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Rivastigmine

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121. Cognitive Impairment in Older Adults: Screening

% of participants who screened positive refused diagnostic assessment and follow-up. Additionally, the trial was missing 42% of HRQOL outcomes data at 12 months. The USPSTF found 48 trials (n = 22,431) that evaluated the effects of AChEIs (donepezil [18 studies; n = 6209], galantamine [10 studies; n = 7464], rivastigmine [8 studies; n = 4569], and memantine [12 studies; n = 4189]) on global cognitive function. Many of these trials reported differences in scores on the Alzheimer Disease Assessment Scale (...) generally not be considered clinically important. AChEIs and memantine increased the likelihood of improving or maintaining patients’ global function, typically as assessed by the Clinician’s Interview-Based Impression of Change Plus Informant Input (CIBIC+), by 15% (for memantine) to 50% (for rivastigmine) in the short term; however, change at longer-term follow-up was not reported. Most of the evidence on the effectiveness of AChEIs and memantine comes from trials involving persons with dementia

2020 U.S. Preventive Services Task Force

122. Diagnosis and Treatment of Clinical Alzheimer’s-Type Dementia

Galantamine Versus Placebo and Galantamine Dose Comparisons 101 Key Messages 101 Eligible Studies 101 Baseline Study Characteristics 101 Outcomes 102 Variation in Outcomes by Participant Characteristics 103 Rivastigmine Versus Placebo 104 Key Messages 104 Eligible Studies 104 Baseline Study Characteristics 104 Outcomes 105 Variation in Outcomes by Participant Characteristics 108 Rivastigmine Dosage Comparisons 108 Key Messages 108 Eligible Studies 109 Baseline Study Characteristics 109 Outcomes 110 (...) 128 Eligible Studies 128 Gingko Biloba Versus Donepezil 128 Vitamin E Versus Donepezil 130 Huannao Yicong Formula Versus Donepezil 131 Vitamin E Versus Rivastigmine 132 Saffron Extract Versus Memantine 133 Additional Drug Versus Drug Comparisons 134 Key Message 134 Eligible Studies 134 Chapter 9. Key Question 6: Prescription Drugs Versus Placebo for Behavioral and Psychological Symptoms of Dementia 135 Antipsychotics Versus Placebo and Antipsychotic Dose Comparisons 135 Key Messages 135 Eligible

2020 Effective Health Care Program (AHRQ)

125. Cholinesterase inhibitors for the treatment of delirium in non-ICU settings. Full Text available with Trip Pro

. The risk of bias was low in all domains.The study compared rivastigmine with placebo. We did not find any clear differences between the two groups in terms of duration of delirium (MD -3.6, 95% CI -15.6 to 8.4), adverse events (nausea, RR 0.30, 95% CI 0.01 to 6.29), use of rescue medications (RR 0.13, 95% CI 0.01 to 2.1), mortality (RR 0.10, 95% CI 0.01 to 1.56), and leaving the study early (RR 0.88, 95% CI 0.07 to 11.54). Evidence was not available regarding the severity of delirium, persistent

2018 Cochrane

126. Peri-operative care of people with dementia

and being in hospital. Key areas of supportconcern: 1 Knowingaboutthepersonwithdementia,forexample, making use of a ‘This is me’ or similar document (see ‘SourcesofFurtherInformation’); Table 2 Importantdruginteractionsbetweendementiamedicationanddrugsusedinanaesthesia. Half-life;hr Recommendation/effect Cholinesteraseinhibitors Galantamine 7 Discontinue a daybeforesurgery Rivastigmine 9 Discontinue a daybeforesurgery Donepezil 70 Notrecommended Memantine 60–100 Carewithketamine

2019 Association of Anaesthetists of GB and Ireland

127. Pharmacologic and Nonpharmacologic Treatments for Posttraumatic Stress Disorder

in the treatment of posttraumatic stress disorder: a randomized, double-blind study. J Res Med Sci. 2004;9(5):240-4. 45. Ardani AR, Hosseini G, Bordbar MRF, et al. Effect of rivastigmine augmentation in treatment of male patients with combat- related chronic posttraumatic stress disorder: a randomized controlled trial. J Clin Psychopharmacol. 2017 Feb;37(1):54-60. doi: 10.1097/jcp.0000000000000624. PMID: 27930500. 46. Baker DG, Diamond BI, Gillette GM, et al. A double-blind, randomized, placebo- controlled

2019 Effective Health Care Program (AHRQ)

129. Appropriate prescribing of psychotropic medication for non-cognitive symptoms in people with dementia

with antipsychotics in people with Parkinson’s disease dementia and dementia with Lewy bodies 3 , rivastigmine or donepezil may be considered for non-cognitive symptoms causing severe distress when non-pharmacological interventions have proved ineffective. People with vascular dementia or frontotemporal dementia who develop non-cognitive symptoms should NOT be prescribed acetylcholinesterase inhibitors. Memantine is indicated as a cognitive enhancer in people with moderate 7 to severe Alzheimer’s disease

2019 National Clinical Guidelines (Ireland)

132. Twenty-Five Pearls from 25 years (part 1)

provide harm data including serious adverse events that are not published elsewhere. 13 Donepezil has not been demonstrat- ed to improve outcomes of impor- tance to patients and caregivers (e.g. institutionalization or disability) Drugs for Alzheimer’s Disease [Apr-Aug 2005, issue 56]. Similarly, rivastigmine, galantamine and memantine have not been studied in terms of these important outcomes. It also concludes that acetylcholinesterase inhibitors cause gastrointestinal, muscular and other adverse

2019 Therapeutics Letter

133. Drugs for Alzheimer's disease: finally delisted in France!

of copies of which have been downloaded from our website english.prescrire.org (1). In May 2018, France's Minister for Health took this negative harm-benefit balance into account. She decided that, from 1 August 2018, these drugs – donepezil, galantamine, rivastigmine and memantine – would be delisted, i.e. no longer reimbursed by the national health insurance system (2,3). This measure was not unexpected. In late 2016, the French Pharmacoeconomic (Transparency) Committee had concluded that these drugs

2018 Prescrire

134. Donepezil

analysis). Secondary efficacy measures evaluated cognition, behavior, and function. The dual primary 2009 4. Donepezil , galantamine, rivastigmine and memantine for the treatment of Alzheimer' Donepezil , galantamine, rivastigmine and memantine for the treatment of Alzheimer's disease | Guidance and guidelines | NICE Donepezil , galantamine, rivastigmine and memantine for the treatment of Alzheimer's disease Technology appraisal guidance [TA217] Published date: 23 March 2011 Last updated: 11 May (...) 2016 Share Save Guidance on donepezil ( Aricept ), galantamine (Reminyl), rivastigmine (Exelon) and memantine (...) (Ebixa) for treating Alzheimer's disease in adults. This guidance has been partially updated by NICE’s guideline on (CG42) and replaces NICE technology appraisal guidance on donepezil , galantamine, rivastigmine and memantine for the treatment of Alzheimer's disease (TA111). Guidance development process Is this guidance up to date? . We identified nothing new that affects

2018 Trip Latest and Greatest

135. Memantine

Guideline for Deprescribing Cholinesterase Inhibitors and Memantine . Sydney: The University of Sydney; 2018. The full guideline 2018 4. Donepezil, galantamine, rivastigmine and memantine for the treatment of Alzheimer' Donepezil, galantamine, rivastigmine and memantine for the treatment of Alzheimer's disease | Guidance and guidelines | NICE Donepezil, galantamine, rivastigmine and memantine for the treatment of Alzheimer's disease Technology appraisal guidance [TA217] Published date: 23 March 2011 (...) Last updated: 11 May 2016 Share Save Guidance on donepezil (Aricept), galantamine (Reminyl), rivastigmine (Exelon) and memantine (...) (Ebixa) for treating Alzheimer's disease in adults. This guidance has been partially updated by NICE’s guideline on (CG42) and replaces NICE technology appraisal guidance on donepezil, galantamine, rivastigmine and memantine for the treatment of Alzheimer's disease (TA111). Guidance development process Is this guidance up to date? . We identified nothing new

2018 Trip Latest and Greatest

136. Parkinson?s disease in adults

for further information. [4] At the time of publication (July 2017), quetiapine did not have a UK marketing authorisation for this indication. The prescriber should follow relevant professional guidance, taking full responsibility for the decision. Informed consent should be obtained and documented. See the General Medical Council's Prescribing guidance: prescribing unlicensed medicines for further information. [5] At the time of publication (July 2017), rivastigmine capsules are the only treatment (...) with a UK marketing authorisation for this indication. Donepezil, galantamine and rivastigmine patches did not have a UK marketing authorisation for this indication. The prescriber should follow relevant professional guidance, taking full responsibility for the decision. Informed consent should be obtained and documented. See the General Medical Council's Prescribing guidance: prescribing unlicensed medicines for further information. [6] At the time of publication (July 2017), cholinesterase inhibitors

2017 National Institute for Health and Clinical Excellence - Clinical Guidelines

138. Drugs to avoid

laxatives Moxifloxacin Bacterial infections Serious toxicity such as liver and cardiac disorders Ciprofloxacin, Ofloxacin Donepezil (Aricept), Galantamine (Reminyl), Rivastigmine (Exelon), Memantine Alzheimer’s and other dementias Minimal efficacy; disproportionate adverse effects such as severe vomiting and syncope Support from caregivers and family Alemtuzumab (Lemtrada), Natalizumab (Tysabri), Teriflunomide (Aubagio) Multiple sclerosis Disproportionate adverse effects such as infections and liver

2018 Therapeutics Letter

139. Pharmacological treatment for memory disorder in multiple sclerosis

, secondary‐progressive and primary‐progressive MS, evaluating the absolute efficacy of donepezil, ginkgo biloba, memantine and rivastigmine versus placebo in improving memory performance with diverse assessment scales. Overall, clinical and methodological heterogeneities existed across these studies. Moreover, most of them had methodological limitations on non‐specific selections of targeted sample, non‐matched variables at baseline or incomplete outcome data (high attrition bias). Only the two studies (...) inconclusive. However, there is moderate‐quality evidence that donepezil 10 mg daily was not effective in improving memory in MS patients with mild memory impairment, but had a good tolerability. Adverse events such as nausea, diarrhoea and abnormal dreams were not frequent but were associated with treatment. Ginkgo biloba, memantine and rivastigmine were safe and well tolerated and no serious adverse effects were reported. Future large‐scale RCTs with higher methodological quality are needed. Plain

2018 European Academy of Neurology

140. Evidence-based Clinical Practice Guideline for Deprescribing Cholinesterase Inhibitors and Memantine

that is characterised by a progressive loss in cognition, function and behaviour [1]. Worldwide, the number of people living with dementia is increasing every year [2]. There are currently two classes of medications available to treat the symptoms of dementia: cholinesterase inhibitors (ChEIs: donepezil, rivastigmine and galantamine) and the N- methyl-D-aspartate (NMDA) receptor antagonist, memantine [3]. These medications are not disease modifying, yet they can have important benefits to people with dementia (...) and harm to the individual. Thus, the purpose of this guideline is to assist healthcare professionals (particularly prescribers) to determine when it might be suitable to trial withdrawal of these medications for an individual. These recommendations only apply to individuals already taking one of the described medications (donepezil, rivastigmine, galantamine and/or memantine). The main points of this guideline are as follows: ? A proportion of people who have used these medications for over 12 months

2018 Clinical Practice Guidelines Portal

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