How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

821 results for

Scleritis

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

1. Combination nivolumab- and cabiralizumab-associated acute bilateral anterior and posterior scleritis and anterior uveitis Full Text available with Trip Pro

Combination nivolumab- and cabiralizumab-associated acute bilateral anterior and posterior scleritis and anterior uveitis To report on a case of uveitis and scleritis resulting as an immune-mediated side effect of cancer immunotherapy with nivolumab and cabiralizumab.Bilateral anterior nongranulomatous anterior uveitis and bilateral diffuse anterior and posterior scleritis occurred following the use of combination cancer immunotherapy. The uveitis and scleritis resolved following temporary

2018 American journal of ophthalmology case reports

2. Nocardial scleritis: A case report and a suggested algorithm for disease management based on a literature review Full Text available with Trip Pro

Nocardial scleritis: A case report and a suggested algorithm for disease management based on a literature review To report a case of nocardial scleritis and to propose a logical treatment algorithm based on a literature review.It is important to suspect a nocardial infection when evaluating anterior unilateral scleritis accompanied by multiple purulent or necrotic abscesses, especially in male patients with a history of chronic ocular pain and redness, trauma inflicted by organic materials (...) data on a total of 43 eyes with nocardial scleritis. Our proposed algorithm may afford a useful understanding of this sight-threatening disease, facilitating easier and faster diagnosis and management.

2018 American journal of ophthalmology case reports

3. Tectonic corneal lamellar grafting for surgically-induced necrotizing scleritis after strabismus surgery: Case report & literature review Full Text available with Trip Pro

Tectonic corneal lamellar grafting for surgically-induced necrotizing scleritis after strabismus surgery: Case report & literature review To report the first case of infectious surgically-induced necrotizing scleritis following strabismus surgery which was treated successfully with a tectonic corneal graft.We report a case of surgically-induced necrotizing scleritis after strabismus surgery in a 61-year-old gentleman with gout and a subconjunctival abscess. Surgical drainage (...) with aggressive local and systemic treatment, tectonic lamellar keratoplasty provides good therapeutic and tectonic results for scleral necrosis after strabismus surgery. This case also demonstrates the importance of screening for associated systemic risk factors in any patient with scleritis for appropriate, targeted therapy.

2018 American journal of ophthalmology case reports

4. Measurement properties of patient-reported outcome measures (PROMs) used in adult patients with ocular immune-mediated inflammatory disease (uveitis, scleritis or optic neuritis): a systematic review

Measurement properties of patient-reported outcome measures (PROMs) used in adult patients with ocular immune-mediated inflammatory disease (uveitis, scleritis or optic neuritis): a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears

2019 PROSPERO

5. A systematic review of the effectiveness of pharmacological agents in the management of non-infectious scleritis

A systematic review of the effectiveness of pharmacological agents in the management of non-infectious scleritis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated

2019 PROSPERO

6. Remission Of Non-Infectious Anterior Scleritis: Incidence And Predictive Factors. (Abstract)

Remission Of Non-Infectious Anterior Scleritis: Incidence And Predictive Factors. To assess how often non-infectious anterior scleritis remits and identify predictive factors.Our retrospective cohort study at four ocular inflammation subspecialty centers collected data for each affected eye/patient at every visit from center inception (1978, 1978, 1984, 2005) until 2010. Remission was defined as inactivity of disease off all suppressive medications at all visits spanning at least three (...) consecutive months or at all visits up to the last visit (to avoid censoring patients stopping follow-up after remission). Factors potentially predictive of remission were assessed using Cox regression models.During 1,391 years' aggregate follow-up of 825 affected eyes, remission occurred in 399 (299 of 588 patients). Median time-to-remission of scleritis=3.1 years (95% confidence interval (CI): 2.6, 3.9). More remissions occurred earlier than later during follow-up. Factors predictive of less scleritis

2019 American Journal of Ophthalmology

7. Scleritis and anterior uveitis may herald the development of an epibulbar tumor in patients with extranodal Rosai-Dorfman disease: a case report. Full Text available with Trip Pro

Scleritis and anterior uveitis may herald the development of an epibulbar tumor in patients with extranodal Rosai-Dorfman disease: a case report. Rosai-Dorfman disease is a rare non-Langerhans cell histiocytosis. Ocular involvement is even rarer, mostly involving the orbit and eyelids, although marginal corneal ulcers, uveitis, and epibulbar masses have also been reported, and is characterized by multiple recurrences. However, the disease course and optimal treatment strategies remain (...) undetermined, in light of the rarity of this disease.We reported a 36-year-old male patient with the extranodal form of Rosai-Dorfman disease, presenting with scleritis and anterior uveitis in the left eye, who experienced subsequent development of an epibulbar tumor in the same eye. The patient was also complicated by a relapsing facial nodule on the right cheek. After the pathological diagnosis of Rosai-Dorfman disease was obtained, the patient underwent surgical excision of the epibulbar tumor

2019 BMC Ophthalmology

8. A case report of infectious scleritis with corneal ulcer caused by Scedosporium aurantiacum. Full Text available with Trip Pro

A case report of infectious scleritis with corneal ulcer caused by Scedosporium aurantiacum. Scedosporium species is rare pathogen of ocular infection. The accurate diagnosis is delaying in many cases and the clinical prognosis is poor due to its resistance to antifungal agents. This report describes a patient with infectious scleritis and corneal ulcer caused by Scedosporium auranticum infection who required enucleation to control the infection.A 70-year-old woman visited our clinic after (...) . Evisceration was performed due to corneal perforation, and enucleation was also performed for dehiscence of the conjunctiva and scleral necrosis.After enucleation, postoperative systemic voriconazole treatment controlled the infection without recurrence.S aurantiacum keratitis is difficult to eradicate, even with several months of treatment with systemic and topical antifungal agents, and tends to progress to scleritis. The infection can be terminated by the orbital enucleation. Infection with this rare

2019 Medicine

9. An unusual case of Behcet disease with posterior scleritis: A case report. Full Text available with Trip Pro

An unusual case of Behcet disease with posterior scleritis: A case report. Posterior scleritis is an ocular inflammatory disorder that can be associated with both infectious and non-infectious immune reactions. Behcet disease is a chronic, relapsing, multisystemic inflammatory disorder with uveitis. There are no reported cases of posterior scleritis with Bechet disease.A 50-year-old man previously diagnosed with systemic Behcet disease presented with ocular pain and decreased vision in the left (...) eye.Posterior scleritis associated with Behcet disease was diagnosed based on optical coherence tomography showing choroidal folds, as well as contrast computed tomography and ultrasound sonography demonstrating thickening of the posterior sclera.Treatment with systemic corticosteroids was initiated. Since inflammation relapsed during steroid tapering, anti-tumor necrosis factor-alpha (TNF-α) therapy was used in combination, and tapering of steroids was possible without recurrence of inflammation for 12

2019 Medicine

10. Histopathological evaluation of scleritis. (Abstract)

Histopathological evaluation of scleritis. The sclera is an uncommon site of primary inflammation. Biopsy is infrequently employed in the evaluation of scleritis, but familiarity with its differential diagnosis is instrumental in ensuring efficient histological evaluation. This review provides a clinical overview of scleritis and describes the context in which scleral biopsy might arise. Most cases are associated with systemic autoimmune disease, but a sizeable proportion occur as an isolated (...) disorder. Conditions mimicking autoimmune scleritis include infection and neoplasm. Histological patterns of inflammation in eyes removed surgically or at autopsy have been placed into three groups: (1) autoimmune scleritis characterised by varying mixtures of palisading granulomas, necrosis and vasculitis; (2) infectious scleritis, characterised by acute inflammation and necrosis; and (3) idiopathic scleritis, characterised by chronic non-specific inflammation with follicles and varying amounts

2019 Journal of Clinical Pathology

11. A Clinical Study to Evaluate the Potential Role of ACTH Gel in Patients With Scleritis

A Clinical Study to Evaluate the Potential Role of ACTH Gel in Patients With Scleritis A Clinical Study to Evaluate the Potential Role of ACTH Gel in Patients With Scleritis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies (...) before adding more. A Clinical Study to Evaluate the Potential Role of ACTH Gel in Patients With Scleritis (ATLAS) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03465111 Recruitment Status : Recruiting First Posted

2018 Clinical Trials

12. Successful management of bee sting induced Aspergillus fumigatus endophthalmitis and scleritis Full Text available with Trip Pro

Successful management of bee sting induced Aspergillus fumigatus endophthalmitis and scleritis Ocular bee stings are known to cause corneal melts, corneal infiltrates, cataracts, and secondary glaucoma. Our patient presented with scleritis, corneal infiltrates, and endophthalmitis after a ocular bee sting. Topical treatment led to resolution of anterior segment inflammation, but the scleritis and vitreous inflammation worsened. Vitrectomy with intravitreal antibiotics was done and scrapings (...) from the scleral abscess showed growth of Aspergillus fumigatus on culture. Repeat vitrectomy with silicone oil was needed for retinal detachment. Oral and intravitreal antifungals led to resolution of inflammation with attached retina. This is the first reported case of bee sting-induced fungal endophthalmitis with scleritis.

2018 Indian journal of ophthalmology

13. Atypical posterior scleritis mimicking choroidal melanoma Full Text available with Trip Pro

Atypical posterior scleritis mimicking choroidal melanoma We report a case of atypical posterior scleritis mimicking amelanotic choroidal melanoma. A 30-year-old healthy Filipino man, with a history of painless subacute loss of vision in his left eye over 5 months, was referred to our institute for further workup and management. On examination, visual acuity of the left eye was 20/200. Anterior segment examination yielded unremarkable results, with injected conjunctiva and quiet episcleral (...) blood vessels, while fundus examination revealed non-pigmented nasal choroidal mass, with significant subretinal fluid resembling amelanotic choroidal melanoma. Right eye examination yielded unremarkable results. The patient was diagnosed with atypical posterior scleritis, and treated with oral steroids for 2 weeks, with no improvement. A periocular steroid was then injected to the left eye, causing dramatic reduction in choroidal mass size, and complete resolution of subretinal fluid. The visual

2018 Saudi medical journal

14. Infectious Scleritis: What the ID Clinician Should Know Full Text available with Trip Pro

Infectious Scleritis: What the ID Clinician Should Know Scleritis is an inflammatory process involving the outer coating of the globe which is characterized by focal or diffuse hyperemia, moderate to severe pain, and frequent impairment of vision. Most cases of scleritis are autoimmune in nature and are managed with topical and/or systemic corticosteroids. Infectious scleritis is a less common entity, occurring in 5%-10% of cases, and requiring directed antimicrobial therapy. We present a case (...) of Nocardia farcinica anterior nodular scleritis diagnosed via positive culture of an excisional biopsy of a scleral nodule. The patient improved after combined surgical and medical therapy with amoxicillin-clavulanate and moxifloxacin for 12 months. Based on a literature review, a summary of reported cases of infectious scleritis is provided, and guidelines pertaining to diagnosis and management are offered.

2018 Open forum infectious diseases

15. Commentary: Posterior scleritis: Nuances to discern and handle effectively! Full Text available with Trip Pro

Commentary: Posterior scleritis: Nuances to discern and handle effectively! 30038153 2018 07 25 2018 12 02 1998-3689 66 8 2018 08 Indian journal of ophthalmology Indian J Ophthalmol Commentary: Posterior scleritis: Nuances to discern and handle effectively! 1113-1114 10.4103/ijo.IJO_639_18 Murugan S Bala SB Uveitis Services, Aravind Eye Hospital, Puducherry, India. eng Journal Article Comment India Indian J Ophthalmol 0405376 0301-4738 0 Immunosuppressive Agents IM Indian J Ophthalmol. 2018 Aug (...) ;66(8):1109-1112 30038152 Fluorescein Angiography Humans Immunosuppressive Agents Scleritis There are no conflicts of interest 2018 7 25 6 0 2018 7 25 6 0 2018 7 26 6 0 ppublish 30038153 IndianJOphthalmol_2018_66_8_1113_237346 10.4103/ijo.IJO_639_18 PMC6080434 Surv Ophthalmol. 1988 Mar-Apr;32(5):297-316 3043740 Indian J Ophthalmol. 1998 Dec;46(4):195-202 10218301 Ophthalmology. 2003 Jan;110(1):15-21; quiz 22-3 12511340 AJNR Am J Neuroradiol. 2016 Dec;37(12):2334-2339 27444937 Indian J Ophthalmol

2018 Indian journal of ophthalmology

16. Clinical profile of patients with posterior scleritis: A report from Eastern India Full Text available with Trip Pro

Clinical profile of patients with posterior scleritis: A report from Eastern India This study aimed to report the clinical profile of patients with posterior scleritis at a tertiary eye center in Eastern India.This was a single-center retrospective case series of patients who were diagnosed as posterior scleritis between January 2010 and December 2014, with a follow-up period of at least 6 months.The study included 18 patients of posterior scleritis with a mean age of 41.2 ± 10.6 years (range (...) : 26-63 years). With female preponderance (55.6%), majority of the posterior scleritis cases were unilateral (88.9%). Sixteen patients reported with diminution of vision, eleven patients (61.1%) had ocular pain on presentation, and five patients complained of headache. Concurrent anterior scleritis was found in three eyes (15%) with posterior scleritis. Choroidal folds and subretinal fluid at the posterior pole were the most common fundus findings and were seen in seven eyes (35%) each. No systemic

2018 Indian journal of ophthalmology

17. Isolation of acid from eye drop bottles being used by patients presenting with presumed scleritis Full Text available with Trip Pro

Isolation of acid from eye drop bottles being used by patients presenting with presumed scleritis The aim of the study was to report the occurrence of contamination/replacement of ophthalmic eye drops with liquids of acidic nature in patients treated for nonresponding scleritis.This was a retrospective interventional case series study.Of the three patients (4 eyes) referred as necrotizing scleritis, two were found to have acid as the content in the bottle/s being used as eye drops, confirmed (...) using biochemical tests. All four eyes had tarsal ischemia and tarsal conjunctival defect in addition to severe scleral ischemia involving the inferior bulbar area. All four eyes required tenonplasty with amniotic membrane transplant more than once for the ocular surface to heal. Two of the three patients were on systemic immunosuppressives including pulse cyclophosphamide for refractory necrotizing scleritis. Sulfuric and hydrochloric acid was isolated from the bottles of 2nd and 3rd patient using

2018 Indian journal of ophthalmology

18. Scleritis in congenital erythropoietic porphyria – infective or inflammatory? Full Text available with Trip Pro

Scleritis in congenital erythropoietic porphyria – infective or inflammatory? 30249837 2018 10 23 2018 11 14 1998-3689 66 10 2018 Oct Indian journal of ophthalmology Indian J Ophthalmol Scleritis in congenital erythropoietic porphyria - infective or inflammatory? 1467-1468 10.4103/ijo.IJO_513_18 Sahay Pranita P Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India. Dhanda Suman S Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All (...) for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India. eng Case Reports Journal Article India Indian J Ophthalmol 0405376 0301-4738 IM Indian J Ophthalmol. 2018 Oct;66(10):1469-1470 30249838 Diagnosis, Differential Eye Infections diagnosis Follow-Up Studies Humans Male Necrosis diagnosis etiology Porphyria, Erythropoietic complications Sclera pathology Scleritis diagnosis etiology Slit Lamp Microscopy Congenital erythropoietic porphyria necrotizing scleritis scleritis

2018 Indian journal of ophthalmology

19. Antineutrophil cytoplasmic antibody-positive scleritis: Clinical profile of patients from a tuberculosis-endemic region Full Text available with Trip Pro

Antineutrophil cytoplasmic antibody-positive scleritis: Clinical profile of patients from a tuberculosis-endemic region To report the clinical profile of a series of antineutrophil cytoplasmic antibody (ANCA)-associated scleritis in Indian population.We conducted a retrospective review of medical records of 33 eyes of 26 consecutive patients with scleritis, who tested positive for either antibody to proteinase 3 [anti-PR3/cytoplasmic antineutrophil cytoplasmic antibody (cANCA (...) )] or myeloperoxidase [anti-MPO/perinuclear anti-neutrophil cytoplasmic antibody (pANCA)] between 2006 and 2015.The mean age at presentation was 54.1 (11.1) years and 61.5% of the patients were female. Underlying systemic disorder was found in 46.2% of patients and includes granulomatosis with polyangitis (30.8%) and tuberculosis (15.4%). Necrotizing scleritis (48.5%) was the most common scleritis observed, followed by diffuse anterior scleritis (42.4%). Positive cANCA was found in 65.4% of patients and 34.6

2018 Indian journal of ophthalmology

20. Dengue fever-associated necrotizing scleritis: A case report with long-term follow-up. Full Text available with Trip Pro

Dengue fever-associated necrotizing scleritis: A case report with long-term follow-up. Dengue fever is a notable emerging infectious disease that is now seen worldwide, with an estimated incidence of approximately 390 million cases per year. Although ocular complications are uncommon among dengue fever-infected patients, caution is needed to prevent vision loss. Here we report a potentially serious sight-threatening complication of dengue fever, dengue fever-associated necrotizing (...) . Since additional systemic examinations identified no autoimmune diseases such as rheumatism, we diagnosed the patient as dengue fever-associated scleritis.Intensive systemic and topical steroids were administrated during the initial acute phase. Over the next 15 months, the amount of steroid was tapered off.Initial findings for the scleritis gradually declined in response to steroid treatment. Although there was no recurrence of active scleritis, gradual thinning of the sclera continued to occur

2018 Medicine

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>