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Sebaceous Hyperplasia

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1. Safety and Efficacy of Nanosecond Pulsed Electric Field Treatment of Sebaceous Gland Hyperplasia. (Abstract)

Safety and Efficacy of Nanosecond Pulsed Electric Field Treatment of Sebaceous Gland Hyperplasia. Nanosecond pulsed electric field (nsPEF) technology involves delivery of ultrashort pulses of electrical energy and is a nonthermal, drug-free technology that has demonstrated favorable effects on cellular structures of the dermis and epidermis.Determine the tolerability and effectiveness of nsPEF treatment of sebaceous gland hyperplasia (SGH).This study was a prospective, randomized, open-label

2019 Dermatologic Surgery

2. Papilloma and sebaceous gland hyperplasia of the lacrimal caruncle: a case report Full Text available with Trip Pro

Papilloma and sebaceous gland hyperplasia of the lacrimal caruncle: a case report To report a case of coincidence of sebaceous gland hyperplasia and papilloma with detection of human papillomavirus-51 in the apical portion by in situ hybridization.A 75-year-old man noted discomfort at the inner canthus of his left eye when he blinked. A tumor of the lacrimal caruncle was identified and resected. The base of the tumor had a smooth surface and was whitish. In addition, a "navel-like structure (...) " was seen, and the findings strongly suggested sebaceous gland hyperplasia of the lacrimal caruncle. The apical portion of the tumor was a papillomatous lesion. Histological examination of the resected tumor led to a diagnosis of sebaceous gland hyperplasia. Human papillomavirus-51 was detected in the apical portion by in situ hybridization. Based on these results, the final diagnosis was sebaceous gland hyperplasia with papilloma. No recurrence of either tumor has been observed up to 3 years

2018 International medical case reports journal

3. Nano-Pulse Stimulation (NPS) in Sebaceous Hyperplasia

Nano-Pulse Stimulation (NPS) in Sebaceous Hyperplasia Nano-Pulse Stimulation (NPS) in Sebaceous Hyperplasia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Nano-Pulse Stimulation (NPS) in Sebaceous (...) to Brief Summary: This prospective, open label, muti-center study evaluates the use of Nano-Pulse Stimulation (NPS) in the treatment of Sebaceous Hyperplasia (SH) lesions less than 2.5mm in size. Condition or disease Intervention/treatment Phase Skin Lesion Skin Abnormalities Sebaceous Hyperplasia Device: Nano-Pulse Stimulation Device Not Applicable Detailed Description: The study is designed with each subject serving as his or her own control. A total of up to 75 subjects with 2-5 qualifying SH

2018 Clinical Trials

4. Sebaceous Hyperplasia

Sebaceous Hyperplasia Sebaceous Hyperplasia Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Sebaceous Hyperplasia Sebaceous (...) Hyperplasia Aka: Sebaceous Hyperplasia , Senile Hyperplasia , Senile Sebaceous Hyperplasia From Related Chapters II. Epidemiology Onset in middle age Rarely occurs at in familial forms III. Pathophysiology Composed of mature s with dilated duct IV. Causes Most cases idiopathic with aging V. Signs Characteristics Pale yellow color Soft, shiny dome-shaped s May be centrally umbilicated Usually 2-4 mm in size May appear cauliflower-like with multiple lobules Distribution Forehead, Cheeks, Nose VI. Labs

2018 FP Notebook

5. KRAS, HRAS and EGFR Mutations in Sporadic Sebaceous Gland Hyperplasia. Full Text available with Trip Pro

KRAS, HRAS and EGFR Mutations in Sporadic Sebaceous Gland Hyperplasia. Sporadic sebaceous gland hyperplasia (SGH) is a benign skin lesion, with a high prevalence in the general population. Although SGH has been attributed to both extrinsic and intrinsic factors, the underlying genetic changes have not yet been characterized. Recently, HRAS and KRAS mutations have been identified in sebaceous naevus, a hamartoma sharing histological characteristics with SGH. Therefore we screened 43 SGH (...) for activating mutations in RAS genes and other oncogenes. We identified a wide spectrum of mutually exclusive activating HRAS (8/43), KRAS (11/43) and EGFR mutations (7/31) in altogether 60% of the lesions investigated. A RAS and EGFR wildtype status was found in 15 normal sebaceous glands in the head and neck area. Our findings indicate that activating HRAS, KRAS and EGFR mutations play a major role in the pathogenesis of sporadic SGH. These results support the concept that SGH is a true benign neoplasm

2016 Acta Dermato-Venereologica

6. Multiple Eruptive Sebaceous Hyperplasia Secondary to Cyclosporin in a Patient with Bone Marrow Transplantation Full Text available with Trip Pro

Multiple Eruptive Sebaceous Hyperplasia Secondary to Cyclosporin in a Patient with Bone Marrow Transplantation Many cutaneous complications have been described in patients treated with cyclosporin. Alterations of the pilosebaceous unit such as hypertrichosis are particularly frequent. However, the occurrence of sebaceous hyperplasia is exceptional. These lesions seem to be specific to cyclosporin rather than secondary to immunosuppression. Here, we report an exceptional case of eruptive (...) and disseminated sebaceous hyperplasia arising in a bone marrow transplant recipient only a few months after starting immunosuppressive treatment with cyclosporin.

2016 Dermatopathology

7. A Case of Cyclosporine-Induced Sebaceous Hyperplasia in a Renal Transplant Patient Successfully Treated with Isotretinoin Full Text available with Trip Pro

A Case of Cyclosporine-Induced Sebaceous Hyperplasia in a Renal Transplant Patient Successfully Treated with Isotretinoin 27081287 2016 04 15 2018 11 13 1013-9087 28 2 2016 Apr Annals of dermatology Ann Dermatol A Case of Cyclosporine-Induced Sebaceous Hyperplasia in a Renal Transplant Patient Successfully Treated with Isotretinoin. 271-2 10.5021/ad.2016.28.2.271 Jung Hwa Young HY Department of Dermatology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea

2016 Annals of dermatology

8. Transgenic expression of human amphiregulin in mouse skin: Inflammatory epidermal hyperplasia and enlarged sebaceous glands. Full Text available with Trip Pro

Transgenic expression of human amphiregulin in mouse skin: Inflammatory epidermal hyperplasia and enlarged sebaceous glands. To explore the role of amphiregulin in inflammatory epidermal hyperplasia, we overexpressed human AREG (hAREG) in FVB/N mice using a bovine K5 promoter. A construct containing AREG coding sequences flanked by 5' and 3' untranslated region sequences (AREG-UTR) led to a >10-fold increase in hAREG expression compared to an otherwise-identical construct containing only (...) in epidermal thickness and keratinocyte hyperplasia. AREG-UTR mice also developed marked and significant sebaceous gland enlargement, with corresponding increases in Ki-67(+) cells. To determine the response of AREG-UTR animals to a pro-inflammatory skin challenge, topical imiquimod (IMQ) or vehicle cream was applied to dorsal and tail skin. IMQ increased dorsal skin thickness similarly in both AREG-UTR and wild type mice (1.7- and 2.2-fold vs vehicle, P < 0.001 each), but had no such effect on tail skin

2015 Experimental Dermatology

9. Hair Follicle Nevus with Sebaceous Hyperplasia: A Dermoscopic Observation Full Text available with Trip Pro

Hair Follicle Nevus with Sebaceous Hyperplasia: A Dermoscopic Observation We herein report a case of hair follicle nevus, a rare hamartoma found on the face and showing follicular differentiation, which was associated with sebaceous hyperplasia. Dermoscopy of the lesion showed yellow globules surrounded by crown vessels/telangiectasias and scattered tiny hairs. Histopathological investigation revealed hyperplasia of the sebaceous glands and proliferation of well-differentiated vellus hair (...) follicles. These pathological findings were thought to correspond to the yellowish globules and tiny hairs observed under dermoscopy. Hair follicle nevus associated with sebaceous hyperplasia is extremely rare; however, dermoscopic examination can suggest an appropriate diagnosis. The present case proved the diagnostic usefulness of dermoscopy for cutaneous tumors with hair follicular and sebaceous glandular differentiation.

2015 Case reports in dermatology

10. Light and laser therapies for the treatment of sebaceous gland hyperplasia a review of the literature. (Abstract)

Light and laser therapies for the treatment of sebaceous gland hyperplasia a review of the literature. Sebaceous gland hyperplasia (SGH) is a benign cutaneous condition that presents primarily on the face and increases with UVB exposure and ageing. These lesions are a common cosmetic concern but are difficult to treat, as the entire sebaceous gland needs to be destroyed to prevent recurrence. Traditional methods of treatment include: cryosurgery, electrodessication, curettage, shave excision (...) treatments were found to offer alternatives to the more conventional techniques with better outcomes. In particular, the use of wavelength-specific laser for the sebaceous gland of 1720 nm were found to have better outcomes and provide minimal damage to surrounding tissues. Additionally, combination PDT with aminolevulinic acid and pre-treatment with carbon dioxide laser ablation or pulse-dyed laser offered higher cure rates over stand-alone laser or PDT treatments in a shorter number of sessions

2015 Journal of the European Academy of Dermatology and Venereology

11. Phospholipase Cγ1 is required for normal irritant contact dermatitis responses and sebaceous gland homeostasis. (Abstract)

the role of PLCγ1 in irritant contact dermatitis (ICD), in which epidermal cells play a pivotal role. Upon irritant stimulation, PLCγ1 cKO mice showed exaggerated ICD responses. Further study revealed that epidermal loss of PLCγ1 induced sebaceous gland hyperplasia, indicating that PLCγ1 regulates homeostasis of one of the epidermal appendages. Taken together, our results indicate that, although PLCγ1 is dispensable in interfollicular keratinocyte for normal differentiation, proliferation and migration (...) Phospholipase Cγ1 is required for normal irritant contact dermatitis responses and sebaceous gland homeostasis. Differentiation and proliferation of keratinocyte are controlled by various signalling pathways. The epidermal growth factor receptor (EGFR) is known to be an important regulator of multiple epidermal functions. Inhibition of EGFR signalling disturbs keratinocyte proliferation, differentiation and migration. Previous studies have revealed that one of the EGFR downstream signalling

2019 Experimental Dermatology

12. Clinico-pathological predictors of mismatch repair deficiency in sebaceous neoplasia: A large case series from a single Australian private pathology service. (Abstract)

should undergo MMR immunohistochemistry (IHC).An audit of sebaceous skin lesions (excluding hyperplasia) where pathologist-initiated MMR IHC was performed between January 2009 to December 2016 was undertaken from a single pathology practice identifying 928 lesions from 882 individuals. Lesions were further analysed for differences in gender, age at diagnosis, lesion type and anatomic location, stratified by MMR status.The 882 individuals (67.7% male) had a mean (SD) age of diagnosis of 68.4 ± 13.3 (...) Clinico-pathological predictors of mismatch repair deficiency in sebaceous neoplasia: A large case series from a single Australian private pathology service. Loss of expression of mismatch repair (MMR) proteins is frequently observed in sebaceous skin lesions and can be a herald for Lynch syndrome. The aim of this study was to identify clinico-pathological predictors of MMR deficiency in sebaceous neoplasia that could aid dermatologists and pathologists in determining which sebaceous lesions

2018 Australasian Journal of Dermatology

13. Rare presentation of sebaceous hyperplasia Full Text available with Trip Pro

Rare presentation of sebaceous hyperplasia A 23-year-old woman presented with an 8-month history of asymptomatic thickening of the central areola bilaterally and oily nipple discharge. On examination, there were yellowish-pink papules coalescing into plaques bilaterally. Biopsy showed ectopic sebaceous glands (Montgomery tubercles), known as bilateral areolar sebaceous hyperplasia.

2014 BMJ case reports

14. Sebaceous Hyperplasia (Overview)

Sebaceous Hyperplasia (Overview) Sebaceous Hyperplasia: Background, Pathophysiology, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA1OTM2OC1vdmVydmlldw== processing > Sebaceous Hyperplasia Updated: Aug (...) 15, 2018 Author: David T Robles, MD, PhD; Chief Editor: William D James, MD Share Email Print Feedback Close Sections Sections Sebaceous Hyperplasia Overview Background Sebaceous hyperplasia is a common, benign condition of sebaceous glands in adults of middle age or older. Lesions can be single or multiple and manifest as yellowish, soft, small papules on the face (particularly nose, cheeks, and forehead). Sebaceous hyperplasia occasionally also occurs on the chest, [ ] areola, [ ] mouth

2014 eMedicine.com

15. Sebaceous Hyperplasia (Diagnosis)

Sebaceous Hyperplasia (Diagnosis) Sebaceous Hyperplasia: Background, Pathophysiology, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA1OTM2OC1vdmVydmlldw== processing > Sebaceous Hyperplasia Updated (...) : Aug 15, 2018 Author: David T Robles, MD, PhD; Chief Editor: William D James, MD Share Email Print Feedback Close Sections Sections Sebaceous Hyperplasia Overview Background Sebaceous hyperplasia is a common, benign condition of sebaceous glands in adults of middle age or older. Lesions can be single or multiple and manifest as yellowish, soft, small papules on the face (particularly nose, cheeks, and forehead). Sebaceous hyperplasia occasionally also occurs on the chest, [ ] areola, [ ] mouth

2014 eMedicine.com

16. Sebaceous Hyperplasia (Treatment)

Sebaceous Hyperplasia (Treatment) Sebaceous Hyperplasia Treatment & Management: Medical Care Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA1OTM2OC10cmVhdG1lbnQ= processing > Sebaceous Hyperplasia Treatment (...) & Management Updated: Aug 15, 2018 Author: David T Robles, MD, PhD; Chief Editor: William D James, MD Share Email Print Feedback Close Sections Sections Sebaceous Hyperplasia Treatment Medical Care Sebaceous hyperplasia is completely benign and does not require treatment; however, lesions can be cosmetically unfavorable and sometimes bothersome when irritated. Treatments are mostly mechanical. Lesions tend to recur unless the entire unit is destroyed or excised. Risk of permanent scarring must

2014 eMedicine.com

17. Sebaceous Hyperplasia (Follow-up)

Sebaceous Hyperplasia (Follow-up) Sebaceous Hyperplasia Treatment & Management: Medical Care Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA1OTM2OC10cmVhdG1lbnQ= processing > Sebaceous Hyperplasia Treatment (...) & Management Updated: Aug 15, 2018 Author: David T Robles, MD, PhD; Chief Editor: William D James, MD Share Email Print Feedback Close Sections Sections Sebaceous Hyperplasia Treatment Medical Care Sebaceous hyperplasia is completely benign and does not require treatment; however, lesions can be cosmetically unfavorable and sometimes bothersome when irritated. Treatments are mostly mechanical. Lesions tend to recur unless the entire unit is destroyed or excised. Risk of permanent scarring must

2014 eMedicine.com

18. Sebaceous Hyperplasia

Sebaceous Hyperplasia Sebaceous Hyperplasia Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Sebaceous Hyperplasia Sebaceous (...) Hyperplasia Aka: Sebaceous Hyperplasia , Senile Hyperplasia , Senile Sebaceous Hyperplasia From Related Chapters II. Epidemiology Onset in middle age Rarely occurs at in familial forms III. Pathophysiology Composed of mature s with dilated duct IV. Causes Most cases idiopathic with aging V. Signs Characteristics Pale yellow color Soft, shiny dome-shaped s May be centrally umbilicated Usually 2-4 mm in size May appear cauliflower-like with multiple lobules Distribution Forehead, Cheeks, Nose VI. Labs

2015 FP Notebook

19. Sebaceous gland atrophy in psoriasis: An explanation for psoriatic alopecia? Full Text available with Trip Pro

morphometric analysis of paired PP and nonlesional psoriatic skin biopsies. Sebaceous glands were markedly atrophic in PP versus nonlesional psoriatic skin (91% average reduction in volume, P = 0.031). Module N5 genes were strongly downregulated in PP versus normal skin (fold change < 0.25, 44.4-fold) and strongly upregulated in sebaceous hyperplasia (fold change > 4, 54.1-fold). The intersection of PP-downregulated and sebaceous hyperplasia-upregulated gene lists generated a gene expression signature (...) Sebaceous gland atrophy in psoriasis: An explanation for psoriatic alopecia? In a transcriptome study of lesional psoriatic skin (PP) versus normal skin, we found a coexpressed gene module (N5) enriched 11.5-fold for lipid biosynthetic genes. We also observed fewer visible hairs in PP skin, compared with uninvolved nonlesional psoriatic skin or normal skin (P < 0.0001). To ask whether these findings might be due to abnormalities of the pilosebaceous unit, we carried out three-dimensional

2016 Journal of Investigative Dermatology

20. Lrig1 Expression in Human Sebaceous Gland Tumors Full Text available with Trip Pro

hyperplasias, 7 sebaceous adenomas, 10 sebaceomas and 4 sebaceous carcinomas) were stained with anti-Lrig1, anti-CD44v3 and anti-Ki67 antibody.Four (100%) sebaceous carcinomas, 8 (80%) sebaceomas, 3 (43%) sebaceous adenomas and no sebaceous hyperplasia showed Lrig1 overexpression.Lrig1 is a known tumor suppressor gene and is usually considered to be an indicator of poorly aggressive tumors. In human sebaceous tumors, the stronger Lrig1 staining in sebaceous carcinoma compared to other sebaceous tumors (...) Lrig1 Expression in Human Sebaceous Gland Tumors Sebaceous glands contribute significantly to the barrier functions of the skin. However, little is known about their homeostasis and tumorigenesis. Recently, increased expression of stem cell marker Lrig1 has been reported in sebaceous carcinoma-like tumors of K14ΔNLef1 transgenic mice. In this study, we analyzed the Lrig1 expression in human sebaceous tumors.Twenty-eight formalin-fixed paraffin-embedded sebaceous tumor specimens (7 sebaceous

2016 Dermatopathology

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