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182. Medication use to manage comorbidities for people with dementia: a systematic review Full Text available with Trip Pro

K . Domperidone is effective in the prevention of rivastigmine‐related gastrointestinal disturbances . Funct Neurol 2007 ; 22 ( 2 ): 101 – 4 . 20 Sadowsky CH , Dengiz A , Olin JT , Koumaras B , Meng X , Brannan S . Switching from donepezil tablets to rivastigmine transdermal patch in alzheimer's disease . Am J Alzheimer's Dis Other Demen 2009 ; 24 ( 3 ): 267 – 75 . 21 Gill SS , Mamdani M , Naglie G , Streiner DL , Bronskill SE , Kopp A , et al . A prescribing cascade involving cholinesterase

2018 Journal of Pharmacy Practice and Research

187. Drugs to avoid in 2015

of their disproportionate adverse effects and many interactions with other drugs. None of the available drugs has been shown to slow progression toward dependency, yet all carry a risk of life-threatening adverse effects and severe drug inter - actions (Prescrire Int n° 128 and Rev Prescrire n° 363, 364). It is better to focus on reorganising the patient’s daily life, keeping him or her active, and providing support and help for caring relatives. – Donepezil, galantamine and rivastigmine, three cholinesterase

2015 Prescrire

188. Clinical practice guidelines and principles of care for people with dementia

AND MEMANTINE 69 EBR Low Any one of the three acetylcholinesterase inhibitors (donepezil, galantamine or rivastigmine) are recommended as options for managing the symptoms of mild to moderately severe Alzheimer's disease. Any one of the three acetylcholinesterase inhibitors could be considered for managing the symptoms of severe Alzheimer’s disease. 2 Prior to initiation of treatment medical practitioners should consider performing an electrocardiogram (ECG), recording weight and undertaking a falls risk

2016 Clinical Practice Guidelines Portal

189. What is happening with not recommended drugs for dementia in Argentina? Prescription patterns and direct costs analysis. (Abstract)

What is happening with not recommended drugs for dementia in Argentina? Prescription patterns and direct costs analysis. The only recommended pharmacological treatments for specific dementias are donepezil, galantamine, rivastigmine, and memantine (recommended drugs, RD). However, other drugs without recommendations (not recommended drugs, NRD) are often used to treat patients with cognitive impairment (CI) in Argentina. The INSSJyP is the largest health insurance in Argentina. The objective

2020 International Journal of Geriatric Psychiatry

190. Diagnosis, treatment and management of apathy in Parkinson's disease: a scoping review. Full Text available with Trip Pro

examining treatment. Twenty screening tools for apathy were identified. Fifty per cent of treatment studies were randomised control trials (RCTs). RCTs applied treatment methods including: exercise, mindfulness, rotigotine (Neupro) transdermal patch and rivastigmine (Exelon).This review identified a large body of literature describing current knowledge on diagnosing, treating and managing apathy in PD. Future research should aim to detect an ideal screening tool for apathy in PD, to identify the best

2020 BMJ open

191. Effect of Idalopirdine as Adjunct to Cholinesterase Inhibitors on Change in Cognition in Patients With Alzheimer Disease: Three Randomized Clinical Trials. Full Text available with Trip Pro

patients at 119 sites; study 2: n = 858 at 158 sites; and study 3: n = 734 at 126 sites). The 24-week studies were conducted from October 2013 to January 2017; final follow-up on January 12, 2017.Idalopirdine (10, 30, or 60 mg/d) or placebo added to cholinesterase inhibitor treatment (donepezil in studies 1 and 2; donepezil, rivastigmine, or galantamine in study 3).Primary end point in all 3 studies: change in cognition total score (range, 0-70; a lower score indicates less impairment) from baseline

2018 JAMA Controlled trial quality: predicted high

192. The efficacy and safety of hachimijiogan for mild Alzheimer disease in an exploratory, open standard treatment controlled, randomized allocation, multicenter trial: A study protocol. Full Text available with Trip Pro

diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders (DSM)-5 and as mild AD according to the Mini Mental State Examination (MMSE ≥21) will be included. All will already have been taking the same dose of Donepezil, Galantamine, or Rivastigmine for more than 3 months. The patients will be randomly assigned to receive additional treatment with HJG or to continue mild AD treatment without additional HJG. The primary endpoint is the change from baseline of the Alzheimer's Disease

2020 Medicine

195. The Comparative Efficacy of Multiple Interventions for Mild Cognitive Impairment in Alzheimer's Disease: A Bayesian Network Meta-Analysis Full Text available with Trip Pro

previously been conducted to assess the efficacy of ChEIs, including donepezil, galantamine, and rivastigmine ( ; ; ). These studies suggested that ChEIs have a low efficacy in the treatment of MCI and many safety issues were raised. Therefore, before using ChEIs for MCI, other methods should be considered. Other studies ( ; ) have suggested that physical exercise and computerized cognitive training could improve cognitive function and neuropsychiatric symptoms. Furthermore, non-pharmacological therapies (...) treatments by measuring comparable probability and then reporting them as the best, the second best, and so on. Through this method, we found that among all interventions, both pharmacological therapies (ChEIs, ginkgo, nimodipine, and Chinese medicine) and non-pharmacological therapies (acupuncture, music therapy, exercise, and nutrition therapy), music therapy and acupuncture were better than other treatments. Some pharmacological treatments like CHEIs such as donepezil, galantamine, and rivastigmine

2020 Frontiers in aging neuroscience

196. Causal association of circulating cholesterol levels with dementia: a mendelian randomization meta-analysis Full Text available with Trip Pro

applications. References 1. Rao, A., Suliman, A., Vuik, S., Aylin, P. & Darzi, A. Outcomes of dementia: Systematic review and meta-analysis of hospital administrative database studies. Arch. Gerontol. Geriatrics 66 , 198–204 (2016). 2. Alva, G., Grossberg, G. T., Schmitt, F. A., Meng, X. & Olin, J. T. Efficacy of rivastigmine transdermal patch on activities of daily living: item responder analyses. Int. J. Geriatr. Psychiatry 26 , 356–363 (2011). 3. Lesser, G. et al. Elevated serum total and LDL

2020 Translational psychiatry

197. Different Doses of Pharmacological Treatments for Mild to Moderate Alzheimer’s Disease: A Bayesian Network Meta-Analysis Full Text available with Trip Pro

identified by searching the PubMed, EMBASE, and Cochrane Library databases (all RCTs published from the date of inception of the databases until September 19, 2019). Trials comparing the efficacy, acceptability, and safety of pharmacological interventions involving donepezil, galantamine, rivastigmine, memantine, huperzine A, and Ginkgo biloba extract EGb761, alone or in combination, were identified. The primary outcomes were efficacy, acceptability, and safety. Results: Our meta-analysis included 37 (...) studies involving 14,705 participants. In terms of improving cognitive function, galantamine 32 mg, galantamine 24 mg, donepezil 5 mg, and donepezil 10 mg were more effective than other interventions, with the surface under the cumulative ranking curve (SUCRA) values of 93.2, 75.5, 73.3, and 65.6%, respectively. According to the SUCRA values, EGb761 240 mg was considered to be the optimal intervention in terms of both acceptability and safety. With regard to clinical global impression, rivastigmine 12

2020 Frontiers in pharmacology

198. Association of Crocus sativus with Cognitive Dysfunctions and Alzheimer’s Disease: A Systematic Review Full Text available with Trip Pro

. These drugs act through two mechanistic pathways; Non-competitive N-methyl-D-aspartate (NMDA) receptor antagonists (memantine) and cholinesterase inhibitors (ChEIs) (donepezil, galantamine, and rivastigmine) [19,20]. These chemicals, synthetic therapeutic agents, have some side effects, short half-life, and fluctuated bioavailability, which leads to narrow indications [18]. There is a growing demand for the usage of phytochemicals, nutraceuticals, and phytochemical components for the control

2020 Biointerface research in applied chemistry

199. Effectiveness and Safety of Acupuncture for the Treatment of Alzheimer's Disease: A Systematic Review and Meta-Analysis Full Text available with Trip Pro

on correcting the cholinergic deficiency in the central nervous system with cholinesterase inhibitors. Donepezil, rivastigmine, and galantamine are commonly recommended ( ). However, none of these drugs can stop the progression of AD, and their therapeutic effects vary from person to person and are limited to the duration of treatment ( ). In addition, adverse events such as nausea, vomiting, and dizziness have been reported to be associated with drug therapy for AD patients ( ). New effective therapies

2020 Frontiers in aging neuroscience

200. Pharmacological treatment of neuropsychiatric symptoms of dementia: a network meta-analysis protocol Full Text available with Trip Pro

, galantamine and rivastigmine; (II) NMDAR antagonist: memantine; (III) antidepressants such as citalopram, escitalopram, or trazodone; (IV) antipsychotics such as risperidone, aripiprazole, quetiapine, or olanzapine; (V) anticonvulsants such as carbamazepine, or valproate. Only study arms randomising patients to drugs within the licensed dose will be included. Although meta-analytic methods considering the effect of drug dose would ideally be limited to fixed dose trials, we aware that some studies allow (...) or Anticonvulsants or Trazodone or Citalopram or Fluoxetine or Antidepressive Agents or Setraline or Antidepressants or Antidepressive Agents or Aripiprazole or Quetiapine or Olanzapine or Clozapine or Acetophenazine or Chlorpromazine or Thiothixene or Thioridazine or Trichlorfon or Rivastigmine or Galantamine or Donepezil or Aripiprazole or Pimozide or Droperidol or Flupenthixol or Methotrimeprazine or Haloperidol or Olanzapine or Risperidone or Butyrophenones or Phenothiazines or Antipsychotic Agents

2020 Annals of Translational Medicine

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