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141. The acute management of paediatric coronavirus disease 2019 (COVID-19)

or neuromuscular condition, and children living with other chronic conditions such as diabetes mellitus, sickle cell disease, malignancies, and/or immunosuppressive conditions (e.g., post-organ transplant, chronic steroids), or those being ventilated at home [ ] . Treating children with acute asthma in the setting of COVID-19 Read this practice point, , for related guidance on managing asthma in community settings [ ] . The risks of COVID-19 aerosolization associated with nebulized therapies are significant (...) , such as tocilizumab, are underway to evaluate immune modulators as treatment for the cytokine release syndrome seen in some patients. Special considerations for COVID-19 infection treatment and management Vulnerable populations Some paediatric populations should be considered at higher risk for severe COVID-19-related disease, even as evidence confirming this status is pending. These groups include infants, and children with a heart or lung disease (e.g., asthma, cystic fibrosis), or a neurological

2020 Canadian Paediatric Society

142. Management of patients with moderate to severe COVID-19

of: haemodynamically unstable, hypoxaemia (SaO2 on room air =92%), comorbidities, or unsuitable home environment. [Adapted from ASID] MANAGING RISK OF INFECTION 49.20 Nurse all patients using contact plus droplet precautions, ideally in a single room, and if no single room available, at least 1.5m between patients with curtains drawn; restrict vistors to one at a time. [Adapted from ASID] 49.21 Use contact plus droplet plus airborne precautions (N95/P2 mask rather than surgical mask) and nurse in a negative (...) Management of patients with moderate to severe COVID-19 MANAGEMENT OF P A TIENTS WITH MODERA TE TO SEVERE COVID- 19 DISEASE Definition of disease severity Moderate illness Stable patient presenting with respiratory and/or systemic symptoms or signs. Able to maintain oxygen saturation above 92% (or above 90% for patients with chronic lung disease) with up to 4L/min oxygen via nasal prongs. Characteristics: • prostration, severe asthenia, fever >38ºC or persistent cough • clinical or radiological

2020 National COVID-19 Clinical Evidence Taskforce

143. Clinical management of children admitted to hospital with suspected COVID-19

Clinical management of children admitted to hospital with suspected COVID-19 COVID-19 - clinical management of children admitted to hospital with suspected COVID-19 Health Policy team This guidance outlines key principles for the clinical management of children admitted to hospital with suspected COVID-19. It is aimed at general paediatricians treating children during the COVID-19 pandemic. It covers medical management of paediatric patients, including advice on use of antiviral treatments (...) . This guidance has been produced with the British Paediatric Respiratory Society and the British Paediatric Allergy, Immunity and Infection Group. Last modified 29 May 2020 Post date 17 April 2020 Table of contents Summary NHS clinical management guidance Key principles of good care during COVID-19 pandemic Pathology of COVID-19 Clinical and laboratory features in children Additional diagnostic tests for severely unwell children Treatment criteria Supportive medical care Use of antiviral and immunomodulatory

2020 Royal College of Paediatrics and Child Health

144. Effectiveness of interventions to manage acute malnutrition in children under five years of age in low- and middle-income countries Full Text available with Trip Pro

Effectiveness of interventions to manage acute malnutrition in children under five years of age in low- and middle-income countries Effectiveness of interventions to manage acute malnutrition in children under 5 years of age in low‐ and middle‐income countries: A systematic review - Das - 2020 - Campbell Systematic Reviews - Wiley Online Library COVID-19 campus closures: see options for to subscribed content. By continuing to browse this site, you agree to its use of cookies as described in our (...) . Search within Search term Search term SYSTEMATIC REVIEW Open Access Effectiveness of interventions to manage acute malnutrition in children under 5 years of age in low‐ and middle‐income countries: A systematic review Corresponding Author E-mail address: Division of Women and Child Health, Aga Khan University Hospital, Karachi, Pakistan Correspondence Jai K. Das, The Hospital for Sick Children, 555 University Ave, Toronto, Ontario M5G 1X8, Canada. Email: Division of Women and Child Health, Aga Khan

2020 Campbell Collaboration

145. Management of essential cancer surgery for adults during the coronavirus pandemic

Management of essential cancer surgery for adults during the coronavirus pandemic A NHS England clinical guide for the management of essential cancer surgery for adults during the coronavirus pandemic: applicable to NHSScotland? HIS Evidence were asked whether the recommendations in the following guidance are evidence based, practical and not in conflict with other advice? Academy of Medical Royal Colleges and NHS England (7 April 2020) Clinical guide for the management of essential cancer (...) that they were based on clinical expert opinion. In the background, the authors state that the guidance ‘builds on the experience of China, Italy and London…on the prioritisation and management of essential cancer surgery’. Contact was made with the authors of the guidance, who provided more information around how China and Italy organised their services. Guidance from other countries on the prioritisation of cancer surgeries often state that they are based on clinical expert opinion – suggesting

2020 Covid-19 Ad hoc papers

146. Management of Tick Bites and Lyme Disease During Pregnancy

Management of Tick Bites and Lyme Disease During Pregnancy Committee Opinion No. 399: Management of Tick Bites and Lyme Disease During Pregnancy - Journal of Obstetrics and Gynaecology Canada Go search , P644-653, May 01, 2020 Powered By Mendeley Share on Committee Opinion No. 399: Management of Tick Bites and Lyme Disease During Pregnancy Graeme N. Smith Affiliations Kingston, ON Kieran M. Moore Affiliations Kingston, ON Todd F. Hatchette Affiliations Halifax, NS Jennifer Nicholson (...) with a tick bite or suspected Lyme disease should be managed similarly to non-pregnant adults, including the consideration of antibiotics for prophylaxis and treatment. The primary objective of this committee opinion is to inform practitioners about Lyme disease and provide an approach to managing the care of pregnant women who may have been infected via a blacklegged tick bite. Intended users Health care providers who care for pregnant women or women of reproductive age. Target population Women

2020 Society of Obstetricians and Gynaecologists of Canada

147. Managing theatre processes for planned surgery between COVID-19 surges

Managing theatre processes for planned surgery between COVID-19 surges 9 June 2020 | icmanaesthesiacovid-19.org 1 Endorsed by Managing theatre processes for planned surgery between COVID-19 surges Tim Cook, Kathleen Ferguson, Helgi Johannsson and William Harrop-Griffiths Context As we emerge from the first pandemic surge, there is a widespread desire to restart planned surgery using patient pathways that seek to minimise COVID-19 risk to patients and healthcare workers (HCWs). Some hospitals (...) to which personal protective equipment (PPE) to wear and whether or how long to wait for aerosols to be cleared from clinical areas by ventilation systems. This document seeks to provide pragmatic recommendations based on currently available guidance, knowledge and opinion. Risk levels Intrinsic risk Risk of transmission of infection in theatre is dependent on: ? The risk of the patient having SARS-CoV-2, which is in turn dependent on the adequacy of isolation and screening, and on community

2020 ICM Anaesthesia COVID-19

148. Risk Assessment of Histamine in Chilled, Frozen, Canned and Semi-Preserved Fish in Morocco; Implementation of Risk Ranger and Recommendations to Risk Managers Full Text available with Trip Pro

Risk Assessment of Histamine in Chilled, Frozen, Canned and Semi-Preserved Fish in Morocco; Implementation of Risk Ranger and Recommendations to Risk Managers A risk assessment of histamine was conducted for different categories of fishery products in the market. Risk estimates were assessed using the Risk Ranger tool. The estimated risks associated with the consumption of canned, semi-preserved and frozen fish are lower than those associated with fresh fish. According to the hypotheses (...) , it ranges from zero to 21. For canned fish, the risk ranking varies between 12 (five patients for 1000 years) and 21 (15 patients for 100 years). As a result, most Moroccan seafood products are classified as "low risk". However, it is recommended that risk managers maintain the adopted measures, strengthen interventions upstream in the food chain and that professionals maintain the HACCP (Hazard Analysis Critical Control Point) system effectively.

2018 Foods

149. Meningococcal disease: guidance on public health management

group W 7 2.3 Meningococcal group Y 8 2.4 Meningococcal group B 8 2.5 Other meningococcal groups 8 3. Vaccination programmes 9 3.1 MenC vaccines 9 3.2 Quadrivalent MenACWY vaccines. 9 3.3 MenB vaccine 10 4. Previous guidance 10 5. Pre-admission management 12 5.1 Recommendation 12 6. Laboratory investigation of suspected cases 13 7. Role of public health 16 8. Public health action after a case 18 8.1 Risk to close contacts 18 8.2 Risk reduction through chemoprophylaxis 22 8.3 Choice of agent (...) of the vaccination status of the risk group ? for a cluster involving confirmed serogroup B cases: MenB vaccine should usually be offered to all individuals of any age who were offered antibiotics and who have not received the vaccine in the previous 12 months Guidance for Public Health Management of Meningococcal Disease in the UK: Updated February 2018 6 1. Background Neisseria meningitidis is a major cause of septicaemia and meningitis worldwide and is associated with significant mortality as well as serious

2019 Public Health England

150. Acute flaccid paralysis: clinical management guidance

risk factors and outcomes for cases reported in 2018. Cases are defined as: Acute flaccid paralysis/myelitis in an individual aged 30 years and under, not explained by an non-infectious cause. This guidance summarises existing evidence for the management of AFP/AFM based on US Centers for Disease Control and Prevention (CDC) guidance (1), a recent review of management considerations (2), and an updated Medline literature review. Infection control procedures are outlined in Appendix 1. Supportive (...) Acute flaccid paralysis: clinical management guidance Clinical management of acute flaccid paralysis / acute flaccid myelitis (AFP/AFM) Information for health professionals Clinical management of acute flaccid paralysis / acute flaccid myelitis (AFP/AFM): Information for health professionals 2 About Public Health England Public Health England exists to protect and improve the nation’s health and wellbeing, and reduce health inequalities. We do this through world-leading science, knowledge

2019 Public Health England

151. Guidance for the clinical management of children admitted to hospital with suspected COVID-19

Guidance for the clinical management of children admitted to hospital with suspected COVID-19 1 MANAGEMENT OF CHILDREN ADMITTED TO HOSPITAL WITH COVID-19 INFE CTION (VERSION 2) Guidance for the clinical management of children admitted to hospital with suspected COVID-19 Current lead: Dr Ian Sinha, Consultant Respiratory Paediatrician, Alder Hey Children’s Hospital, Liverpool (iansinha@liv.ac.uk) Other contributors, advisors, and reviewers listed in Appendix 4 This guidance is aimed at general (...) paediatricians. Separate guidance has been produced by the Paediatric Intensive Care Society on Covid-19 infection relevant to the paediatric critical care community: https://picsociety.uk/covid19/ 1 Summary of the guidance: Reassure parents and involve them in caring for their child, keep up-to-date using the evidence in Appendix 1 of this guidance, and communicate well with colleagues Be extra-vigilant in children with pre-existing conditions but reassure parents that the risks of comorbidities is much

2020 British Thoracic Society

152. Guidance for community management of patients receiving Long-Term Ventilation (LTV) during COVID-19

Guidance for community management of patients receiving Long-Term Ventilation (LTV) during COVID-19 V1.0 9 April 2020 1 Guidance for community management of patients receiving Long-Term Ventilation (LTV) during COVID-19 Please note; this guidance is purely a consensus statement based on advice from NHS England (NHSE) and expertise within the long term ventilation clinical community. It does not substitute recommendations made by the local long term ventilation service. Please clarify any (...) aspects of clinical management with the service who oversees the patient’s LTV care. The guidance may need to be updated as the knowledge base and expert experience develops. Long Term Ventilation (LTV) services provide specialist care and support for patients who require long term ventilation (invasive or non-invasive) outside of the traditional inpatient setting. This is for a range of medical conditions characterised by chronic respiratory failure. All patients under the care of such teams

2020 British Thoracic Society

153. BTS guidance for managing patients with interstitial lung disease

BTS guidance for managing patients with interstitial lung disease V2.0 30/3/2020 1 British Thoracic Society Advice for Managing Interstitial Lung Disease Patients during COVID-19 pandemic Purpose: This advice is designed to help clinicians looking after Interstitial Lung Disease (ILD) patients during the COVID-19 pandemic. Principles and Scope: This is a fast evolving situation and this document will be updated regularly. All advice is general. Clinicians, after discussion with their patients (...) with ILD and sarcoidosis are advised to ‘shield’ where possible On March 21 st 2020 a letter was sent to all English medical and nursing directors from Ruth May, Chief Nursing Officer, England and Professor Stephen Powis National Medical Director, NHS England and NHS Improvement. The letter “Caring for people at highest risk during the Covid-19 incident” specified which patient groups the government advised should ‘shield’ to try and maximally protect themselves from infection. Several respiratory

2020 British Thoracic Society

154. COVID-19: Interim Guidance on Management Pending Empirical Evidence. From an American Thoracic Society?led International Task Force

COVID-19: Interim Guidance on Management Pending Empirical Evidence. From an American Thoracic Society?led International Task Force 1 Updated April 3, 2020 COVID-19: Interim Guidance on Management Pending Empirical Evidence. From an American Thoracic Society-led International Task Force * Kevin C. Wilson 1,2, Sanjay H. Chotirmall 3 , Chunxue Bai 4 , and Jordi Rello 5 on behalf of the International Task Force on COVID-19 1 Department of Medicine, Boston University School of Medicine, Boston (...) in the guidance document and serves at the Chief of Guidelines and Documents for the American Thoracic Society. SHC, CB, and JR have nothing to disclose. * Correspondence: Kevin C. Wilson, MD Chief of Guidelines and Documents, American Thoracic Society Professor of Medicine, Boston University School of Medicine Email: kwilson@thoracic.org, kcwilson@bu.edu Note to readers: There is little empirical evidence to guide management of COVID-19. However, with 80,000 new cases being confirmed daily and the rate still

2020 American Thoracic Society

155. Guidance for the Management of Myasthenia Gravis (MG) and Lambert-Eaton Myasthenic Syndrome (LEMS) During the COVID-19 Pandemic

Guidance for the Management of Myasthenia Gravis (MG) and Lambert-Eaton Myasthenic Syndrome (LEMS) During the COVID-19 Pandemic ContentslistsavailableatScienceDirect JournaloftheNeurologicalSciences journal homepage: www.elsevier.com/locate/jns Clinicalshortcommunication Guidanceforthemanagementofmyastheniagravis(MG)andLambert- Eatonmyasthenicsyndrome(LEMS)duringtheCOVID-19pandemic InternationalMG/COVID-19WorkingGroup 1 ,SaijuJacob a,?,2 ,SrikanthMuppidi b,?,2 , AmandaGuidon c ,JeffreyGuptill d (...) Organization. There are no known proven therapies for treating this virusandnovaccinetopreventtheinfectionatthistime. No data currently exist on how COVID-19 affects people with myasthenia gravis (MG)/LEMS or patients with other diseases on im- munosuppressive therapies. However, because most patients with MG are on immunosuppressive or immunomodulatory therapies and may also have respiratory muscle weakness, there is a theoretical concern that MG/LEMS patients may be at higher risk of contracting

2020 American Association of Neuromuscular & Electrodiagnostic Medicine

156. Covid-19: Clinical Guidance for the Management of Skin Cancer Patients during the Coronavirus Pandemic

Covid-19: Clinical Guidance for the Management of Skin Cancer Patients during the Coronavirus Pandemic British Association of Dermatologists & British Society for Dermatological Surgery COVID-19 – Skin cancer surgery guidance First published 24.03.20 (v 1); updated 26.03.30 (v 1.1), 30.03.20 (v1.2), 07.04.20 (v 1.3) 1 CLINICAL GUIDANCE FOR THE MANAGEMENT OF SKIN CANCER PATIENTS DURING THE CORONAVIRUS PANDEMIC This is a very fluid situation and guidance may change over the next days (...) -differentiated tumours, perineural tumours, ulcerated and symptomatic lesions; lesions in patients with significant risk factors (while balancing the risk of COVID-19 complications for these high-risk patients). ? Consider deferring treatment of melanoma in situ for 2-3 months. British Association of Dermatologists & British Society for Dermatological Surgery COVID-19 – Skin cancer surgery guidance First published 24.03.20 (v 1); updated 26.03.30 (v 1.1), 30.03.20 (v1.2), 07.04.20 (v 1.3) 2 ? Consider

2020 British Association of Dermatologists

157. Covid-19: Guidance For Managing Urticaria Patients on Omalizumab During the Coronavirus Pandemic

Covid-19: Guidance For Managing Urticaria Patients on Omalizumab During the Coronavirus Pandemic British Association of Dermatologists COVID-19 – Omalizumab guidance First published 26.03.20 1 GUIDANCE FOR MANAGING URTICARIA PATIENTS ON OMALIZUMAB DURING THE CORONAVIRUS PANDEMIC This is a very fluid situation and guidance may change Please note that any BAD advice and guidance produced as a result of COVID-19 would still require authorisation by Trusts which indemnify members. Most (...) will be guided by available evidence and responsible medical opinion, and that any deviation from standard practice needs to be documented clearly and the reasons stated. In the face of COVID-19 and the need to keep people away from hospital as far as we are able, you may wish to consider the following, where possible: • The first two injections of omalizumab need to be given in hospital due to the (small) risk of anaphylaxis. • However, patients can be taught to self-inject at the second visit to continue

2020 British Association of Dermatologists

158. Covid-19: Guidance For Managing Patients On Isotretinoin During the Coronavirus Pandemic

Covid-19: Guidance For Managing Patients On Isotretinoin During the Coronavirus Pandemic British Association of Dermatologists COVID-19 – Isotretinoin guidance First published 26.03.20 1 GUIDANCE FOR MANAGING PATIENTS ON ISOTRETINOIN DURING THE CORONAVIRUS PANDEMIC This is a very fluid situation and guidance may change Please note that any BAD advice and guidance produced as a result of COVID-19 would still require authorisation by Trusts which indemnify members. Most will be guided (...) are not aligned with MHRA guidance, which is applicable under normal circumstances. • Please liaise with your local pharmacy departments. • Additionally, advice has been sought on the theoretical increased risk of COVID-19 viral load in patients on isotretinoin due to its drying effect on the mucous membrane.

2020 British Association of Dermatologists

159. Concise Advice on Inpatient Diabetes during COVID-19 - Guidance for managing inpatient hyperglycaemia

local diabetes team for advice in this circumstance. ? After 9pm consider risk of hypoglycaemia overnight when thinking about the use of a corrective dose COncise adVice on Inpatient Diabetes (COVID:Diabetes): GUIDANCE FOR MANAGING INPATIENT HYPERGLYCAEMIA IF GLUCOSE > 12 MMOL/L AND NO INSULIN ADMINISTERED IN PREVIOUS 4 HRS CONSIDER A CORRECTIVE DOSE OF RAPID-ACTING ANALOGUE INSULIN (NOVORAPID®/HUMALOG®/APIDRA®) › Re-check glucose after 4 hours OR before next meal - further action may be required (...) Concise Advice on Inpatient Diabetes during COVID-19 - Guidance for managing inpatient hyperglycaemia Version 4.2 29/4/2020 Page 1 NATIONAL INPATIENT DIABETES COVID-19 RESPONSE GROUP* Use when: o Glucose above 12 mmol/l and a correction dose is appropriate for the individual patient o DKA/HHS not present Can be used in place of variable rate intravenous insulin when infusion pumps not available ? DO NOT use for people with COVID-19 causing severe insulin resistance in the ICU. Contact your

2020 Association of British Clinical Diabetologists

160. SMARThealth India: A stepped-wedge, cluster randomised controlled trial of a community health worker managed mobile health intervention for people assessed at high cardiovascular disease risk in rural India. Full Text available with Trip Pro

SMARThealth India: A stepped-wedge, cluster randomised controlled trial of a community health worker managed mobile health intervention for people assessed at high cardiovascular disease risk in rural India. Cardiovascular diseases (CVD) are rising in India resulting in major health system challenges.Eighteen primary health centre (PHC) clusters in rural Andhra Pradesh were randomised over three, 6-month steps to an intervention comprising: (1) household CVD risk assessments by village-based (...) community health workers (CHWs) using a mobile tablet device; (2) electronic referral and clinical decision support for PHC doctors; and (3) a tracking system for follow-up care. Independent data collectors screened people aged ≥ 40 years in 54 villages serviced by the PHCs to create a high CVD risk cohort (based on WHO risk charts and blood pressure thresholds). Randomly selected, independent samples, comprising 15% of this cohort, were reviewed at each 6-month step. The primary outcome

2019 PLoS ONE Controlled trial quality: predicted high

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