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Sclera

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101. Blue sclerae and keratoglobus. Ocular signs of a systemic connective tissue disorder. (PubMed)

Blue sclerae and keratoglobus. Ocular signs of a systemic connective tissue disorder. 5775573 1969 05 08 2018 11 13 0007-1161 53 1 1969 Jan The British journal of ophthalmology Br J Ophthalmol Blue sclerae and keratoglobus. Ocular signs of a systemic connective tissue disorder. 53-8 Hyams S W SW Kar H H Neumann E E eng Case Reports Journal Article England Br J Ophthalmol 0421041 0007-1161 IM Child, Preschool Connective Tissue Consanguinity Cornea Dentinogenesis Imperfecta complications (...) Diagnosis, Differential Ehlers-Danlos Syndrome diagnosis Eye Diseases complications diagnosis genetics Eye Manifestations Female Humans Joint Diseases genetics Keratoconus genetics Osteogenesis Imperfecta diagnosis Sclera 1969 1 1 1969 1 1 0 1 1969 1 1 0 0 ppublish 5775573 PMC1207096 AMA Arch Ophthalmol. 1953 Jan;49(1):6-16 12996143 Am J Ophthalmol. 1964 Oct;58:678-82 14218178 Boll Ocul. 1954 Dec;33(12):789-95 14363424 Am J Ophthalmol. 1968 Jul;66(1):67-9 4872990

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1969 The British journal of ophthalmology

102. Blue sclerae with keratoglobus and brittle cornea. (PubMed)

Blue sclerae with keratoglobus and brittle cornea. 5090282 1971 08 13 2018 11 13 0007-1161 55 6 1971 Jun The British journal of ophthalmology Br J Ophthalmol Blue sclerae with keratoglobus and brittle cornea. 424-6 Gregoratos N D ND Bartsocas C S CS Papas K K eng Journal Article England Br J Ophthalmol 0421041 0007-1161 IM Adult Child, Preschool Cornea abnormalities Corneal Injuries Corneal Opacity Female Humans Hydrocephalus complications Intraocular Pressure Male Pedigree Sclera abnormalities

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1971 The British journal of ophthalmology

103. Choroidopathy produced by pressure on the sclera by synthetic buckling material. (PubMed)

Choroidopathy produced by pressure on the sclera by synthetic buckling material. 4707625 1973 07 31 2018 11 13 0007-1161 57 4 1973 Apr The British journal of ophthalmology Br J Ophthalmol Choroidopathy produced by pressure on the sclera by synthetic buckling material. 274-80 Mortada A A eng Journal Article England Br J Ophthalmol 0421041 0007-1161 0 Silicone Elastomers 0 Silicones IM Animals Choroid drug effects pathology Cornea pathology Humans Iris pathology Pressure Rabbits Retinal (...) Detachment surgery Sclera Silicone Elastomers adverse effects Silicones 1973 4 1 1973 4 1 0 1 1973 4 1 0 0 ppublish 4707625 PMC1214880 Br J Ophthalmol. 1957 May;41(5):257-300 13426465 AMA Arch Ophthalmol. 1957 Dec;58(6):797-811 13478226

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1973 The British journal of ophthalmology

104. RATE AT WHICH MUSCLE BECOMES JOINED TO SCLERA AFTER OPERATIONS OF RECESSION AND RESECTION (PubMed)

RATE AT WHICH MUSCLE BECOMES JOINED TO SCLERA AFTER OPERATIONS OF RECESSION AND RESECTION "The major contributions of surgical interest which have been made to our understanding of wound healing since Virchow and Paget rest with quantifying the rate of repair and the appraisal of factors which affect it." (Dunphy, 1960.)

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1965 The British journal of ophthalmology

105. A Case of Wound of the Sclera treated by Suture, with Remarks (PubMed)

A Case of Wound of the Sclera treated by Suture, with Remarks 25258754 2014 09 30 2014 10 03 0065-9533 2 1873 Transactions of the American Ophthalmological Society Trans Am Ophthalmol Soc A Case of Wound of the Sclera treated by Suture, with Remarks. 43-9 Pooley T R TR eng Journal Article United States Trans Am Ophthalmol Soc 7506106 0065-9533 2014 9 27 6 0 1873 1 1 0 0 1873 1 1 0 1 ppublish 25258754 PMC1361668

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1873 Transactions of the American Ophthalmological Society

106. Report of a Case of Tuberculosis of the Sclera of Probable Primary Origin (PubMed)

Report of a Case of Tuberculosis of the Sclera of Probable Primary Origin 16692325 2006 06 01 2008 11 20 0065-9533 13 Pt 3 1914 Transactions of the American Ophthalmological Society Trans Am Ophthalmol Soc Report of a Case of Tuberculosis of the Sclera of Probable Primary Origin. 787-95 Bell G H GH eng Journal Article United States Trans Am Ophthalmol Soc 7506106 0065-9533 1914 1 1 0 0 1914 1 1 0 1 1914 1 1 0 0 ppublish 16692325 PMC1322831

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1914 Transactions of the American Ophthalmological Society

107. Massive Granuloma of the Sclera (Brawny Scleritis), with the Report of an Unusual Case: Pathologic Examination by Dr. F. H. Verhoeff (PubMed)

Massive Granuloma of the Sclera (Brawny Scleritis), with the Report of an Unusual Case: Pathologic Examination by Dr. F. H. Verhoeff 16692330 2006 06 01 2008 11 20 0065-9533 14 Pt 1 1915 Transactions of the American Ophthalmological Society Trans Am Ophthalmol Soc Massive Granuloma of the Sclera (Brawny Scleritis), with the Report of an Unusual Case: Pathologic Examination by Dr. F. H. Verhoeff. 110-24 Derby G S GS eng Journal Article United States Trans Am Ophthalmol Soc 7506106 0065-9533 1915

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1915 Transactions of the American Ophthalmological Society

108. A Positive Focal Tuberculin Reaction in a Spindle-Cell Sarcoma which Had Perforated the Sclera (PubMed)

A Positive Focal Tuberculin Reaction in a Spindle-Cell Sarcoma which Had Perforated the Sclera 16692490 2006 06 01 2008 11 20 0065-9533 17 1919 Transactions of the American Ophthalmological Society Trans Am Ophthalmol Soc A Positive Focal Tuberculin Reaction in a Spindle-Cell Sarcoma which Had Perforated the Sclera. 416-9 Charles J W JW eng Journal Article United States Trans Am Ophthalmol Soc 7506106 0065-9533 1919 1 1 0 0 1919 1 1 0 1 1919 1 1 0 0 ppublish 16692490 PMC1318205

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1919 Transactions of the American Ophthalmological Society

109. The Treatment of Detachment of the Retina, with Special Reference to Müller's Resection of the Sclera (PubMed)

The Treatment of Detachment of the Retina, with Special Reference to Müller's Resection of the Sclera 16692426 2006 06 01 2008 11 20 0065-9533 15 1917 Transactions of the American Ophthalmological Society Trans Am Ophthalmol Soc The Treatment of Detachment of the Retina, with Special Reference to Müller's Resection of the Sclera. 74-84 Török E E eng Journal Article United States Trans Am Ophthalmol Soc 7506106 0065-9533 1917 1 1 0 0 1917 1 1 0 1 1917 1 1 0 0 ppublish 16692426 PMC1318106

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1917 Transactions of the American Ophthalmological Society

110. Results Obtained with Müller's Resection of the Sclera in Detachment of Retina Due to High Myopia (PubMed)

Results Obtained with Müller's Resection of the Sclera in Detachment of Retina Due to High Myopia 16692538 2006 06 01 2008 11 20 0065-9533 18 1920 Transactions of the American Ophthalmological Society Trans Am Ophthalmol Soc Results Obtained with Müller's Resection of the Sclera in Detachment of Retina Due to High Myopia. 83-91 Török E E eng Journal Article United States Trans Am Ophthalmol Soc 7506106 0065-9533 1920 1 1 0 0 1920 1 1 0 1 1920 1 1 0 0 ppublish 16692538 PMC1318227

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1920 Transactions of the American Ophthalmological Society

111. THE PATHOLOGY OF SCLERAL PLAQUES: Report of five cases of degenerative plaques in the sclera mesially, one studied histologically (PubMed)

THE PATHOLOGY OF SCLERAL PLAQUES: Report of five cases of degenerative plaques in the sclera mesially, one studied histologically 18169591 2008 01 11 2008 11 20 0007-1161 23 1 1939 Jan The British journal of ophthalmology Br J Ophthalmol THE PATHOLOGY OF SCLERAL PLAQUES: Report of five cases of degenerative plaques in the sclera mesially, one studied histologically. 44-50 Culler A M AM Dayton, Ohio. eng Journal Article England Br J Ophthalmol 0421041 0007-1161 1939 1 1 0 0 1939 1 1 0 1 1939 1 1

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1939 The British journal of ophthalmology

112. BILATERAL MESIAL SUPERFICIAL “DEFICIENCY” OF THE SCLERA [SCLERAL PLAQUES] (PubMed)

BILATERAL MESIAL SUPERFICIAL “DEFICIENCY” OF THE SCLERA [SCLERAL PLAQUES] 18169605 2008 01 11 2008 11 20 0007-1161 23 3 1939 Mar The British journal of ophthalmology Br J Ophthalmol BILATERAL MESIAL SUPERFICIAL "DEFICIENCY" OF THE SCLERA [SCLERAL PLAQUES]. 191-204 Graves B B eng Journal Article England Br J Ophthalmol 0421041 0007-1161 1939 3 1 0 0 1939 3 1 0 1 1939 3 1 0 0 ppublish 18169605 PMC1143036

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1939 The British journal of ophthalmology

113. Iontophoretic Transport of Charged Macromolecules across Human Sclera (PubMed)

Iontophoretic Transport of Charged Macromolecules across Human Sclera The mechanisms of transscleral iontophoresis have been investigated previously with small molecules in rabbit sclera. The objective of the present study was to examine transscleral iontophoretic transport of charged macromolecules across excised human sclera. Passive and 2mA iontophoretic transport experiments were conducted in side-by-side diffusion cells with human sclera. The effects of iontophoresis upon transscleral (...) transport of model permeants bovine serum albumin (BSA) and polystyrene sulfonic acid (PSS) as well as a model drug bevacizumab (BEV) were determined. Passive and iontophoretic transport experiments of tetraethylammonium (TEA) and salicylic acid (SA) and passive transport experiments of the macromolecules served as the controls. The results of iontophoresis enhanced transport of TEA and SA across human sclera were consistent with those in a previous rabbit sclera study. For the iontophoretic transport

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2010 International journal of pharmaceutics

114. All-trans retinoic acid regulates the expression of the extracellular matrix protein fibulin-1 in the guinea pig sclera and human scleral fibroblasts (PubMed)

All-trans retinoic acid regulates the expression of the extracellular matrix protein fibulin-1 in the guinea pig sclera and human scleral fibroblasts Fibulin-1 (FBLN1) mRNA is expressed in human sclera and is an important adhesion modulatory protein that can affect cell-matrix interactions and tissue remodeling. Scleral remodeling is influenced by all-trans retinoic acid (RA). Our purpose was to confirm the presence of fibulin-1 protein in guinea pig sclera and investigate the effect of RA (...) on the expression of fibulin-1 in guinea pig sclera in vivo and in cultured human scleral fibroblasts (HSFs).Confocal fluorescence microscopy was used to study fibulin-1 and aggrecan expression and localization in sclera from control guinea pigs and in animals given RA by daily gavage from 4 to 8 days of age. The effects of RA (from 10(-9) to 10(-5) M) on fibulin-1 expression in HSFs were observed by immunohistochemistry and assayed by real-time PCR and western blot analysis.Fibulin-1 protein expression

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2010 Molecular vision

115. A 54-year-old woman with bluish discoloration of her sclera (PubMed)

A 54-year-old woman with bluish discoloration of her sclera 23362374 2013 01 31 2018 11 13 1542-8958 16 2 2010 Digital journal of ophthalmology : DJO Digit J Ophthalmol A 54-year-old woman with bluish discoloration of her sclera. 6-8 10.5693/djo.03.2010.02.002 Phan Isabella I Oregon Health and Science University; Kaiser Rachel R Chiu Cynthia C eng Journal Article 2010 05 08 United States Digit J Ophthalmol 9605355 1542-8958 2013 1 31 6 0 2010 1 1 0 0 2010 1 1 0 1 ppublish 23362374 10.5693/djo

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2010 Digital Journal of Ophthalmology : DJO

116. Inhibition of matrix metalloproteinase activity in the chick sclera and its effect on myopia development. (PubMed)

Inhibition of matrix metalloproteinase activity in the chick sclera and its effect on myopia development. To investigate the contribution of matrix degradation in the two-layer avian sclera to the development of myopia.Tissue inhibitor of metalloproteinase-2 (TIMP-2) was used to inhibit chick scleral collagen degradation with (3)H-proline, a marker for this effect. Ex vivo scleral culture experiments confirmed TIMP-2 doses for in vivo experimentation. Ocular growth and refractive response (...) to exogenous TIMP-2 (11.25, 2.25, and 0.45 picomoles, plus vehicle only) were monitored in 7-day-old chicks during the induction of myopia over 4 days with a translucent occluder. Collagen degradation was assessed, in whole sclera and in separated scleral layers by using the same paradigm (11.25 picomoles TIMP-2; vehicle only).Approximately 60% of collagen degradation was inhibited with low (2 nM) doses of TIMP-2 in the ex vivo sclera. Degradative activity in the in vivo chick sclera increased

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2010 Investigative Ophthalmology & Visual Science

117. Microstructural Differences in the Human Posterior Sclera As a Function of Age and Ethnicity. (PubMed)

Microstructural Differences in the Human Posterior Sclera As a Function of Age and Ethnicity. The purpose of this study was to quantify the age and race-related differences in the microstructural organization of the human posterior sclera. Such differences may contribute to the predisposition of primary open-angle glaucoma in various high-risk populations.Posterior-temporal scleras from 75 right eyes were procured at an average distance of 3.5 mm from the center of the optic nerve head (ONH (...) scleral layers, normalized for depth, were examined.For all ages and both races, fibers were preferentially oriented equatorially at all layers (P < 0.001). The African Americans had a significantly higher percentage of occurrence of meridional fibers than did the Caucasians (P < 0.001). The percentage occurrence of meridional fibers decreased significantly from the inner to the outer layers of the posterior sclera (P < 0.001).Statistically significant microstructural differences were found

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2010 Investigative Ophthalmology & Visual Science

118. Enhanced Depth Imaging Optical Coherence Tomography of the Sclera in Dome-Shaped Macula. (PubMed)

Enhanced Depth Imaging Optical Coherence Tomography of the Sclera in Dome-Shaped Macula. To examine the posterior anatomic structure of eyes with dome-shaped macula using enhanced depth imaging spectral-domain optical coherence tomography (EDI-OCT).Retrospective observational case series.Patients with dome-shaped macula, a condition defined as convex elevation of the macula as compared with the surrounding staphylomatous region in a highly myopic eye, were identified through routine (...) macula bilaterally. The mean subfoveal scleral thickness in 23 eyes with dome-shaped macula was 570 (± 221) μm, and that in 25 eyes of 15 myopic patients with staphyloma but without dome-shaped macula was 281 (± 85) μm (P < .001) even though both groups had similar myopic refractive error. The scleral thickness 3000 μm temporal to the fovea was not different in the 2 groups.Dome-shaped macula is the result of a relative localized thickness variation of the sclera under the macula in highly myopic

2010 American Journal of Ophthalmology

119. Neonatal jaundice

includes phototherapy and/or exchange transfusion. The major complication of unconjugated hyperbilirubinaemia is kernicterus. Definition Neonatal jaundice is the yellowing discoloration of the skin and sclera of a neonate, which is caused by increased levels of bilirubin in the blood. A neonate refers to an infant in the first 28 days of life. This topic focuses on recognising and managing early neonatal jaundice, which is most commonly caused by unconjugated hyperbilirubinaemia. While prolonged

2019 BMJ Best Practice

120. Porcine sclera as a model of human sclera for in vitro transport experiments: histology, SEM, and comparative permeability (PubMed)

Porcine sclera as a model of human sclera for in vitro transport experiments: histology, SEM, and comparative permeability To evaluate porcine sclera as a model of human sclera for in vitro studies of transscleral drug delivery of both low and high molecular weight compounds.Human and porcine scleras were characterized for thickness and water content. The tissue surface was examined by scanning electron microscopy (SEM), and the histology was studied with hematoxylin-eosin staining. Comparative (...) permeation experiments were performed using three model molecules, acetaminophen as the model compound for small molecules; a linear dextran with a molecular weight of 120 kDa as the model compound for high molecular weight drugs; and insulin, which was chosen as the model protein. Permeation parameters such as flux, lag time, and permeability coefficient were determined and compared.Human and porcine scleras have a similar histology and collagen bundle organization. The water content is approx 70

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2009 Molecular vision

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