How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

2,288 results for

Sclera

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

41. Estimation of axial curvature of anterior sclera: correlation between axial length and anterior scleral curvature as affected by angle kappa. (PubMed)

Estimation of axial curvature of anterior sclera: correlation between axial length and anterior scleral curvature as affected by angle kappa. BACKGROUND: Though the development and fitting of scleral contact lenses are expanding steadily, there is no simple method to provide scleral metrics for scleral contact lens fitting yet. The aim of this study was to establish formulae for estimation of the axial radius of curvature (ARC) of the anterior sclera using ocular biometric parameters that can (...) the axis line, with good determinant power (72 - 80 %; SPSS ver. 22.0). Angle kappa showed strong correlation with axial length (Pearson's r = -0.813, P <0.001), and the different correlation patterns of nasal and temporal ARC with axial length can be explained by the ocular surface deviation represented by angle kappa.Axial length, ACD, and WTW are useful parameters for estimating the ARC of the anterior sclera, which is important for the haptic design of scleral contact lenses. Angle kappa affects

Full Text available with Trip Pro

2016 BMC Ophthalmology

42. Characterization of Antigen-Presenting Macrophages and Dendritic Cells in the Healthy Human Sclera. (PubMed)

Characterization of Antigen-Presenting Macrophages and Dendritic Cells in the Healthy Human Sclera. The sclera is mainly made of collagen and fibroblasts. The aim of this study was to analyze whether immune cells are present in the healthy human sclera.Ten human anterior episcleral or stromal tissue samples from globe donors were immunohistochemically examined using confocal microscopy. The expression of the macrophage markers CD68, CD163 and CD11b, CD45 (a general leukocyte marker), MHCII (...) immunoreactive for CD68, CD45, MHCII, CCR7, LYVE1, and CD11b. Lower numbers (<20 cells/mm2) were positive for CXCL12, CCR2, and GFAP. The episclera showed a significantly higher number of cells compared to the stroma (P = 0.008). MHCII+ cells could be double positive for CCR7, CD45, CD11c, or CD11b and seldom CXCL12. Macrophages were most likely from the M1 type (CD68+, CD163-).The healthy human sclera contains several macrophage populations, which can function as APCs, with the highest density being present

Full Text available with Trip Pro

2016 Investigative Ophthalmology & Visual Science

43. The efficacy and safety of posterior scleral reinforcement using genipin cross-linked sclera for macular detachment and retinoschisis in highly myopic eyes. (PubMed)

The efficacy and safety of posterior scleral reinforcement using genipin cross-linked sclera for macular detachment and retinoschisis in highly myopic eyes. To evaluate the efficacy and safety of posterior scleral reinforcement (PSR) using genipin cross-linked sclera as the material to treat macular detachment and retinoschisis, both without macular hole, in highly myopic eyes.Twenty-one patients with highly myopic eyes (24 eyes) with macular detachment and retinoschisis were treated (...) ±2.08 mm) after the operation. The retina in 21 eyes (87.5%) was successful reattached and the macular detachment was significantly decreased in two eyes; a macular hole occurred in one eye.For at least a 1 year period of follow-up, PSR with genipin cross-linked sclera was safe and effective to treat macular detachment and retinoschisis in high myopia when a macular hole was not present. The reinforcement effect tended to be stabilised and maintained for 6 months after treatment.Published by the BMJ

2016 British Journal of Ophthalmology

44. Donor sclera-wrapped acrylic orbital implants following enucleation: experience in 179 patients in the Netherlands. (PubMed)

Donor sclera-wrapped acrylic orbital implants following enucleation: experience in 179 patients in the Netherlands. To report the postoperative results after enucleation of using an acrylic orbital implant covered in donor sclera for implantation.We retrospectively analysed the charts of patients who were enucleated between 2007 and 2011. Only patients who received an acrylic implant covered with donor sclera were included.A total of 179 patients were included in our analysis. About 15.6 (...) % experienced postoperative problems of which the majority were related to the position of the eyelid. Only one patient (0.6%) had an exposure of the orbital implant.Placing an acrylic orbital implant covered with donor sclera is a safe and effective method for reconstruction after enucleation.© 2016 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.

Full Text available with Trip Pro

2016 Acta ophthalmologica

45. Three-Dimensional Strains in Human Posterior Sclera Using Ultrasound Speckle Tracking (PubMed)

Three-Dimensional Strains in Human Posterior Sclera Using Ultrasound Speckle Tracking Intraocular pressure (IOP) induced strains in the peripapillary sclera may play a role in glaucoma progression. Using inflation testing and ultrasound speckle tracking, the 3D strains in the peripapillary sclera were measured in nine human donor globes. Our results showed that the peripapillary sclera experienced through-thickness compression and meridional stretch during inflation, while minimal (...) circumferential dilation was observed when IOP was increased from 10 to 19 mmHg. The maximum shear was primarily oriented in the through-thickness, meridional cross sections and had a magnitude slightly larger than the first principal strain. The tissue volume had minimal overall change, confirming near-incompressibility of the sclera. Substantial strain heterogeneity was present in the peripapillary region, with local high strain areas likely corresponding to structural heterogeneity caused by traversing

Full Text available with Trip Pro

2016 Journal of biomechanical engineering

46. Sclera

Sclera Sclera Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Sclera Sclera Aka: Sclera , Scleral Icterus , Yellow Sclera , Episclera (...) II. Physiology Sclera Thick, protective outer coat of the eye underlying the Poorly vascularized Normally white (with possible bluish discoloration) and opaque Scleral inflammation is very painful, and associated with Episclera Covers the anterior Sclera and lacks the Scleral bluish discoloration Continuous with the Episcleral inflammation is not typically painful, and does not cause vision change III. Findings: Normal Normally white and opaque IV. Causes: Scleral Inflammation V. Causes: Scleral

2018 FP Notebook

47. Congenital keratoglobus with blue sclera in two siblings with overlapping Marshall/Stickler phenotype (PubMed)

Congenital keratoglobus with blue sclera in two siblings with overlapping Marshall/Stickler phenotype We aimed to describe congenital keratoglobus with blue sclera in two siblings with overlapping Marshall/Stickler phenotype. Two sisters (ages four and six) with bilateral high astigmatism were evaluated by slit-lamp microscopy. Corneal topography and pachymetry maps were also obtained. Slit-lamp examination revealed that both corneas were globular in shape with peripheral corneal thinning (...) . Pachymetry maps showed diffuse corneal thinning. Two siblings had in common the features of keratoglobus, blue sclera, atypical face, hearing loss, and hypermobile joints. We tentatively diagnosed the sisters as having an overlapping Marshall-Stickler phenotype based on clinical and radiological findings. Marshall-Stickler syndrome may exist in the differential diagnosis of keratoglobus with blue sclera.

Full Text available with Trip Pro

2016 Indian journal of ophthalmology

48. Biomechanics of the sclera and effects on intraocular pressure (PubMed)

Biomechanics of the sclera and effects on intraocular pressure Accumulating evidence indicates that glaucoma is a multifactorial neurodegenerative disease characterized by the loss of retinal ganglion cells (RGC), resulting in gradual and progressive permanent loss of vision. Reducing intraocular pressure (IOP) remains the only proven method for preventing and delaying the progression of glaucomatous visual impairment. However, the specific role of IOP in optic nerve injury remains (...) controversial, and little is known about the biomechanical mechanism by which elevated IOP leads to the loss of RGC. Published studies suggest that the biomechanical properties of the sclera and scleral lamina cribrosa determine the biomechanical changes of optic nerve head, and play an important role in the pathologic process of loss of RGC and optic nerve damage. This review focuses on the current understanding of biomechanics of sclera in glaucoma and provides an overview of the possible interactions

Full Text available with Trip Pro

2016 International journal of ophthalmology

49. The contribution of glycosaminoglycans to the mechanical behaviour of the posterior human sclera (PubMed)

The contribution of glycosaminoglycans to the mechanical behaviour of the posterior human sclera We characterized the structural and mechanical changes after experimental digestion of sulfated glycosaminoglycans (s-GAGs) in the human posterior sclera, using ultrasound thickness measurements and an inflation test with three-dimensional digital image correlation (3D-DIC). Each scleral specimen was first incubated in a buffer solution to return to full hydration, inflation tested, treated (...) behaviour of the posterior human sclera.© 2016 The Author(s).

Full Text available with Trip Pro

2016 Journal of the Royal Society Interface

50. Simultaneous treatment of pterygium complicated with conjunctivochalasis: analysis of pterygium excision and conjunctival autotransplantation combined with sclera fixation. (PubMed)

Simultaneous treatment of pterygium complicated with conjunctivochalasis: analysis of pterygium excision and conjunctival autotransplantation combined with sclera fixation. This prospective study investigated the safety and efficacy of a therapeutic method of treating pterygium complicated with conjunctivochalasis, using pterygium excision and conjunctival autotransplantation combined with sclera fixation, followed by therapeutic contact lens application.Fifty-seven patients (83 eyes) diagnosed (...) as pterygium complicated with conjunctivochalasis, at our hospital from July 2011 to June 2012, were selected. Patients were treated with pterygium excision and conjunctival autotransplantation combined with sclera fixation surgery, then therapeutic bandage contact lenses were applied. The efficacy of simultaneous surgery was evaluated based on vision changes, tear dynamics, and other complications. Histopathological changes were investigated on removed bulbar conjunctival tissue, using hematoxylin eosin

Full Text available with Trip Pro

2015 BMC Ophthalmology

51. Bare sclera resection followed by mitomycin C and/or autograft limbus conjunctiva in the surgery for pterygium: a Meta-analysis. (PubMed)

Bare sclera resection followed by mitomycin C and/or autograft limbus conjunctiva in the surgery for pterygium: a Meta-analysis. To evaluate the recurrence and complications after bare sclera resection (BSR) combined with mitomycin C (MMC) treatment and/or autograft limbus conjunctiva (ALC) in the surgery for pterygium.Meta-analysis was used to evaluate the differences in patient outcomes between BSR of pterygium with or without MMC and/or ALC. All included studies were randomized trials

Full Text available with Trip Pro

2015 International journal of ophthalmology

52. A Review of Collagen Cross-Linking in Cornea and Sclera (PubMed)

A Review of Collagen Cross-Linking in Cornea and Sclera Riboflavin/UVA cross-linking is a technique introduced in the past decades for the treatment of keratoconus, keratectasia, and infectious keratitis. Its efficacy and safety have been investigated with clinical and laboratory studies since its first clinical application by Wollensak for the treatment of keratoconus. Although its complications are encountered during clinical practice, such as infection inducing risk, minimal invasion merits (...) a further investigation on its future application in clinical practice. Recently, collagen cross-linking in sclera shows a promising prospect. In present study, we summarized the representative studies describing the clinical and laboratory application of collagen cross-linking published in past decades and provided our opinion on the positive and negative results of cross-linking in the treatment of ophthalmic disorders.

Full Text available with Trip Pro

2015 Journal of ophthalmology

53. In vivo volumetric depth-resolved vasculature imaging of human limbus and sclera with 1μm swept source phase-variance optical coherence angiography (PubMed)

In vivo volumetric depth-resolved vasculature imaging of human limbus and sclera with 1μm swept source phase-variance optical coherence angiography We present nnnnnin vivo volumetric depth-resolved vasculature images of the anterior segment of the human eye acquired with phase-variance based motion contrast using a high-speed (100 kHz, 105 A-scans/s) swept source optical coherence tomography system (SSOCT). High phase stability SSOCT imaging was achieved by using a computationally efficient (...) phase stabilization approach. The human corneo-scleral junction and sclera were imaged with swept source phase-variance optical coherence angiography and compared with slit lamp images from the same eyes of normal subjects. Different features of the rich vascular system in the conjunctiva and episclera were visualized and described. This system can be used as a potential tool for ophthalmological research to determine changes in the outflow system, which may be helpful for identification

Full Text available with Trip Pro

2015 Journal of optics (2010)

54. Glaucoma-related Changes in the Mechanical Properties and Collagen Micro-architecture of the Human Sclera (PubMed)

Glaucoma-related Changes in the Mechanical Properties and Collagen Micro-architecture of the Human Sclera The biomechanical behavior of the sclera determines the level of mechanical insult from intraocular pressure to the axons and tissues of the optic nerve head, as is of interest in glaucoma. In this study, we measure the collagen fiber structure and the strain response, and estimate the material properties of glaucomatous and normal human donor scleras.Twenty-two posterior scleras from (...) normal and diagnosed glaucoma donors were obtained from an eyebank. Optic nerve cross-sections were graded to determine the presence of axon loss. The specimens were subjected to pressure-controlled inflation testing. Full-field displacement maps were measured by digital image correlation (DIC) and spatially differentiated to compute surface strains. Maps of the collagen fiber structure across the posterior sclera of each inflated specimen were obtained using synchrotron wide-angle X-ray scattering

Full Text available with Trip Pro

2015 PloS one

55. Heterologous, Fresh, Human Donor Sclera as Patch Graft Material in Glaucoma Drainage Device Surgery. (PubMed)

Heterologous, Fresh, Human Donor Sclera as Patch Graft Material in Glaucoma Drainage Device Surgery. To determine the safety and efficacy of fresh, human sclera allografts as a patch graft material in glaucoma drainage device (GDD) surgery.Retrospective, noncomparative, interventional, consecutive case series.All GDD cases operated between 2008 and 2013 in which fresh human corneoscleral rims were used immediately after the central corneal button was used for penetrating or endothelial (...) , respectively, using Tube Versus Trabeculectomy study criteria.Heterologous, fresh, human donor sclera appears to be a safe material for GDD tube coverage. It provides a cost-efficient alternative compared with traditional patch graft materials associated with a low risk of pathogen transmission.

2015 Journal of Glaucoma

56. Changing Material Properties of the Tree Shrew Sclera during Minus Lens Compensation and Recovery. (PubMed)

Changing Material Properties of the Tree Shrew Sclera during Minus Lens Compensation and Recovery. To estimate two collagen-specific material properties (crimp angle and elastic modulus of collagen fibrils) of the remodeling tree shrew sclera during monocular -5 diopter (D) lens wear and recovery.Tensile tests were performed on scleral strips obtained from juvenile tree shrews exposed to three different visual conditions: normal, monocular -5 D lens wear to induce myopia, and recovery. Collagen (...) fibrils are crimped in the unloaded sclera and uncrimp as the tissue stiffens under load. Inverse numerical analyses were performed to estimate the (unloaded) crimp angle and elastic modulus of collagen fibrils using a microstructure-based constitutive model.Compared with the control eye, the crimp angle was significantly higher in the treated eye after 2 days and remained significantly higher until 21 days of lens wear (P < 0.05). The difference between the crimp angle of the treated and control eye

Full Text available with Trip Pro

2015 Investigative Ophthalmology & Visual Science

57. [The clinical comparison of conjunctival resection with conjunctival resection and sclera fixation in the treatment of conjunctivochalasis]. (PubMed)

[The clinical comparison of conjunctival resection with conjunctival resection and sclera fixation in the treatment of conjunctivochalasis]. To evaluate the efficacy of two surgical treatments for conjunctivochalasis.Prospective randomized control study. Thirty-three conjunctivochalasis patients (33 eyes) were randomly divided into two groups:simple resection group, and resection and fixation group. The former received simple conjunctival resection, and the latter received conjunctival (...) the two groups on month 6 postoperatively (t = 0.647, P = 0.537).Both conjunctival resection and conjunctival resection with sclera fixation can effectively improve symptoms, but the latter has a lower recurrence rate.

2014 [Zhonghua yan ke za zhi] Chinese journal of ophthalmology

58. Characterisation of the gelatinase system of the laminar human optic nerve and surrounding annulus of Bruch's membrane, choroid, and sclera. (PubMed)

Characterisation of the gelatinase system of the laminar human optic nerve and surrounding annulus of Bruch's membrane, choroid, and sclera. We determined the presence and levels of gelatinase matrix metalloproteinases (MMPs) in the optic nerve and surrounding rim region of the human fundus.Samples of optic nerve, rim region, and Bruch's membrane-choroid from macular and peripheral regions were isolated from 9 pairs of human donor eyes. The MMPs were extracted and separated by gelatin

Full Text available with Trip Pro

2014 Investigative Ophthalmology & Visual Science

59. Enrichment Of Lymphatic Vessel Endothelial Hyaluronan Receptor 1(LYVE-1)-Positive Macrophages Around Blood Vessels In The NormalHuman Sclera. (PubMed)

Enrichment Of Lymphatic Vessel Endothelial Hyaluronan Receptor 1(LYVE-1)-Positive Macrophages Around Blood Vessels In The NormalHuman Sclera. To investigate whether the normal adult human sclera contains lymphatic vessels and to study their relation to immune cells and blood vessel anatomy.Scleral tissue probes from 35 adult human donor bulbi were analyzed by immunohistochemistry and confocal microscopy for blood vessels (CD31+), lymphatic vessels (lymphatic vessel endothelial hyaluronan (...) receptor 1 [LYVE1]+, podoplanin+), and macrophages (CD68+) at 12 locations (anterior, equatorial, and posterior at 3, 6, 9, and 12 o'clock positions of the eye) in all three scleral layers (episclera, stroma, and lamina fusca). Approval for scientific examination was obtained.CD31+ blood vessels were detectable in the human sclera, where the percentage area covered by CD31+ blood vessels was highest in the anterior episclera, followed by equatorial and posterior episclera, and was lowest in the scleral

Full Text available with Trip Pro

2014 Investigative Ophthalmology & Visual Science

60. Dome-Shaped Macular Configuration: Longitudinal Changes in the Sclera and Choroid by Swept-Source Optical Coherence Tomography Over Two Years. (PubMed)

Dome-Shaped Macular Configuration: Longitudinal Changes in the Sclera and Choroid by Swept-Source Optical Coherence Tomography Over Two Years. To study longitudinal changes in the posterior pole in eyes with dome-shaped macular configuration within the staphyloma.Prospective, longitudinal study.We prospectively examined the macular area in 35 eyes (26 patients) with dome-shaped macular configuration and high myopia (mean spherical equivalent, -14.83 ± 4.50 diopters) using swept-source optical

2014 American Journal of Ophthalmology

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>