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Scleritis

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21. Necrotizing Scleritis after Cosmetic Conjunctivectomy with Mitomycin C. (Abstract)

Necrotizing Scleritis after Cosmetic Conjunctivectomy with Mitomycin C. To report cases of necrotizing scleritis, a sight-threatening complication that can result from cosmetic conjunctivectomy procedures.Retrospective case series.The medical records of consecutive patients who underwent eye-whitening conjunctivectomy with mitoycin C (MMC) treatment performed by 1 surgeon in South Korea and were referred to the authors' clinic between January 2011 and December 2015 were reviewed. The patients (...) in whom findings of necrotizing scleritis with active inflammation were detected in an avascular area of previous conjunctivectomy were included.Of a total of 231 patients who had received cosmetic eye whitening, 4 patients who met the inclusion criteria were identified. The average length of time from cosmetic eye surgery to a diagnosis of necrotizing scleritis was 51 months and all patients had unilateral findings of necrotizing scleritis. There was no underlying systemic autoimmunity or infectious

2018 American Journal of Ophthalmology

22. A case of scleritis associated rheumatoid arthritis accompanying an intraocular elevated lesion. Full Text available with Trip Pro

A case of scleritis associated rheumatoid arthritis accompanying an intraocular elevated lesion. Scleritis and/or uveitis sometimes accompanies patients who suffer from rheumatoid arthritis. However, few studies have reported scleritis and/or uveitis accompanying a fundus elevated lesion, such as an intraocular tumor. In this study, we report a case of rheumatoid uveitis associated with an intraocular elevated lesion.A 66-year-old female visited another eye clinic and was diagnosed as bilateral

2018 BMC Ophthalmology

23. Iontophoretic delivery of dexamethasone phosphate for non-infectious, non-necrotising anterior scleritis, dose-finding clinical trial. Full Text available with Trip Pro

Iontophoretic delivery of dexamethasone phosphate for non-infectious, non-necrotising anterior scleritis, dose-finding clinical trial. Currently available treatment options for non-infectious scleritis, including non-steroidal anti-inflammatory drugs, systemic corticosteroids and immunosuppressive therapies, have both efficacy and side effect limitations. Iontophoretic delivery of corticosteroids has been demonstrated to be effective for anterior uveitis and represents a potential new approach (...) to scleritis therapy. We hypothesised that iontophoretic delivery would provide effective and precise medication delivery to the sclera, while limiting systemic exposure and side effects. This first-in-human randomised, double-masked, dose-escalating study of iontophoretic administration of dexamethasone phosphate for scleritis suggests the treatment to be well tolerated and safe (within the limitations of the 18 patients sample size). There was a suggestion of efficacy in the lowest (1.2 mA/min at 0.4 mA

2018 British Journal of Ophthalmology

24. Scedosporium apiospermum infectious scleritis following posterior subtenon triamcinolone acetonide injection: a case report and literature review. Full Text available with Trip Pro

Scedosporium apiospermum infectious scleritis following posterior subtenon triamcinolone acetonide injection: a case report and literature review. Ubiquitous fungi of the Scedosporium apiospermum species complex (SASC) cause various opportunistic infections. Posterior subtenon triamcinolone acetonide (STTA) injection is a standard therapy for intraocular inflammation and macular edema. We report a case of Scedosporium apiospermum infectious scleritis after a posterior STTA injection.A 75-year (...) debridement and topical VRCZ were resumed, with the eye finally improving after 5 months of management. The fungal species was identified as Scedosporium apiospermum sensu stricto morphologically and by DNA sequencing.This case was successfully treated by topical and systemic VRCZ and repeated surgical debridement. Infectious scleritis caused by SASC rarely develops after posterior STTA. SASC can produce conidia in the enclosed subtenon space. Late-onset infectious scleritis after a posterior STTA

2018 BMC Ophthalmology

25. Surgically induced necrotizing scleritis following strabismus surgery treated successfully with topical N-acetylcysteine in a child with congenital fibrosis of extraocular muscles and Varadi Papp syndrome. (Abstract)

Surgically induced necrotizing scleritis following strabismus surgery treated successfully with topical N-acetylcysteine in a child with congenital fibrosis of extraocular muscles and Varadi Papp syndrome. Surgically induced necrotizing scleritis (SINS) is a rare but serious disorder that can develop many years after strabismus surgery. It is generally treated with high-dose steroids or immunosuppression.We describe a patient with Varadi Papp syndrome and congenital fibrosis of the extraocular (...) muscles, who developed surgically induced necrotizing scleritis a month after strabismus surgery and was successfully managed by oral vitamin C and topical N-acetylcysteine 10%.While SINS is conventionally treated with steroids/immunosuppression, a conservative approach may be tried in milder cases. The role of topical N-acetylcysteine in managing this complication needs to be explored.

2017 Strabismus

26. Cyclophosphamide vs. Infliximab for Refractory Idiopathic Scleritis (CIRIS)

Cyclophosphamide vs. Infliximab for Refractory Idiopathic Scleritis (CIRIS) Cyclophosphamide vs. Infliximab for Refractory Idiopathic Scleritis (CIRIS) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Cyclophosphamide vs. Infliximab for Refractory Idiopathic Scleritis (CIRIS) (CIRIS) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03088293 Recruitment Status : Not yet recruiting First Posted : March 23, 2017 Last Update Posted

2017 Clinical Trials

27. Chemotherapy-induced anterior necrotising scleritis: A case report Full Text available with Trip Pro

Chemotherapy-induced anterior necrotising scleritis: A case report We describe a case of anterior necrotising scleritis secondary to Gemcitabine and Carboplatin chemotherapy agents in a patient with metastatic breast cancer, which has not been previously reported.A 50-year-old lady with recurrent metastatic breast cancer presented with unilateral subconjunctival haemorrhage secondary to severe thrombocytopenia eight days following palliative chemotherapy in the form of Gemcitabine (...) and Carboplatin. Twelve days following the initial presentation, the subconjunctival haemorrhage had resolved, however there was evidence of anterior necrotising scleritis with anterior chamber reaction and hypotony with choroidal effusion. This resolved with three days of intravenous Methylprednisolone along with topical steroids and the area of necrosis remained stable.Due to the chronological order of events, we infer a Gemcitabine and Carboplatin-induced anterior necrotising scleritis, which has not been

2016 American journal of ophthalmology case reports

28. Unilateral surgically induced Necrotizing Scleritis after trabeculectomy with Ologen in a patient with pigmentary glaucoma Full Text available with Trip Pro

Unilateral surgically induced Necrotizing Scleritis after trabeculectomy with Ologen in a patient with pigmentary glaucoma In this report we record the first surgically induced Necrotizing Scleritis case related to trabeculectomy with the use of Ologen Collagen Matrix Implant.Surgically induced Necrotizing Scleritis is a rare pathological entity that complicates ocular (sclera) surgery.Prompt management of surgically induced Necrotizing Scleritis related to trabeculectomy with the use of Ologen

2016 American journal of ophthalmology case reports

29. When an Easy Thing Goes Wrong: Foreign Body Induced Granuloma-Associated Scleritis Following Pterygium Surgery Full Text available with Trip Pro

When an Easy Thing Goes Wrong: Foreign Body Induced Granuloma-Associated Scleritis Following Pterygium Surgery To report a case of pterygium surgery with conjunctival autograft followed by focal necrotizing scleritis due to foreign body entrapment in the scleral bed.This is a case report of a 76-years-old male patient who underwent nasal pterygium surgery and developed focal necrotizing scleritis secondary to foreign body entrapment under conjunctival autograft. One month following surgery

2017 Case reports in ophthalmology

30. IgG4-Related Disease Presenting as Isolated Scleritis Full Text available with Trip Pro

IgG4-Related Disease Presenting as Isolated Scleritis A rare case of IgG4-related disease (IgG4-RD) manifesting as nodular scleritis is presented in a 20-year-old female. Patient complained of left eye pain and redness for one week. Ocular examination together with ancillary testing led to the diagnosis of nodular scleritis. Since the patient did not show apparent improvement after one week of systemic steroidal treatment, she underwent a biopsy of the affected area revealing histopathological (...) characteristics of IgG4-RD. Long-term treatment with corticosteroids and a steroid-sparing agent (methotrexate) led to significant improvement in signs and symptoms. This case highlights the significance of IgG4-RD in the differential diagnosis of scleritis and raises the question as to whether various organs affected by IgG4-RD may have different underlying pathophysiological mechanisms in which pathogenic T cells play a role.

2017 Case reports in ophthalmological medicine

31. Virulence genome analysis of Pseudomonas aeruginosa VRFPA10 recovered from patient with scleritis Full Text available with Trip Pro

Virulence genome analysis of Pseudomonas aeruginosa VRFPA10 recovered from patient with scleritis Infectious keratitis is a major cause of blindness, next to cataract and majority of cases are mainly caused by gram negative bacterium Pseudomonas aeruginosa (P. aeruginosa). In this study, we investigated a P. aeruginosa VRFPA10 genome which exhibited susceptibility to commonly used drugs in vitro but the patient had poor prognosis due to its hyper virulent nature. Genomic analysis of VRFPA10

2017 Genomics data

32. Ocular Autoimmune Systemic Inflammatory Infectious Study (OASIS)—report 4: analysis and outcome of scleritis in an East Asian population Full Text available with Trip Pro

Ocular Autoimmune Systemic Inflammatory Infectious Study (OASIS)—report 4: analysis and outcome of scleritis in an East Asian population The purpose of this study is to evaluate the spectrum of scleritis from database of Ocular Autoimmune Systemic Inflammatory Infectious Study (OASIS) at a tertiary eye referral eye institute in Singapore. Clinical records of 120 patients with scleritis from a database of 2200 patients from Ocular Autoimmune Systemic Inflammatory Infectious Study (OASIS) were (...) reviewed.56.6% were females, with a mean age of 48.6 ± 15.9 years. 75 (62.5%) had diffuse anterior scleritis, 25 (20.8%) had nodular anterior scleritis, 7 (5.8%) had necrotizing anterior scleritis and 13 (10.8%) had posterior scleritis. Ocular complications were observed in 53.3% of patients, including anterior uveitis (42.5%), raised intraocular pressure (12.5%), and corneal involvement (11.7%). Autoimmune causes were associated with 31 (25.8%) of patients, and 10 (8.3%) patients had an associated

2017 Journal of ophthalmic inflammation and infection

33. Three atypical manifestations of granulomatosis with polyangiitis: lateral medullary syndrome, anterior cheek mass and melting scleritis of eye Full Text available with Trip Pro

Three atypical manifestations of granulomatosis with polyangiitis: lateral medullary syndrome, anterior cheek mass and melting scleritis of eye Granulomatosis with polyangiitis (GPA, formerly Wegener granulomatosis) is a vasculitis with various organ involvement. There have been a few cases of CNS stroke and rare cases of lateral medullary infarction (LMI) as a manifestation of GPA. Also there have been reports of sinuses, nose and laryngeal masses mistakenly referred as carcinomas (...) and subsequently GPA was diagnosed in their pathological reports. Another severe fulminant manifestation can be necrotizing scleritis leading to perforation of sclera. Therefore, here we present some rare and fulminant manifestations of GPA in 3 separate cases for further emphasis of the unusual manifestations of GPA that should always be kept in mind.

2017 Reumatologia

34. Pseudomonas Scleritis following Pterygium Excision Full Text available with Trip Pro

Pseudomonas Scleritis following Pterygium Excision The aim of this case report was to describe a patient who presented with Pseudomonas scleritis after pterygium excision. The study was conducted at the Department of Ophthalmology, Faculty of Medicine, Chiang Mai University in Chiang Mai, Thailand.The record of a patient who was diagnosed as Pseudomonas scleritis after pterygium excision was retrospectively reviewed for history, clinical characteristics, laboratory findings, treatments (...) , and outcomes.We described a 66-year-old male patient with a history of pterygium excision in his right eye 10 years ago, he presented with infectious scleritis. Scleral thinning, tissue necrosis, and overlying calcified plaque were found. The culture of scleral scraping revealed Pseudomonas aeruginosa. Topical fortified amikacin (20 mg/mL) and intravenous ceftazidime were started. Urgent surgical debridement of scleral infiltrates and irrigation of necrotic sclera and surrounding conjunctiva with fortified

2017 Case reports in ophthalmology

35. Hypertrophic Pachymeningitis Accompanying Scleritis Full Text available with Trip Pro

Hypertrophic Pachymeningitis Accompanying Scleritis 28794383 2018 11 13 1349-7235 56 17 2017 09 01 Internal medicine (Tokyo, Japan) Intern. Med. Hypertrophic Pachymeningitis Accompanying Scleritis. 2383-2384 10.2169/internalmedicine.8850-17 Oka Kosuke K Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan. Ocho Kazuki K Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry (...) and Pharmaceutical Sciences, Japan. Iwamuro Masaya M Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan. Otsuka Fumio F Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan. eng Journal Article 2017 08 10 Japan Intern Med 9204241 0918-2918 headache hypertrophic pachymeningitis scleritis 2017 8 11 6 0 2017 8 11 6 1 2017 8 11 6 0 ppublish 28794383 10.2169

2017 Internal Medicine

36. Ocular metastasis from breast carcinoma simulating anterior scleritis: a case report Full Text available with Trip Pro

Ocular metastasis from breast carcinoma simulating anterior scleritis: a case report Breast cancer is one of the commonest sources of ocular metastasis. Patients with ocular metastatic disease can present with a variable clinical picture. Patients with a history of breast cancer presenting with any eye symptom should be evaluated with consideration of ocular metastasis.We report a case of ocular metastasis in a 46-year-old Brahmin woman presenting with right eye pain. She had been treated (...) for stage IIIc left-sided breast cancer 2 years ago with six cycles of chemotherapy with docetaxel, adriamycin, and cyclophosphamide after undergoing modified radical mastectomy. An ophthalmic examination revealed a tender subconjunctival swelling superotemporally on retracting right upper eyelid. This finding alone indicated anterior scleritis. On examining fundus under mydriasis, an amelanotic subretinal mass could be visualized in the posterior pole superotemporal to macula. An orbital magnetic

2017 Journal of medical case reports

37. Necrobiotic xanthogranuloma scleritis in a case of granulomatosis with polyangiitis (Wegener’s granulomatosis) Full Text available with Trip Pro

Necrobiotic xanthogranuloma scleritis in a case of granulomatosis with polyangiitis (Wegener’s granulomatosis) The purpose of this study was to describe a case of necrobiotic xanthogranuloma scleritis in a 53-year-old male with unilateral progressive visual loss, scleritis, prolonged fever, and multiple mononeuropathy. Scleral biopsy showed necrosis with small abscess, and the pathological tissues revealed submucosal infiltration of mononucleated foamy histiocytes (xanthoma cells (...) and later with intravenous cyclophosphamide monthly. He responded well to treatment, both eye and systemic conditions. Necrobiotic xanthogranuloma scleritis could be an early presentation of granulomatosis with polyangiitis.

2017 International medical case reports journal

38. An OCT Study of Anterior Nodular Episcleritis and Scleritis Full Text available with Trip Pro

An OCT Study of Anterior Nodular Episcleritis and Scleritis Anterior scleritis and episcleritis are a well-known presentation in tuberculosis. The case of a female patient with presumed tuberculous anterior scleritis and episcleritis is discussed in this article. Anterior segment OCT was efficient in diagnosis and evaluation of the therapeutic outcome. Antituberculosis chemotherapy was sufficient to achieve clinical remission.

2017 Case reports in ophthalmological medicine

39. Anterior infectious necrotizing scleritis secondary to Pseudomonas aeruginosa infection following intravitreal ranibizumab injection Full Text available with Trip Pro

Anterior infectious necrotizing scleritis secondary to Pseudomonas aeruginosa infection following intravitreal ranibizumab injection To report the occurrence and management of severe infectious scleritis in a 75 year-old woman following intravitreal ranibizumab injection.A 75 year-old monocular woman receiving monthly intravitreal ranibizumab injection for wet age related macular degeneration in the left eye presented with severe dull pain, decreased vision, and scleral melt with discharge 2 (...) after two weeks of intravenous, oral and, topical antibiotics.To our knowledge, this is the first case of anterior infectious necrotizing scleritis secondary to Pseudomonas aeruginosa infection following intravitreal ranibizumab injection. Clinicians performing intravitreal injections should have a high index of suspicion for iatrogenic infections including scleritis and endophthalmitis, as these infections require aggressive topical and systemic antibiotics as well as possible hospitalization.

2016 American journal of ophthalmology case reports

40. Anterior scleritis following intravitreal injections in a patient with rheumatoid arthritis: A case report. Full Text available with Trip Pro

Anterior scleritis following intravitreal injections in a patient with rheumatoid arthritis: A case report. Surgically induced scleritis is a rare complication following ophthalmologic surgery such as cataract surgery, pterygium excision, strabismus surgery, and retinal detachment repair. Rheumatoid arthritis (RA) is the connective tissue disease most commonly associated with scleritis.A 70-year-old woman visited our clinic with complaint of visual disturbance, ocular pain, and conjunctival (...) injection in her right eye of 1 month's duration. She had a stable state of rheumatoid factor positive RA and had a history of multiple intravitreal injections placed in the symptomatic right eye due to age-related macular degeneration.Anterior scleritis induced by multiple intravitreal injections.Topical and systemic steroids were administered.Her symptoms and signs were relieved and no significant recurrence has been occurred with the maintenance of low dose oral steroid.Surgically induced scleritis

2017 Medicine

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