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Seborrheic Keratosis

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1. Seborrhoeic keratosis

Seborrhoeic keratosis Seborrhoeic keratosis - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Seborrhoeic keratosis Last reviewed: February 2019 Last updated: December 2018 Summary Lesions are common, multiple, benign tumours of the skin. Most people over the age of 50 years are affected. They appear as well-circumscribed 'stuck-on' plaques or papules and may look like warts. They are usually asymptomatic but can (...) become irritated and inflamed spontaneously or because of friction from clothing. Treatment is not necessary because of their benign nature, but if irritated, itching, and displeasing, can be initially treated with cryotherapy and curettage. Most important differential diagnosis, and of patient concern, is malignant melanoma. Definition Seborrhoeic keratosis is a common, multiple, benign skin tumour most commonly found on the torso and usually appears in the fourth and fifth decades of life. From 80

2018 BMJ Best Practice

2. Seborrhoeic keratosis

Seborrhoeic keratosis Seborrhoeic keratosis - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Seborrhoeic keratosis Last reviewed: February 2019 Last updated: December 2018 Summary Lesions are common, multiple, benign tumours of the skin. Most people over the age of 50 years are affected. They appear as well-circumscribed 'stuck-on' plaques or papules and may look like warts. They are usually asymptomatic but can (...) become irritated and inflamed spontaneously or because of friction from clothing. Treatment is not necessary because of their benign nature, but if irritated, itching, and displeasing, can be initially treated with cryotherapy and curettage. Most important differential diagnosis, and of patient concern, is malignant melanoma. Definition Seborrhoeic keratosis is a common, multiple, benign skin tumour most commonly found on the torso and usually appears in the fourth and fifth decades of life. From 80

2017 BMJ Best Practice

3. Dermoscopy Improves the Diagnostic Accuracy of Melanomas Clinically Resembling Seborrheic Keratosis: Cross-Sectional Study of the Ability to Detect Seborrheic Keratosis-Like Melanomas by a Group of Dermatologists with Varying Degrees of Experience. Full Text available with Trip Pro

Dermoscopy Improves the Diagnostic Accuracy of Melanomas Clinically Resembling Seborrheic Keratosis: Cross-Sectional Study of the Ability to Detect Seborrheic Keratosis-Like Melanomas by a Group of Dermatologists with Varying Degrees of Experience. Malignant melanomas mimicking seborrheic keratosis (SK-like MMs) carry the risk of delayed diagnosis and inadequate treatment. The value of dermoscopy to improve the correct detection of these mimickers has not been previously studied.To evaluate

2018 Dermatology

4. Management of seborrhoeic keratosis and actinic keratosis with an erbium:YAG laser-experience with 547 patients. (Abstract)

Management of seborrhoeic keratosis and actinic keratosis with an erbium:YAG laser-experience with 547 patients. Seborrhoeic keratosis and actinic keratosis are common skin lesions, and the latter is a precursor for skin malignancy. The treatment regime can be lesion-directed or field-directed. Current lesion-directed treatments include cryotherapy, shave excision, and laser ablation. Field-directed treatment typically encompasses multiple topical agents. This article presents the authors (...) ' experience of lesion- and field-directed erbium:YAG laser treatment of 547 patients (Fotona Dualis XS Laser). In this series of patients, those who had resurfacing as field therapy showed no recurrence during the 12-month review period. However, there were six cases of recurrence in the group who underwent lesion-directed treatment over the same period. Furthermore, the results illustrated that the incidence of recurrence of actinic keratosis with malignant transformation was around 2.5%. The production

2018 International Journal of Oral and Maxillofacial Surgery

5. Giant perianal Seborrheic keratosis: A case report Full Text available with Trip Pro

Giant perianal Seborrheic keratosis: A case report Seborrheic keratosis is one of the most common benign epidermal cutaneous lesions encountered by dermatologists and plastic surgeons in their daily practice.A 66-year-old man was presented with a large verrucous mass on the sacrum and perianal area of 10 years duration. After the diagnosis of SK was confirmed, a complete excision of the lesion was done with coverage of the defect with a partial thikness skin graft, with a good outcome.Giant (...) Seborrheic keratosis are very rare, and their location on the perianal area is rarer still, with no more than 10 published cases of genital area involvement.Giant perianal seborrheic keratoses is a very rare presentation, that may resemble many of the skin disease of that area and should be managed with excision and biopsy to confirm the diagnosis.Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.

2018 International journal of surgery case reports

6. Detection of Merkel Cell Polyomavirus in Seborrheic Keratosis Full Text available with Trip Pro

Detection of Merkel Cell Polyomavirus in Seborrheic Keratosis Seborrheic keratosis (SK) is the most common benign cutaneous neoplasm. A subset shows increased p16 expression. Since SK shares several features with verruca vulgaris, e.g., increased p16 expression, human papillomaviruses (HPV) have been suggested as possible causal agents. However, a relevant association could not be established between HPV and SK. In the present study we aimed to investigate the presence of Merkel cell

2018 Frontiers in microbiology

7. Differentiation of seborrheic keratosis from basal cell carcinoma, nevi and melanoma by RGB autofluorescence imaging Full Text available with Trip Pro

Differentiation of seborrheic keratosis from basal cell carcinoma, nevi and melanoma by RGB autofluorescence imaging A clinical trial on the autofluorescence imaging of skin lesions comprising 16 dermatologically confirmed pigmented nevi, 15 seborrheic keratosis, 2 dysplastic nevi, histologically confirmed 17 basal cell carcinomas and 1 melanoma was performed. The autofluorescence spatial properties of the skin lesions were acquired by smartphone RGB camera under 405 nm LED excitation (...) . The diagnostic criterion is based on the calculation of the mean autofluorescence intensity of the examined lesion in the spectral range of 515 nm-700 nm. The proposed methodology is able to differentiate seborrheic keratosis from basal cell carcinoma, pigmented nevi and melanoma. The sensitivity and specificity of the proposed method was estimated as being close to 100%. The proposed methodology and potential clinical applications are discussed in this article.

2018 Biomedical optics express

8. Artemether for Topical Use in Patients with Seborrheic Keratosis. (Abstract)

Artemether for Topical Use in Patients with Seborrheic Keratosis. 29957837 2018 11 02 1365-2133 179 5 2018 Nov The British journal of dermatology Br. J. Dermatol. Artemether for topical use in patients with seborrhoeic keratosis. 1225-1226 10.1111/bjd.16930 Härtel A A Somamedica, Basel, Switzerland. Jung T T http://orcid.org/0000-0003-1772-549X Jung & Partners, Life Science Consultancy GmbH, Zug, Switzerland. Sift Carter R R EpiPharm AG, Binningen, Switzerland. eng Letter 2018 09 17 England Br

2018 British Journal of Dermatology

9. Two cases of seborrheic keratosis of the external ear canal: involvement of PIK3CA and FGFR3 genes. (Abstract)

Two cases of seborrheic keratosis of the external ear canal: involvement of PIK3CA and FGFR3 genes. Seborrheic keratosis (SK) of the outer ear canal is rarely described in literature. Etiological risk factors involved in SK such as exposure to human papillomavirus (HPV) and ultraviolet (UV) light are established but must still be confirmed. In recent years, new insights into the pathogenesis of SKs occurred in the area of molecular pathogenesis. Fibroblast growth factor receptor 3 (FGFR3) gene (...) lesions.We did not find any mutations in both genes in all samples.Additional research is needed to further establish possible etiological risk factors and to clarify the involvement of PIK3CA and FGFR3 genes in the pathogenesis of seborrheic keratosis of the outer ear canal. These cases underscore the need for meticulous diagnosis, treatment, and sufficient long-term follow-up.© 2018 The International Society of Dermatology.

2018 International Journal of Dermatology

10. Overexpression of Amyloid Precursor Protein Promotes the Onset of Seborrhoeic Keratosis and is Related to Skin Ageing. Full Text available with Trip Pro

Overexpression of Amyloid Precursor Protein Promotes the Onset of Seborrhoeic Keratosis and is Related to Skin Ageing. Seborrhoeic keratosis (SK) is an age-related skin disease. Amyloid precursor protein (APP) plays an important role in the pathogenesis of age-related Alzheimer's disease. The aim of this study was to elucidate the expression characteristics of APP in SK tissues (n = 50), and explore whether the production of APP is related to the onset of SK and skin ageing, including

2018 Acta Dermato-Venereologica

11. A-101, a Proprietary Topical Formulation of High-Concentration Hydrogen Peroxide Solution: A Randomized, Double-Blind, Vehicle-Controlled, Parallel Group Study of the Dose-Response Profile in Subjects With Seborrheic Keratosis of the Face. (Abstract)

A-101, a Proprietary Topical Formulation of High-Concentration Hydrogen Peroxide Solution: A Randomized, Double-Blind, Vehicle-Controlled, Parallel Group Study of the Dose-Response Profile in Subjects With Seborrheic Keratosis of the Face. Seborrheic keratosis (SK) is a common benign skin tumor, yet no topical treatments are approved in the United States.To evaluate the proprietary, stabilized, high-concentration hydrogen peroxide-based topical solution A-101 (32.5% and 40% concentrations

2017 Dermatologic Surgery Controlled trial quality: uncertain

12. Cutaneous horn masquerading as a seborrheic keratosis Full Text available with Trip Pro

Cutaneous horn masquerading as a seborrheic keratosis To report a case of seborrheic keratosis of the inner canthus presenting as cutaneous horn.A 67-year-old Asian male presented with a rod-shaped, pedunculated mass on his inner canthus. The mass grew rapidly and within 2 months measured 3.0 cm in length and 0.5 cm in diameter. It was completely excised and submitted for microscopic examination. The specimen consisted of a proliferation of basaloid cells arranged in a papillary pattern (...) and associated with significant hyperkeratosis and parakeratosis of the overlying squamous epithelium. The pathological diagnosis was reported as seborrheic keratosis from the skin of the inner canthus.Seborrheic keratosis can develop into a rapidly expanding lesion such as a cutaneous horn and can be found in unusual locations. To our knowledge, this is the first report of a seborrheic keratosis from the skin of the inner canthus.

2016 American journal of ophthalmology case reports

13. Irritated Subtype of Seborrheic Keratosis in the External Auditory Canal Full Text available with Trip Pro

Irritated Subtype of Seborrheic Keratosis in the External Auditory Canal 29069875 2018 11 13 2234-6163 44 6 2017 Nov Archives of plastic surgery Arch Plast Surg Irritated Subtype of Seborrheic Keratosis in the External Auditory Canal. 570-572 10.5999/aps.2017.01081 Park June Kyu JK Department of Plastic and Reconstructive Surgery, Myong-Ji Hospital, Goyang, Korea. Kim Kyung Sik KS 0000-0002-2101-9654 Department of Plastic and Reconstructive Surgery, Myong-Ji Hospital, Goyang, Korea. Kim Seung

2017 Archives of plastic surgery

14. A Randomized, Vehicle-Controlled Study of 2 Concentrations of A-101 for the Treatment of Seborrheic Keratosis

A Randomized, Vehicle-Controlled Study of 2 Concentrations of A-101 for the Treatment of Seborrheic Keratosis A Randomized, Vehicle-Controlled Study of 2 Concentrations of A-101 for the Treatment of Seborrheic Keratosis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (...) (100). Please remove one or more studies before adding more. A Randomized, Vehicle-Controlled Study of 2 Concentrations of A-101 for the Treatment of Seborrheic Keratosis The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03148691 Recruitment Status : Completed First Posted : May 11, 2017 Last Update

2017 Clinical Trials

15. The role of immunosuppression in squamous cell carcinomas arising in seborrheic keratosis. (Abstract)

The role of immunosuppression in squamous cell carcinomas arising in seborrheic keratosis. Seborrheic keratoses (SK) are common skin neoplasms considered to be benign. Reports of associated squamous cell carcinoma arising within seborrheic keratosis (SCC-SK) have been described.To describe the histopathologic characteristics of SCC-SK and identify predisposing factors in formation of these rare lesions.There were 162 cases of SCC-SK in a span of a decade (2003-2014). All of the histopathologic (...) specimens and medical records were reviewed. Data from these patients were compared to a control group with seborrheic keratosis who were matched by age, sex, and location of lesion from the same time period (n = 162).SCC-SK has the classic histopathologic features of SK, such as hyperkeratosis, parakeratosis, papillomatosis, and pseudohorn cysts. The areas of squamous cell carcinoma were characterized by areas of squamous dysplasia (100%), hypogranulosis (79.6%), squamous eddies (79.6%), solar

2017 Journal of American Academy of Dermatology

16. Increasing Frequency of Seborrheic Keratosis Diagnoses as a Favorable Consequence of Teledermatology-Based Skin Cancer Screening: A Cross-sectional Study of 34,553 Patients. (Abstract)

Increasing Frequency of Seborrheic Keratosis Diagnoses as a Favorable Consequence of Teledermatology-Based Skin Cancer Screening: A Cross-sectional Study of 34,553 Patients. Screening of skin cancer by teledermatology (TD) has improved the early detection of skin cancer by enhancing access to skin cancer clinics.We sought to analyze how TD-based skin cancer screening has changed the frequency of consultations for benign lesions.A cross-sectional study including teleconsultations received during (...) a 7-year period was conducted to analyze and compare the trendlines of each lesion type over the study period. Trendlines were analyzed using a linear regression model with the R-squared (R 2) test for goodness of fit.A total of 34,553 teleconsultations were included in the study. Seborrheic keratoses, followed by benign melanocytic lesions, were the most frequent lesions diagnosed. The pick-up rate for malignant lesions was 1:8.6 teleconsultations. Seborrheic keratoses and precancerous lesions

2017 American journal of clinical dermatology

17. Familial seborrhoeic keratosis associated with multiple "pure reticulated acanthomas" and infundibulocystic basal cell carcinomas. (Abstract)

Familial seborrhoeic keratosis associated with multiple "pure reticulated acanthomas" and infundibulocystic basal cell carcinomas. A variety of genodermatoses with multiple cutaneous tumours and germline genetic alterations, such as PTCH1 mutations, have been described. Other cutaneous syndromes have been associated with somatic gene mutations, such as FGFR3 in familial seborrhoeic keratosis.To describe the clinical, dermoscopic and histopathological features of multiple cutaneous lesions (...) , mostly infundibulocystic basal cell carcinomas (ICBCCs) and pure reticulated acanthomas, present in a family affected by familial seborrhoeic keratosis. In addition, we tested for possible germline alterations in FGFR3 and PTCH1.Ten members of one family were clinically examined and 92 skin biopsy specimens were evaluated. Blood samples from six individuals were analysed for FGFR3 and PTCH1 germline alterations. We reviewed the literature concerning genetic FGFR3 alterations in seborrhoeic

2017 British Journal of Dermatology

18. Dermoscopic Clues for Diagnosing Melanomas That Resemble Seborrheic Keratosis. Full Text available with Trip Pro

Dermoscopic Clues for Diagnosing Melanomas That Resemble Seborrheic Keratosis. Melanomas that clinically mimic seborrheic keratosis (SK) can delay diagnosis and adequate treatment. However, little is known about the value of dermoscopy in recognizing these difficult-to-diagnose melanomas.To describe the dermoscopic features of SK-like melanomas to understand their clinical morphology.This observational retrospective study used 134 clinical and dermoscopic images of histopathologically proven (...) melanomas.Seborrheic keratosis-like melanomas can be dermoscopically challenging, but the presence of the blue-black sign, pigment network, pseudopods or streaks, and/or blue-white veil, despite the presence of other SK features, allows the correct diagnosis of most of the difficult melanoma cases.

2017 JAMA dermatology (Chicago, Ill.)

19. Seborrheic Keratosis

, Senile keratosis , BCP - Basal cell papilloma , Keratosis senilis , Pigmented basal cell papilloma , Seborrheic wart , Seborrhoeic keratosis , Seborrhoeic wart , Senile wart , Keratosis seborrheica , Verruca seborrheica , Keratosis seborrhoeica , Seborrheic keratosis (morphologic abnormality) , Seborrhoeic verruca , Senile hyperkeratosis (disorder) , Verruca seborrhoeica , keratosis; seborrheic , old age; wart , seborrhea; keratosis , seborrheic; keratosis , seborrheic; wart , seborrheica; verruca (...) keratosis NOS , Keratosis, Seborrheic [Disease/Finding] , Keratosis Seborrheica , seborrheic keratoses , keratosis seborrheic , seborrhoeic warts , senile keratosis , basal cell papilloma , seborrhoeic wart , inverted follicular keratosis , keratoses seborrheic , senile warts , Wart(s);senile , seborrheic wart , seborrheic warts , keratosis senilis , keratosis seborrheica , Seborrhoeic keratosis (disorder) , Senile hyperkeratosis , Basal cell papilloma , Basosquamous papilloma , Seborrheic verruca

2018 FP Notebook

20. Actinic keratosis

with light-coloured skin and a history of chronic sun exposure. They can potentially progress into squamous cell carcinoma (SCC). History and exam presence of risk factors single or multiple scaly macules or plaques scaly lesions with a hyperkeratotic surface well-defined, scaly, brown lesions lesions resembling seborrhoeic keratosis, melanocytic naevus, and early malignant melanoma hypertrophic conical-shaped protuberances growing from the surface of the skin scaly red roughness with induration (...) Actinic keratosis Actinic keratosis - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Actinic keratosis Last reviewed: February 2019 Last updated: February 2018 Summary Chronic keratotic lesions on adult skin that has been chronically exposed to ultraviolet (UV) rays. Has the potential to progress into an invasive squamous cell carcinoma (SCC). Although diagnosed clinically, a biopsy may help to rule out SCC. Treatment

2018 BMJ Best Practice

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