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Seborrheic Keratosis

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1. Dermoscopy Improves the Diagnostic Accuracy of Melanomas Clinically Resembling Seborrheic Keratosis: Cross-Sectional Study of the Ability to Detect Seborrheic Keratosis-Like Melanomas by a Group of Dermatologists with Varying Degrees of Experience. (PubMed)

Dermoscopy Improves the Diagnostic Accuracy of Melanomas Clinically Resembling Seborrheic Keratosis: Cross-Sectional Study of the Ability to Detect Seborrheic Keratosis-Like Melanomas by a Group of Dermatologists with Varying Degrees of Experience. Malignant melanomas mimicking seborrheic keratosis (SK-like MMs) carry the risk of delayed diagnosis and inadequate treatment. The value of dermoscopy to improve the correct detection of these mimickers has not been previously studied.To evaluate

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2018 Dermatology

2. Cutaneous horn masquerading as a seborrheic keratosis (PubMed)

Cutaneous horn masquerading as a seborrheic keratosis To report a case of seborrheic keratosis of the inner canthus presenting as cutaneous horn.A 67-year-old Asian male presented with a rod-shaped, pedunculated mass on his inner canthus. The mass grew rapidly and within 2 months measured 3.0 cm in length and 0.5 cm in diameter. It was completely excised and submitted for microscopic examination. The specimen consisted of a proliferation of basaloid cells arranged in a papillary pattern (...) and associated with significant hyperkeratosis and parakeratosis of the overlying squamous epithelium. The pathological diagnosis was reported as seborrheic keratosis from the skin of the inner canthus.Seborrheic keratosis can develop into a rapidly expanding lesion such as a cutaneous horn and can be found in unusual locations. To our knowledge, this is the first report of a seborrheic keratosis from the skin of the inner canthus.

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2016 American journal of ophthalmology case reports

3. Two cases of seborrheic keratosis of the external ear canal: involvement of PIK3CA and FGFR3 genes. (PubMed)

Two cases of seborrheic keratosis of the external ear canal: involvement of PIK3CA and FGFR3 genes. Seborrheic keratosis (SK) of the outer ear canal is rarely described in literature. Etiological risk factors involved in SK such as exposure to human papillomavirus (HPV) and ultraviolet (UV) light are established but must still be confirmed. In recent years, new insights into the pathogenesis of SKs occurred in the area of molecular pathogenesis. Fibroblast growth factor receptor 3 (FGFR3) gene (...) lesions.We did not find any mutations in both genes in all samples.Additional research is needed to further establish possible etiological risk factors and to clarify the involvement of PIK3CA and FGFR3 genes in the pathogenesis of seborrheic keratosis of the outer ear canal. These cases underscore the need for meticulous diagnosis, treatment, and sufficient long-term follow-up.© 2018 The International Society of Dermatology.

2018 International Journal of Dermatology

4. Artemether for Topical Use in Patients with Seborrheic Keratosis. (PubMed)

Artemether for Topical Use in Patients with Seborrheic Keratosis. 29957837 2018 11 02 1365-2133 179 5 2018 Nov The British journal of dermatology Br. J. Dermatol. Artemether for topical use in patients with seborrhoeic keratosis. 1225-1226 10.1111/bjd.16930 Härtel A A Somamedica, Basel, Switzerland. Jung T T http://orcid.org/0000-0003-1772-549X Jung & Partners, Life Science Consultancy GmbH, Zug, Switzerland. Sift Carter R R EpiPharm AG, Binningen, Switzerland. eng Letter 2018 09 17 England Br

2018 British Journal of Dermatology

5. Detection of Merkel Cell Polyomavirus in Seborrheic Keratosis (PubMed)

Detection of Merkel Cell Polyomavirus in Seborrheic Keratosis Seborrheic keratosis (SK) is the most common benign cutaneous neoplasm. A subset shows increased p16 expression. Since SK shares several features with verruca vulgaris, e.g., increased p16 expression, human papillomaviruses (HPV) have been suggested as possible causal agents. However, a relevant association could not be established between HPV and SK. In the present study we aimed to investigate the presence of Merkel cell

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2018 Frontiers in microbiology

6. Giant perianal Seborrheic keratosis: A case report (PubMed)

Giant perianal Seborrheic keratosis: A case report Seborrheic keratosis is one of the most common benign epidermal cutaneous lesions encountered by dermatologists and plastic surgeons in their daily practice.A 66-year-old man was presented with a large verrucous mass on the sacrum and perianal area of 10 years duration. After the diagnosis of SK was confirmed, a complete excision of the lesion was done with coverage of the defect with a partial thikness skin graft, with a good outcome.Giant (...) Seborrheic keratosis are very rare, and their location on the perianal area is rarer still, with no more than 10 published cases of genital area involvement.Giant perianal seborrheic keratoses is a very rare presentation, that may resemble many of the skin disease of that area and should be managed with excision and biopsy to confirm the diagnosis.Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.

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2018 International journal of surgery case reports

7. Differentiation of seborrheic keratosis from basal cell carcinoma, nevi and melanoma by RGB autofluorescence imaging (PubMed)

Differentiation of seborrheic keratosis from basal cell carcinoma, nevi and melanoma by RGB autofluorescence imaging A clinical trial on the autofluorescence imaging of skin lesions comprising 16 dermatologically confirmed pigmented nevi, 15 seborrheic keratosis, 2 dysplastic nevi, histologically confirmed 17 basal cell carcinomas and 1 melanoma was performed. The autofluorescence spatial properties of the skin lesions were acquired by smartphone RGB camera under 405 nm LED excitation (...) . The diagnostic criterion is based on the calculation of the mean autofluorescence intensity of the examined lesion in the spectral range of 515 nm-700 nm. The proposed methodology is able to differentiate seborrheic keratosis from basal cell carcinoma, pigmented nevi and melanoma. The sensitivity and specificity of the proposed method was estimated as being close to 100%. The proposed methodology and potential clinical applications are discussed in this article.

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2018 Biomedical optics express

8. A-101, a Proprietary Topical Formulation of High-Concentration Hydrogen Peroxide Solution: A Randomized, Double-Blind, Vehicle-Controlled, Parallel Group Study of the Dose-Response Profile in Subjects With Seborrheic Keratosis of the Face. (PubMed)

A-101, a Proprietary Topical Formulation of High-Concentration Hydrogen Peroxide Solution: A Randomized, Double-Blind, Vehicle-Controlled, Parallel Group Study of the Dose-Response Profile in Subjects With Seborrheic Keratosis of the Face. Seborrheic keratosis (SK) is a common benign skin tumor, yet no topical treatments are approved in the United States.To evaluate the proprietary, stabilized, high-concentration hydrogen peroxide-based topical solution A-101 (32.5% and 40% concentrations

2017 Dermatologic Surgery

9. Increasing Frequency of Seborrheic Keratosis Diagnoses as a Favorable Consequence of Teledermatology-Based Skin Cancer Screening: A Cross-sectional Study of 34,553 Patients. (PubMed)

Increasing Frequency of Seborrheic Keratosis Diagnoses as a Favorable Consequence of Teledermatology-Based Skin Cancer Screening: A Cross-sectional Study of 34,553 Patients. Screening of skin cancer by teledermatology (TD) has improved the early detection of skin cancer by enhancing access to skin cancer clinics.We sought to analyze how TD-based skin cancer screening has changed the frequency of consultations for benign lesions.A cross-sectional study including teleconsultations received during (...) a 7-year period was conducted to analyze and compare the trendlines of each lesion type over the study period. Trendlines were analyzed using a linear regression model with the R-squared (R 2) test for goodness of fit.A total of 34,553 teleconsultations were included in the study. Seborrheic keratoses, followed by benign melanocytic lesions, were the most frequent lesions diagnosed. The pick-up rate for malignant lesions was 1:8.6 teleconsultations. Seborrheic keratoses and precancerous lesions

2017 American journal of clinical dermatology

10. Dermoscopic Clues for Diagnosing Melanomas That Resemble Seborrheic Keratosis. (PubMed)

Dermoscopic Clues for Diagnosing Melanomas That Resemble Seborrheic Keratosis. Melanomas that clinically mimic seborrheic keratosis (SK) can delay diagnosis and adequate treatment. However, little is known about the value of dermoscopy in recognizing these difficult-to-diagnose melanomas.To describe the dermoscopic features of SK-like melanomas to understand their clinical morphology.This observational retrospective study used 134 clinical and dermoscopic images of histopathologically proven (...) melanomas.Seborrheic keratosis-like melanomas can be dermoscopically challenging, but the presence of the blue-black sign, pigment network, pseudopods or streaks, and/or blue-white veil, despite the presence of other SK features, allows the correct diagnosis of most of the difficult melanoma cases.

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2017 JAMA dermatology (Chicago, Ill.)

11. The role of immunosuppression in squamous cell carcinomas arising in seborrheic keratosis. (PubMed)

The role of immunosuppression in squamous cell carcinomas arising in seborrheic keratosis. Seborrheic keratoses (SK) are common skin neoplasms considered to be benign. Reports of associated squamous cell carcinoma arising within seborrheic keratosis (SCC-SK) have been described.To describe the histopathologic characteristics of SCC-SK and identify predisposing factors in formation of these rare lesions.There were 162 cases of SCC-SK in a span of a decade (2003-2014). All of the histopathologic (...) specimens and medical records were reviewed. Data from these patients were compared to a control group with seborrheic keratosis who were matched by age, sex, and location of lesion from the same time period (n = 162).SCC-SK has the classic histopathologic features of SK, such as hyperkeratosis, parakeratosis, papillomatosis, and pseudohorn cysts. The areas of squamous cell carcinoma were characterized by areas of squamous dysplasia (100%), hypogranulosis (79.6%), squamous eddies (79.6%), solar

2017 Journal of American Academy of Dermatology

12. Irritated Subtype of Seborrheic Keratosis in the External Auditory Canal (PubMed)

Irritated Subtype of Seborrheic Keratosis in the External Auditory Canal 29069875 2018 11 13 2234-6163 44 6 2017 Nov Archives of plastic surgery Arch Plast Surg Irritated Subtype of Seborrheic Keratosis in the External Auditory Canal. 570-572 10.5999/aps.2017.01081 Park June Kyu JK Department of Plastic and Reconstructive Surgery, Myong-Ji Hospital, Goyang, Korea. Kim Kyung Sik KS 0000-0002-2101-9654 Department of Plastic and Reconstructive Surgery, Myong-Ji Hospital, Goyang, Korea. Kim Seung

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2017 Archives of plastic surgery

13. A Randomized, Vehicle-Controlled Study of 2 Concentrations of A-101 for the Treatment of Seborrheic Keratosis

A Randomized, Vehicle-Controlled Study of 2 Concentrations of A-101 for the Treatment of Seborrheic Keratosis A Randomized, Vehicle-Controlled Study of 2 Concentrations of A-101 for the Treatment of Seborrheic Keratosis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (...) (100). Please remove one or more studies before adding more. A Randomized, Vehicle-Controlled Study of 2 Concentrations of A-101 for the Treatment of Seborrheic Keratosis The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03148691 Recruitment Status : Completed First Posted : May 11, 2017 Last Update

2017 Clinical Trials

14. Pigmented eccrine poroma of the palm clinically mimicking a seborrheic keratosis (PubMed)

Pigmented eccrine poroma of the palm clinically mimicking a seborrheic keratosis 27222880 2016 05 25 2019 02 26 2352-5126 2 2 2016 Mar JAAD case reports JAAD Case Rep Pigmented eccrine poroma of the palm clinically mimicking a seborrheic keratosis. 171-3 10.1016/j.jdcr.2016.01.007 MeiQi May Liau L Division of Dermatology, University Medicine Cluster, National University Health System, Republic of Singapore. Sam Yang Shiyao YS Division of Dermatology, University Medicine Cluster, National (...) University Health System, Republic of Singapore. Jingxiang Huang H Division of Dermatology, University Medicine Cluster, National University Health System, Republic of Singapore. Chen-Wee Derrick Aw A Division of Dermatology, University Medicine Cluster, National University Health System, Republic of Singapore. eng Case Reports 2016 04 20 United States JAAD Case Rep 101665210 2352-5126 CEA, Carcinoembryonic antigens EP, Eccrine poroma histopathology pigmented eccrine poroma seborrheic keratosis 2016 5 26

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2016 JAAD Case Reports

15. A Randomized, Double-Blind, Vehicle-Controlled Study in Subjects With Seborrheic Keratosis

A Randomized, Double-Blind, Vehicle-Controlled Study in Subjects With Seborrheic Keratosis A Randomized, Double-Blind, Vehicle-Controlled Study in Subjects With Seborrheic Keratosis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more (...) studies before adding more. A Randomized, Double-Blind, Vehicle-Controlled Study in Subjects With Seborrheic Keratosis (SK) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02667275 Recruitment Status : Completed First Posted : January 28, 2016 Results First Posted : November 13, 2017 Last Update Posted

2016 Clinical Trials

16. A Study of A-101 Solution 40% in Subjects With Seborrheic Keratosis.

A Study of A-101 Solution 40% in Subjects With Seborrheic Keratosis. A Study of A-101 Solution 40% in Subjects With Seborrheic Keratosis. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Study of A-101 (...) Solution 40% in Subjects With Seborrheic Keratosis. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02667236 Recruitment Status : Completed First Posted : January 28, 2016 Results First Posted : November 13, 2017 Last Update Posted : February 6, 2018 Sponsor: Aclaris Therapeutics, Inc. Information

2016 Clinical Trials

17. Seborrheic Keratosis-like Lesions of the Cervix and Vagina: Report of a New Entity Possibly Related to Low-risk Human Papillomavirus Infection. (PubMed)

Seborrheic Keratosis-like Lesions of the Cervix and Vagina: Report of a New Entity Possibly Related to Low-risk Human Papillomavirus Infection. We report a series of 7 unusual and morphologically distinct cervical or upper vaginal lesions in women aged 41 to 70 years. The lesions involved the cervix in 3 cases, the upper vagina in 2, the cervix and vagina in 1, and in 1 case the site of origin could not be determined. The lesions had a consistent morphologic appearance with a surface "plaque (...) transitional lesions. We suggest the term seborrheic keratosis-like lesions to designate this new and rare entity, which may be associated with low-risk human papillomavirus infection. Limited follow-up in a small number of cases suggests that these lesions follow a benign clinical course.

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2016 American Journal of Surgical Pathology

18. Clinical and Histopathological Investigation of Seborrheic Keratosis (PubMed)

Clinical and Histopathological Investigation of Seborrheic Keratosis Seborrheic keratosis (SK) is one of the most common epidermal tumors of the skin. However, only a few large-scale clinicohistopathological investigations have been conducted on SK or on the possible correlation between histopathological SK subtype and location.The aim of this study was to analyze the clinical and histopathological features of a relatively large number of cases of diagnosed SK.Two hundred and seventy-one

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2016 Annals of dermatology

19. Seborrheic Keratosis

Seborrheic Keratosis Seborrheic Keratosis Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Seborrheic Keratosis Seborrheic Keratosis (...) Aka: Seborrheic Keratosis , Seborrheic Keratoses , Stucco keratoses , Dermatosis papulosa , Leser-Trelat Sign From Related Chapters II. Epidemiology Most common benign epithelial tumor Occurs in patients over age 30 years old Number of lesions increase with age Men and women affected equally inheritance III. Pathophysiology Common benign, hereditary tumor Hyperkeratotic epidermal lesion IV. Signs Characteristics Early (Flat lesions) Small (<3mm) Slightly elevated Variable hyperpigmented coloration

2018 FP Notebook

20. Unusual Dermoscopic Patterns of Seborrheic Keratosis. (PubMed)

Unusual Dermoscopic Patterns of Seborrheic Keratosis. Seborrheic keratoses (SKs) may sometimes mimic benign and malignant skin tumors, and a biopsy can be necessary in order to rule out malignancy.From the database of our pigmented lesion clinic, we evaluated the dermoscopic features of difficult-to-diagnose SKs that were biopsied between January 2010 and December 2014.SKs represented 3.8% of all excised lesions (161/ 4,182). Specifically, 91 (56.5%) were excised to rule out melanoma, 63 (39.1

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2016 Dermatology

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