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Self Skin Exam

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161. Association of Vitamin D Receptor Polymorphisms With the Risk of Nonmelanoma Skin Cancer in Adults. Full Text available with Trip Pro

Association of Vitamin D Receptor Polymorphisms With the Risk of Nonmelanoma Skin Cancer in Adults. Protective effects of UV-B radiation against nonmelanoma skin cancer (NMSC) are exerted via signaling mechanisms involving the vitamin D receptor (VDR). Recent studies have examined single-nucleotide polymorphisms (SNPs) in the VDR, resulting in contradictory findings as to whether these polymorphisms increase a person's risk for NMSC.To examine whether the polymorphisms in the VDR gene (...) (46%) were men and 54 (54%) were women, with a mean (SD) age of 63 (9) years. All participants self-identified as non-Hispanic white. A model including age, sex, and skin color was created to most effectively predict the incidence of skin cancer. Risk factors that significantly increased the odds of an NMSC diagnosis were light skin color (OR, 5.79 [95% CI, 2.79-11.99]), greater number of severe sunburns (OR, 2.59 [95% CI, 1.31-5.10]), light eye color (OR, 2.47 [95% CI, 1.30-4.67]), and less

2017 JAMA dermatology (Chicago, Ill.)

162. Clinical and Histologic Evaluation of Ingenol Mebutate 0.015% Gel for the Cosmetic Improvement of Photoaged Skin. (Abstract)

Clinical and Histologic Evaluation of Ingenol Mebutate 0.015% Gel for the Cosmetic Improvement of Photoaged Skin. No studies have examined the use of topical ingenol mebutate for improvement of photoaged skin.To evaluate clinical results of ingenol mebutate gel applied to photoaged skin and to quantify improvement at 7, 30, and 60 days after application.Twenty-five subjects were enrolled in the study. Picato (ingenol mebutate) (LEO Pharma, Parsippany, NJ) gel was applied to an area with a known (...) actinic keratosis daily for 3 days. Subjects self-evaluated and were investigator evaluated on 6 characteristics on Days 7, 30, and 60 using an objective scale. The scale evaluated actinic keratosis, overall skin appearance, wrinkling, dyschromia, erythema, and texture. The subjects were also evaluated using the Griffiths' Photonumeric Photoaging Scale for overall improvement.Twenty-two subjects completed the clinical study and demonstrated statistically significant improvement by Day 60 in actinic

2017 Dermatologic Surgery

163. CD8<sup>+</sup> lineage dendritic cells determine adaptive immune responses to inflammasome activation upon sterile skin injury. (Abstract)

CD8+ lineage dendritic cells determine adaptive immune responses to inflammasome activation upon sterile skin injury. The molecular links between sterile inflammation and induction of adaptive immunity have not been fully identified. Here, we examine how damage-associated molecular patterns (DAMPs), as opposed to pathogen-associated molecules (PAMPs), regulate the immune response to non-self-antigens presented at the site of a physical injury. Heat applied briefly to the skin invokes (...) sterile inflammation, characterized by local cell death and caspase-1 activation without demonstrably disrupting skin integrity. Co-delivery of ovalbumin (OVA) with heat injury induces OVA-specific CD8+ T-cell responses, and this is dependent on caspase-1 activation and MyD88 signalling. Using Id2flox/flox-CD11cCre+ mice, we demonstrate that CD8+ lineage DCs are required to induce OVA-specific CD8+ T-cell responses following heat injury. Consistent with this observation, intradermal administration

2017 Experimental Dermatology

164. The Effect of Skin Pigmentation on Determination of Limb Ischemia. (Abstract)

The Effect of Skin Pigmentation on Determination of Limb Ischemia. Timely identification of tissue ischemia is critical, both in the traumatized limb and following free tissue transfer. The purpose of this study was to determine if skin pigmentation affects the ability to detect limb ischemia.We conducted a study of healthy controls exposed to limb ischemia. The subjects were classified based on skin pigmentation using a defined skin type assessment tool, a visual color scale, and self (...) -description of race. Participants were randomized by limb and tourniquet status; surgeons were blinded to both. Ischemia was induced by tourniquet insufflations, and board-certified orthopedic and plastic surgeons who had completed an accredited hand surgery fellowship conducted physical examinations. The surgeons monitored the forearms at 2, 6, and 10 minutes based on appearance of ischemia, capillary refill, and color in 3 locations on the limbs (posterior interosseous artery flap skin territory, radial

2017 Journal of Hand Surgery - American

165. Evaluation of the Nutritional Supplement Lycoderm on Its Impact on Skin Parameters

, and this damage results in aging of the skin (as well as other systems). The aim of this study is to examine the effects of an oral antioxidant supplement on skin aging and skin condition. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 60 participants Allocation: Randomized Intervention Model: Parallel Assignment Intervention Model Description: Double Blind, Randomized, Placebo-Controlled Masking: Quadruple (Participant, Care Provider (...) and 55 years old, inclusive at enrollment Subjects in good general health with no serious illnesses which might interfere with study participation per assessment of investigator. Subjects with BMI <30 kg/m2 Nonsmokers (self-reported) Agree to maintain current dietary regimen Agree to maintain current cosmetic regimen Skin Type II/ III. Subjects with dull skin, lack of radiance, uneven skin tone, lines and wrinkles as determined by an expert grader at Baseline. Exclusion Criteria: Subjects with known

2017 Clinical Trials

166. The Mole Mapper Study, mobile phone skin imaging and melanoma risk data collected using ResearchKit Full Text available with Trip Pro

The Mole Mapper Study, mobile phone skin imaging and melanoma risk data collected using ResearchKit Sensor-embedded phones are an emerging facilitator for participant-driven research studies. Skin cancer research is particularly amenable to this approach, as phone cameras enable self-examination and documentation of mole abnormalities that may signal a progression towards melanoma. Aggregation and open sharing of this participant-collected data can be foundational for research

2017 Scientific data

167. Relationship of shoulder activity and skin intrinsic fluorescence with low level shoulder pain and disability in people with type 2 diabetes Full Text available with Trip Pro

with shoulder pain and disability.Eighty-one participants, T2DM (n=52) and controls (n=29), were examined for magnitude and duration of shoulder activity (measured using accelerometers), skin intrinsic florescence (SIF) as a surrogate measure of AGE level, and the Shoulder Pain and Disability Index (SPADI) as a self-report of shoulder pain and disability.Compared with controls, T2DM participants had 23% less shoulder activity (p=0.01), greater SIF level (3.6±1.7 vs 2.7±0.6AU, p=0.01), less shoulder strength (...) Relationship of shoulder activity and skin intrinsic fluorescence with low level shoulder pain and disability in people with type 2 diabetes People with type 2 diabetes (T2DM) have a high incidence of musculoskeletal disorders thought to be influenced by high non-enzymatic advanced glycated end-products (AGEs). The goals of this study were to determine differences in shoulder activity level and AGEs in people with T2DM compared to matched controls, and to determine factors associated

2017 Journal of diabetes and its complications

168. Skin-nipple-sparing mastectomy: The first approach in primary myxoid chondrosarcoma of the breast Full Text available with Trip Pro

Skin-nipple-sparing mastectomy: The first approach in primary myxoid chondrosarcoma of the breast The primary mammary chondrosarcoma corresponds to less than 0,5% of the mammary malignancies. For the period ranging from 1967 to 2014, only 18 cases were reported in the literature. A 41year old woman found a hard nodule on her external right superior quadrant/axillary prolongation through breast self-examination. The vacuum-assisted core biopsy (VACB) revealed "high grade extra-skeletal myxoid (...) chondrosarcoma". A skin-nipple-sparing mastectomy with the insertion of a mammary expander was performed. A protocol of adjuvant radiotherapy was also indicated. Until 2013, the gold standard was the radical mastectomy. By 2014, there were two cases of conservative approach to quadrantectomy. To our knowledge, this represents the first case in the literature in which a skin-nipple-sparing mastectomy has been performed on a primitive mesenchymal neoplasm of the breast. Such an oncoplastic approach

2017 International journal of surgery case reports

169. A quantitative and non-contact technique to characterise microstructural variations of skin tissues during photo-damaging process based on Mueller matrix polarimetry Full Text available with Trip Pro

, then analysed the transformed parameters to characterise microstructural changes during the skin photo-damaging and self-repairing processes. Comparisons between samples with and without the application of a sunscreen showed that the Mueller matrix-derived parameters are potential indicators for fibrous microstructure in skin tissues. Histological examination and Monte Carlo simulations confirmed the relationship between the Mueller matrix parameters and changes to fibrous structures. This technique paves (...) A quantitative and non-contact technique to characterise microstructural variations of skin tissues during photo-damaging process based on Mueller matrix polarimetry Skin tissue consists of collagen and elastic fibres, which are highly susceptible to damage when exposed to ultraviolet radiation (UVR), leading to skin aging and cancer. However, a lack of non-invasive detection methods makes determining the degree of UVR damage to skin in real time difficult. As one of the fundamental features

2017 Scientific reports

170. A qualitative exploration of Latinos’ perceptions about skin cancer: The role of gender and linguistic acculturation Full Text available with Trip Pro

A qualitative exploration of Latinos’ perceptions about skin cancer: The role of gender and linguistic acculturation Latinos have the highest rate of skin cancers among U.S. minorities. Despite a rising incidence of melanoma-the deadliest form of skin cancer-and greater disease burden, Latinos tend to have poor awareness of skin cancer risk factors which may inhibit preventive action. We expanded on prior work by qualitatively examining potential moderators (i.e., gender, acculturation (...) ) of skin cancer perceptions among Latinos from El Barrio in Harlem, New York City. Four focus groups stratified by language (English/Spanish) and gender were conducted. Discussions were recorded, transcribed, and coded using thematic analysis. Thirty-eight self-identified Latinos (32 % male) participated. Across groups, median age was 35 years; 50 % completed

2017 Journal of cancer education : the official journal of the American Association for Cancer Education

171. Tattoos as a window to the psyche: How talking about skin art can inform psychiatric practice Full Text available with Trip Pro

clinicians working with tattooed patients to facilitate an exploration of the personal meaning of skin art and self-identity. We suggest that as a kind of augmentation of the physical exam, looking at and talking to patients about their tattoos can provide a valuable window into the psyche, informing clinical practice. (...) Tattoos as a window to the psyche: How talking about skin art can inform psychiatric practice Tattooing the skin as a means of personal expression is a ritualized practice that has been around for centuries across many different cultures. Accordingly, the symbolic meaning of tattoos has evolved over time and is highly individualized, from both the internal perspective of the wearer and the external perspective of an observer. Within modern Western societies through the 1970s, tattoos

2017 World journal of psychiatry

172. Implementing an Internet-Delivered Skin Cancer Genetic Testing Intervention to Improve Sun Protection Behavior in a Diverse Population: Protocol for a Randomized Controlled Trial Full Text available with Trip Pro

in Hispanics.Variants in the melanocortin-1 receptor (MC1R) gene are present in approximately 50% of the population, are major factors in determining sun sensitivity, and confer a 2-to-3-fold increase in melanoma risk in the general population, even in populations with darker skin. Therefore, feedback regarding MC1R risk status may raise risk awareness and protective behavior in the general population.We are conducting a randomized controlled trial examining Internet presentation of the risks and benefits (...) risk arm; n=135 in control arm), and will be recruited from a general population cohort in Albuquerque, New Mexico, which is subject to year-round sun exposure. Baseline surveys will be completed in-person with study staff and follow-up measures will be completed via telephone.Aim 1 of the trial will examine the personal utility of personalized genomic testing for melanoma risk in terms of short-term (3-month) sun protection and skin screening behaviors, family and physician communication

2017 JMIR Research Protocols Controlled trial quality: uncertain

173. Evaluation Study of SPOTme® Skin Cancer Screenings

will have participated in the AAD SPOTmeⓇ skin cancer screening program in either 2016 or 2017 only. Other: AAD SPOTmeⓇ skin cancer screening All study participants will have participated in the AAD SPOTmeⓇ skin cancer screening program in either 2016 or 2017. Outcome Measures Go to Primary Outcome Measures : Completion of a physician skin examination [ Time Frame: Baseline ] Self-report of a physician skin examination will be defined as a health care provider examining the patient's entire body for any (...) sign of skin cancer during the period following patient's receipt of an AAD SPOTme® skin cancer screening to the baseline assessment. Secondary Outcome Measures : Completion of a physician skin examination [ Time Frame: 6 months ] Self-report of a physician skin examination will be defined as a health care provider examining the patient's entire body for any sign of skin cancer during the 3 months prior to the 6-month follow up assessment Patient thorough skin self-examination (TSSE) [ Time Frame

2017 Clinical Trials

174. Exploration of the Modulation of Skin Microbiota and Odor Components by Introduction of Stress in Healthy Male Subjects

Exploration of the Modulation of Skin Microbiota and Odor Components by Introduction of Stress in Healthy Male Subjects Exploration of the Modulation of Skin Microbiota and Odor Components by Introduction of Stress in Healthy Male Subjects - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum (...) number of saved studies (100). Please remove one or more studies before adding more. Exploration of the Modulation of Skin Microbiota and Odor Components by Introduction of Stress in Healthy Male Subjects (MOIST) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03384030 Recruitment Status : Completed

2017 Clinical Trials

175. Skin Ageing Signatures and Cancer

or other skin diseases. 5 of these patients will have high levels of skin ageing and 5 will have low levels of skin ageing as defined by a set of pre-defined criteria. The criteria will be identified by examining the skin on the participants face and forearm. The study sponsor will collect skin and blood samples from all participants in the high and low skin ageing groups and these will be sent to a specialist laboratory for DNA and RNA analysis (genetic analysis). The study sponsor hope (...) , electrocoagulation, laser, sclerotherapy, reconstructive surgery, botox injection, filler injection. Currently using a hormone based cream that is applied on the forearm for hormonal replacement therapy. Have had a change in skin colour during within one month prior to study entry due to sun exposure Had a session of UV therapy for treatment purposes or in a beauty salon within one month prior to study entry. Use of a self-tanning product Contacts and Locations Go to Information from the National Library

2017 Clinical Trials

176. Cosmetic Study of AO+Mist in Improving the Appearance of Skin Afflicted With Keratosis Pilaris

bottle and asked to self-administer the Test Product as follows: LEFT side of the body where skin is affected: Five (5) pumps of Spray (BOTTLE LABELED: LEFT) must be applied twice-a-day to the entire area affected by KP once in the morning and once in the evening for 28 days. RIGHT side of the body where skin is affected: Five (5) pumps of Spray (BOTTLE LABELED: RIGHT) must be applied twice-a-day to the entire area affected by KP once in the morning and once in the evening for 28 days. Subjects may (...) not wash their body with soap and water AFTER the applications Other: AO+Mist Subjects are instructed in the use of the spray bottle and asked to self-administer the Test Product as follows: LEFT side of the body where skin is affected: Five (5) pumps of Spray (BOTTLE LABELED: LEFT) must be applied twice-a-day to the entire area affected by KP once in the morning and once in the evening for 28 days. RIGHT side of the body where skin is affected: Five (5) pumps of Spray (BOTTLE LABELED: RIGHT) must

2017 Clinical Trials

177. Cosmetic Study to Improve the Appearance of Skin Afflicted With Mild to Moderate Atopic Dermatitis.

the arm the product is to be applied to. Subjects will be instructed in the use of the spray bottle and asked to self-administer the Test Product as follows: LEFT arm where skin is affected: 4 pumps of Spray which is labeled accordingly must be applied twice-a-day to the area on the arm affected by AD- once in the morning and once in the evening for 30 days. RIGHT arm where skin is affected: 4pumps of Spray which is labeled accordingly must be applied twice-a-day to the area on the arm affected by AD (...) - once in the morning and once in the evening for 30 days. Placebo Comparator: Placebo Placebo Other: Placebo Subjects receive 2 bottles of product at the Baseline visit for left and right side application. One bottle will contain Placebo only, the other bottle will contain "AO+Mist". Label on each bottle will indicate the arm the product is to be applied to. Subjects will be instructed in the use of the spray bottle and asked to self-administer the Test Product as follows: LEFT arm where skin

2017 Clinical Trials

178. Determination of the Sun Protection Factor (SPF) of a Cosmetic Daily De-fence Skin Cream

abnormalities in medical history or upon physical examination Subjects with a Fitzpatrick Skin Type of I, II or III Subjects with an Individual typological angle (ITA°) greater than 28° Exclusion Criteria: Women who are known to be pregnant or who are intending to become pregnant over the duration of the study Women who are breast-feeding or lactating Subjects having used medication with known photo-toxic and/or photosensitizing potential (e.g. hypericum perforatum, antibiotics, blood pressure regulating (...) Determination of the Sun Protection Factor (SPF) of a Cosmetic Daily De-fence Skin Cream Determination of the Sun Protection Factor (SPF) of a Cosmetic Daily De-fence Skin Cream - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies

2017 Clinical Trials

179. To Investigate the Cutaneous and Ocular Local Tolerance of Two Cosmetic Facial Cleanser in Healthy Females With Sensitive Skin

and has received a signed and dated copy of the informed consent form Good general and mental health with, in the opinion of the investigator or medically qualified designee no clinically significant and relevant abnormalities in medical history or upon physical (dermatologist or ophthalmologist) examination Fitzpatrick phototype I to IV Sensitive Skin (as determined by the lactic acid Stinging test) Dermatologist score of zero Ophthalmologist score of zero Dermatologist assessed Dry or Normal (...) To Investigate the Cutaneous and Ocular Local Tolerance of Two Cosmetic Facial Cleanser in Healthy Females With Sensitive Skin To Investigate the Cutaneous and Ocular Local Tolerance of Two Cosmetic Facial Cleanser in Healthy Females With Sensitive Skin - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached

2017 Clinical Trials

180. SMART Project in Preventing Skin Cancer

Study Description Go to Brief Summary: This pilot clinical trial studies how well Self Monitoring And Readiness Texting (SMART) project works in sun exposure and protection behaviors. Measuring how behavior tracking and individually tailored messages affect risk behaviors in patients with skin cancer may help doctors plan the best prevention plan and decrease national melanoma incidence and mortality. Condition or disease Intervention/treatment Phase Skin Carcinoma Behavioral: Compliance Monitoring (...) will be considered worthy of further study. Secondary Outcome Measures : Mediators and moderators of the intervention on behavior [ Time Frame: At 2 weeks ] Mediation will be assessed by examining indirect effects, with bootstrapped confidence intervals to be calculated around the mediated effects. For participants who use the self-monitoring app, hierarchical linear modeling will be used to examine associations between tanning and sun protection as they occur daily, and motives for doing so. Using lagged multi

2017 Clinical Trials

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