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Secondary Syphilis

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2. What is the effect of syphilis testing frequency on the incidence of syphilis in men who have sex with men (MSM)?

detection of asymptomatic syphilis, reduced complications of syphilis infection and led to relative falls in secondary syphilis for MSM ? mathematical models suggest that increasing the frequency of syphilis testing is more important than increasing the proportion of at-risk population tested ? the models suggest that syphilis testing would need to occur at least twice a year, and involve those at highest risk in order to see annual syphilis diagnoses fall to low levels ? one model indicated (...) include primary, secondary, and tertiary syphilis. Risk factors for acquiring syphilis include a previous syphilis infection, an infected sexual partner, current HIV infection, or >4 sexual partners in the preceding year (1). In Australia and the UK, syphilis cases have risen steadily from about 2000, and it is once again an established endemic infection (2). Public Health England reported that there were 7,137 diagnoses of syphilis in 2017, a 20% increase (from 5,955 cases) relative to 2016

2018 Public Health England - Evidence Briefings

3. Oral forms of secondary syphilis, an illustration of the pitfalls set by the great imitator. (Abstract)

Oral forms of secondary syphilis, an illustration of the pitfalls set by the great imitator. Syphilis is reemerging in certain populations, such as men who have sex with men (MSM), in particular. Oral manifestations are not uncommon and can render diagnosis difficult, particularly if seen in isolation.We recovered clinical data for all patients diagnosed with secondary syphilis referred to the national reference center for syphilis in Paris, France, from January 2000 to July 2019. We selected (...) for patients with isolated oral symptoms (8.8 vs. 1.8 months p = 0.02).Oral presentations of secondary syphilis are frequent and challenging for diagnosis, even in patients with epidemiological risk factors. Clinicians confronted with subacute oral lesions in such patients should bear in mind the possibility of this contagious, curable and sometimes severe disease.Copyright © 2020. Published by Elsevier Inc.

2020 Journal of American Academy of Dermatology

4. Increased syphilis testing of men who have sex with men: greater detection of asymptomatic early syphilis and relative reduction in secondary syphilis. Full Text available with Trip Pro

Increased syphilis testing of men who have sex with men: greater detection of asymptomatic early syphilis and relative reduction in secondary syphilis. Syphilis rates have increased markedly among men who have sex with men (MSM) internationally. We examined trends in syphilis testing and detection of early syphilis among MSM in Australia.Serial cross-sectional analyses on syphilis testing and diagnoses among MSM attending a national sentinel network of 46 clinics in Australia between 2007 (...) of infections that were early latent increased from 27% to 44% (Ptrend < .0001), while the proportion that were secondary decreased from 24% to 19% (Ptrend = .030). Among HIV-positive MSM, early latent infections increased from 23% to 45% (Ptrend < .0001), while secondary infections decreased from 45% to 26% (Ptrend = .0003). Among HIV-positive MSM, decreasing secondary syphilis correlated with increasing testing coverage (r = -0.87; P = .005) or frequency (r = -0.93; P = .001).Increases in syphilis

2017 Clinical Infectious Diseases

5. A lung abscess caused by secondary syphilis - the utility of polymerase chain reaction techniques in transbronchial biopsy: a case report. Full Text available with Trip Pro

A lung abscess caused by secondary syphilis - the utility of polymerase chain reaction techniques in transbronchial biopsy: a case report. In Japan and other countries, the number of patients with syphilis is increasing year by year. Recently, the cases of the pulmonary involvement in patients with secondary syphilis have been reported. However, it is still undetermined how to obtain a desirable specimen for a diagnosis of the pulmonary involvement, and how to treat it if not cured.A 34-year (...) -old man presented with cough and swelling of the right inguinal nodes. A physical examination revealed erythematous papular rash over the palms, soles and abdomen. A 4 cm mass in the right lower lobe of the lung was detected on computed tomography. He was diagnosed as having secondary syphilis, because he was tested positive for the rapid plasma reagin and Treponema pallidum hemagglutination assay. Amoxycillin and probenecid were orally administered for 2 weeks. Subsequently, rash and serological

2019 BMC Infectious Diseases

6. Histopathological Features Distinguishing Secondary Syphilis from its Mimickers. (Abstract)

Histopathological Features Distinguishing Secondary Syphilis from its Mimickers. Syphilis is often misdiagnosed clinically, and biopsies may be required.To determine histopathological features that distinguish secondary syphilis from pityriasis lichenoides (PL), pityriasis rosea (PR), and early mycosis fungoides (MF).Histopathological features of 100 cases of syphilis, 110 cases of PL, 72 cases of PR, and 101 cases of MF were compared.Elongated rete ridges and interstitial inflammation favor (...) syphilis over PL (likelihood ratios 3.44 and 2.72 respectively), but no feature reliably distinguishes between them. Secondary syphilis and PR may be distinguished by neutrophils in the stratum corneum, plasma cells, interface dermatitis with lymphocytes and vacuoles, and lymphocytes with ample cytoplasm. Plasma cells and lymphocytes with ample cytoplasm are rare in early MF and can be distinguishing features.Histopathological features characteristic of syphilis may be seen in PL, PR and early MF

2019 Journal of American Academy of Dermatology

7. Histologic Features of Secondary Syphilis. (Abstract)

Histologic Features of Secondary Syphilis. Secondary syphilis is a sexually transmitted infection, which is referred to as "the great imitator" and has a wide spectrum of clinical manifestations. As a result, it is essential to identify potential secondary syphilis patients with ambiguous clinical manifestation through pathology.We sought to analyze the pathological features of secondary syphilis.We analyzed 59 biopsy specimens from 56 patients with secondary syphilis. Cases were classified (...) according to the histological characteristics and clinical features.Necrotic keratinocytes could be observed in 39 of 59 (66.1%) secondary specimens. Plasma cells (86.4%) were the most common finding overall. The presence of Treponema pallidum was detected mostly at the dermal-epidermal junction. There was no statistical significance between pathological features and age, HIV status, or RPR titer.Necrotic keratinocytes are one of the characteristics of secondary syphilis. The combination of plasma cells

2019 Dermatology

8. Vegetating lesions in secondary syphilis. Reply from authors. (Abstract)

Vegetating lesions in secondary syphilis. Reply from authors. We thank Dr del Giudice1 for his interest in our recent article in Clinical and Experimental Dermatology.2 Our review encompassed the topic of oral ulceration as a manifestation of secondary syphilis and provided by way of example the case histories of two patients. While we agree that the lesions shown in Fig. 2 are raised above the mucosal surface and are in their view 'vegetating', we described the lesions as 'mucous patches

2019 Clinical & Experimental Dermatology

9. Vegetating lesions in secondary syphilis. (Abstract)

Vegetating lesions in secondary syphilis. 30748034 2019 03 09 1365-2230 2019 Feb 12 Clinical and experimental dermatology Clin. Exp. Dermatol. Vegetating lesions in secondary syphilis. 10.1111/ced.13949 Del Giudice P P Infectiology-Dermatology Unit, Centre Hospitalier Intercommunal de Fréjus Saint Raphaël, Fréjus, France. eng Letter 2019 02 12 England Clin Exp Dermatol 7606847 0307-6938 2019 02 11 2019 2 13 6 0 2019 2 13 6 0 2019 2 13 6 0 aheadofprint 30748034 10.1111/ced.13949

2019 Clinical & Experimental Dermatology

10. Secondary syphilis presenting as a corymbiform syphilide: case report and review Full Text available with Trip Pro

Secondary syphilis presenting as a corymbiform syphilide: case report and review It is essential that healthcare providers are familiar with the full spectrum of clinical presentations of syphilis. A rare manifestation of secondary syphilis is the corymbiform (or corymbose) arrangement, in which a central greater papule is surrounded by smaller satellite lesions. Very few reports of corymbiform syphilis are available in current biomedical databases. We present the case of a 28 year-old HIV (...) -infected male patient on regular, successful antiretroviral therapy who developed an asymptomatic corymbiform maculopapular lesion in the medial aspect of the right thigh. There were also a few brownish macular lesions on the left sole. New serological tests for syphilis (which had been negative in the past) were reactive. The coymbiform lesion slowly regressed and the non-treponemal test reverted to negative after benzathine penicillin G treatment. A review of the literature is provided

2018 Revista do Instituto de Medicina Tropical de São Paulo

11. Liver Cholestasis Secondary to Syphilis in an Immunocompetent Patient Full Text available with Trip Pro

Liver Cholestasis Secondary to Syphilis in an Immunocompetent Patient Liver involvement is a known feature of secondary syphilis. The prevalence of hepatitis in secondary syphilis ranges broadly from 1 to 50%. We report a case of a 37-year-old man with type 1 diabetes mellitus and sickle cell trait presenting with jaundice and acute liver cholestasis. Abdominal ultrasound revealed mild hepatic fatty infiltration. RPR and Treponema pallidum IgG results were positive with a reflex titer of 1:64

2018 Case Reports in Hepatology

12. Rare Case of Four Osseous Lesions of the Skull in a Patient with Secondary Syphilis Full Text available with Trip Pro

Rare Case of Four Osseous Lesions of the Skull in a Patient with Secondary Syphilis Syphilis is a sexually transmitted infection that is caused by the bacterium Treponema pallidum. Syphilis can present as primary, secondary, tertiary, or congenital. It can have an effect on many different organ systems and tissues leading to a wide variety of symptoms and complications; one rare manifestation is bone involvement. The patient in this case was diagnosed with secondary and early neurosyphilis (...) and was also found to have skull lesions that were due to Treponema pallidum. There are guidelines for the treatment of primary, secondary, tertiary, and congenital syphilis; however, there are currently no guidelines for the treatment of syphilis with bone involvement.

2018 Case reports in infectious diseases

13. Secondary Syphilis with Tonsillar and Cervical Lymphadenopathy and a Pulmonary Lesion Mimicking Malignant Lymphoma Full Text available with Trip Pro

Secondary Syphilis with Tonsillar and Cervical Lymphadenopathy and a Pulmonary Lesion Mimicking Malignant Lymphoma BACKGROUND Syphilis is a sexually transmitted disease caused by the pathogen Treponema pallidum. Prevalence continues to rise, especially among men who have sex with men (MSM). Due to changes in patterns of sexual activity, manifestations of the disease are highly variable. CASE REPORT A 27-year-old male visited the hospital for a low-grade fever and tender 5-cm mass in the right (...) plasma reagin (RPR) and T. pallidum latex agglutination (TPLA) tests were positive. The patient was MSM and reported oral sex with many sexual partners. A diagnosis of secondary syphilis was made. Oral amoxicillin was effective, and all symptoms other than periportal lymph node resolved. CONCLUSIONS Tonsillitis, cervical lymphadenopathy, and lung lesions can be manifestations of secondary syphilis. A detailed history, pathology, and serology are crucial for diagnosis.

2018 The American journal of case reports

14. Oral ulcers as a presentation of secondary syphilis. Full Text available with Trip Pro

Oral ulcers as a presentation of secondary syphilis. The incidence of syphilis is increasing, and it typically presents in patients with known risk factors, often to genitourinary physicians. Patients presenting to a dermatologist or ophthalmologist will more likely have secondary syphilis, with the potential for having the associated complications. Early recognition is therefore vital to limit both the disease and risk of further contact spread. In this review, we include two case histories

2018 Clinical & Experimental Dermatology

15. The disappearance of femoral head and neck resulting from extensive bone defect caused by secondary syphilis: a case report and literature review. Full Text available with Trip Pro

The disappearance of femoral head and neck resulting from extensive bone defect caused by secondary syphilis: a case report and literature review. Treponema Pallidum (TP), the pathogen of syphilis, commonly infects bones in cases of congenital and tertiary syphilis, but it is rare in the primary and secondary stages. With its mild symptoms and rare clinical findings, it might be easy to dismiss the diagnosis of early syphilis. Usually, effective results can be achieved after the conventional (...) strategy of antibiotic treatments, mainly penicillin. To our knowledge, our case is so far the most serious reported case of destructive bone lesion in secondary syphilis, and our treatment for the case is the first strategy using total hip arthroplasty in secondary syphilis.We present the case of a 71-year-old man with local repeated pain and dysfunction in the right hip. Radiologic examinations showed the disappearance of the ipsilateral femoral head and neck. After excluding the aetiologies

2018 BMC Musculoskeletal Disorders

16. Oral findings in secondary syphilis Full Text available with Trip Pro

Oral findings in secondary syphilis Syphilis is a sexually transmitted disease caused by Treponema pallidum. However, there are of hematogenic and vertical transmission. All health care professionals must be aware of the manifestations of this condition, such as oral lesions.This study to analyze and compare four clinical cases of syphilis that were diagnosed based on lesions in the oral cavity with published literature.Four patients with a confirmed sorologic and clinical diagnosis of syphilis (...) were examined, confirmated from manifestation of oral lesions together with analysis of serological laboratory tests and histopathological analyses.Lesions were found in classic sites such as lips, tongue and skin. However, there were also lesions on the hard palate, and labial commissure, which correspond to less than 5% of the syphilis oral manifestations.The practice of unprotected oral sex may result in infection and development of syphilis. The acknowledgment of the oral manifestations

2018 Medicina oral, patología oral y cirugía bucal

17. Secondary Syphilis Without Any History of Primary Infection Full Text available with Trip Pro

Secondary Syphilis Without Any History of Primary Infection 29366456 2018 12 11 2018 12 11 1866-0452 115 3 2018 Jan 19 Deutsches Arzteblatt international Dtsch Arztebl Int Secondary Syphilis Without Any History of Primary Infection. 40 10.3238/arztebl.2018.0040 arztebl.2018.0040 Grade Matthias M Bronnert Jan J eng Case Reports Journal Article Germany Dtsch Arztebl Int 101475967 1866-0452 Syphilis, secondary IM Humans Male Syphilis diagnosis Travel Young Adult 2018 1 26 6 0 2018 1 26 6 0 2018 12

2018 Deutsches Ärzteblatt international

18. A secondary syphilis rash with scaly target lesions Full Text available with Trip Pro

A secondary syphilis rash with scaly target lesions A 40-year-old man reported a 5-day history of fever and malaise, followed by a pruritic generalized rash. He had well-demarcated erythematous papules and plaques with scaling. The patient was diagnosed with secondary syphilis. The skin biopsy showed a psoriasiform lichenoid dermatitis with plasma cells. The anti-T. pallidum antibody confirmed the presence of spirochetes. He was also found to be hepatitis C virus and human immunodeficiency (...) virus positive. The characteristic rash of secondary syphilis may appear as maculopapular, evolving initially from macules to small reddish-brown papules with minor scaling later. When the scaling is prominent, lesions can be difficult to differentiate from guttate psoriasis. Typical target lesions are most often associated with erythema multiforme, but they can rarely occur in secondary and congenital syphilis. Syphilis should be suspected in high-risk patients presenting a variety of atypical

2018 Oxford Medical Case Reports

19. Primary lung carcinoma combined with pulmonary amyloidosis secondary to syphilis infection Full Text available with Trip Pro

Primary lung carcinoma combined with pulmonary amyloidosis secondary to syphilis infection A 55-year-old female patient was found to have a pulmonary nodule combined with multiple lung cysts detected on CT scan. Video-assisted thoracoscopic surgery (VATS) lobectomy was performed and the nodule showed adenocarcinoma while the whole left upper lobe showed a heavy deposition of amyloid. Syphilis infection was detected and was suspected contributing to secondary pulmonary amyloidosis. Although very (...) rare, pulmonary amyloidosis should be added to the differential diagnosis for solid pulmonary nodules. Furthermore, widespread lung cysts located apart from pulmonary nodules is especially rare in pulmonary amyloidosis secondary to syphilis infection.

2018 Journal of thoracic disease

20. Syphilis infection

infection caused by the spirochaetal bacterium Treponema pallidum , subspecies pallidum . It is found only in human hosts. Acquired infection is transmitted through direct person-to-person sexual contact with an individual with early syphilis. Vertical transmission from mother to baby causes a congenital infection. Most sexual transmission of syphilis probably occurs from the genital and mucous membrane lesions of primary and secondary syphilis. Syphilis has often been described as the great imitator (...) Syphilis infection Syphilis infection - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Syphilis infection Last reviewed: February 2019 Last updated: May 2018 Summary A common sexually transmitted infection. Approximately 10 million to 12 million new infections worldwide each year. Caused by the spirochaetal bacterium Treponema pallidum , subspecies pallidum . Clinical presentation is often asymptomatic, but can

2018 BMJ Best Practice

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