How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

2,288 results for

Sclera

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

81. Sustained release micellar carrier systems for iontophoretic transport of dexamethasone across human sclera (PubMed)

Sustained release micellar carrier systems for iontophoretic transport of dexamethasone across human sclera A challenge in ocular drug delivery is to maintain the therapeutic concentration of a drug at the site of action in the eye. The objective of the present study was to investigate the feasibility of micellar carrier systems for sustained drug delivery in transscleral iontophoresis in vitro. Simple and mixed micelles prepared using sodium taurocholate (TA) alone or with egg lecithin (LE (...) ) were the carrier systems studied. Dexamethasone (DEX), a poorly water soluble corticosteroid, was the model drug. The micellar carrier systems were first characterized for their solubilization and encapsulation of the drug. Passive and 2-mA iontophoretic (both cathodal and anodal) transport experiments were conducted using these micellar carrier systems in side-by-side diffusion cells with excised human sclera in vitro. Drug release studies were performed after the transport experiments. Saturated

Full Text available with Trip Pro

2012 Journal of Controlled Release

82. Standard Enucleation with Aluminium Oxide Implant (Bioceramic) Covered with Patient's Sclera (PubMed)

Standard Enucleation with Aluminium Oxide Implant (Bioceramic) Covered with Patient's Sclera We describe in our study a modified standard enucleation, using sclera harvested from the enucleated eye to cover the prosthesis in order to insert a large porous implant and to reduce postoperative complication rates in a phthisis globe.We perform initially a standard enucleation. The porous implant (Bioceramic) is then covered only partially by the patient's sclera. The implant is inserted

Full Text available with Trip Pro

2012 The Scientific World Journal

83. Sclera

Sclera Sclera Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Sclera Sclera Aka: Sclera , Scleral Icterus , Yellow Sclera , Episclera (...) II. Physiology Sclera Thick, protective outer coat of the eye underlying the Poorly vascularized Normally white (with possible bluish discoloration) and opaque Scleral inflammation is very painful, and associated with Episclera Covers the anterior Sclera and lacks the Scleral bluish discoloration Continuous with the Episcleral inflammation is not typically painful, and does not cause vision change III. Findings: Normal Normally white and opaque IV. Causes: Scleral Inflammation V. Causes: Scleral

2015 FP Notebook

84. Mapping the differential distribution of proteoglycan core proteins in the adult human retina, choroid and sclera. (PubMed)

Mapping the differential distribution of proteoglycan core proteins in the adult human retina, choroid and sclera. To examine the presence and distribution of proteoglycan (PG) core proteins in the adult human retina, choroid, and sclera.Postmortem human eye tissue was dissected into Bruch's membrane/choroid complex, isolated Bruch's membrane, or neurosensory retina. PGs were extracted and partially purified by anion exchange chromatography. Trypsinized peptides were analyzed by tandem mass (...) the retina, choroid, and sclera. The cartilage link protein HAPLN1 was abundant in the interphotoreceptor matrix and sclera, while HAPLN4 (brain link protein 2) was found throughout the retina and choroid. The small leucine-rich repeat PG (SLRP) family members biglycan, decorin, fibromodulin, lumican, mimecan, opticin, and prolargin were present, with different patterns of distribution in the retina, choroid, and sclera.A combination of proteomics and immunohistochemistry approaches has provided

Full Text available with Trip Pro

2012 Investigative Ophthalmology & Visual Science

85. Association between Shape of Sclera and Myopic Retinochoroidal Lesions in Patients with Pathologic Myopia. (PubMed)

Association between Shape of Sclera and Myopic Retinochoroidal Lesions in Patients with Pathologic Myopia. The purpose of the study was to analyze the shape of the sclera determined by swept-source optical coherence tomography (OCT) and to determine the relationship between the shape and the myopic retinochoroidal lesions.We studied 488 eyes of 272 patients with high myopia (refractive error ≥-8.00 diopters [D] or axial length >26.5 mm) and 43 emmetropic eyes of 43 controls (refractive error (...) ≤±3 D). An image of the sclera was obtained by a swept-source OCT prototype instrument that uses a wavelength sweeping laser centered on 1 μm wavelength with an A-scan repetition rate of 100,000 Hz. The scans were 12 mm radial scans centered on the fovea. Seventy eyes were also examined by three-dimensional magnetic resonance imaging (3D MRI) to obtain the contour of the outer surface of the eyes. The main outcome measures, visibility of the entire sclera layer, scleral thickness, scleral contour

Full Text available with Trip Pro

2012 Investigative Ophthalmology & Visual Science

86. Patterns of mRNA and protein expression during minus-lens compensation and recovery in tree shrew sclera (PubMed)

Patterns of mRNA and protein expression during minus-lens compensation and recovery in tree shrew sclera To increase our understanding of the mechanisms that remodel the sclera during the development of lens-induced myopia, when the sclera responds to putative "go" signals of retinal origin, and during recovery from lens-induced myopia, when the sclera responds to retinally-derived "stop" signals.Seven groups of tree shrews were used to examine mRNA levels during minus lens compensation (...) " and "stop" conditions. There is evidence of binocular global downregulation of genes at the start of both lens wear and recovery. As additional information accumulates about changes in gene expression that occur during compensation and recovery the "signature" of differential changes may help us to understand in more detail how the sclera responds in "go" and "stop" conditions.

Full Text available with Trip Pro

2011 Molecular vision

87. Biomechanical Changes in the Sclera of Monkey Eyes Exposed to Chronic IOP Elevations. (PubMed)

Biomechanical Changes in the Sclera of Monkey Eyes Exposed to Chronic IOP Elevations. To characterize scleral biomechanics in both eyes of eight monkeys in which chronic intraocular pressure (IOP) elevation was induced in one eye.Each posterior sclera was mounted on a pressurization apparatus, IOP was elevated from 5 to 45 mm Hg while the 3D displacements of the scleral surface were measured by speckle interferometry. Finite element (FE) models of each scleral shell were constructed (...) that incorporated stretch-induced stiffening and multidirectionality of the collagen fibers. FE model predictions were then iteratively matched to experimental displacements to extract unique sets of scleral biomechanical properties.For all eyes, the posterior sclera exhibited inhomogeneous, anisotropic, nonlinear biomechanical behavior. Biomechanical changes caused by chronic IOP elevation were complex and specific to each subject. Specifically: (1) Glaucomatous eyes in which the contralateral normal eyes

Full Text available with Trip Pro

2011 Investigative Ophthalmology & Visual Science

88. Alterations in Protein Expression in Tree Shrew Sclera during Development of Lens-induced Myopia and Recovery. (PubMed)

Alterations in Protein Expression in Tree Shrew Sclera during Development of Lens-induced Myopia and Recovery. During the development of, and recovery from, negative lens-induced myopia there is regulated remodeling of the scleral extracellular matrix (ECM) that controls the extensibility of the sclera. Difference gel electrophoresis (DIGE) was used to identify and categorize proteins whose levels are altered in this process.Two groups of five tree shrews started monocular lens wear 24 days (...) , and transcriptional regulation and extend our understanding of the remodeling that controls the extensibility of the sclera. Reductions in these proteins during minus lens wear may produce the increased scleral viscoelasticity that results in faster axial elongation. Recovery is not a mirror image of lens-induced myopia-many protein levels, decreased during LIM, returned to normal, or slightly above normal, and additional cytoskeleton proteins were upregulated. However, no single protein or pathway appeared

Full Text available with Trip Pro

2011 Investigative Ophthalmology & Visual Science

89. Sclera as a surrogate marker for determining AGE-modifications in Bruch's membrane using a Raman spectroscopy based index of aging. (PubMed)

Sclera as a surrogate marker for determining AGE-modifications in Bruch's membrane using a Raman spectroscopy based index of aging. Raman spectroscopy is an effective probe of advanced glycation end products (AGEs) in Bruch's membrane. However, because it is the outermost layer of the retina, this extracellular matrix is difficult to analyze in vivo with current technology. The sclera shares many compositional characteristics with Bruch's membrane, but it is much easier to access for in vivo (...) Raman analysis. This study investigated whether sclera could act as a surrogate tissue for Raman-based investigation of pathogenic AGEs in Bruch's membrane.Human sclera and Bruch's membrane were dissected from postmortem eyes (n = 67) across a wide age range (33-92 years) and were probed by Raman spectroscopy. The biochemical composition, AGEs, and their age-related trends were determined from data reduction of the Raman spectra and compared for the two tissues.Raman microscopy demonstrated

Full Text available with Trip Pro

2011 Investigative Ophthalmology & Visual Science

90. Sclera-choroid-RPE Transport of Eight Beta-blockers in Human, Bovine, Porcine, Rabbit, and Rat Models. (PubMed)

Sclera-choroid-RPE Transport of Eight Beta-blockers in Human, Bovine, Porcine, Rabbit, and Rat Models. To determine the influence of drug lipophilicity, ocular pigmentation, and species differences on transscleral solute transport.The transport of eight β-blockers across excised sclera/sclera-choroid-RPE (SCRPE) of albino rabbit, pigmented rabbit, human, porcine, and bovine eyes was determined over 6 hours. The ex vivo transscleral β-blocker transport to the vitreous at the end of 6 hours (...) was determined in euthanatized, pigmented Brown Norway rats. The thicknesses of the sclera and SCRPE and the melanin content in choroid-RPE (CRPE) were measured to determine whether species differences in drug transport can be explained on this basis.Solute lipophilicity inversely correlated with the SCRPE cumulative percentage of transport in all species (R(2) ≥ 0.80). The CRPE impeded the SCRPE transport of all β-blockers (51%-64% resistance in the rabbits; 84%-99.8% in the bovine and porcine eyes) more

Full Text available with Trip Pro

2011 Investigative Ophthalmology & Visual Science

91. Thickness of the lamina cribrosa and peripapillary sclera in Rhesus monkeys with nonglaucomatous or glaucomatous optic neuropathy. (PubMed)

Thickness of the lamina cribrosa and peripapillary sclera in Rhesus monkeys with nonglaucomatous or glaucomatous optic neuropathy. To measure the thickness of the lamina cribrosa and peripapillary sclera in monkeys with a nonglaucomatous optic nerve damage and to compare that with those of monkeys with glaucomatous optic neuropathy.The study included 22 monkey eyes (Macaca mulatta) which had undergone a temporary experimental central retinal artery occlusion (CRAO) and seven monkey eyes (...) in which experimental glaucoma was unilaterally produced. We measured histomorphometrically the thickness of the lamina cribrosa and peripapillary sclera.The lamina cribrosa was significantly thicker in the CRAO group than in the glaucoma group (central region: 212 ± 46 μm versus 167 ± 17 μm; p = 0.009). The thickness of the peripapillary sclera at the optic disc border (253 ± 39 μm versus 192 ± 21 μm; p = 0.001) and outside of the optic nerve meninges (408 ± 70 μm versus 314 ± 64 μm; p = 0.006

Full Text available with Trip Pro

2011 Acta ophthalmologica

92. Effects of 7-methylxanthine on the sclera in form deprivation myopia in guinea pigs. (PubMed)

Effects of 7-methylxanthine on the sclera in form deprivation myopia in guinea pigs. The aim of this study was to determine the effect of the adenosine receptor antagonist 7-methylxanthine (7-MX) on form deprivation myopia in 3-week-old guinea pigs.Two groups of 3-week-old guinea pigs were subjected to monocular deprivation (MD) using a diffuser and fed either 7-MX (300 mg/kg body weight; n = 7) or vehicle control (saline at an equal volume to 7-MX; n = 7). A control group (n = 6 (...) ) was not subjected to form deprivation. Ocular refraction, axial length and body weight were measured at the start and after 21 days. The thickness of the posterior sclera was measured by light microscopy and the collagen fibril diameter in the inner, middle and outer layers of the sclera was measured by electron microscopy.In the vehicle control group, 21 days of MD produced significant amounts of myopia, axial elongation, thinning of the posterior sclera and thinning of the median collagen fibril diameter

Full Text available with Trip Pro

2011 Acta ophthalmologica

93. Mapping the differential distribution of glycosaminoglycans in the adult human retina, choroid and sclera. (PubMed)

Mapping the differential distribution of glycosaminoglycans in the adult human retina, choroid and sclera. PURPOSE. To map the distribution of different classes of glycosaminoglycans (GAGs) in the healthy human retina, choroid, and sclera. METHODS. Frozen tissue sections were made from adult human donor eyes. The GAG chains of proteoglycans (PGs) were detected with antibodies directed against various GAG structures (either directly or after pretreatment with GAG-degrading enzymes); hyaluronan (...) (HA) was detected using biotinylated recombinant G1-domain of human versican. The primary detection reagents were identified with FITC-labeled probes and analyzed by fluorescence microscopy. RESULTS. Heparan sulfate (HS), chondroitin sulfate (CS), dermatan sulfate (DS), and HA were present throughout the retina and choroid, but keratan sulfate (KS) was detected only in the sclera. HS labeling was particularly strong in basement membrane-containing structures, the nerve fiber layer (NFL

Full Text available with Trip Pro

2011 Investigative Ophthalmology & Visual Science

94. Proceedings: Thin sclerae. A clinical illusion. (PubMed)

Proceedings: Thin sclerae. A clinical illusion. 1221930 1976 06 02 2018 11 13 0003-4967 34 5 1975 Oct Annals of the rheumatic diseases Ann. Rheum. Dis. Proceedings: Thin sclerae. A clinical illusion. 465 Rooney P J PJ McGavin D D DD Sutherland G R GR Railton R R eng Journal Article England Ann Rheum Dis 0372355 0003-4967 IM Humans Sclera abnormalities Ultrasonography 1975 10 1 1975 10 1 0 1 1975 10 1 0 0 ppublish 1221930 PMC1006453 Ann Rheum Dis. 1975 Aug;34(4):312-20 1190851

Full Text available with Trip Pro

1975 Annals of the Rheumatic Diseases

95. STATISTICAL DATA OF MY CATARACT OPERATIONS PERFORMED WITH A NEW SUTURE OF THE SCLERA (PubMed)

STATISTICAL DATA OF MY CATARACT OPERATIONS PERFORMED WITH A NEW SUTURE OF THE SCLERA 18127113 2007 12 27 2018 12 01 0007-1161 33 5 1949 May The British journal of ophthalmology Br J Ophthalmol Statistical data of my cataract operations performed with a new suture of the sclera. 296-305 POPOLCZY F F eng Journal Article England Br J Ophthalmol 0421041 0007-1161 OM Cataract Cataract Extraction Humans Lens, Crystalline Sclera surgery Sutures 4917:34p CATARACT/extraction SCLERA/surgery SUTURES 1949

Full Text available with Trip Pro

1949 The British journal of ophthalmology

96. Effect of Cortisone on Rheumatoid Nodules of the Sclera (Scleromalacia Perforans) (PubMed)

Effect of Cortisone on Rheumatoid Nodules of the Sclera (Scleromalacia Perforans) 14935113 2004 02 15 2018 12 01 0007-1161 36 7 1952 Jul The British journal of ophthalmology Br J Ophthalmol Effect of cortisone on rheumatoid nodules of the sclera (scleromalacia perforans). 373-84 ASHTON N N HOBBS H E HE eng Journal Article England Br J Ophthalmol 0421041 0007-1161 V27W9254FZ Cortisone OM Cortisone therapeutic use Humans Rheumatoid Nodule Sclera Scleral Diseases 5222:21251:121:414 CORTISONE (...) /therapeutic use SCLERA/diseases 1952 7 1 1952 7 1 0 1 1952 7 1 0 0 ppublish 14935113 PMC1323953 Br J Ophthalmol. 1951 Nov;35(11):708-17 14895838 Ann Rheum Dis. 1951 Sep;10(3):337-46 14878354 Ann Ocul (Paris). 1950 Sep;183(9):737-44 14790400 Br J Ophthalmol. 1951 Nov;35(11):695-707 14895837 Am J Pathol. 1951 Nov-Dec;27(6):925-49 14885394 Ann Ocul (Paris). 1951 Aug;184(8):679-95 14878256 Am J Med. 1949 Dec;7(6):741-50 15394604 Am J Pathol. 1950 Jul;26(4):505-19 15419282 AMA Arch Ophthalmol. 1951 Mar;45(3

Full Text available with Trip Pro

1952 The British journal of ophthalmology

97. Blue sclerae, fragilitas ossium, arachnodactyly and deafness in an Indian family (PubMed)

Blue sclerae, fragilitas ossium, arachnodactyly and deafness in an Indian family 13158332 2003 05 01 2018 12 01 0002-9297 6 2 1954 Jun American journal of human genetics Am. J. Hum. Genet. Blue sclerae, fragilitas ossium, arachnodactyly and deafness in an Indian family. 270-8 TOBIAS P V PV eng Journal Article United States Am J Hum Genet 0370475 0002-9297 OM Arachnodactyly Bone and Bones abnormalities Congenital Abnormalities Deafness Hearing Disorders complications Hearing Loss Humans (...) Osteogenesis Imperfecta Sclera Scleral Diseases 5426:20981:2:79:200:319:399 ABNORMALITIES BONES/abnormalities HEARING DISORDERS/complications OSTEOGENESIS IMPERFECTA SCLERA/diseases 1954 6 1 1954 6 1 0 1 1954 6 1 0 0 ppublish 13158332 PMC1716544

Full Text available with Trip Pro

1954 American Journal of Human Genetics

98. Hernia of the Choroid treated by Scleral Grafting followed by Direct Suturing of the Sclera (PubMed)

Hernia of the Choroid treated by Scleral Grafting followed by Direct Suturing of the Sclera 13126422 2003 05 01 2018 12 01 0007-1161 38 2 1954 Feb The British journal of ophthalmology Br J Ophthalmol Hernia of the choroid treated by scleral grafting followed by direct suturing of the sclera. 126-7 SIVASUBRAMANIAM P P HOOLE T T eng Journal Article England Br J Ophthalmol 0421041 0007-1161 OM Choroid Choroid Diseases Hernia Humans Sclera Sutures 5425:47865:109 CHOROID/diseases 1954 2 1 1954 2 1 0

Full Text available with Trip Pro

1954 The British journal of ophthalmology

99. The passive electrical properties of the frog's retina, choroid and sclera for radial fields and currents (PubMed)

The passive electrical properties of the frog's retina, choroid and sclera for radial fields and currents 13398915 2002 05 01 2018 12 01 0022-3751 134 2 1956 Nov 28 The Journal of physiology J. Physiol. (Lond.) The passive electrical properties of the frog's retina, choroid and sclera for radial fields and currents. 339-52 BRINDLEY G S GS eng Journal Article England J Physiol 0266262 0022-3751 OM Animals Anura Choroid Ocular Physiological Phenomena Retina Sclera 5731:45538 EYE/physiology 1956

Full Text available with Trip Pro

1956 The Journal of physiology

100. EXTENSIBILITY OF STRIPS OF SCLERA AND CORNEA (PubMed)

EXTENSIBILITY OF STRIPS OF SCLERA AND CORNEA 13396178 2002 05 01 2018 12 01 0007-1161 41 2 1957 Feb The British journal of ophthalmology Br J Ophthalmol Extensibility of strips of sclera and cornea. 103-10 GLOSTER J J PERKINS E S ES POMMIER M L ML eng Journal Article England Br J Ophthalmol 0421041 0007-1161 OM Cornea physiology Sclera physiology 5731:42800 CORNEA/physiology SCLERA/physiology 1957 2 1 1957 2 1 0 1 1957 2 1 0 0 ppublish 13396178 PMC509507 Br J Ophthalmol. 1957 Feb;41(2):93-102

Full Text available with Trip Pro

1957 The British journal of ophthalmology

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>