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Scleritis

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161. Usefulness of B-scan ocular ultrasound images for diagnosis of optic perineuritis Full Text available with Trip Pro

visit to our clinic, she still complained of blurred vision. She was found to have mild vitreous cells in the left eye and optic disc swelling in both eyes. However, the choroidal folds had already resolved in both eyes. B-scan ultrasound images displayed the optic nerve sheath as a highly reflective circle with shadowing around the optic disc in both eyes and scleral thickening in the left eye with fluid in sub-Tenon's space. Bilateral optic perineuritis with posterior scleritis seemed highly

2018 American journal of ophthalmology case reports

162. Retinal detachment

to chronic traction from scars on the retinal surface. See the CKS topics on and for more information. Inflammatory conditions (for example uveitis and scleritis) — these may predispose to exudative retinal detachment. See the CKS topic on for more information. Malignancy (for example choroidal melanoma or ocular metastasis) — predisposes to exudative retinal detachment. Congenital eye diseases, such as glaucoma, cataract, or retinopathy of prematurity. See the CKS topics on and for more information

2019 NICE Clinical Knowledge Summaries

163. Identification of multipotent stem/progenitor cells in murine sclera. Full Text available with Trip Pro

to differentiate to adipogenic, chondrogenic, and neurogenic lineages.This study indicates that the sclera contains multipotent mesenchymal stem cells. Further study of SSPCs may help elucidate the cellular and molecular mechanism of scleral diseases such as scleritis and myopia.

2020 Investigative Ophthalmology & Visual Science

164. Intraocular (Uveal) Melanoma Treatment (PDQ®): Health Professional Version

detachment (choroidal melanoma). Serous detachment of the retina may occur. If extensive detachment occurs, secondary angle-closure glaucoma occasionally develops. Clinically, several lesions simulate uveal melanoma, including metastatic carcinoma, posterior scleritis, and benign tumors, such as nevi and hemangiomas.[ ] Anatomy of the eye. Diagnosis Careful examination by an experienced clinician remains the most important test to establish the presence of intraocular melanoma. A small uveal melanoma

2018 PDQ - NCI's Comprehensive Cancer Database

165. Conjunctivitis - infective

, scleritis, or trauma) — for further information, see the CKS topic on . Take a history asking about: Onset and duration of symptoms. : Distribution of symptoms — unilateral or bilateral. Amount and character (watery, purulent, or mucopurulent) of discharge and when it is worst (for example on waking from sleep). Itching. Changes in vision such as blurring. Eyelid changes such as swelling, flaking and vesicles. Recent exposure to an infected person. Red flags which indicate the need for such as: Reduced (...) oedema and erythema which indicates a serious cause such as scleritis. Pupil — assess shape, size and pupillary reaction (with a pen torch) and look for asymmetric or unreactive pupils. Visual acuity (using a Snellen chart) and visual fields — compare with previous measurements of visual acuity, if possible. Eyelids – look for discharge, swelling, inflammation, malposition, nodules, loss of lashes (may indicate sebaceous gland carcinoma), vesicles (herpes) or blepharitis. Herpes simplex (HSV) — may

2018 NICE Clinical Knowledge Summaries

166. Prevalence of extraintestinal manifestations in Korean inflammatory bowel disease patients. Full Text available with Trip Pro

the general population of Korea.A total of 13,925 CD patients and 29,356 UC patients were identified. CD and UC patients were different in terms of demographics and utilization of medication. Among the 17 EIMs investigated, pyoderma gangrenosum, osteomalacia, Sweet syndrome, and scleritis were observed in very few patients. The SPRs were greater than 1 for all EIMs. Aphthous stomatitis, rheumatoid arthritis, and osteoporosis were highly prevalent in both CD and UC patients, but the SPRs of the EIMs were

2018 PLoS ONE

168. Ocular involvement in granulomatosis with polyangiitis: A single-center cohort study on 63 patients. (Abstract)

nomenclature definitions, we identified those with ocular involvement and a subsequent follow up in our center.The prevalence of ocular involvement in our GPA series was 38.6%; 63 patients were analysed with a median follow-up of 50.5 months (IQR: 17.8-82.8). Scleritis (18 patients, 26.8%) and episcleritis (18 patients, 26.8%) were the most common ophthalmologic manifestations, followed by orbital disease (13 patients, 20.6%). Bilateral involvement and visual acuity loss was seen in 29.1% and 16.7

2019 Autoimmunity reviews

169. Long-term efficacy and tolerability of TNFα inhibitors in the treatment of non-infectious ocular inflammation: an 8-year prospective surveillance study. Full Text available with Trip Pro

Long-term efficacy and tolerability of TNFα inhibitors in the treatment of non-infectious ocular inflammation: an 8-year prospective surveillance study. To report the efficacy and tolerability of antitumour necrosis factor-alpha therapy (TNF inhibitors [TNFi]) in the management of non-infectious ocular inflammation, including uveitis and scleritis, in adult patients over an 8-year period.This is a prospective cohort study of infliximab and adalimumab in the treatment of non-infectious ocular (...) inflammatory disease. 43 of 85 adult patients on TNFi (34 infliximab, 9 adalimumab) for ≥1 year with non-infectious uveitis or scleritis were followed from 2006 to 2014. Clinical assessments, medication, adverse events and history of steroid rescues were collected at 6 monthly intervals. General quality of life (Short Form Health Survey (SF-36)) and visual quality of life (Vision-related quality of life Core Measure (VCM1)) were assessed annually. Outcome measures included rate of sustained remission, rate

2019 British Journal of Ophthalmology

170. Predictive risk factors for exudative retinal detachment after vitrectomy for proliferative diabetic retinopathy. Full Text available with Trip Pro

laser photocoagulation); ocular trauma; systemic diseases; ocular diseases; uveitis; scleritis; tumor; congenital ocular disorders; or others.Included were 205 eyes of 169 patients, of whom 18 (8.78%) developed ERD with varying degrees of exudative choroidal detachment after 1 to 3 days. Binary logistic regression showed the following association with the development of ERD: lower serum albumin concentration (P = .001); without intravitreal anti-vascular endothelial growth factor (anti-VEGF) drug

2019 Medicine

171. Aminobisphosphonate-associated orbital and ocular inflammatory disease. (Abstract)

and a literature review to differentiate disease presentation and course between various aminobisphosphonates.Eight patients from our institution (6 women and 2 men, median age 62 years) were included. The used drugs were zoledronate, alendronate and risedronate. The most common clinical presentation was conjunctival hyperaemia/chemosis. Scleritis was the most common manifestation, followed by diffuse orbital inflammation and anterior uveitis. Ultrasound aided in diagnosis in all our patients

2019 Acta ophthalmologica

172. Conjunctivitis - allergic

(excluding vernal and atopic keratoconjunctivitis) conjunctivitis does not cause permanent visual loss or structural damage. The most consistent clinical feature of allergic conjunctivitis is itching. Other features include watery or mucoid discharge, conjunctival redness (injection) and oedema of the conjunctiva (chemosis) and eyelid. Serious causes of red eye (such as acute glaucoma, corneal ulcer, keratitis, iritis, scleritis and trauma) must be excluded — urgent referral to ophthalmology is required (...) do I assess a person with suspected allergic conjunctivitis? Assess all people presenting with a unilateral red eye for features indicating a serious and potentially sight-threatening cause (such as acute glaucoma, corneal ulcer, anterior uveitis, scleritis, or trauma) — for further information, see the CKS topic on . Take a history asking about: Onset and duration of symptoms. including: Variation of symptoms with location, season and exposure to specific triggers and whether symptoms

2017 NICE Clinical Knowledge Summaries

173. Corneal superficial injury

or geographic shapes. A foreign body under the upper lid may produce multiple vertical lines on the superior cornea. Injury from contact lenses may be seen as several punctate lesions coalescing around a central defect. The eyelids — look for oedema and erythema. Swelling and burns to the eyelids can occur with chemical injury. The sclera — look for signs of such as scleritis or episcleritis. The anterior chamber — look for blood (hyphema) or pus (hypopyon). Eye movements. Basis for recommendation Basis

2017 NICE Clinical Knowledge Summaries

174. Zoledronic acid Teva Pharma

Routine pharmacovigilance Routine risk minimization activities: Labelling: Risk has been highlighted in the product information for 5 mg solution; ocular undesirable effects are listed in [Section 4.8] SPC (common: ocular hyperaemia; uncommon: conjunctivitis, eye pain; rare: uveitis, episcleritis, iritis; not known: scleritis, orbital inflammation) and in PL. Post-dose symptoms Routine pharmacovigilance Routine risk minimization activities: Labelling: SPC [in Section 4.4] states "The incidence of post

2012 European Medicines Agency - EPARs

175. Zoledronic acid Teva

highlighted in the product information for 4 mg/5 ml concentrate; ocular undesirable effects are listed in [Section 4.8] SPC (common: conjunctivitis, uncommon: blurred vision, scleritis and orbital inflammation, very rare: uveitis, episcleritis) and in PL (tearing of the eye, eye sensitivity to light, painful redness and/or swelling of the eye). Acute phase reaction Routine pharmacovigilance Routine risk minimization activities: Labelling: Acute phase reaction has been highlighted in [Section 4.8] SPC/PL

2012 European Medicines Agency - EPARs

176. Zoledronic acid medac

zoledronate theraopy. If hypocalcaemia, hypophosphataemia, or hypomagnesaemia occurs, short-term supplemental therapy may be necessary. SPC Section 4.8 Undesirable effects: Hypocalcaemia is included in the ADRs. Ocular adverse events Routine pharmacovigilance Routine risk minimisation activities: SPC Section 4.8 Undesirable effects: Conjunctivitis, uveitis, episcleritis, scleritis, and orbital inflammation are included in the ADRs. Atrial fibrillation Routine pharmacovigilance Routine risk minimisation

2012 European Medicines Agency - EPARs

177. DRy Eye Outcome and Prescription Study

in at least one eye of at least 6/12. Exclusion Criteria: lacks capacity (e.g. dementia) poor understanding of English active other apparent ocular surface disease (including conjunctivitis, abrasion, recurrent erosion syndrome, episcleritis, inflamed pingueculum or pterygium, tumour, infectious keratitis). immune ocular pathology (including scleritis and uveitis). recent (within the last 3 months) or planned ocular surgery or intravitreal injections. current use of other ocular medication, e.g

2018 Clinical Trials

178. A Safety and Tolerability Study of NC318 in Subjects With Advanced or Metastatic Solid Tumors

(≤ Grade 2) not expected to resolve (such as neuropathy and alopecia) are exceptions and may enroll. Note: Subjects with a history of any grade immune-related ocular AE (e.g., episcleritis, scleritis, uveitis) will be excluded. Receipt of a live vaccine within 30 days of planned start of study therapy. Note: Examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, chicken pox/zoster, yellow fever, rabies, Bacillus Calmette-Guérin, and typhoid vaccine. Seasonal

2018 Clinical Trials

179. LSFG-SKIN, Laser Speckle Flowgraphy

normal and abnormal skin blood flow regionally in different areas of the body(face, extremities, over burns and wounds) at baseline and over time in response to treatment or environmental changes, such as temperature, light and pressure. Condition or disease Intervention/treatment Phase Hypertension Heart Failure Vascular Ischemia Burns Chemotherapy Effect Radiation Injuries Uveitis Scleritis Multiple Sclerosis Autonomic Neuropathy Stroke Intracranial Hemorrhages TIA Migraine Headache Pain Device (...) in and Exported from the U.S.: No Keywords provided by Randy Kardon, University of Iowa: perfusion inflammatory ischemia lesions neuropathy burns cancer stroke Additional relevant MeSH terms: Layout table for MeSH terms Heart Failure Multiple Sclerosis Hemorrhage Ischemia Headache Uveitis Intracranial Hemorrhages Scleritis Radiation Injuries Heart Diseases Cardiovascular Diseases Demyelinating Autoimmune Diseases, CNS Autoimmune Diseases of the Nervous System Nervous System Diseases Demyelinating Diseases

2018 Clinical Trials

180. Ocular Manifestations in Rheumatic Diseases

Description Go to Brief Summary: This is a search strategy for determining the prevalence of ocular complications in inflammatory rheumatic diseases for the purposes of a meta analysis. Condition or disease Intervention/treatment Uveitis Conjunctivitis Keratoconjunctivitis Sicca Xerophthalmia Eye Hemorrhage Optic Neuritis Papilledema Orbital Diseases Retinal Vein Occlusion Retinal Artery Occlusion Macular Edema Retinitis Chorioretinitis Iridocyclitis Scleritis Choroid Hemorrhage Blindness Amaurosis Fugax (...) Other: No intervention used Detailed Description: For the purposes of determining the prevalence of ocular complications in inflammatory rheumatic diseases, the following search terms were used: conjunctivitis, keratoconjunctivitis sicca, xerophthalmia, uveitis, eye hemorrhage, optic neuritis, papilledema, orbital disease, retinal artery/vein occlusion, macular edema, retinitis, chorioretinitis, scleritis, iridocyclitis, choroid hemorrhage, blindness and amaurosis fugax. These terms were searched

2018 Clinical Trials

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