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Sentinel Node Breast Biopsy

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2401. Concordance and validation study of sentinel lymph node biopsy for breast cancer using subareolar injection of blue dye and technetium 99m sulfur colloid. (PubMed)

Concordance and validation study of sentinel lymph node biopsy for breast cancer using subareolar injection of blue dye and technetium 99m sulfur colloid. We have previously demonstrated the utility, accuracy, and advantages of a subareolar (SA) site of injection for blue dye compared with an intraparenchymal site. In later studies we advocated the additional use of preoperative SA-injected technetium 99m-labeled sulfur colloid as a directional aid in finding blue-stained sentinel lymph nodes (...) (SLNs). Paramount to the usefulness of this dual-tracer, same-site technique is the degree to which SA-injected blue dye and SA-injected radiocolloid migrate concordantly and are deposited within the same sentinel nodes. The purpose of this study was to document the correlation and accuracy of SLN biopsy using blue dye and radiocolloid when both nodal markers are injected by the same SA route.Between September 1999 and February 2002 (29 months), 185 consecutive patients with 187 operable breast

2002 Journal of the American College of Surgeons

2402. Sentinel lymph node biopsy in breast cancer. (PubMed)

Sentinel lymph node biopsy in breast cancer. The concept of sentinel lymph node (SLN) biopsy in breast cancer patients is simple, attractive and rapidly emerging as a new standard of care. Several aspects of the technique of lymphatic mapping, case selection, pathologic analysis and the finding of micrometastases, and the accuracy of the technique are important subjects of study and debate in the literature and will be discussed in this review. High identification rates can be attained (...) disease control and survival will be assessed in a trial of the NSABP (National Adjuvant Breast and Bowel Project). The influence of a positive SLN biopsy with and without axillary dissection on survival and local control will be studied in trials of the BASO (British Association of Surgical Oncology), ACOSOG (American College of Surgeons Oncology Group) and EORTC (European Organisation for Research and Treatment of Cancer). These phase III trials and related studies on the importance

2002 Annals of Oncology

2403. A selection algorithm for internal mammary sentinel lymph node biopsy in breast cancer. (PubMed)

A selection algorithm for internal mammary sentinel lymph node biopsy in breast cancer. Internal mammary lymph-node (IMN) metastases in breast carcinomas have a major influence on survival, comparable with the influence of axillary lymph-node metastases (ALNM). Prospective, randomized trials have demonstrated that complete IMN dissection as part of extended radical mastectomy does not improve overall or disease-free survival. In the subset of patients with tumours 1cm or less in size (...) sentinel lymph-node (IM-SLN) biopsy. Here we review the general prognostic and clinical significance of tumor location and lymph-node metastases in breast cancer and discuss the specific factors associated with IMN identification, metastases and treatment in the pre-SLN and SLN eras. Based on our review, we propose an algorithm for a selective approach to IM-SLN in breast cancer.

2002 European Journal of Surgical Oncology

2404. Shoulder-arm morbidity following axillary dissection and sentinel node only biopsy for breast cancer. (PubMed)

Shoulder-arm morbidity following axillary dissection and sentinel node only biopsy for breast cancer. The purpose of this study was to examine the outcome of shoulder-arm morbidity in patients with breast cancer after various axillary staging procedures. We used a new specific summation score to compare conventional axillary node dissection (AD) and sentinel node only biopsy for postoperative shoulder-arm morbidity.Eighty-five patients undergoing conventional AD and 66 patients undergoing (...) sentinel node biopsy were evaluated both subjectively (questionnaire) and objectively (clinical examination) for reduced muscle strength, limited range of motion, lymphedema and pain, dysesthesias and loss of sensitivity. The symptoms elicited were rated by their severity with a single summation score describing all symptoms reported.Subjective evaluation of patients undergoing breast conserving surgery showed a highly significant difference in favor of SNB only (P< or =0.002). On clinical examination

2002 European Journal of Surgical Oncology

2405. Meta-analysis of sentinel lymph node biopsy in breast cancer. (PubMed)

Meta-analysis of sentinel lymph node biopsy in breast cancer. Sentinel lymph node biopsy (SLNB) is a minimally invasive way to diagnose axillary lymph node (ALN) metastases in breast cancer. The most important features are ability to identify the SLN (I.D. rate), how often the SLN and ALN pathology match (concordance), and how often the SLN is negative for cancer when the ALNs are positive (false negative). Technique and patient criteria for SLNB vary among studies. This study performed meta (...) -analysis of published studies to determine the I.D., concordance, and false negative rate (1) overall and for (2) both blue dye and radiocolloid, (3) the injection method, (3) palpable and nonpalpable ALNs, and (4) invasive and in situ disease.Inclusion criteria were patients with breast cancer who had SLNB followed by ALN dissection with H&E staining. Meta-analysis was performed using analysis of variance with each observation weighted inversely to its variance. P < 0.05 was considered

1999 The Journal of surgical research

2406. Sentinel node biopsy in breast cancer: A promising technique, but it should not be introduced without proper trials  (PubMed)

Sentinel node biopsy in breast cancer: A promising technique, but it should not be introduced without proper trials  9685271 1998 09 03 2018 11 13 0959-8138 317 7154 1998 Aug 01 BMJ (Clinical research ed.) BMJ Sentinel node biopsy in breast cancer. A promising technique, but it should not be introduced without proper trials. 295-6 Dixon M M eng Editorial England BMJ 8900488 0959-8138 AIM IM BMJ. 1999 Feb 27;318(7183):599 10037649 BMJ. 1999 Feb 27;318(7183):599-600 10189213 Biopsy, Needle (...) methods Breast Neoplasms pathology Female Humans Lymphatic Metastasis pathology Sensitivity and Specificity 1998 7 31 1998 7 31 0 1 1998 7 31 0 0 ppublish 9685271 PMC1113628 Ann Surg. 1994 Sep;220(3):391-8; discussion 398-401 8092905 Eur J Surg Oncol. 1998 Apr;24(2):93-5 9591021 Arch Surg. 1984 Sep;119(9):1067-72 6383272 Arch Surg. 1992 Apr;127(4):392-9 1558490 Ann Surg. 1998 May;227(5):645-51; discussion 651-3 9605656 BMJ. 1994 Nov 5;309(6963):1222-5 7987158 J Clin Oncol. 1997 Jun;15(6):2345-50

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1998 BMJ : British Medical Journal

2407. Sentinel node biopsy in breast cancer : Effect on patients must be considered (PubMed)

Sentinel node biopsy in breast cancer : Effect on patients must be considered 10037649 1999 03 30 2018 11 13 0959-8138 318 7183 1999 Feb 27 BMJ (Clinical research ed.) BMJ Sentinel node biopsy in breast cancer. Effect on patients must be considered. 599 Thornton H H eng Comment Letter England BMJ 8900488 0959-8138 AIM IM BMJ. 1998 Aug 1;317(7154):295-6 9685271 Anxiety etiology Biopsy methods Breast Neoplasms pathology Female Humans Lymph Nodes pathology 1999 2 26 1999 2 26 0 1 1999 2 26 0 0

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1999 BMJ : British Medical Journal

2408. Functional Lymphatic Anatomy for Sentinel Node Biopsy in Breast Cancer: Echoes from the Past and the Periareolar Blue Method (PubMed)

Functional Lymphatic Anatomy for Sentinel Node Biopsy in Breast Cancer: Echoes from the Past and the Periareolar Blue Method To simplify and improve the technique of axillary sentinel node biopsy, based on a concept of functional lymphatic anatomy of the breast.Because of their common origin, the mammary gland and its skin envelope share the same lymph drainage pathways. The breast is essentially a single unit and has a specialized lymphatic system with preferential drainage, through select (...) analyzed.Radiolabeled axillary nodes were identified in 210 procedures, and these were colored blue in 200 cases (94%). The targeting concordance between peritumoral radiocolloid and intradermal blue dye was unrelated to the breast tumor location or the site of dye injection. Radioactive sentinel nodes were not stained blue in 10 procedures (5%), but this mismatching could be explained by technical problems in all cases. In two cases (1%), the (pathologic) sentinel node was blue but had no detectable radiocolloid

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2000 Annals of Surgery

2409. Dermal Injection of Radioactive Colloid Is Superior to Peritumoral Injection for Breast Cancer Sentinel Lymph Node Biopsy: Results of a Multiinstitutional Study (PubMed)

Dermal Injection of Radioactive Colloid Is Superior to Peritumoral Injection for Breast Cancer Sentinel Lymph Node Biopsy: Results of a Multiinstitutional Study To determine the optimal radioactive colloid injection technique for sentinel lymph node (SLN) biopsy for breast cancer.The optimal radioactive colloid injection technique for breast cancer SLN biopsy has not yet been defined. Peritumoral injection of radioactive colloid has been used in most studies. Although dermal injection (...) of radioactive colloid has been proposed, no published data exist to establish the false-negative rate associated with this technique.The University of Louisville Breast Cancer Sentinel Lymph Node Study is a multiinstitutional study involving 229 surgeons. Patients with clinical stage T1-2, N0 breast cancer were eligible for the study. All patients underwent SLN biopsy, followed by level I/II axillary dissection. Peritumoral, subdermal, or dermal injection of radioactive colloid was performed

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2001 Annals of Surgery

2410. Defining the Optimal Surgeon Experience for Breast Cancer Sentinel Lymph Node Biopsy: A Model for Implementation of New Surgical Techniques (PubMed)

Defining the Optimal Surgeon Experience for Breast Cancer Sentinel Lymph Node Biopsy: A Model for Implementation of New Surgical Techniques To determine the optimal experience required to minimize the false-negative rate of sentinel lymph node (SLN) biopsy for breast cancer.Before abandoning routine axillary dissection in favor of SLN biopsy for breast cancer, each surgeon and institution must document acceptable SLN identification and false-negative rates. Although some studies have examined (...) the impact of individual surgeon experience on the SLN identification rate, minimal data exist to determine the optimal experience required to minimize the more crucial false-negative rate.Analysis was performed of a large prospective multiinstitutional study involving 226 surgeons. SLN biopsy was performed using blue dye, radioactive colloid, or both. SLN biopsy was performed with completion axillary LN dissection in all patients. The impact of surgeon experience on the SLN identification and false

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2001 Annals of Surgery

2411. Sentinel lymph node biopsy in breast cancer: the GIVOM experience in Veneto, Italy. (PubMed)

Sentinel lymph node biopsy in breast cancer: the GIVOM experience in Veneto, Italy. 12369554 2002 10 11 2017 12 13 0300-8916 88 3 2002 May-Jun Tumori Tumori Sentinel lymph node biopsy in breast cancer: the GIVOM experience in Veneto, Italy. S52-4 Zavagno G G Clinica Chirurgica II, Università di Padova, Italy. giorgio.zavagno@unipd.it Meggiolaro F F Bozza F F Scalco G G Racano C C Rubello D D Pescarini L L De Salvo G G Lise M M eng Clinical Trial Journal Article Multicenter Study Randomized (...) Controlled Trial Research Support, Non-U.S. Gov't United States Tumori 0111356 0300-8916 0 Radiopharmaceuticals 0 Technetium Tc 99m Aggregated Albumin 0 technetium Tc 99m nanocolloid IM Adult Aged Axilla Breast Neoplasms diagnostic imaging pathology surgery Female Humans Italy Lymph Nodes diagnostic imaging pathology surgery Lymphatic Metastasis Middle Aged Radionuclide Imaging Radiopharmaceuticals Sentinel Lymph Node Biopsy methods Technetium Tc 99m Aggregated Albumin Treatment Outcome 2002 10 9 4 0

2002 Tumori Controlled trial quality: uncertain

2412. Sentinel lymph node biopsy in breast cancer patients: subdermal versus peritumoural radiocolloid injection. (PubMed)

Sentinel lymph node biopsy in breast cancer patients: subdermal versus peritumoural radiocolloid injection. Sentinel lymph node (SLN) biopsy has been widely used in the management of melanoma and breast cancer. The aims of this study were (1) to compare the results obtained with the two main injection techniques, the peritumoural and subdermal; and (2) to determine the reliability of SLN to predict the regional lymph node status.We prospectively studied 80 women (mean age 56 years) with breast (...) to reach the SLN. All nodes harvested were analysed by classic pathology techniques.Overall, lymphoscintigraphy allowed the detection of SLN in 75/80 patients (94%). All subdermal lymphoscintigraphies were positive (36/36) compared with 89% of peritumoural (39/44). Blue dye detected SLN in 23/31 patients (74%) after subdermal injection and in 24/34 patients (71%) after peritumoural injection. The sensitivity to localize the SLN with lymphoscintigraphy+blue dye+gamma probe was 92% (33/36) within

2001 Nuclear medicine communications Controlled trial quality: uncertain

2413. The impact of preoperative breast biopsy on the risk of sentinel lymph node metastases: analysis of 2502 cases from the Austrian sentinel node biopsy study group (PubMed)

The impact of preoperative breast biopsy on the risk of sentinel lymph node metastases: analysis of 2502 cases from the Austrian sentinel node biopsy study group Preoperative breast biopsy might cause disaggregation of tumour cells and tumour cell spread. The purpose of this study was to investigate the impact of preoperative biopsy on the rate of metastases to the sentinel lymph node (SLN) of patients with primary breast cancer. We report the results of 2502 patients with primary breast cancer (...) , who were operated, and a sentinel node biopsy was performed. The association of preoperative biopsy with the risk of SLN metastases was examined by regression analyses and tested for possible confounding well-known factors for axillary node metastases. In all, 1890 patients were available for final analyses; 1048 (55.4%) patients had a preoperative diagnosis performed by fine-needle aspiration or core biopsy; 641 (33.9%) patients had a positive SLN when conventional H&E and IHC staining

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2004 British journal of cancer

2414. Second biopsy of axillary sentinel lymph node for reappearing breast cancer after previous sentinel lymph node biopsy. (PubMed)

Second biopsy of axillary sentinel lymph node for reappearing breast cancer after previous sentinel lymph node biopsy. Sentinel lymph node biopsy (SLNB) is a safe and accurate axillary staging procedure for patients with primary operable breast cancer. An increasing proportion of these patients undergo breast-conserving surgery, and 5% to 15% will develop local relapses that necessitate reoperation. Although a previous SLNB is often considered a contraindication for a subsequent SLNB, few data (...) recurrences), preoperative lymphoscintigraphy showed an axillary sentinel lymph node, with a preoperative identification rate of 100%, and 1 or more SLNs (an average of 1.3 per patient) were surgically removed. Sentinel lymph node metastases were detected in two patients with invasive recurrence, and a complete axillary dissection followed. At a median follow up of 12.7 months, no axillary recurrences have occurred in patients who did not undergo axillary dissection.Second SLNB after previous SLNB

2005 Annals of Surgical Oncology

2415. Sentinel Lymph Node Biopsy to Assess Axillary Lymph Nodes in Women With Stage I or Stage II Breast Cancer

Sentinel Lymph Node Biopsy to Assess Axillary Lymph Nodes in Women With Stage I or Stage II Breast Cancer Sentinel Lymph Node Biopsy to Assess Axillary Lymph Nodes in Women With Stage I or Stage II Breast Cancer - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100 (...) ). Please remove one or more studies before adding more. Sentinel Lymph Node Biopsy to Assess Axillary Lymph Nodes in Women With Stage I or Stage II Breast Cancer The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00005821 Recruitment Status : Unknown Verified March 2003 by National Cancer Institute (NCI

2000 Clinical Trials

2416. Sentinel node biopsy as a practical alternative to axillary lymph node dissection in breast cancer patients: an approach to its validity. (PubMed)

Sentinel node biopsy as a practical alternative to axillary lymph node dissection in breast cancer patients: an approach to its validity. Sentinel node biopsy (SNB) has been proposed as an alternative to axillary lymph-node dissection (ALND) in breast cancer. Before implementing SNB in our practice, we wished to test its validity by comparing it to the standard ALND, both in our hands and with other reported series.One hundred thirty-two patients were included prospectively. SNB and immediate

2001 Annals of oncology : official journal of the European Society for Medical Oncology / ESMO

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