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1. Tectonic corneal lamellar grafting for surgically-induced necrotizing scleritis after strabismus surgery: Case report & literature review Full Text available with Trip Pro

Tectonic corneal lamellar grafting for surgically-induced necrotizing scleritis after strabismus surgery: Case report & literature review To report the first case of infectious surgically-induced necrotizing scleritis following strabismus surgery which was treated successfully with a tectonic corneal graft.We report a case of surgically-induced necrotizing scleritis after strabismus surgery in a 61-year-old gentleman with gout and a subconjunctival abscess. Surgical drainage (...) with aggressive local and systemic treatment, tectonic lamellar keratoplasty provides good therapeutic and tectonic results for scleral necrosis after strabismus surgery. This case also demonstrates the importance of screening for associated systemic risk factors in any patient with scleritis for appropriate, targeted therapy.

2018 American journal of ophthalmology case reports

2. Nocardial scleritis: A case report and a suggested algorithm for disease management based on a literature review Full Text available with Trip Pro

Nocardial scleritis: A case report and a suggested algorithm for disease management based on a literature review To report a case of nocardial scleritis and to propose a logical treatment algorithm based on a literature review.It is important to suspect a nocardial infection when evaluating anterior unilateral scleritis accompanied by multiple purulent or necrotic abscesses, especially in male patients with a history of chronic ocular pain and redness, trauma inflicted by organic materials (...) data on a total of 43 eyes with nocardial scleritis. Our proposed algorithm may afford a useful understanding of this sight-threatening disease, facilitating easier and faster diagnosis and management.

2018 American journal of ophthalmology case reports

3. Combination nivolumab- and cabiralizumab-associated acute bilateral anterior and posterior scleritis and anterior uveitis Full Text available with Trip Pro

Combination nivolumab- and cabiralizumab-associated acute bilateral anterior and posterior scleritis and anterior uveitis To report on a case of uveitis and scleritis resulting as an immune-mediated side effect of cancer immunotherapy with nivolumab and cabiralizumab.Bilateral anterior nongranulomatous anterior uveitis and bilateral diffuse anterior and posterior scleritis occurred following the use of combination cancer immunotherapy. The uveitis and scleritis resolved following temporary

2018 American journal of ophthalmology case reports

4. An OCT Study of Anterior Nodular Episcleritis and Scleritis Full Text available with Trip Pro

An OCT Study of Anterior Nodular Episcleritis and Scleritis Anterior scleritis and episcleritis are a well-known presentation in tuberculosis. The case of a female patient with presumed tuberculous anterior scleritis and episcleritis is discussed in this article. Anterior segment OCT was efficient in diagnosis and evaluation of the therapeutic outcome. Antituberculosis chemotherapy was sufficient to achieve clinical remission.

2017 Case reports in ophthalmological medicine

5. Episcleral brachytherapy for retinoblastoma. (Abstract)

Episcleral brachytherapy for retinoblastoma. To report visual outcomes, survival outcomes and complications following episcleral brachytherapy (EB) for retinoblastoma.Retrospective review of retinoblastoma cases treated with EB in a single institution. Survival outcomes were analysed using the Kaplan-Meier method.Eleven tumours of 11 eyes were treated with either iodine-125 or ruthenium-106 EB with a mean apical dose of 44 Gy. The tumours were classified as group B in 5 (46%), C in 3 (27%) or D

2019 British Journal of Ophthalmology

6. Episcleral Venous Pressure and the Ocular Hypotensive Effects of Topical and Intracameral Prostaglandin Analogs. Full Text available with Trip Pro

Episcleral Venous Pressure and the Ocular Hypotensive Effects of Topical and Intracameral Prostaglandin Analogs. There is a limit beyond which increasing either the concentration of a prostaglandin analog (PGA) or its dosing frequency fails to produce increases in ocular hypotensive efficacy with topical dosing. Intracameral PGA dosing with a bimatoprost implant, however, does not exhibit the same intraocular pressure (IOP)-lowering plateau at studied concentrations and the maximum-achievable (...) ocular hypotensive effects are not yet known. This suggests that the bimatoprost intracameral implant may activate another mechanism of action in addition to the mechanism(s) activated by topical application. Episcleral venous pressure (EVP) is a key determinant of IOP, and experimental manipulation of the episcleral vasculature can change both EVP and IOP. The recent observation that topical and intracameral PGA drug delivery routes produce different patterns of conjunctival hyperemia suggested

2019 Journal of Glaucoma

7. Scleritis and anterior uveitis may herald the development of an epibulbar tumor in patients with extranodal Rosai-Dorfman disease: a case report. Full Text available with Trip Pro

Scleritis and anterior uveitis may herald the development of an epibulbar tumor in patients with extranodal Rosai-Dorfman disease: a case report. Rosai-Dorfman disease is a rare non-Langerhans cell histiocytosis. Ocular involvement is even rarer, mostly involving the orbit and eyelids, although marginal corneal ulcers, uveitis, and epibulbar masses have also been reported, and is characterized by multiple recurrences. However, the disease course and optimal treatment strategies remain (...) undetermined, in light of the rarity of this disease.We reported a 36-year-old male patient with the extranodal form of Rosai-Dorfman disease, presenting with scleritis and anterior uveitis in the left eye, who experienced subsequent development of an epibulbar tumor in the same eye. The patient was also complicated by a relapsing facial nodule on the right cheek. After the pathological diagnosis of Rosai-Dorfman disease was obtained, the patient underwent surgical excision of the epibulbar tumor

2019 BMC Ophthalmology

8. A case report of infectious scleritis with corneal ulcer caused by Scedosporium aurantiacum. Full Text available with Trip Pro

A case report of infectious scleritis with corneal ulcer caused by Scedosporium aurantiacum. Scedosporium species is rare pathogen of ocular infection. The accurate diagnosis is delaying in many cases and the clinical prognosis is poor due to its resistance to antifungal agents. This report describes a patient with infectious scleritis and corneal ulcer caused by Scedosporium auranticum infection who required enucleation to control the infection.A 70-year-old woman visited our clinic after (...) . Evisceration was performed due to corneal perforation, and enucleation was also performed for dehiscence of the conjunctiva and scleral necrosis.After enucleation, postoperative systemic voriconazole treatment controlled the infection without recurrence.S aurantiacum keratitis is difficult to eradicate, even with several months of treatment with systemic and topical antifungal agents, and tends to progress to scleritis. The infection can be terminated by the orbital enucleation. Infection with this rare

2019 Medicine

9. An unusual case of Behcet disease with posterior scleritis: A case report. Full Text available with Trip Pro

An unusual case of Behcet disease with posterior scleritis: A case report. Posterior scleritis is an ocular inflammatory disorder that can be associated with both infectious and non-infectious immune reactions. Behcet disease is a chronic, relapsing, multisystemic inflammatory disorder with uveitis. There are no reported cases of posterior scleritis with Bechet disease.A 50-year-old man previously diagnosed with systemic Behcet disease presented with ocular pain and decreased vision in the left (...) eye.Posterior scleritis associated with Behcet disease was diagnosed based on optical coherence tomography showing choroidal folds, as well as contrast computed tomography and ultrasound sonography demonstrating thickening of the posterior sclera.Treatment with systemic corticosteroids was initiated. Since inflammation relapsed during steroid tapering, anti-tumor necrosis factor-alpha (TNF-α) therapy was used in combination, and tapering of steroids was possible without recurrence of inflammation for 12

2019 Medicine

10. Histopathological evaluation of scleritis. (Abstract)

Histopathological evaluation of scleritis. The sclera is an uncommon site of primary inflammation. Biopsy is infrequently employed in the evaluation of scleritis, but familiarity with its differential diagnosis is instrumental in ensuring efficient histological evaluation. This review provides a clinical overview of scleritis and describes the context in which scleral biopsy might arise. Most cases are associated with systemic autoimmune disease, but a sizeable proportion occur as an isolated (...) disorder. Conditions mimicking autoimmune scleritis include infection and neoplasm. Histological patterns of inflammation in eyes removed surgically or at autopsy have been placed into three groups: (1) autoimmune scleritis characterised by varying mixtures of palisading granulomas, necrosis and vasculitis; (2) infectious scleritis, characterised by acute inflammation and necrosis; and (3) idiopathic scleritis, characterised by chronic non-specific inflammation with follicles and varying amounts

2019 Journal of Clinical Pathology

11. Remission Of Non-Infectious Anterior Scleritis: Incidence And Predictive Factors. (Abstract)

Remission Of Non-Infectious Anterior Scleritis: Incidence And Predictive Factors. To assess how often non-infectious anterior scleritis remits and identify predictive factors.Our retrospective cohort study at four ocular inflammation subspecialty centers collected data for each affected eye/patient at every visit from center inception (1978, 1978, 1984, 2005) until 2010. Remission was defined as inactivity of disease off all suppressive medications at all visits spanning at least three (...) consecutive months or at all visits up to the last visit (to avoid censoring patients stopping follow-up after remission). Factors potentially predictive of remission were assessed using Cox regression models.During 1,391 years' aggregate follow-up of 825 affected eyes, remission occurred in 399 (299 of 588 patients). Median time-to-remission of scleritis=3.1 years (95% confidence interval (CI): 2.6, 3.9). More remissions occurred earlier than later during follow-up. Factors predictive of less scleritis

2019 American Journal of Ophthalmology

12. Bimatoprost sustained-release intracameral implant reduces episcleral venous pressure in dogs. Full Text available with Trip Pro

Bimatoprost sustained-release intracameral implant reduces episcleral venous pressure in dogs. To determine the effect of a bimatoprost sustained-release intracameral implant (Bimatoprost SR) on episcleral venous pressure (EVP) in normal dogs.Normotensive beagle dogs were randomized to receive Bimatoprost SR 30 μg (n = 7) or sham injection (needle insertion only, n = 7) in one eye on day 1. EVP was measured with an episcleral venomanometer through day 65. Episcleral aqueous outflow vessels were

2018 Veterinary ophthalmology Controlled trial quality: uncertain

13. Episcleral racemose hemangioma. (Abstract)

Episcleral racemose hemangioma. Racemose hemangioma is a rare, benign vascular malformation. In the episclera, it appears as dilated, tortuous blood vessels that pass from the fornix over the globe surface to the limbal area, without capillary architecture, and then loop backward into the fornix. Fluorescein angiogram reveals the vascular malformation with rapid flow and confirms the episcleral vessels to be large in caliber and with a curvilinear, twisted configuration. We report the case

2018 JAAPOS - Journal of the American Association for Pediatric Ophthalmology and Strabismus

14. A Clinical Study to Evaluate the Potential Role of ACTH Gel in Patients With Scleritis

A Clinical Study to Evaluate the Potential Role of ACTH Gel in Patients With Scleritis A Clinical Study to Evaluate the Potential Role of ACTH Gel in Patients With Scleritis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies (...) before adding more. A Clinical Study to Evaluate the Potential Role of ACTH Gel in Patients With Scleritis (ATLAS) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03465111 Recruitment Status : Recruiting First Posted

2018 Clinical Trials

15. Advanced glaucoma secondary to bilateral idiopathic dilated episcleral veins - a case report. Full Text available with Trip Pro

Advanced glaucoma secondary to bilateral idiopathic dilated episcleral veins - a case report. Idiopathic elevated episcleral venous pressure (IEEVP) or idiopathic dilated episcleral veins (IDEV) is a rare abnormality, and thus therapeutic treatment for this condition rarely is discussed. We report a case of a patient with bilateral glaucoma secondary to IDEV for whom intraocular pressures (IOPs) were controlled successfully by trabeculectomy.A 50 year-old female with a complaint of persistent (...) red eyes for over 30 years, presented with numerous tortuous and engorged episcleral vessels in both eyes (OU), open angles OU with spontaneous blood in Schlemm's canal 360 degrees bilaterally. Orbital color Doppler examination showed the superior ophthalmic veins to be of normal calibre, with no reversal of flow. Head MRI with contrast and cerebral angiography were negative for arteriovenous fistula. Coronary angiography, color Doppler echocardiography and chest radiographs were within normal

2018 BMC Ophthalmology

16. Clinical profile of patients with posterior scleritis: A report from Eastern India Full Text available with Trip Pro

Clinical profile of patients with posterior scleritis: A report from Eastern India This study aimed to report the clinical profile of patients with posterior scleritis at a tertiary eye center in Eastern India.This was a single-center retrospective case series of patients who were diagnosed as posterior scleritis between January 2010 and December 2014, with a follow-up period of at least 6 months.The study included 18 patients of posterior scleritis with a mean age of 41.2 ± 10.6 years (range (...) : 26-63 years). With female preponderance (55.6%), majority of the posterior scleritis cases were unilateral (88.9%). Sixteen patients reported with diminution of vision, eleven patients (61.1%) had ocular pain on presentation, and five patients complained of headache. Concurrent anterior scleritis was found in three eyes (15%) with posterior scleritis. Choroidal folds and subretinal fluid at the posterior pole were the most common fundus findings and were seen in seven eyes (35%) each. No systemic

2018 Indian journal of ophthalmology

17. Isolation of acid from eye drop bottles being used by patients presenting with presumed scleritis Full Text available with Trip Pro

Isolation of acid from eye drop bottles being used by patients presenting with presumed scleritis The aim of the study was to report the occurrence of contamination/replacement of ophthalmic eye drops with liquids of acidic nature in patients treated for nonresponding scleritis.This was a retrospective interventional case series study.Of the three patients (4 eyes) referred as necrotizing scleritis, two were found to have acid as the content in the bottle/s being used as eye drops, confirmed (...) using biochemical tests. All four eyes had tarsal ischemia and tarsal conjunctival defect in addition to severe scleral ischemia involving the inferior bulbar area. All four eyes required tenonplasty with amniotic membrane transplant more than once for the ocular surface to heal. Two of the three patients were on systemic immunosuppressives including pulse cyclophosphamide for refractory necrotizing scleritis. Sulfuric and hydrochloric acid was isolated from the bottles of 2nd and 3rd patient using

2018 Indian journal of ophthalmology

18. Commentary: Posterior scleritis: Nuances to discern and handle effectively! Full Text available with Trip Pro

Commentary: Posterior scleritis: Nuances to discern and handle effectively! 30038153 2018 07 25 2018 12 02 1998-3689 66 8 2018 08 Indian journal of ophthalmology Indian J Ophthalmol Commentary: Posterior scleritis: Nuances to discern and handle effectively! 1113-1114 10.4103/ijo.IJO_639_18 Murugan S Bala SB Uveitis Services, Aravind Eye Hospital, Puducherry, India. eng Journal Article Comment India Indian J Ophthalmol 0405376 0301-4738 0 Immunosuppressive Agents IM Indian J Ophthalmol. 2018 Aug (...) ;66(8):1109-1112 30038152 Fluorescein Angiography Humans Immunosuppressive Agents Scleritis There are no conflicts of interest 2018 7 25 6 0 2018 7 25 6 0 2018 7 26 6 0 ppublish 30038153 IndianJOphthalmol_2018_66_8_1113_237346 10.4103/ijo.IJO_639_18 PMC6080434 Surv Ophthalmol. 1988 Mar-Apr;32(5):297-316 3043740 Indian J Ophthalmol. 1998 Dec;46(4):195-202 10218301 Ophthalmology. 2003 Jan;110(1):15-21; quiz 22-3 12511340 AJNR Am J Neuroradiol. 2016 Dec;37(12):2334-2339 27444937 Indian J Ophthalmol

2018 Indian journal of ophthalmology

19. Scleritis in congenital erythropoietic porphyria – infective or inflammatory? Full Text available with Trip Pro

Scleritis in congenital erythropoietic porphyria – infective or inflammatory? 30249837 2018 10 23 2018 11 14 1998-3689 66 10 2018 Oct Indian journal of ophthalmology Indian J Ophthalmol Scleritis in congenital erythropoietic porphyria - infective or inflammatory? 1467-1468 10.4103/ijo.IJO_513_18 Sahay Pranita P Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India. Dhanda Suman S Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All (...) for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India. eng Case Reports Journal Article India Indian J Ophthalmol 0405376 0301-4738 IM Indian J Ophthalmol. 2018 Oct;66(10):1469-1470 30249838 Diagnosis, Differential Eye Infections diagnosis Follow-Up Studies Humans Male Necrosis diagnosis etiology Porphyria, Erythropoietic complications Sclera pathology Scleritis diagnosis etiology Slit Lamp Microscopy Congenital erythropoietic porphyria necrotizing scleritis scleritis

2018 Indian journal of ophthalmology

20. Sustained and targeted episcleral delivery of celecoxib in a rabbit model of retinal and choroidal neovascularization Full Text available with Trip Pro

Sustained and targeted episcleral delivery of celecoxib in a rabbit model of retinal and choroidal neovascularization To evaluate the efficacy of selective episcleral delivery of celecoxib formulated in a sustained-release episcleral exoplant on a model of retinal and choroidal neovascularization induced in rabbits by subretinal injection of matrigel combined with vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF).Nine New Zealand white rabbits were randomly (...) assigned to three groups (episcleral celecoxib exoplant, intravitreal bevacizumab injection and control group). The bFGF was mixed with matrigel at a concentration of 10 ug/0.1 mL, and VEGF was mixed with matrigel at a concentration of 2 ug/0.1 mL. Animals assigned to celecoxib or intravitreal bevacizumab groups were treated within 03 days from matrigel injection. Fluorescein angiography (FA) and electroretinography (ERG) were performed 5 days, 2, 4 and 8 weeks after matrigel injection. Persistence

2018 International journal of retina and vitreous

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