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Salivary Gland Enlargement

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1. Salivary Gland Enlargement

Salivary Gland Enlargement Salivary Gland Enlargement Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Salivary Gland Enlargement (...) Salivary Gland Enlargement Aka: Salivary Gland Enlargement , Salivary Hypertrophy , Sialadenosis II. Causes Unilateral ry enlargement l Bilateral ry enlargement with hypofunction ( or ) Chronic granulomatous disease Sialadenosis (asymptomatic parotid enlargement) ( , ) Endocrine Disorder Gonadal hypofunction III. References Daniels in Goldman (2000) Cecil Medicine, p. 2245 Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Salivary

2018 FP Notebook

2. Salivary Gland Cancer Treatment (Adult) (PDQ®): Health Professional Version

.[ ] In these data, acinic cell carcinoma comprised 17% of primary malignant salivary gland tumors or about 6% of all salivary gland neoplasms; more than 80% occur in the parotid gland; women were affected more than men; and the mean age was 44 years. Other studies have reported a relative frequency of acinic cell carcinoma from 0% to 19% of malignant salivary gland neoplasms.[ ] Clinically, patients typically present with a slowly enlarging mass in the parotid region. Pain is a symptom in more than 33 (...) accounted for 16.3% of all malignant tumors that occurred in the major salivary glands; disease in the parotid gland accounted for about 80% of all cases.[ ] Patients with benign lymphoepithelial lesion (e.g., Mikulicz disease), which is a manifestation of the autoimmune disease, Sjögren syndrome, are at an increased risk for development of non-Hodgkin lymphoma.[ - ] Benign lymphoepithelial lesion is clinically characterized by diffuse and bilateral enlargement of the salivary and lacrimal glands

2018 PDQ - NCI's Comprehensive Cancer Database

3. Juvenile Sjögren's syndrome: clinical characteristics with focus on salivary gland ultrasonography. (PubMed)

(SGUS+) were observed in 41/67 (61%) patients; 26/41 (63%) SGUS+ fulfilled pSS criteria. Salivary gland enlargements/parotitis was noted in 37/58 patients and non-significantly associated with SGUS+ (p=0.066). Mean levels of saliva was 5.6 ml/15 minutes in SGUS- patients compared to 3.3 ml/15 minutes in the SGUS+ patients (p=0.049). 36/41 (88%) SGUS+ patients were anti-Ro/La+ compared to 14/26 (54%) SGUS- patients (p=0.001). 24/39 (62%) SGUS+ patients were RF+, whereas only 5/25 (20%) SGUS- patients (...) Juvenile Sjögren's syndrome: clinical characteristics with focus on salivary gland ultrasonography. Juvenile Sjögren's syndrome (jSS) is a rare, poorly defined and possibly underdiagnosed condition affecting children/adolescents. The aim of this study was to characterize symptoms and clinical findings of jSS, and to explore the clinical application of major salivary gland ultrasonography (SGUS) in patients with jSS.A cross-sectional multicenter study recruited patients with disease onset until

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2019 Arthritis care & research

4. Rescue of autophagy and lysosome defects in salivary glands of MRL/lpr mice by a therapeutic phosphopeptide. (PubMed)

Rescue of autophagy and lysosome defects in salivary glands of MRL/lpr mice by a therapeutic phosphopeptide. Sjögren's syndrome is a multifactorial systemic autoimmune disorder characterized by lymphocytic infiltrates in exocrine organs. Patients present with sicca symptoms, such as extensive dry eyes and dry mouth, and parotid enlargement. Other serious complications include profound fatigue, chronic pain, major organ involvement, neuropathies and lymphomas. Current treatments only focus (...) on relieving symptoms and do not target the origin of the disease, which is largely unknown. The question we addressed here was whether some defects exist in autophagy processes in Sjögren's syndrome and if they can be corrected or minimized using an appropriate mechanism-driven treatment targeting this central survival pathway. Using a recognized murine model of secondary Sjögren's syndrome, we identified molecular alterations of autophagy occurring in the salivary glands of MRL/lpr mice, and discovered

2018 Journal of Autoimmunity

5. Tongue Atrophy in Sjögren Syndrome Patients with Mucosa-associated Lymphoid Tissue Lymphoma: Autoimmune Epithelitis beyond the Epithelial Cells of Salivary Glands? (PubMed)

, and megaloblastic anemia, 19 pSS patients with salivary MALT were matched 1:3 for age, sex, and disease duration with 57 pSS patients without MALT. The pSS-MALT patients had increased prevalence of salivary gland enlargement, lymphadenopathy, monoclonal gammopathy, rheumatoid factor positivity, higher focus and Tarpley scores in the minor salivary gland biopsy, and hyposalivation, compared to the pSS non-MALT patients. A significantly higher prevalence of tongue atrophy (68% vs 30%, p = 0.006) and fissured (...) Tongue Atrophy in Sjögren Syndrome Patients with Mucosa-associated Lymphoid Tissue Lymphoma: Autoimmune Epithelitis beyond the Epithelial Cells of Salivary Glands? Primary Sjögren syndrome (pSS), an autoimmune epithelitis, bears the risk of evolving to non-Hodgkin lymphoma and most frequently to the mucosa-associated lymphoid tissue (MALT) subtype. Based on the observation that pSS patients with MALT present a more atrophic and more intensely fissured tongue, we aimed to semiquantify severity

2018 Journal of Rheumatology

6. Bilateral subacute lacrimal gland enlargement mimicking dacryoadenitis in a 7-year-old boy: a rare adverse effect of valproic acid (sodium valproate). (PubMed)

Bilateral subacute lacrimal gland enlargement mimicking dacryoadenitis in a 7-year-old boy: a rare adverse effect of valproic acid (sodium valproate). A healthy 7-year-old boy presented with bilateral symmetrical lacrimal gland enlargement; a week later salivary gland enlargement was also noted. Clinical investigations suggested no diagnosis, and surgical biopsy was considered. Valproic acid (sodium valproate), which he was taking for absence seizures, has been reported to cause salivary gland (...) swelling in adults. Suspecting that a similar mechanism could be causal, the drug was discontinued. Complete resolution of the lacrimal and salivary gland enlargement rapidly ensued. This is the first report of lacrimal gland enlargement caused by valproic acid.Copyright © 2017 American Association for Pediatric Ophthalmology and Strabismus. Published by Elsevier Inc. All rights reserved.

2017 JAAPOS - Journal of the American Association for Pediatric Ophthalmology and Strabismus

7. MALT Lymphoma of Minor Salivary Glands in a Sjögren’s Syndrome Patient: a Case Report and Review of Literature (PubMed)

the major salivary glands. In this report, a rare case of MALT lymphoma of minor salivary glands in a patient with Sjögren's syndrome is described. A review of the published cases of MALT lymphoma located in the minor salivary glands of patients with Sjögren's syndrome is provided.In a 64-year-old female patient previously diagnosed with Sjögren's syndrome, an asymptomatic soft tissue mass at the palate was noticed, exhibiting rapid enlargement within one month. With a main differential diagnosis (...) MALT Lymphoma of Minor Salivary Glands in a Sjögren’s Syndrome Patient: a Case Report and Review of Literature Sjögren's syndrome is a chronic systemic disease, characterized by lymphocytic infiltration and destruction mainly of the salivary and lacrimal glands, resulting in xerostomia and xeropthalmia. Sjögren's syndrome patients have a 44-fold excess risk for the development of non-Hodgkin's lymphoma particularly mucosa-associated lymphoid tissue (MALT) lymphoma, prevalently affecting

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2017 Journal of oral & maxillofacial research

8. Mucinous Carcinoma with Neuroendocrine Differentiation of Salivary Gland Origin (PubMed)

Mucinous Carcinoma with Neuroendocrine Differentiation of Salivary Gland Origin Primary mucinous adenocarcinomas of the salivary gland are rare malignancies defined by aggregates of epithelial cells suspended in large pools of extracellular mucin. We report a case of a giant mucinous adenocarcinoma of salivary gland origin, with low-grade cytoarchitectural features and neuroendocrine differentiation arising in the submental region. Grossly, the tumor measured 12.5 × 13.4 × 8.2 cm and replaced (...) the bone and soft tissues of the anterior oral cavity. Microscopically, the neoplasm was composed of large extracellular pools of mucin, which contained papillary and acinar aggregates, and small nodules of ductal type epithelium with minimal nuclear enlargement, powdery chromatin and little pleomorphism. The nodules comprised 20 % of the tumor and showed morphologic and immunohistochemical evidence of neuroendocrine differentiation. Examination revealed histologic features comparable to mammary gland

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2016 Head and neck pathology

9. Lymphoepithelial infiltrate of palatal minor salivary glands: implications for diagnostic work-up. (PubMed)

Lymphoepithelial infiltrate of palatal minor salivary glands: implications for diagnostic work-up. Benign lymphoepithelial lesions (BLLs) usually affect the parotid glands, resulting in their asymmetrical enlargement. The condition can be associated with Sjögren's syndrome (SS), which in turn may predispose the affected patient to the development of malignant lymphoma. BLLs arising in the intraoral minor salivary glands are rare; such a lesion should prompt the work-up for SS. In some instances (...) , a BLL of a minor salivary gland could represent the initial stage of a mucosa-associated lymphoid tissue (MALT) lymphoma. A case of BLL arising in the palatal minor salivary glands is reported here. The importance of an appropriate diagnostic work-up is emphasized and the relationship of BLL with SS is reinforced.Copyright © 2016 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.

2016 International Journal of Oral and Maxillofacial Surgery

10. Standards for the assessment of salivary glands – an update (PubMed)

, collagenosis, injuries and proliferative processes, with particular emphasis on lesions indicating high risk of malignancy. In acute bacterial inflammation, the salivary glands appear as hypoechoic, enlarged or normal-sized, with increased parenchymal flow. The echogenicity is significantly increased in viral infections. Degenerative lesions may be seen in chronic inflammations. Hyperechoic deposits with acoustic shadowing can be visualized in lithiasis. Parenchymal fibrosis is a dominant feature (...) Standards for the assessment of salivary glands – an update The paper is an update of 2011 Standards for Ultrasound Assessment of Salivary Glands, which were developed by the Polish Ultrasound Society. We have described current ultrasound technical requirements, assessment and measurement techniques as well as guidelines for ultrasound description. We have also discussed an ultrasound image of normal salivary glands as well as the most important pathologies, such as inflammation, sialosis

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2016 Journal of Ultrasonography

11. Pediatric salivary gland carcinomas: Diagnostic and therapeutic management. (PubMed)

Pediatric salivary gland carcinomas: Diagnostic and therapeutic management. To analyze clinical presentations, treatment modalities, and evolution of pediatric cases of salivary gland carcinomas to standardize care for these rare diseases.Multicentric, retrospective study.We included in this retrospective study all children and adolescents (aged ≤18 years) treated from 1992 to 2012 in six pediatric centers in Paris, France. Pathological tumor specimens of these cases were reviewed.Forty-three (...) dissection was performed in 28 patients (homolateral: 27, bilateral: 1) and showed lymph node metastases in only two patients. One patient had distant metastases. Adjuvant irradiation was delivered to 11 patients (median: 60 Gy; range: 50-65) and chemotherapy in five cases. After a median follow-up of 5 years, six tumors relapsed, but no deaths occurred.Childhood salivary gland carcinomas have a good prognosis despite possible recurrences. Treatment is mainly based on surgery, with simultaneous node

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2016 Laryngoscope

12. Disseminated non-Hodgkin's lymphoma presenting as bilateral salivary gland enlargement: a case report (PubMed)

Disseminated non-Hodgkin's lymphoma presenting as bilateral salivary gland enlargement: a case report Non-Hodgkin's lymphoma (NHL) constitutes a group of malignancies those arises from cellular components of lymphoid or extranodal tissues. The head and neck is the most common area for the presentation of these lymphoproliferative disorders. Primary involvement of salivary glands is uncommon. This report described a case of a 73-year-old female patient who presented with involvement of both (...) nodal and extranodal sites, with predominant involvement of salivary glands. The tumor staging worked up along with imaging, histopathological, and immunohistochemical findings were discussed. Computed tomographic images showed the involvement of Waldeyer's ring, larynx, orbit, and spleen. This report described imaging and prognostic tumor markers in diagnosing, treatment planning, and prognosis.

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2013 Imaging Science in Dentistry

13. Salivary Gland Cancer Treatment (PDQ®): Health Professional Version

.[ ] In these data, acinic cell carcinoma comprised 17% of primary malignant salivary gland tumors or about 6% of all salivary gland neoplasms; more than 80% occur in the parotid gland; women were affected more than men; and the mean age was 44 years. Other studies have reported a relative frequency of acinic cell carcinoma from 0% to 19% of malignant salivary gland neoplasms.[ ] Clinically, patients typically present with a slowly enlarging mass in the parotid region. Pain is a symptom in more than 33 (...) accounted for 16.3% of all malignant tumors that occurred in the major salivary glands; disease in the parotid gland accounted for about 80% of all cases.[ ] Patients with benign lymphoepithelial lesion (e.g., Mikulicz disease), which is a manifestation of the autoimmune disease, Sjögren syndrome, are at an increased risk for development of non-Hodgkin lymphoma.[ - ] Benign lymphoepithelial lesion is clinically characterized by diffuse and bilateral enlargement of the salivary and lacrimal glands

2015 PDQ - NCI's Comprehensive Cancer Database

14. Salivary Gland Enlargement

Salivary Gland Enlargement Salivary Gland Enlargement Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Salivary Gland Enlargement (...) Salivary Gland Enlargement Aka: Salivary Gland Enlargement , Salivary Hypertrophy , Sialadenosis II. Causes Unilateral ry enlargement l Bilateral ry enlargement with hypofunction ( or ) Chronic granulomatous disease Sialadenosis (asymptomatic parotid enlargement) ( , ) Endocrine Disorder Gonadal hypofunction III. References Daniels in Goldman (2000) Cecil Medicine, p. 2245 Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Salivary

2015 FP Notebook

15. Epstein-Barr virus in the enlarged salivary tissues of patients with IgG4-related disease. (PubMed)

Epstein-Barr virus in the enlarged salivary tissues of patients with IgG4-related disease. Immunoglobulin G4-related disease (IgG4-RD) is a recently recognized disease entity characterized by high-serum IgG4 concentration and IgG4-producing plasma cell production with fibrotic or sclerotic changes in affected organs. We aimed to clarify the roles of Epstein-Barr virus (EBV) in patients with IgG4-RDs.A retrospective clinical study at the Yamagata University School of Medicine, Yamagata (...) , Japan.The patient group consisted of four males and four females with an average age of 62 years (range: 48-73). Expression of IgG4, latent member protein 1, EBV nuclear antigens-2, and EBV-encoded RNA in affected salivary glands from patients with IgG4-RD was examined by using immunohistochemistry and in situ hybridization. The copy number of EBV DNA in the salivary glands was also investigated by real-time polymerase chain reaction.All patients had hard masses in the salivary or lacrimal glands

2015 Laryngoscope

16. Primary Submandibular Tuberculosis: An Unusual Cause of Submandibular Salivary Gland Enlargement (PubMed)

Primary Submandibular Tuberculosis: An Unusual Cause of Submandibular Salivary Gland Enlargement A case report of very rare Primary Tuberculosis of Submandibular Gland. This is presented in view of its rarity and highlighting the importance of histopathological examination and Polymerase chain reaction (PCR) to reach the final and exact diagnosis of disease.

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2011 Indian Journal of Otolaryngology and Head & Neck Surgery

17. Salivary Gland Enlargement and Phenylbutazone (PubMed)

Salivary Gland Enlargement and Phenylbutazone 5940230 1966 09 29 2018 11 13 0007-1447 1 5503 1966 Jun 25 British medical journal Br Med J Salivary gland enlargement and phenylbutazone. 1599-600 Murray-Bruce D J DJ eng Case Reports Journal Article England Br Med J 0372673 0007-1447 GN5P7K3T8S Phenylbutazone AIM IM Adult Humans Male Phenylbutazone adverse effects Salivary Gland Diseases etiology 1966 6 25 1966 6 25 0 1 1966 6 25 0 0 ppublish 5940230 PMC1844773 Br Med J. 1966 Jun 4;1(5500):1420

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1966 British medical journal

18. Pembrolizumab and Vorinostat in Treating Patients With Recurrent Squamous Cell Head and Neck Cancer or Salivary Gland Cancer That Is Metastatic and/or Cannot Be Removed by Surgery

Pembrolizumab and Vorinostat in Treating Patients With Recurrent Squamous Cell Head and Neck Cancer or Salivary Gland Cancer That Is Metastatic and/or Cannot Be Removed by Surgery Pembrolizumab and Vorinostat in Treating Patients With Recurrent Squamous Cell Head and Neck Cancer or Salivary Gland Cancer That Is Metastatic and/or Cannot Be Removed by Surgery - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results (...) information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Pembrolizumab and Vorinostat in Treating Patients With Recurrent Squamous Cell Head and Neck Cancer or Salivary Gland Cancer That Is Metastatic and/or Cannot Be Removed by Surgery The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing

2015 Clinical Trials

19. Ultrasonographic salivary gland response to rituximab in primary Sjögren's syndrome. (PubMed)

Ultrasonographic salivary gland response to rituximab in primary Sjögren's syndrome. To evaluate changes in salivary gland echostructure and vascularization after rituximab treatment in patients with primary Sjögren's syndrome (SS).Twenty-eight patients with primary SS included in the multicenter, randomized, double-blind, placebo-controlled Tolerance and Efficacy of Rituximab in Primary Sjögren's Syndrome (TEARS) trial underwent salivary gland ultrasonography before the first placebo (...) , with improvement defined as a ≥1-point decrease), size of each gland, and vascularization based on the resistive index of the transverse facial artery of the parotid gland before and after lemon juice stimulation.Of the 28 patients, 5 (18%; 3 in the placebo group and 2 in the rituximab group) had clinically detectable bilateral parotid gland enlargement at baseline. Parotid parenchyma echostructure improved in 50% of the rituximab-treated patients versus 7% of the placebo-treated patients (P = 0.03

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2015 Arthritis & rheumatology (Hoboken, N.J.)

20. HIV-associated salivary gland disease - clinical or imaging diagnosis? (PubMed)

glands.Information regarding the observation of parotid gland enlargement, PGL, LIP, and clinical and immunological features of AIDS was gathered from medical records, and a saliva sample for unstimulated salivary flow rate and pH measurement was collected from 142 children aged 3 through 10 years treated at the Department of Infectious Diseases of Joana de Gusmão Children's Hospital, Florianópolis, SC, Brazil. High-resolution ultrasonography was performed in 58 children. Pearson's chi-square test and t-test (...) HIV-associated salivary gland disease - clinical or imaging diagnosis? This work aimed at studying the salivary gland disease (SGD) as it relates to associated factors, such as persistent generalised lymphadenopathy (PGL), lymphocytic interstitial pneumonia (LIP), clinical and immunological features of AIDS, and salivary flow rate and pH, as well as at exploring the relationship between the clinical diagnosis and the imaging diagnosis by ultrasound (US) examination of the parotid

2014 International Journal of Paediatric Dentistry

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