How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

2,265 results for

Sclera

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

61. Effect of irradiation time on riboflavin-ultraviolet-A collagen crosslinking in rabbit sclera. (PubMed)

Effect of irradiation time on riboflavin-ultraviolet-A collagen crosslinking in rabbit sclera. To determine the effect of the duration of irradiation on the biomechanical parameters of combined riboflavin-ultraviolet-A (UVA) collagen crosslinking (CXL) in rabbit sclera.Department of Ophthalmology, Provincial Hospital affiliated with Shandong University, Shandong, China.Experimental study.Thirty-six New Zealand rabbits were divided into 6 groups based on the duration of irradiation (10, 20, 30 (...) lead to a noticeable increase in the biomechanical stiffness of the sclera. The physiological modulus is the most sensitive tool to measure stiffness. In this study, the optimum duration of irradiation was 40 minutes.Copyright © 2013 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.

2013 Journal of cataract and refractive surgery

62. Diffusion of macromolecules through sclera. (PubMed)

Diffusion of macromolecules through sclera. To quantify the in vitro permeability coefficient over different topographical locations of porcine sclera to macromolecules with different molecular weight.Fresh equatorial and posterior superotemporal porcine sclera was mounted in a two-chamber diffusion apparatus, and its permeability to fluorescein isothiocyanate (FITC)-conjugated dextrans ranging in molecular weight from 40 kDa to 150 kDa was determined by fluorescence spectrophotometry (...) . The sclera was processed as frozen sections and viewed with a fluorescence microscope. The thickness of the area and the thickness that macromolecules enriched in the surface of sclera were measured.The permeability coefficient (Pc) of porcine sclera to macromolecules was significantly higher (40 kDa, p = 0.028; 70 kDa, p = 0.033; 150 kDa, p = 0.007) in equatorial region than posterior, which could be attributed to the significant difference of thickness (p < 0.001, Kruskal-Wallis) between them. Moreover

Full Text available with Trip Pro

2013 Acta ophthalmologica

63. Collagen crosslinking of porcine sclera using genipin. (PubMed)

Collagen crosslinking of porcine sclera using genipin. To evaluate the effect of collagen cross-linking induced by genipin in porcine sclera.Porcine cadaver eyes were treated with genipin at concentrations (by w/v) of 0.01%, 0.03%, 0.1%, 0.3%, 1.0% for 15 and 30 min. Riboflavin/ultraviolet A(UVA)-treated and untreated samples were used as controls. After treatment, scleral strips of 4.0 × 10.0 mm were cut. Twenty-four hours later, the stress-strain parameters of the strips were measured using (...) difference between the untreated group and the genipin 30-min groups (all p < 0.05). Of 0.3% genipin for 15 min or 0.01% genipin for 30 min had a similar stress-strain curve with those of eyes treated with the riboflavin/UVA group. The sclera exhibited a bluish colour which became deeper with increase concentration and cross-linking time.Collagen cross-linking induced by genipin could increase the biomechanical strength in porcine sclera. The effect depends on the concentration and treatment time

Full Text available with Trip Pro

2013 Acta ophthalmologica

64. Correlation between biomechanical responses of posterior sclera and IOP elevations during micro-volumetric change in the eye. (PubMed)

Correlation between biomechanical responses of posterior sclera and IOP elevations during micro-volumetric change in the eye. This study tested the hypothesis that intraocular pressure (IOP) elevations, induced by controlled increase of intraocular volume, are correlated with the biomechanical responses of the posterior sclera.Porcine globes were tested within 48 hours postmortem. The first group of globes (n = 11) was infused with 15 μL of phosphate-buffered saline at three different rates (...) to investigate rate-dependent IOP elevations. The second group (n = 16) was first infused at the fast rate and then underwent inflation tests to investigate the relationship between IOP elevations (ΔIOP) and scleral strains. The strains in the superotemporal region of the posterior sclera were measured by ultrasound speckle tracking. Linear regression was used to examine the association between ΔIOP due to micro-volumetric infusion and the scleral strains at a specific inflation pressure.The average ΔIOP

Full Text available with Trip Pro

2013 Investigative Ophthalmology & Visual Science

65. Gene expression signatures in tree shrew sclera in response to three myopiagenic conditions. (PubMed)

Gene expression signatures in tree shrew sclera in response to three myopiagenic conditions. We compared gene expression signatures in tree shrew sclera produced by three different visual conditions that all produce ocular elongation and myopia: minus-lens wear, form deprivation, and dark treatment.Six groups of tree shrews (n = 7 per group) were used. Starting 24 days after normal eye-opening (days of visual experience [DVE]), two minus-lens groups wore a monocular -5 diopter (D) lens for 2 (...) days (ML-2) or 4 days (ML-4); two form-deprivation groups wore a monocular translucent diffuser for 2 days (FD-2) or 4 days (FD-4). A dark-treatment (DK) group was placed in continuous darkness for 11 days after experiencing a light/dark environment until 17 DVE. A normal colony-reared group was examined at 28 DVE. Quantitative PCR was used to measure the relative differences in mRNA levels for 55 candidate genes in the sclera that were selected, either because they showed differential expression

Full Text available with Trip Pro

2013 Investigative Ophthalmology & Visual Science

66. Feeling blue? Minocycline-induced staining of the teeth, oral mucosa, sclerae and ears - a case report. (PubMed)

Feeling blue? Minocycline-induced staining of the teeth, oral mucosa, sclerae and ears - a case report. Minocycline is a broad-spectrum antibiotic belonging to the tetracycline family, often prescribed in infective skin conditions such as acne and rosacea. Minocycline-induced staining of the sclerae, ears, oral mucosa and teeth are rare but troublesome conditions. If patients already have concerns about their appearance due to an unsightly skin condition, careful consideration ought to be given

Full Text available with Trip Pro

2013 British Dental Journal

67. ACCOMMODATIVE MOVEMENTS OF THE VITREOUS MEMBRANE, CHOROID, AND SCLERA IN YOUNG AND PRESBYOPIC HUMAN AND NONHUMAN PRIMATE EYES. (PubMed)

ACCOMMODATIVE MOVEMENTS OF THE VITREOUS MEMBRANE, CHOROID, AND SCLERA IN YOUNG AND PRESBYOPIC HUMAN AND NONHUMAN PRIMATE EYES. We report, for the first time to our knowledge, dynamic movements of the vitreous membrane and peripheral choroid during accommodation, and age-related changes in the anterior sclera.We studied 11 rhesus monkeys (ages 6-27 years) and 12 human subjects (ages 19-65 years). Accommodation was induced pharmacologically in human subjects and by central electrical stimulation (...) anterior hyaloid bends posteriorly during accommodation in proportion to accommodative amplitude and the sclera bows inward with increasing age in both species. Future descriptions of the accommodative mechanism, and approaches to presbyopia therapy, may need to incorporate these findings.

Full Text available with Trip Pro

2013 Investigative Ophthalmology & Visual Science

68. Biomechanical Properties and Correlation With Collagen Solubility Profile in the Posterior Sclera of Canine Eyes With an ADAMTS10 Mutation. (PubMed)

Biomechanical Properties and Correlation With Collagen Solubility Profile in the Posterior Sclera of Canine Eyes With an ADAMTS10 Mutation. We examined the biomechanical properties and correlation with the collagen solubility profile of the posterior sclera in a canine model of primary open-angle glaucoma caused by the G661R missense mutation in the ADAMTS10 gene.Scleral strips from ADAMTS10-mutant (affected) dogs and age-matched controls were collected. Viscoelastic properties (i.e., complex (...) = 0.88, P < 0.005).An inherently weaker and biochemically distinct posterior sclera was observed in dogs with the G661R missense mutation in ADAMTS10 before clinical indications of optic nerve damage. It remains to be shown whether and how the altered scleral biomechanics may affect the rate of glaucoma progression following intraocular pressure elevation.

Full Text available with Trip Pro

2013 Investigative Ophthalmology & Visual Science

69. Differences in the region and depth-dependent microstructural organization in normal versus glaucomatous human posterior sclerae. (PubMed)

Differences in the region and depth-dependent microstructural organization in normal versus glaucomatous human posterior sclerae. This study quantitatively investigated differences in the regional- and depth-dependent human posterior scleral microstructure in glaucomatous (G) and nonglaucomatous (NG) donors.Twenty-five posterior poles from six G and seven NG donors were analyzed using small angle light scattering (SALS) to investigate the organization of scleral fibers around the optic nerve (...) by an average of 0.14 from the episcleral surface to the intraocular surface. The percentage of equatorial fibers decreased universally through the depth from approximately 61% to 33%. Generally, the inferior and superior regions had a lower Ecc and PEF compared to the nasal and temporal regions.Region and depth of the posterior sclera are important factors that should be included when comparing scleral microstructure of G and NG tissue in experimental and computational work. The dramatic changes

Full Text available with Trip Pro

2013 Investigative Ophthalmology & Visual Science

70. Whole Globe Inflation Testing of Exogenously Crosslinked Sclera Using Genipin and Methylglyoxal (PubMed)

Whole Globe Inflation Testing of Exogenously Crosslinked Sclera Using Genipin and Methylglyoxal Exogenous collagen cross-linking has been investigated as method of reinforcing scleral biomechanics, with the goal of counteracting scleral weakening that occurs at the onset of myopia. This study uses whole globe inflation testing to investigate the biomechanical effect of treating posterior sclera with the collagen cross-linking agents methylglyoxal and genipin. Pairs of porcine eyes were treated (...) in four ways. Three groups involved 1% methylglyoxal: two-hour (Group I) or thirty-minute (Group II) incubation of the whole globe, and thirty-minute incubation of only the posterior sclera of the intact eye (Group III). Group IV consisted of a thirty-minute incubation of the posterior sclera in 1% genipin. Following treatment, each eye was subjected to inflation testing under physiological pressure levels (0-150 mmHg); four strain markers on the posterior pole were tracked, providing displacement

Full Text available with Trip Pro

2012 Experimental eye research

71. Surgical repair of bilateral full thickness macular holes in a patient with blue sclera secondary to osteogenesis imperfecta (PubMed)

Surgical repair of bilateral full thickness macular holes in a patient with blue sclera secondary to osteogenesis imperfecta 22498800 2012 09 28 2018 11 13 1476-5454 26 7 2012 Jul Eye (London, England) Eye (Lond) Surgical repair of bilateral full thickness macular holes in a patient with blue sclera secondary to osteogenesis imperfecta. 1023-4 10.1038/eye.2012.63 Benzimra J D JD Kapoor B B Edmeades N N Burger A A Simcock P R PR eng Case Reports Letter 2012 04 13 England Eye (Lond) 8703986 0950 (...) -222X IM Aged Female Humans Osteogenesis Imperfecta complications Retinal Perforations surgery Sclera pathology Suture Techniques Treatment Outcome Vitrectomy methods 2012 4 14 6 0 2012 4 14 6 0 2012 9 29 6 0 ppublish 22498800 eye201263 10.1038/eye.2012.63 PMC3396165 Ophthalmology. 2004 Jul;111(7):1428-31 15234150 Arch Ophthalmol. 2003 Jul;121(7):1062-4 12860823 Trans Ophthalmol Soc U K. 1985;104 ( Pt 2):191-5 3857778 J Pediatr Ophthalmol Strabismus. 1994 Jul-Aug;31(4):268-9 7807308 Retin Cases

Full Text available with Trip Pro

2012 Eye

72. Distribution of bone morphogenetic protein receptors in human scleral fibroblasts cultured in vitro and human sclera (PubMed)

Distribution of bone morphogenetic protein receptors in human scleral fibroblasts cultured in vitro and human sclera To investigate the distribution of bone morphogenetic protein receptors (BMPRs) in human scleral fibroblsasts (HSFs) and in human sclera.Primary HSFs were cultured in vitro. The mRNA levels of BMP-2 and BMPRs in HSFs were assayed by reverse transcription-polymerase chain reaction (RT-PCR). The protein distributions of BMP-2 and BMPRs in HSFs were further detected (...) by immunocytofluorescence and western blot. Their protein expression was also detected in frozen human posterior scleral sections by immunohistofluorescence.BMP-2 and BMPRs were expressed in both HSFs and human sclera not only at mRNA level but also at protein level. The expressions of BMPRIA and BMPRII were higher than that of BMPRIB in the cytoplasm and cell membrane of HSFs in vitro. Western blot further verified the results of immunocytofluorescence. In human sclera, BMP2, BMPR IB and BMPR II were found

Full Text available with Trip Pro

2012 International journal of ophthalmology

73. Sustained release micellar carrier systems for iontophoretic transport of dexamethasone across human sclera (PubMed)

Sustained release micellar carrier systems for iontophoretic transport of dexamethasone across human sclera A challenge in ocular drug delivery is to maintain the therapeutic concentration of a drug at the site of action in the eye. The objective of the present study was to investigate the feasibility of micellar carrier systems for sustained drug delivery in transscleral iontophoresis in vitro. Simple and mixed micelles prepared using sodium taurocholate (TA) alone or with egg lecithin (LE (...) ) were the carrier systems studied. Dexamethasone (DEX), a poorly water soluble corticosteroid, was the model drug. The micellar carrier systems were first characterized for their solubilization and encapsulation of the drug. Passive and 2-mA iontophoretic (both cathodal and anodal) transport experiments were conducted using these micellar carrier systems in side-by-side diffusion cells with excised human sclera in vitro. Drug release studies were performed after the transport experiments. Saturated

Full Text available with Trip Pro

2012 Journal of Controlled Release

74. Standard Enucleation with Aluminium Oxide Implant (Bioceramic) Covered with Patient's Sclera (PubMed)

Standard Enucleation with Aluminium Oxide Implant (Bioceramic) Covered with Patient's Sclera We describe in our study a modified standard enucleation, using sclera harvested from the enucleated eye to cover the prosthesis in order to insert a large porous implant and to reduce postoperative complication rates in a phthisis globe.We perform initially a standard enucleation. The porous implant (Bioceramic) is then covered only partially by the patient's sclera. The implant is inserted

Full Text available with Trip Pro

2012 The Scientific World Journal

75. Sclera

Sclera Sclera Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Sclera Sclera Aka: Sclera , Scleral Icterus , Yellow Sclera , Episclera (...) II. Physiology Sclera Thick, protective outer coat of the eye underlying the Poorly vascularized Normally white (with possible bluish discoloration) and opaque Scleral inflammation is very painful, and associated with Episclera Covers the anterior Sclera and lacks the Scleral bluish discoloration Continuous with the Episcleral inflammation is not typically painful, and does not cause vision change III. Findings: Normal Normally white and opaque IV. Causes: Scleral Inflammation V. Causes: Scleral

2015 FP Notebook

76. Mapping the differential distribution of proteoglycan core proteins in the adult human retina, choroid and sclera. (PubMed)

Mapping the differential distribution of proteoglycan core proteins in the adult human retina, choroid and sclera. To examine the presence and distribution of proteoglycan (PG) core proteins in the adult human retina, choroid, and sclera.Postmortem human eye tissue was dissected into Bruch's membrane/choroid complex, isolated Bruch's membrane, or neurosensory retina. PGs were extracted and partially purified by anion exchange chromatography. Trypsinized peptides were analyzed by tandem mass (...) the retina, choroid, and sclera. The cartilage link protein HAPLN1 was abundant in the interphotoreceptor matrix and sclera, while HAPLN4 (brain link protein 2) was found throughout the retina and choroid. The small leucine-rich repeat PG (SLRP) family members biglycan, decorin, fibromodulin, lumican, mimecan, opticin, and prolargin were present, with different patterns of distribution in the retina, choroid, and sclera.A combination of proteomics and immunohistochemistry approaches has provided

Full Text available with Trip Pro

2012 Investigative Ophthalmology & Visual Science

77. Association between Shape of Sclera and Myopic Retinochoroidal Lesions in Patients with Pathologic Myopia. (PubMed)

Association between Shape of Sclera and Myopic Retinochoroidal Lesions in Patients with Pathologic Myopia. The purpose of the study was to analyze the shape of the sclera determined by swept-source optical coherence tomography (OCT) and to determine the relationship between the shape and the myopic retinochoroidal lesions.We studied 488 eyes of 272 patients with high myopia (refractive error ≥-8.00 diopters [D] or axial length >26.5 mm) and 43 emmetropic eyes of 43 controls (refractive error (...) ≤±3 D). An image of the sclera was obtained by a swept-source OCT prototype instrument that uses a wavelength sweeping laser centered on 1 μm wavelength with an A-scan repetition rate of 100,000 Hz. The scans were 12 mm radial scans centered on the fovea. Seventy eyes were also examined by three-dimensional magnetic resonance imaging (3D MRI) to obtain the contour of the outer surface of the eyes. The main outcome measures, visibility of the entire sclera layer, scleral thickness, scleral contour

Full Text available with Trip Pro

2012 Investigative Ophthalmology & Visual Science

78. Evaluation of lamina cribrosa and peripapillary sclera stiffness in pseudoexfoliation and normal eyes by atomic force microscopy. (PubMed)

Evaluation of lamina cribrosa and peripapillary sclera stiffness in pseudoexfoliation and normal eyes by atomic force microscopy. Pseudoexfoliation (PEX) syndrome is a systemic disorder of the elastic fiber system that can lead to PEX glaucoma. Elastotic alterations in the lamina cribrosa (LC) of PEX eyes suggested biomechanical implications predisposing to pressure-induced optic nerve damage. In this pilot study, the stiffness of LC and peripapillary sclera (ppSC) in eyes with and without PEX

Full Text available with Trip Pro

2012 Investigative Ophthalmology & Visual Science

79. Quantitative Mapping of Collagen Fiber Orientation in Non-Glaucoma and Glaucoma Posterior Human Scleras. (PubMed)

Quantitative Mapping of Collagen Fiber Orientation in Non-Glaucoma and Glaucoma Posterior Human Scleras. The posterior sclera has a major biomechanical influence on the optic nerve head, and may therefore be important in glaucoma. Scleral material properties are influenced significantly by collagen fiber architecture. Here we quantitatively map fiber orientation in non-glaucoma and glaucoma posterior human sclerae.Wide-angle x-ray scattering quantified fiber orientation at 0.5-mm intervals (...) across seven non-glaucoma post-mortem human sclerae, and five sclerae with glaucoma history and confirmed axon loss. Multiphoton microscopy provided semiquantitative depth-profiling in the peripapillary sclera.Midposterior fiber orientation was either uniaxial (one preferred direction) or biaxial (two directions). The peripapillary sclera was characterized by a ring of fibers located mainly in the mid-/outer stromal depth and encompassing ∼50% of the total tissue thickness. Fiber anisotropy was 37

Full Text available with Trip Pro

2012 Investigative Ophthalmology & Visual Science

80. Observations of vascular structures within and posterior to sclera in eyes with pathologic myopia by swept-source optical coherence tomography. (PubMed)

Observations of vascular structures within and posterior to sclera in eyes with pathologic myopia by swept-source optical coherence tomography. We examined the intrascleral and retrobulbar blood vessels in highly myopic eyes by swept-source optical coherence tomography (swept-source OCT).We included in the study 662 of 357 patients with pathologic myopia (spherical equivalent of myopic refractive error ≥ 8.00 diopters or axial length > 26.5 mm). A swept-source OCT system that uses a wavelength (...) sweeping laser with A-scan repetition rate of 100,000 Hz and 1 μm wavelength was used. Radial scans along 12 meridians of 12 mm scan length centered on the fovea were made. Indocyanine green angiography (ICGA) also was performed to identify the intrascleral and retrobulbar vessels that were observed by swept-source OCT.Intrascleral and retrobulbar blood vessels were observed in the macular area of the highly myopic eyes. Linear hyporeflective structures running in the sclera were observed in 474

Full Text available with Trip Pro

2012 Investigative Ophthalmology & Visual Science

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>