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Subconjunctival dexamethasone implant for non-necrotizing scleritis The purpose of this study is to report the management of non-necrotizing anterior scleritis with a single-dose subconjunctival 0.7 mg dexamethasone implant (Ozurdex®, Allergan, Inc., CA, USA). Six patients with clinical diagnosis of non-necrotizing anterior scleritis (diffuse, sectorial, and nodular) were submitted to subconjunctival injection of dexamethasone implant. The injection was performed under topical anesthesia (...) recurrence was noted in the 6-month follow-up in a patient with rheumatoid arthritis and non-necrotizing diffuse scleritis and was treated with oral steroids. No patient developed ocular hypertension or any kind of complications during the follow-up period, except for subconjunctival hemorrhage.Dexamethasone implant was safely and effectively used as a local therapy for non-necrotizing scleritis.
Secondary glaucoma due to chronic scleritis: trabeculectomy in scleromalacia: a case report 24232311 2014 07 23 2018 11 13 1476-5454 28 1 2014 Jan Eye (London, England) Eye (Lond) Secondary glaucoma due to chronic scleritis: trabeculectomy in scleromalacia: a case report. 104-6 10.1038/eye.2013.215 Dean W H WH Ophthalmology Department, Gloucestershire Hospitals NHS Foundation Trust, Cheltenham, UK. Turner S A SA Ophthalmology Department, Gloucestershire Hospitals NHS Foundation Trust (...) , Cheltenham, UK. McNaught A I AI 1] Ophthalmology Department, Gloucestershire Hospitals NHS Foundation Trust, Cheltenham, UK  Cranfield University, Bedfordshire, UK. eng Case Reports Letter 2013 11 15 England Eye (Lond) 8703986 0950-222X 0 Alkylating Agents 50SG953SK6 Mitomycin IM Aged Alkylating Agents administration & dosage Chronic Disease Female Follow-Up Studies Glaucoma, Open-Angle etiology surgery Humans Intraocular Pressure Mitomycin administration & dosage Sclera pathology Scleritis
Gevokizumab for Active Scleritis Gevokizumab for Active Scleritis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Gevokizumab for Active Scleritis The safety and scientific validity of this study (...) ) ( National Eye Institute (NEI) ) Study Details Study Description Go to Brief Summary: Background: - Scleritis is the inflammation of the white outer coating of the eye, known as the sclera. In severe cases, it can cause blindness. It is commonly associated with autoimmune disorders such as rheumatoid arthritis. Mild scleritis can be treated with drugs such as ibuprofen. More severe scleritis may need oral steroids or immunosuppressive treatments; however, these treatments can cause side effects
Optical Coherence Tomography in the Diagnosis of Scleritis and Episcleritis Optical Coherence Tomography in the Diagnosis of Scleritis and Episcleritis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Optical Coherence Tomography in the Diagnosis of Scleritis and Episcleritis The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01958567 Recruitment Status : Completed First Posted : October 9, 2013 Last Update Posted : September 1, 2014 Sponsor: The Eye Center and The Eye Foundation for Research
Incidence of Scleritis and Episcleritis: Results From the Pacific Ocular Inflammation Study. To ascertain the incidence of scleritis and episcleritis in a Hawaiian population and describe variations by age, sex, and race.Retrospective, population-based cohort study.All electronic medical records for enrollees in Kaiser Permanente Hawaii (n = 217,061) from January 1, 2006 to December 31, 2007 were searched for International Classification of Diseases, 9th Edition (ICD-9) codes associated (...) with ocular inflammation. Chart review was conducted to verify a clinical diagnosis of scleritis or episcleritis. Confirmed cases were used to calculate incidence rates per 100,000 person-years. Ninety-five percent confidence intervals (CI) were calculated for each incidence rate, including age-, sex-, and race-specific rates, using bias-corrected Poisson regression. To assess for confounding, a multivariate analysis adjusting for age, sex, and race was also performed.Of 217,061 eligible patients, 17
Scleritis: Immunopathogenesis and molecular basis for therapy. Scleritis is a heterogeneous group of diseases characterized by inflammation of the sclera, which may be due to local or systemic infections or immune mediated diseases. Numerous studies over the last decade have lead to significant progress in understanding the pathogenesis and treatment of this severe and potentially blinding disease. Immunological investigations of non-infectious scleritis and associated diseases have indicated (...) that scleritis is an autoimmune disease and studies on the nature of the local inflammatory response have revealed the prominent role of T and B cells and cytokines, such as TNF-alpha, which in turn has resulted in clinical trials showing the effectiveness of local steroid treatment, anti-TNF and anti-B cell therapy. The widespread use of imaging has led to the realization that posterior scleritis is more common than previously recognized and testing for ANCA antibodies has revealed the prominent role
Imaging Studies in a Case of Infectious Scleritis after Pterygium Excision A 44-year-old woman presented with a painful red eye for 2 weeks. Ultrasound biomicroscopy and optical coherence tomography were instrumental in the diagnosis and management of this case of infectious scleritis associated with previous pterygium excision complicated by choroidal and retinal detachments.
Combined anterior and posterior scleritis associated with central retinal vein occlusion: a case report The purpose of this study is to report an uncommon presentation of anterior and posterior scleritis with central retinal vein occlusionWe report a 30-year-old female presenting with unilateral anterior and posterior scleritis with concurrent central retinal vein occlusion, the subsequent work-up, and the management. The patient presented with decreased vision and extraocular and intraocular (...) inflammatory signs in the left eye.At presentation, the best corrected visual acuity in the right eye (OD) was 20/20 and left eye (OS) was perception of light, with inaccurate projection of rays in all quadrants. Intraocular pressure was 12 mmHg in both eyes. OS showed mild proptosis with lid edema. Ocular movements were free and full in both eyes. The bulbar conjunctiva showed nodular anterior scleritis. OS showed mild vitreous haze with an exudative detachment at the posterior pole, disc edema
Necrobiotic xanthogranuloma and chronic lymphocytic leukemia of the conjunctiva masquerading as scleritis and uveitis This report describes a unique case of coexisting necrobiotic xanthogranuloma and chronic lymphocytic leukemia in a patient presenting with scleritis and uveitis. A 53-year-old Caucasian man diagnosed with anterior uveitis and scleritis for the prior year was referred to our uveitis clinic for further evaluation. Prior uveitis/scleritis workup performed by the referring (...) ophthalmologist was negative. Examination demonstrated unilateral uveitis and posterior scleritis along with bilateral conjunctival lesions. Incisional biopsy of the conjunctiva was carried out. The excised tissue was sent fresh for histopathologic studies. Slit-lamp examination revealed bilateral yellow-white bulbar conjunctival lesions, 1+ conjunctival injection OU, stellate keratic precipitates OS with 25 cells per high-powered field. Funduscopic examination was significant for subretinal fluid OS
Unilateral optic neuritis, scleritis and exudative retinal detachment due to recurrent orbital pseudotumor Idiopathic orbital inflammation, also known as orbital pseudotumor, describes a spectrum of idiopathic, non-neoplastic, non-infectious, space-occupying orbital lesions without identifiable local or systemic cause. The condition occurs mainly in young adults who may present with acute pain, proptosis, chemosis and limitations of extraocular movements. Decreased vision due to optic nerve (...) infiltration and macular edema as a result of scleritis is less common sequel of orbital pseudotumor. Herein, we present a case of unilateral orbital pseudotumor in a young male who presented with chief complaints of painful decreased vision which was attributed to optic neuritis and macular edema as a result of scleritis. Imaging studies were helpful in the establishment of the correct diagnosis and patient's complaints improved with administration of systemic corticosteroids.
ScleritisScleritis Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 ScleritisScleritis Aka: Scleritis , Nodular Scleritis (...) , Necrotizing Scleritis From Related Chapters II. Epidemiology Rare III. Pathophysiology Severe l inflammation Variations Nodular Scleritis Necrotizing Scleritis (most destructive) Anterior Scleritis (deep to ) Posterior Scleritis (overlying ) IV. Causes Idiopathic in 50% of cases (most common cause) Accounts for up to one third of Scleritis cases Scleritis occurs in 4-10% of RA cases (previously known as ) Infectious (uncommon) Pseudomonas V. Symptoms involving one or both eyes Blurred vision Photophobia
Sirolimus Injections for Autoimmune Scleritis Sirolimus Injections for Autoimmune Scleritis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Sirolimus Injections for Autoimmune Scleritis (ISAS) The safety (...) Center (CC) ( National Eye Institute (NEI) ) Study Details Study Description Go to Brief Summary: Background: Autoimmune scleritis is an inflammatory disease that affects the white outer part of the eye. It is associated with immune system disorders like rheumatoid arthritis. It can cause blindness in severe cases. Most treatments for scleritis involve steroid or immune-suppressing drugs, but these can cause side effects in the whole body. Sirolimus is a drug used to help prevent transplant rejection
Clinical Features and Presentation of Infectious Scleritis from Herpes Viruses: A Report of 35 Cases. To describe clinical features and presentation of infectious scleritis resulting from herpes viruses.Retrospective case series.Thirty-five patients out of 500 with scleritis.We reviewed the electronic health records of 500 patients with scleritis, 35 of whom were diagnosed with herpes virus infection, seen at 2 tertiary referral centers. We studied the clinical features and ocular complications (...) of this subset of patient with scleritis.Correlation between classification, severity, and symptoms (i.e., pain) and diagnosis of herpetic-associated scleritis. Vision loss, presence of associated uveitis, keratitis, glaucoma, or systemic disease were documented over the follow-up period. Other outcome measures included epidemiologic data: age, gender, laterality, visual acuity, duration of symptoms, and underlying systemic or ocular diseases.Of 500 patients with scleritis, 47 (9.4%) had an underlying
Adalimumab in the treatment of recurrent idiopathic bilateral nodular scleritis Our objective is to report a case of bilateral nodular scleritis in a 34-year-old patient, resistant to steroids and traditional disease modifying anti-rheumatic drugs, who was successfully treated with subcutaneous injections of 40 mg adalimumab. Adalimumab resulted in rapid control of scleritis in both eyes within 3 months with no recurrence over 5 years of follow-up. No side effects were reported during
Refractive changes in patients with autoimmune scleritis 21484176 2012 10 02 2018 11 13 1869-5760 1 4 2011 Dec Journal of ophthalmic inflammation and infection J Ophthalmic Inflamm Infect Refractive changes in patients with autoimmune scleritis. 173-5 10.1007/s12348-011-0023-0 Arellanes-Garcia Lourdes L Clinic of Inflammatory Eye Disease, "Dr. Luis Sanchez Bulnes" Hospital Asociación para Evitar la Ceguera en México IAP, Mexico, Mexico. Del Carmen Preciado-Delgadillo Maria M Garza-Leon Manuel M
Optimizing Diagnosis and Management of Nocardia Keratitis, Scleritis, and Endophthalmitis: 11-Year Microbial and Clinical Overview. To identify clinical factors and microbiological assays that facilitate a rapid diagnosis of Nocardia keratitis, scleritis, and endophthalmitis, and to determine optimal medical and surgical management strategies.Retrospective, consecutive case series.A total of 111 cases of keratitis, 11 cases of scleritis, and 16 cases of endophthalmitis, all culture-proven (...) Nocardia infections, were identified between January 1999 and January 2010.The keratitis cases underwent intensive medical management, and the scleritis and endophthalmitis cases required concurrent surgical intervention for disease control. Corneal and scleral scrapings, as well as undiluted vitreous sample, were submitted for microbiologic evaluation (direct smear and culture).Historical points, clinical findings, and microbiologic assays that facilitated a prompt Nocardia diagnosis were identified