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161. Screening and Management of Lipids

is indicated only for those with abnormal baseline ALT, known liver disease, risk factors for liver disease, or in patients who are on other potentially hepatotoxic medications. Liver function tests (LFTs) should also be measured if symptoms suggesting hepatotoxicity arise (e.g., unusual fatigue or weakness, loss of appetite, abdominal pain, dark-colored urine or yellowing of the skin or sclera).For other patients with abnormal baseline LFTs, see Table 4 for monitoring based on level of abnormality

2016 University of Michigan Health System

162. Ab externo canaloplasty for primary open-angle glaucoma

, viscocanalostomy or laser trabeculoplasty may also be used. 3 3 The procedure The procedure 3.1 Ab externo canaloplasty is a surgical technique that aims to reduce intraocular pressure by improving drainage of aqueous fluid from the eye. It is done under local or general anaesthetic. A superficial hinged flap of sclera is made and a deeper flap excised, exposing the Schlemm's canal. An ultrasound imaging system is used to identify the canal and to visualise the surgical instruments when they are in the canal

2017 National Institute for Health and Clinical Excellence - Interventional Procedures

163. Sequential traumatic corneal open globe rupture in a patient with osteogenesis imperfecta type I (PubMed)

at school while wearing protective lenses. One year ago, he required surgical repair of a left open globe following blunt trauma during a middle school basketball game. His exam was significant for a full-thickness corneal laceration, necessitating open globe repair of his right eye, which was remarkably difficult given the poor tissue constitution of the cornea and sclera. He was referred to a genetics specialist, where he was found to have a pathogenic heterozygous splice site variant in the COL1A1

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2018 American journal of ophthalmology case reports

164. Conservative management of penetrating ocular trauma caused by a nail gun (PubMed)

Conservative management of penetrating ocular trauma caused by a nail gun To report the conservative management of a penetrating ocular trauma caused by a nail gun with a six-month follow up.A 21 year-old healthy female suffered an ocular penetrating trauma with a nail gun. She presented with a metallic foreign body that partially entered her left eye through the nasal sclera via pars plana, 3 mm posterior to the limbus, but did not reach the retina. Surgical removal of the foreign body

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2018 American journal of ophthalmology case reports

165. In-utero epigenetic factors are associated with early-onset myopia in young children. (PubMed)

identified within the following genes: FGB (4q28, p = 3.60×10-7), PQLC1 (18q23, p = 8.9×10-7) and KRT12 (17q21.2, p = 1.2×10-6). Both PQLC1 and KRT12 were found to be significantly expressed in fetal and adult cornea and sclera tissues in both human and mouse.We identified five CpG methylation sites that demonstrate a statistically significant association with increased risk of developing early-onset myopia. These findings suggest that variability in the neonatal cord epigenome may influence early-onset

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2019 PLoS ONE

166. Posterior staphylomas and scleral curvature in highly myopic children and adolescents investigated by ultra-widefield optical coherence tomography. (PubMed)

according to the Ministry of Health and Welfare, Japan classification. A posterior displacement of the sclera and two OCT features indicating the staphyloma edges were used as markers of a staphyloma.Fifty-five eyes of 30 patients with the mean age of 12.3 years, and the mean axial length of 27.9 mm were studied. Seven of the 55 eyes (12.7%) had a posterior displacement of the sclera and were diagnosed as having a staphyloma. Among the two OCT features of the staphyloma edges, a gradual thinning (...) of the choroid toward the staphyloma edge and gradual re-thickening of choroid from the staphyloma edge toward the posterior pole were found in these 7 eyes. However, the other feature of an inward protrusion of the sclera at the staphyloma edge, was obvious in only 2 eyes. The subfoveal choroid and choroid nasal to the optic disc were significantly thinner in eyes with a staphyloma than those without it.The changes of the choroidal thickness toward the staphyloma edge with the posterior displacement

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2019 PLoS ONE

167. Lamina cribrosa and peripapillary sclera histomorphometry in normal and advanced glaucomatous Chinese eyes with various axial length. (PubMed)

Lamina cribrosa and peripapillary sclera histomorphometry in normal and advanced glaucomatous Chinese eyes with various axial length. To measure laminar and peripapillary scleral architecture in normal and glaucomatous Chinese eyes with normal and those with elongated axial length.The histomorphometric investigation included a normal group (nonaxially elongated eyes) of 40 human globes (40 patients; mean age, 41.3 +/- 13.4 years; range,15-68) enucleated because of malignant choroidal melanoma (...) significantly between the glaucomatous group and the normal group. The distance between the intraocular space and cerebrospinal fluid space was (P < 0.001) shorter in the two glaucomatous groups than in the normal group.Lamina cribrosa thickness and peripapillary sclera thickness decreased significantly with axial length, in addition to a glaucoma-related thinning of the lamina cribrosa. In non-axially elongated eyes, the peripapillary sclera thickness did not vary significantly between glaucomatous eyes

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2009 Investigative Ophthalmology & Visual Science

168. 5-Fluorouracil for glaucoma surgery. (PubMed)

5-Fluorouracil for glaucoma surgery. Trabeculectomy is performed as a treatment for many types of glaucoma in an attempt to lower the intraocular pressure. The surgery involves creating a channel through the sclera, through which intraocular fluid can leave the eye. If scar tissue blocks the exit of the surgically created channel, intraocular pressure rises and the operation fails. Antimetabolites such as 5-Fluorouracil (5-FU) are used to inhibit wound healing to prevent the conjunctiva (...) scarring down on to the sclera. This is an update of a Cochrane review first published in 2000, and previously updated in 2009.To assess the effects of both intraoperative application and postoperative injections of 5-FU in eyes of people undergoing surgery for glaucoma at one year.We searched CENTRAL (which contains the Cochrane Eyes and Vision Group Trials Register) (The Cochrane Library 2013, Issue 6), Ovid MEDLINE, Ovid MEDLINE In-Process and Other Non-Indexed Citations, Ovid MEDLINE Daily, Ovid

2014 Cochrane

169. Guidance for the reporting of ophthalmic pathology specimens

of the Joint Working Party of The Royal Colleges of Ophthalmologists and Pathologists and was ratified by both these Royal Colleges. Ophthalmic pathology encompasses specimens originating from the eyelid, conjunctiva, cornea, sclera, all intraocular sites, extraocular muscles, orbital tissues, optic nerve and sheath, optic chiasm, lacrimal gland and drainage apparatus and bony wall of orbit. Whilst some pathologists will regularly see the full range of ophthalmic pathology specimens, other pathologist

2015 Royal College of Pathologists

171. Retinoblastoma Treatment (PDQ®): Health Professional Version

as the tumor progresses. Invasion of the choroid is common, although occurrence of massive invasion is usually limited to advanced disease. After invading the choroid, the tumor gains access to systemic circulation and creates the potential for metastases. Further progression through the ocular coats leads to invasion of the sclera and the orbit. Anteriorly, tumor invading the anterior chamber may gain access to systemic circulation through the canal of Schlemm. Progression through the optic nerve and past (...) the lamina cribrosa increases the risk of systemic and CNS dissemination (refer to ). Figure 1. Anatomy of the eye showing the outside and inside of the eye, including the eyelid, pupil, sclera, iris, ciliary body, canal of Schlemm, cornea, lens, vitreous humor, retina, choroid, optic nerve, and lamina cribrosa. The vitreous humor is a gel that fills the center of the eye. Screening The following screening and monitoring strategies reflect common practices in the management of retinoblastoma. In children

2018 PDQ - NCI's Comprehensive Cancer Database

172. Intraocular (Uveal) Melanoma Treatment (PDQ®): Health Professional Version

or more in thickness can be demonstrated provided it is located behind the equator where the intraocular tumor, sclera, and adjacent orbital fat are readily imaged.[ ] Orbital extraocular extension of choroidal melanoma may be found in eyes with medium and large tumors, but it is very rare in eyes with small melanomas. Metastatic Disease Systemic metastases are evident in only 1% to 4% of patients at the time of diagnosis of the primary ocular melanoma.[ ] Because the uveal tract is a vascular

2018 PDQ - NCI's Comprehensive Cancer Database

173. Novel use of fibrin sealant for scleral suture free placement of a glaucoma drainage device in advanced scleral thinning (PubMed)

Novel use of fibrin sealant for scleral suture free placement of a glaucoma drainage device in advanced scleral thinning This reports a case using fibrin glue to secure a glaucoma drainage device plate to the sclera where there is a concern with the use of suture.A 13-year-old patient with congenital aniridia and associated glaucoma refractory to topical medications underwent implantation of a glaucoma drainage device (GDD) for improved intraocular pressure (IOP) control. The patient had (...) to the sclera in patients with suturing contraindications.

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2017 American journal of ophthalmology case reports

174. Newborn Nursing Care Pathway

history) Assess mother’s/ family/ supports understanding of newborn physiology and capacity to identify variances that may require further assessments Refer to: • Skin Norm and Normal Variations • Outer canthus aligned with upper ear • Dark or slate blue color • Blink reflex present • Edematous lids • Sclera clear • No tears • Pupils equal and reactive to light • May see subconjunctival hemorrhage • Administer eye prophylaxis (after completion of initial feeding or by 1 hour after birth) 20 promotes (...) attention by looking, lifting upper eyelids, ‘brightening’ Attracted to human face Display visual abilities most consistently in quiet alert state Norm and Normal Variations • Refer to POS • Resolving or decreasing edema of eyelids and chemical conjunctivitis • May have slight jaundice of sclera Parent education/ Anticipatory Guidance • Refer to 12 – 24 hr • Jaundice progression/ treatment Norm and Normal Variations • Refer to POS and >24-72 hr • May have transient strabismus or nystagmus until 3 – 4

2015 British Columbia Perinatal Health Program

176. The removal of imbedded corneal foreign bodies to any person presenting to an optometrist

by optometrists is shown below in Table 1. The wording of the proposed item is based on MBS item 42644, for removal of CFB by an ophthalmologist (with the omission of the word ‘sclera’). Should the proposed MBS item be approved, the Department of Health recommended that additional explanatory notes be added to para O6 of the Medicare Benefits Schedule Book Optometrical Services Schedule, as shown in Table 1. A fee of $90.25 was proposed by the applicant, based on direct and indirect practice costs (...) to a corneal ulcer. The applicant has proposed the existing item descriptor (42644) be adopted for the optometry item with the removal of 'sclera’ and PASC proposed the same schedule fee as for 42644. ESC agreed that there should not be a requirement for co-claiming with a consultation item. ESC noted that PASC recommended that if a new item be listed it be claimed with a consultation item, on the basis that this was how GPs claimed the item. However, MBS data showed that only about 70% of these services

2014 Medical Services Advisory Committee

177. Miniature lens system implantation for advanced age-related macular degeneration

no standard treatment for dry AMD. 3 3 The procedure The procedure 3.1 The aim of an implantable miniature lens system is either to magnify the image on the macula, or to optically move the image onto an undamaged part of the retina. Implantation of lens systems for advanced age-related macular degeneration (AMD) is usually done under local anaesthesia. The natural lens of the eye is removed through a small incision at the limbus (the area where the cornea meets the sclera) and the new lens system

2016 National Institute for Health and Clinical Excellence - Interventional Procedures

178. Insertion of a subretinal prosthesis system for retinitis pigmentosa

. 3.2 Implantation of the microchip is done with the patient under general anaesthesia. A vitrectomy is performed and the microchip is implanted underneath the macula using a transscleral, then subretinal approach. The microchip connects to a thin cable that exits the eye at the equator, through the choroid and sclera, and runs under the skin to a power source which is fixed to bone in the retroauricular region. This, in turn, connects to an external power source/control unit via a removable

2016 National Institute for Health and Clinical Excellence - Interventional Procedures

179. Lipid Emulsion-Based OCT Angiography for Ex Vivo Imaging of the Aqueous Outflow Tract. (PubMed)

Lipid Emulsion-Based OCT Angiography for Ex Vivo Imaging of the Aqueous Outflow Tract. Contrast agents applicable for optical coherence tomography (OCT) imaging are rare. The intrascleral aqueous drainage system would be a potential application for a contrast agent, because the aqueous veins are of small diameter and located deep inside the highly scattering sclera. We tested lipid emulsions (LEs) as candidate OCT contrast agents in vitro and ex vivo, including milk and the anesthetic substance

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2019 Investigative Ophthalmology & Visual Science

180. A Case Report of Complete Blockage of a Baerveldt Glaucoma Implant Following Insertion of a 3-0 Supramid Suture. (PubMed)

to the sclera, the device was flow tested. No flow was observed through the device tube and a significant ballooning of the tube diameter occurred with increased pressure on the device. The device was explanted from the eye and replaced with a different implant without further post-operative complication. The explanted device was assessed using custom microfluidic equipment in an in vitro environment.This phenomenon occurred despite using several different batches of the 3-0 Supramid stent suture

2019 Journal of Glaucoma

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