analysis of patients with clinically node-positive breast cancer undergoing neoadjuvant systemic therapy and the combination procedure (with or without axillary lymph node dissection). The identification rate and detection of axillary residual disease were calculated for the combination procedure, and for MLNs and SLNs separately.At least one MLN and/or SLN(s) were identified by the combination procedure in 138 of 139 patients

2019 British Journal of Surgery

102. Predictors of nonsentinel lymph node metastasis in patients with breast cancer with metastasis in the sentinel node. Full Text available with Trip Pro

Predictors of nonsentinel lymph node metastasis in patients with breast cancer with metastasis in the sentinel node. To predict the factors related to axillary nonsentinel lymph node (NSLN) metastasis in patients with positive sentinel lymph node (SLN) of early breast cancer.The retrospective data are collected from the patients with positive SLN who received further completion axillary lymph node dissection (cALND) in Peking Union Medical Hospital between March 2016 and December 2017 (...) correlated with NSLN involvement: tumor size (X = 10.384, P = .001), SLN metastasis ratio (number of positive SLNs/number of SLNs removed × 100%) (X = 10.365, P = .001) and the number of negative sentinel nodes (X = 10.384, P = .006). In multivariate analysis and logistic regression, tumor size (odds ratio [OR] = 3.392, 95% confidence interval [CI]: 1.409-8.166, P = .006) and SLN metastasis ratio (OR = 3.514, 95% CI: 1.416-8.72, P = .007) were the independent risk factors. While the number of negative

2019 Medicine

103. Intraoperative tests (RD-100i OSNA system and Metasin test) for detecting sentinel lymph node metastases in breast cancer

system is recommended as an option for detecting sentinel lymph node metastases during breast surgery in people with early invasive breast cancer who have a sentinel lymph node biopsy and in whom axillary lymph node dissection will be considered. Details of the development of a national registry are included in section 7 of this guidance. 1.2 The Metasin test is not recommended for detecting sentinel lymph node metastases in people with early invasive breast cancer in routine clinical NHS practice (...) of lymph node surgery is lymphoedema, which is more likely after axillary lymph node dissection than after sentinel lymph node biopsy. The most common symptom is swelling of the arm, hands and fingers on the side of the body that has been operated on, which can persist for months or years. Swelling can also affect the breast, chest and shoulder. Lymphoedema does not affect all people who have lymph node surgery but, in some people, it can develop soon after treatment or years later because

2013 National Institute for Health and Clinical Excellence - Diagnostics Guidance

104. Systematic versus sentinel-lymph-node-driven axillary-lymph-node dissection in clinically node-negative patients with operable breast cancer. Results of the GF-GS01 randomized trial Full Text available with Trip Pro

Systematic versus sentinel-lymph-node-driven axillary-lymph-node dissection in clinically node-negative patients with operable breast cancer. Results of the GF-GS01 randomized trial Sentinel-lymph-node (SLN) resection seems to minimize systematic axillary-lymph-node dissection (sALND) side effects in operated breast cancer patients. We explored whether SLN resection achieves similar therapeutic outcomes as sALND but with fewer side effects.A randomized, controlled, open-label trial (...) with parallel-group design compared sALND restricted to cases with positive SLN biopsy (test arm, n = 774) versus SLN biopsy followed by sALND (control arm, n = 770).The five-year overall survivals in control and test arms were 96.42 and 95.64% (P = 0.2925). The estimated difference was nearly zero (precisely, - 0.79%, one-tailed 95% confidence interval (CI) limit - 2.44%). In a multivariate Cox model, the adjusted hazard ratio in the test arm was HR 0.81 (upper 95% CI limit 1.17). Advanced age (HR 1.05 per

2018 Breast cancer research and treatment Controlled trial quality: predicted high

105. The role of sentinel lymph node biopsy in the treatment of women with early stage vulval cancer: A summary of the evidence

The role of sentinel lymph node biopsy in the treatment of women with early stage vulval cancer: A summary of the evidence The role of sentinel lymph node biopsy in the treatment of women with early vulval cancer: A summary of the evidence Early-stage cancer of the vulva The International Federation of Gynaecology and Obstetrics (FIGO) categorises cancer of the vulva into stages, with early-stage (1A or 1B) defined as being confined to the vulva or perineum, with stromal invasion, and negative (...) , depending on tumour factors. Complete inguino-femoral lymph node dissection (IFLND) is associated with a high frequency of early and late complications, specifically wound infection, wound breakdown, lymphocyst and lymphoedema of the leg. 3 Sentinel lymph node biopsy (SLNB) is a procedure used to identify the first lymph node(s) to which a carcinoma drains. 4, 5 Identifying sentinel lymph nodes (SLN) allows for the resection of limited nodal tissue without removal of the entire lymph node chain

2015 Cancer Australia

106. Sentinel Node Breast Biopsy

Sentinel Node Breast Biopsy Sentinel Node Breast Biopsy Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Sentinel Node Breast Biopsy (...) Sentinel Node Breast Biopsy Aka: Sentinel Node Breast Biopsy II. Indications III. Advantages Much less invasive than axillary node dissection IV. Technique Albumin labeled with technetium-99m injected Scanning times Fifteen minutes Thirty minutes Three hours appears first or most radioactive V. Efficacy: Sentinel Node versus Axillary node dissection Studied 160 Italian women ages 25-77 years Focal tumors 5-6 cm in diameter Sensitivity: 95% : 97% Missed 5 cases Micrometastases Multifocal tumors Choose

2018 FP Notebook

107. Comparing observation alone, axillary radiotherapy, and completion axillary dissection for the management of breast cancer patients with a positive sentinel lymph node biopsy: a systematic review and network meta-analysis

Comparing observation alone, axillary radiotherapy, and completion axillary dissection for the management of breast cancer patients with a positive sentinel lymph node biopsy: a systematic review and network meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any

2018 PROSPERO

108. Risk factors of sentinel and non-sentinel lymph node metastases in patients with ductal carcinoma in situ of the breast: A nationwide study. (Abstract)

Risk factors of sentinel and non-sentinel lymph node metastases in patients with ductal carcinoma in situ of the breast: A nationwide study. Unexplained axillary metastases have been detected in some patients with ductal carcinoma in situ (DCIS), possibly because of occult invasion or iatrogenic tumor cell displacement. The significance of these metastases is unknown and brings into questions the need for upstaging and axillary surgery. What are the risk factors for sentinel lymph node (SN (...) ) and non-SN metastases, including the risk of iatrogenic displacement of tumor cells in relation to an excisional biopsy, in patients diagnosed with DCIS?Nationwide data on 1787 women diagnosed with DCIS between 2001 and 2015 were retrieved from the Danish Breast Cancer Group database. The association of clinicopathological variables with a positive SN (isolated tumor cells (ITCs), micro- or macrometastases) was evaluated using univariate and multivariate analyses.Of the 1787 patients, 71 (4.0%) had

2018 Breast

109. SentiMag and Sienna+ for sentinel lymph node localisation in breast cancer

to the standard technique (radioisotope ± blue dye). 12 In total, 115 patients were prospectively enrolled in a non- randomised method (Level III-2). Included patients had T0-T2 breast cancer proven by histology or cytology, were clinically node negative, and were scheduled for sentinel node biopsy. Patients received the radioisotope tracer either the day prior to surgery, or up to two hours before surgery. The Sienna+® tracer was administered intraoperatively following anaesthesia. SLN identification (...) -surgical LN localisation methods, including either blinded or open lymphoscintigraphy, and clinical or ultrasound examination. There was only a single study (Piñero-Madrona et al., 2015) that reported location of five extra-axillary LNs, associated with peri-tumour injection of radiotracer. Three were detected by gamma probe only, and were located within the internal mammary chain. The remaining SentiMag® and Sienna+® for sentinel lymph node localisation in breast cancer: Update April 2016 13 two were

2016 COAG Health Council - Horizon Scanning Technology Briefs

110. Evaluation of intraoperative touch imprint cytology on axillary sentinel lymph nodes in invasive breast carcinomas, a retrospective study of 1227 patients comparing sensitivity in the different tumor subtypes. Full Text available with Trip Pro

clinically node negative breast cancer patients treated with sentinel lymph node biopsy (SLNB) with intraoperative TIC between the years 2003 and 2008. The SLN was bisected and stained using the May-Grünwald-Giemsa method and immunocytochemically with the antibody MNF-116.The overall sensitivity of the TIC test was 68.6% and the specificity was 99.8%. There was no statistically significant difference between the detection of SLN metastases from ductal carcinoma versus lobular carcinoma. The sensitivity (...) Evaluation of intraoperative touch imprint cytology on axillary sentinel lymph nodes in invasive breast carcinomas, a retrospective study of 1227 patients comparing sensitivity in the different tumor subtypes. Intraoperative evaluation of the axillary sentinel lymph node (SLN) in patients with breast carcinoma reduces the need of re-operations in cases where an axillary completion lymph node dissection (CLND) is indicated. Different methods have been used to determine the SLN status

2018 PLoS ONE

111. Clinically node negative breast cancer patients undergoing breast conserving therapy, sentinel lymph node procedure versus follow-up: a Dutch randomized controlled multicentre trial (BOOG 2013-08). Full Text available with Trip Pro

Clinically node negative breast cancer patients undergoing breast conserving therapy, sentinel lymph node procedure versus follow-up: a Dutch randomized controlled multicentre trial (BOOG 2013-08). Studies showed that axillary lymph node dissection can be safely omitted in presence of positive sentinel lymph node(s) in breast cancer patients treated with breast conserving therapy. Since the outcome of the sentinel lymph node biopsy has no clinical consequence, the value of the procedure itself (...) is being questioned. The aim of the BOOG 2013-08 trial is to investigate whether the sentinel lymph node biopsy can be safely omitted in clinically node negative breast cancer patients treated with breast conserving therapy.The BOOG 2013-08 is a Dutch prospective non-inferiority randomized multicentre trial. Women with pathologically confirmed clinically node negative T1-2 invasive breast cancer undergoing breast conserving therapy will be randomized for sentinel lymph node biopsy versus no sentinel

2017 BMC Cancer Controlled trial quality: uncertain

112. Accuracy of sentinel lymph node biopsy in large and multifocal/multicentric breast carcinoma - a systematic review

Accuracy of sentinel lymph node biopsy in large and multifocal/multicentric breast carcinoma - a systematic review Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2011 DARE.

113. Systematic review of the effect of external beam radiation therapy to the breast on axillary recurrence after negative sentinel lymph node biopsy

Systematic review of the effect of external beam radiation therapy to the breast on axillary recurrence after negative sentinel lymph node biopsy Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2011 DARE.

114. Validation study for the hypothesis of internal mammary sentinel lymph node lymphatic drainage in breast cancer Full Text available with Trip Pro

significantly. To verify the hypothesis, two kinds of tracers were injected at different sites of breast. The radiotracer was injected with the modified technique, and the fluorescence tracer was injected in the peritumoral intra-parenchyma. The location of IM-SLN was identified by preoperative lymphoscintigraphy and intraoperative gamma probe. Then, internal mammary sentinel lymph node biopsy (IM-SLNB) was performed. The fluorescence status of IM-SLN was identified by the fluorescence imaging system (...) Validation study for the hypothesis of internal mammary sentinel lymph node lymphatic drainage in breast cancer According to axilla sentinel lymph node lymphatic drainage pattern, we hypothesized that internal mammary sentinel lymph node (IM-SLN) receives lymphatic drainage from not only the primary tumor area, but also the entire breast parenchyma. Based on the hypothesis a modified radiotracer injection technique was established and could increase the visualization rate of the IM-SLN

2016 Oncotarget

115. Comparative Study between Sentinel Lymph Node Biopsy and Axillary Dissection in Patients with One or Two Lymph Node Metastases Full Text available with Trip Pro

Comparative Study between Sentinel Lymph Node Biopsy and Axillary Dissection in Patients with One or Two Lymph Node Metastases Sentinel lymph node biopsy (SLNB) is a standard axillary surgery in early breast cancer. If the SLNB result is positive, subsequent axillary lymph node dissection (ALND) is a routine procedure. In 2011, the American College of Surgeons Oncology Group Z0011 trial revealed that ALND may not be necessary in early breast cancer with one or two positive sentinel lymph nodes (...) . The purpose of this study was to compare outcomes among Korean patients with one or two positive axillary lymph nodes in the final pathology who did and did not undergo ALND.A total of 131,717 patients from the Korea Breast Cancer Society registry database received breast cancer surgery from January 1995 to December 2014. Inclusion criteria were T stage 1 or 2, one or two positive lymph nodes, and having received breast-conserving surgery (BCS), whole breast radiation therapy, and no neoadjuvant therapy

2018 Journal of breast cancer

116. Improved False-Negative Rates with Intraoperative Identification of Clipped Nodes in Patients Undergoing Sentinel Lymph Node Biopsy After Neoadjuvant Chemotherapy. (Abstract)

Improved False-Negative Rates with Intraoperative Identification of Clipped Nodes in Patients Undergoing Sentinel Lymph Node Biopsy After Neoadjuvant Chemotherapy. Identification and resection of a clipped node was shown to decrease the false-negative rate (FNR) of sentinel lymph node biopsy (SLNB) after neoadjuvant chemotherapy (NAC) for patients presenting with initially node-positive breast cancer.Between March 2014 and March 2016, a prospective trial analyzed 98 patients with axilla (...) -positive locally advanced breast cancer (T1-4, N1-3) to assess the feasibility and efficacy of placing clips into most suspicious biopsy-proven node. The study considered blue, radioisotope active, and suspiciously palpable nodes as sentinel lymph nodes (SLNs).The SLN identification rate was 87.8%. The median age of the patients with an SLNB (n = 86) was 44 years (range 28-66 years). Of these patients, 77 (88.4%) had cT1-3 disease, and 10 (11.6%) had cT4 disease. The majority of the patients (n = 66

2018 Annals of Surgical Oncology

117. The effect of internal mammary lymph node biopsy on the therapeutic decision and survival of patients with breast cancer. (Abstract)

The effect of internal mammary lymph node biopsy on the therapeutic decision and survival of patients with breast cancer. The role of internal mammary lymph node biopsy (IMLNB) is still being discussed in breast cancer treatment. The aim of this study was to investigate the role of IMLNB on adjuvant therapy and survival of patients with breast cancer.The data of 72 patients with clinically negative axilla and IMLNB were evaluated. IMLNB was performed either through a small separate intercostal (...) incision or from the same incision for tumor resection or mastectomy by using both blue dye and radioisotope. Pathological analysis was performed on formalin-fixed paraffin-embedded tissues.Ten of the patients (14%) were IMLNB-positive. The axillary sentinel lymph node and IMLN were negative in most of the patients (52.8%). In one patient (1.4%), the axilla was negative but the IMLNB was positive. IMLNB changed the pathologic stage in eight patients (11%). Adjuvant internal mammary radiotherapy

2015 European Journal of Surgical Oncology

118. Internal mammary sentinel lymph node biopsy: abandon or persist? Full Text available with Trip Pro

Internal mammary sentinel lymph node biopsy: abandon or persist? Although the 2009 American Joint Committee on Cancer incorporated the internal mammary sentinel lymph node biopsy (IM-SLNB) concept, there has been little change in surgical practice patterns due to the low visualization rate of internal mammary sentinel lymph nodes with the traditional injection technique. Meanwhile, as internal mammary lymph nodes (IMLN) metastases are mostly found concomitantly with axillary lymph nodes (ALN (...) ) metastases, previous IM-SLNB clinical trials fail to evaluate the status of IMLN in patients who are really in need (only in clinically ALN negative patients). Our modified injection technique (periareolar intraparenchymal, high volume, and ultrasonographic guidance) significantly improved the visualization rate of internal mammary sentinel lymph nodes, making the routine IM-SLNB possible in daily practice. IM-SLNB could provide individual minimally invasive staging, prognosis, and decision-making

2016 OncoTargets and therapy

119. Role of number of sentinel nodes in predicting non-sentinel node metastasis in breast cancer Full Text available with Trip Pro

Role of number of sentinel nodes in predicting non-sentinel node metastasis in breast cancer Objective The aim of the present study was to determine how many sentinel lymph nodes (SLNs) are appropriate for predicting non-SLN metastasis in breast cancer. Methods The association between clinicopathological features and non-SLN metastasis was retrospectively analyzed in 472 patients who underwent axillary lymph node dissection (ALND) following SLN biopsy. Another 251 patients who underwent only (...) SLN biopsy without ALND were analyzed and followed up for 2 years. Results A large tumor size, positive SLN, and HER-2 positivity were independent predictors of non-SLN metastasis. There were significant differences in non-SLN metastasis between patients with one negative SLN and patients with an absence of negative SLNs. There was no significant difference in non-SLN metastasis between patients with one negative SLN and two or more negative SLNs. The recurrence-free survival rate for patients who

2017 The Journal of international medical research

120. EANM practice guidelines for lymphoscintigraphy and sentinel lymph node biopsy in melanoma ? SNMMI Endorsement

EANM practice guidelines for lymphoscintigraphy and sentinel lymph node biopsy in melanoma ? SNMMI Endorsement GUIDELINES EANMpracticeguidelinesforlymphoscintigraphyandsentinel lymphnodebiopsyinmelanoma ChristinaBluemel 1 &KenHerrmann 1 &FrancescoGiammarile 2 &OmgoE.Nieweg 3 & JulienDubreuil 2 &AlessandroTestori 4 & RiccardoA.Audisio 5 &OdysseasZoras 6 & MichaelLassmann 1 &AnnetteH.Chakera 3 &RogerUren 7,8 &SotiriosChondrogiannis 9 & PatrickM.Colletti 10 &DomenicoRubello 9 Received:2July2015 (...) /Accepted:7July2015/Published online:25 July 2015 # Springer-VerlagBerlinHeidelberg2015 Abstract Purpose Sentinel lymph node biopsy is an essential staging tool in patients with clinically localized melanoma. The har- vestingofa sentinellymph nodeentailsa sequenceofproce- dures with participation of specialists in nuclear medicine, radiology, surgery and pathology. The aim of this document is to provide guidelines for nuclear medicine physicians performing lymphoscintigraphy for sentinel lymph node de

2015 Society of Nuclear Medicine and Molecular Imaging

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