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181. To Evaluate the Comparative Efficacy of Lucentis (Ranibizumab) 0.5mg Intravitreal Injection in Patients With Diabetic Macular Oedema (DME) With Well Controlled and Poorly Controlled Diabetes Mellitus

inflammation (grade trace or above) in either eye Any active infection (e.g. conjunctivitis, keratitis, scleritis, uveitis, endophthalmitis) in either eye History of uveitis in either eye Structural damage within 1 disc diameter of the center of the macula in the study eye likely to preclude an improvement in visual acuity following the resolution of macular oedema, including (geographic) atrophy of the retinal pigment epithelium, subretinal fibrosis, laser scar(s), or organized hard exudates plaques

2018 Clinical Trials

182. Two-week Retreatment Interval Study for Treated Age-related Macular Degeneration Refractory to Monthly Aflibercept

- 4) in the study eye Active infectious conjunctivitis, keratitis, scleritis, or endophthalmitis in either eye Aphakia in the study eye Uncontrolled glaucoma in the study eye (defined as intraocular pressure ≥30 mmHg despite treatment with anti-glaucoma medication) Systemic Exclusion Criteria Use of systemic anti-VEGF medications within 6 months of screening visit History of cerebrovascular accident, myocardial infarction, ventricular arrhythmia, unstable angina, coronary or peripheral artery

2018 Clinical Trials

183. Effects of a Single Osteopathic Manipulative Treatment (OMT) on Intraocular Pressure (IOP) Reduction

for the study, to be confirmed by a urine pregnancy if the woman is still menstruating. Subjects who have a history of chronic or recurrent severe inflammatory eye disease (e.g., scleritis - inflammation of the white part of the eye or uveitis - eye redness, pain and blurred vision) in either eye as determined by patient history and/or examination. Subjects who have a history of clinically significant or progressive retinal disease in either eye such as retinal degeneration (which is the breakdown

2018 Clinical Trials

184. DRy Eye Outcome and Prescription Study

in at least one eye of at least 6/12. Exclusion Criteria: lacks capacity (e.g. dementia) poor understanding of English active other apparent ocular surface disease (including conjunctivitis, abrasion, recurrent erosion syndrome, episcleritis, inflamed pingueculum or pterygium, tumour, infectious keratitis). immune ocular pathology (including scleritis and uveitis). recent (within the last 3 months) or planned ocular surgery or intravitreal injections. current use of other ocular medication, e.g

2018 Clinical Trials

185. A Safety and Tolerability Study of NC318 in Subjects With Advanced or Metastatic Solid Tumors

(≤ Grade 2) not expected to resolve (such as neuropathy and alopecia) are exceptions and may enroll. Note: Subjects with a history of any grade immune-related ocular AE (e.g., episcleritis, scleritis, uveitis) will be excluded. Receipt of a live vaccine within 30 days of planned start of study therapy. Note: Examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, chicken pox/zoster, yellow fever, rabies, Bacillus Calmette-Guérin, and typhoid vaccine. Seasonal

2018 Clinical Trials

186. LSFG-SKIN, Laser Speckle Flowgraphy

normal and abnormal skin blood flow regionally in different areas of the body(face, extremities, over burns and wounds) at baseline and over time in response to treatment or environmental changes, such as temperature, light and pressure. Condition or disease Intervention/treatment Phase Hypertension Heart Failure Vascular Ischemia Burns Chemotherapy Effect Radiation Injuries Uveitis Scleritis Multiple Sclerosis Autonomic Neuropathy Stroke Intracranial Hemorrhages TIA Migraine Headache Pain Device (...) in and Exported from the U.S.: No Keywords provided by Randy Kardon, University of Iowa: perfusion inflammatory ischemia lesions neuropathy burns cancer stroke Additional relevant MeSH terms: Layout table for MeSH terms Heart Failure Multiple Sclerosis Hemorrhage Ischemia Headache Uveitis Intracranial Hemorrhages Scleritis Radiation Injuries Heart Diseases Cardiovascular Diseases Demyelinating Autoimmune Diseases, CNS Autoimmune Diseases of the Nervous System Nervous System Diseases Demyelinating Diseases

2018 Clinical Trials

187. Tofacitinib for Inflammatory Eye Disease

University School of Medicine Study Details Study Description Go to Brief Summary: Non-infectious inflammatory eye disease, such as uveitis and scleritis, is a chronic, auto-immune process that leads to vision loss. While steroids are effective in the short term, the side-effect profile of chronic steroid use necessitates the identification of effective steroid-sparing therapies. Tofacitinib is a small molecule that inhibits the signaling pathways of multiple inflammatory cytokines. The investigators (...) plan to evaluate whether tofacitinib may have efficacy for patients with uveitis and / or scleritis. Condition or disease Intervention/treatment Phase Uveitis Scleritis Drug: tofacitinib Phase 2 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 5 participants Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment Official Title: Tofacitinib for the Treatment of Inflammatory Eye Disease

2018 Clinical Trials

188. MSC-Exos Promote Healing of MHs

not keep prone position. Secondary macular lesions The equivalent spherical diopter of the study eye before any refractive correction or cataract surgery, which is greater than 6.0d or above 26mm of the ocular axis of the study eye. Intraocular pressure is higher than 25mmHg Within ocular inflammation, such as eye blepharitis, scleritis, keratitis and conjunctivitis. Systemic condition is poor, such as the poor control of diabetes and hypertension, myocardial infarction, cerebrovascular accident, renal

2018 Clinical Trials

189. Clinical outcomes of 4-point scleral fixated 1-piece hydrophobic acrylic equiconvex intraocular lens using polytetrafluoroethylene suture (PubMed)

%). There was one case of recurrent retinal detachment. One patient presented with an erosion of the Gore-Tex suture through the conjunctiva resulting in a purulent scleritis 6 months after the initial surgery, and was managed with removal of the IOL, debridement, and cryotherapy. Forty-one of 49 patients completed 3-month follow-up, among which visual acuity improved, deteriorated, or remained same compared to baseline in 27/49 (55.1%), 8/49 (16.3%), and 6/49 (12.2%) eyes, respectively.In the current study

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2018 Clinical ophthalmology (Auckland, N.Z.)

190. Clinical Manifestations and Ophthalmic Outcomes of Ocular Syphilis at a Time of Re-Emergence of the Systemic Infection (PubMed)

for human immunodeficiency virus (HIV), 34.6% were positive. Ophthalmological evaluations included measurement of Snellen visual acuity and intraocular pressure, and assessment of inflammation by slit lamp examination and dilated posterior eye examination. Involvements in 214 eyes were anterior (6.1%), intermediate (8.4%), posterior (76.2%) and pan- (8.4%) uveitis, and scleritis (0.9%). Multiple anterior and posterior eye complications were observed, including cataract in the anterior eye (incidence

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2018 Scientific reports

191. Panscleritis as an Unusual Complication of Gonioscopy-assisted Transluminal Trabeculotomy. (PubMed)

on palpation of the eye. Ophthalmic examination revealed significant diffuse hyperemia, elongated and tortuous upper bulbar conjunctival/scleral vessels, and exudative retinal detachment at the superior nasal quadrant, with diffuse scleral thickening. The patient was diagnosed as having panscleritis, which was attributed to the GATT surgery. Although the scleritis resolved completely with intravenous and oral methylprednisolone treatment, localized retinal detachment persisted.Surgery-induced posterior (...) scleritis may occur following minimally invasive glaucoma surgeries such as GATT. Control of uveitis for at least 3 months before surgery is indicated in patients with uveitis if GATT surgery is planned.

2018 Journal of Glaucoma

192. Drug-induced uveitis. (PubMed)

Drug-induced uveitis. Nearly one-half of all uveitis cases seen at tertiary referral centers have no identifiable cause. Many systemic, paraocular, intraocular, topical medications, and even vaccines can induce intraocular inflammation, scleritis, and rarely orbititis and are often overlooked as causes of uveitis. This review was undertaken to elucidate the strength of association of these medications with uveitis and to make clinicians aware of these associations, especially among newer

2018 Current Opinion in Ophthalmology

193. Histoplasmosis following Systemic Immunomodulatory Therapy for Ocular Inflammation. (PubMed)

with uveitis or scleritis who subsequently developed pulmonary or disseminated histoplasmosis at the Mayo Clinic in Rochester, Minnesota between September 1, 1994 and July 1, 2017, with a 3:1 age- and sex-matched control cohort who did not develop histoplasmosis. This was a single institutional study examining patients that developed histoplasmosis after the initiation of systemic immunomodulatory therapy (IMT). Patients had to develop either disseminated or pulmonary histoplasmosis while receiving

2018 American Journal of Ophthalmology

194. Clinical features of Chinese patients with relapsing polychondritis. (PubMed)

and manifested as scleritis (n=10) or uveitis (n=6). Generalised, anterior and posterior uveitis was found in three, two and one patients, respectively. The frequencies of inner ear involvement and arthritis were lower in Chinese patients compared with that observed in Caucasians. Nine patients had a follow-up of 2-44 months, and in these individuals a better visual prognosis was observed in female patients compared with males.Our study shows that uveitis associated with RP may manifest as generalised

2018 British Journal of Ophthalmology

195. Macular Involvement in Diabetic Retinopathy Evaluated With Swept-Source OCT

with any DR severity level: no DR, mild NPDR, mod NPDR, sev NPDR, PDR Exclusion Criteria: Substantial media opacities that would preclude successful imaging Active intraocular inflammation (grade trace or above) in either eye like infectious conjunctivitis, keratitis, scleritis, endophthalmitis as well as idiopathic or autoimmune-associated uveitis in either eye Structural damage to the center of macula in the study eye History of prior panretinal photocoagulation History of treatment with intravitreal

2018 Clinical Trials

196. Study to Evaluate an Aflibercept (EYLEA®) Prefilled Syringe

, keratitis, scleritis, or conjunctivitis in either eye Any active intraocular inflammation or infection in either eye or history of intraocular inflammation or infection after past intravitreal injection treatment (IVT) injections with any agent in either eye History of or any current indication of excessive bleeding and recurrent hemorrhages, including any prior excessive intraocular (including subconjunctival) bleeding or hemorrhages after IVT injection or intraocular procedures in either eye Any

2018 Clinical Trials

197. Herpes simplex - ocular

in a person older than 50 years of age. The pupil may be semi-dilated, fixed and oval in shape. For more information, see the CKS topic on . Iritis or uveitis (from other causes) — see the CKS topic on . Scleritis or episcleritis — inflammation of the sclera or episclera causing red eye, eye pain, visual disturbance, and photophobia. Keratitis due to other infections — such as Epstein-Barr virus and adenovirus, Chlamydia, and Acanthamoeba protozoan infection (which is more common in contact lens wearers

2016 NICE Clinical Knowledge Summaries

198. Red eye

Red eye Red eye - NICE CKS Clinical Knowledge Summaries Share Red eye: Summary There is a wide differential diagnosis for red eye. It is important to differentiate whether the person presenting with red eye needs same day assessment by an ophthalmologist, or if they can be safely managed in primary care. Serious and potentially sight-threatening causes of red eye include: Acute glaucoma. Corneal ulcer, contact lens-related red eye and corneal foreign body. Anterior uveitis. Scleritis. Trauma (...) of the anterior segment of the eye. It may be associated with other inflammatory disorders, such as ankylosing spondylitis, but the cause of the inflammation is usually not known. Clinical features include pain, which may be worse when the person is contracting the ciliary muscles, photophobia, watering of the eye, ciliary injection and constricted or distorted pupil. Vision may be normal or reduced. For more information, see the CKS topic on . Scleritis. This is inflammation of the sclera (the white outer

2016 NICE Clinical Knowledge Summaries

199. Outpatient Performed Pterygium Surgery Study

to one or more of the study drugs. Patients who are on systemic immunosuppressive therapy or chemotherapy. Patients with a condition requiring topical steroid drops in the study eye or oral prednisone at a dose of more than 5mg/day. Patients with a history of scleritis or other severe ocular surface disease such as limbal stem cell deficiency. Patients with poor vision (defined as VA 20/200 or worse) in the contralateral eye. Patients with a large pterygium judged clinically to need amniotic membrane

2017 Clinical Trials

200. A Study of Multiple Intravitreal Injection TK001 in Patients With Neovascular Age-related Macular Degeneration

histoplasmosis, pathologic myopia, trauma) in studied eyes With apparent afferent pupillary defect(APD) in studied eyes With Polypoidal Choroidal Vasculopathy (PCV) or Retinal Angiomatous Proliferation (PAP) in studied eyes With intraocular pressure higher than 25mmHg despite treatment With VA for the fellow eyes<20/200 With active inflammation in any eye, such as conjunctivitis, keratitis, scleritis, blepharitis, endophthalmitis and uveitis The treatment of the eye The studied eye received topical or grid

2017 Clinical Trials

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