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141. Persuasive System Design Principles and Behavior Change Techniques to Stimulate Motivation and Adherence in Electronic Health Interventions to Support Weight Loss Maintenance: Scoping Review. Full Text available with Trip Pro

Persuasive System Design Principles and Behavior Change Techniques to Stimulate Motivation and Adherence in Electronic Health Interventions to Support Weight Loss Maintenance: Scoping Review. Maintaining weight after weight loss is a major health challenge, and eHealth (electronic health) solutions may be a way to meet this challenge. Application of behavior change techniques (BCTs) and persuasive system design (PSD) principles in eHealth development may contribute to the design of technologies (...) that positively influence behavior and motivation to support the sustainable health behavior change needed.This review aimed to identify BCTs and PSD principles applied in eHealth interventions to support weight loss and weight loss maintenance, as well as techniques and principles applied to stimulate motivation and adherence for long-term weight loss maintenance.A systematic literature search was conducted in PsycINFO, Ovid MEDLINE (including PubMed), EMBASE, Scopus, Web of Science, and AMED, from January 1

2019 Journal of medical Internet research

142. Effects of Clinical Pathways for COPD on Patient, Professional, and Systems Outcomes: A Systematic Review. (Abstract)

Effects of Clinical Pathways for COPD on Patient, Professional, and Systems Outcomes: A Systematic Review. COPD has a substantial burden seen in both patient quality of life and health-care costs. One method of minimizing this burden is the implementation of clinical pathways (CPWs). CPWs bring the best available evidence to a range of health-care professionals by adapting guidelines to a local context and detailing essential steps in care.A systematic review was conducted to address (...) the following question: What are the effects of CPWs for COPD on patient-, professional-, and systems-level outcomes? The review used methods outlined by the Cochrane Collaboration. We included all studies that met our operational definition for CPWs and focused on COPD. All studies were evaluated for risk of bias, and all data regarding patient, professional, and systems outcomes were extracted.The search strategy identified 497 potentially relevant titles. Of these, 13 studies were included in the review

2019 Chest

143. Strategizing health technology assessment for containment of cancer drug costs in a universal health care system: Case of the pan-Canadian oncology drug review. (Abstract)

Strategizing health technology assessment for containment of cancer drug costs in a universal health care system: Case of the pan-Canadian oncology drug review. A universal health care system has been a source of both identity and pride for Canadians for the last 6 decades. Currently, Canada actively negotiates the prices of cancer drugs but is not immune to their overwhelming financial toxicities. Prices of cancer drugs are set to ensure maximal profit based on what the market will bear rather (...) than by the value they offer or solely because of the cost of research and development, as often is claimed by the manufacturers. The pan-Canadian Oncology Drug Review (pCODR) is mandated to provide funding recommendations to Canada's provinces and territories. For the most part, the pCODR has been crucial in assessing the cost-effectiveness and feasibility of new drugs in the Canadian context but it could assist more in safeguarding payers against extreme drug costs. Herein, the author suggests

2019 Cancer

144. PREVALENCE AND TIME TRENDS OF MYOPIA IN CHILDREN AND ADOLESCENTS IN CHINA: A Systemic Review and Meta-Analysis. (Abstract)

PREVALENCE AND TIME TRENDS OF MYOPIA IN CHILDREN AND ADOLESCENTS IN CHINA: A Systemic Review and Meta-Analysis. To estimate prevalence, associated factors, and time trends of myopia in Chinese children and adolescents.We searched PubMed, EMBASE, and Web of Science for studies examining the prevalence of myopia in children and adolescents aged 3 years to 19 years in China before October 2018. We pooled the prevalence and associated factors for myopia and estimated time trends.In 22 eligible

2019 Retina

145. Empirical or microbiologically-guided systemic antimicrobials as adjuncts to non-surgical periodontal therapy? a systematic review. (Abstract)

Empirical or microbiologically-guided systemic antimicrobials as adjuncts to non-surgical periodontal therapy? a systematic review. It is unclear if patients with specific subgingival microbiological profiles benefit more from adjunctive systemic antibiotics.To answer the question: 'What is the clinical benefit in periodontitis patients taking adjunctive systemic antimicrobials to non-surgical therapy, depending on pre-treatment detection of periodontopathogenic bacteria?'A search was conducted

2019 Journal of Clinical Periodontology

146. The effect of computerized decision support systems on cardiovascular risk factors: a systematic review and meta-analysis. Full Text available with Trip Pro

The effect of computerized decision support systems on cardiovascular risk factors: a systematic review and meta-analysis. Cardiovascular risk management (CVRM) is notoriously difficult because of multi-morbidity and the different phenotypes and severities of cardiovascular disease. Computerized decision support systems (CDSS) enable the clinician to integrate the latest scientific evidence and patient information into tailored strategies. The effect on cardiovascular risk factor management (...) is yet to be confirmed.We performed a systematic review and meta-analysis evaluating the effects of CDSS on CVRM, defined as the change in absolute values and attainment of treatment goals of systolic blood pressure (SBP), low density lipoprotein cholesterol (LDL-c) and HbA1c. Also, CDSS characteristics related to more effective CVRM were identified. Eligible articles were methodologically appraised using the Cochrane risk of bias tool. We calculated mean differences, relative risks

2019 Medical Informatics and Decision Making

147. Placebo-responses in randomized controlled trials for systemic therapy in atopic dermatitis: a systematic review and meta-analysis. (Abstract)

Placebo-responses in randomized controlled trials for systemic therapy in atopic dermatitis: a systematic review and meta-analysis. Atopic dermatitis (AD) has variable disease course, intermittent triggers, and responses to topical therapy, which may impact placebo-response in AD trials.To determine the predictors of placebo-response in randomized controlled trials (RCT) of AD.We performed a systematic review and meta-analysis of RCT for systemic therapy in AD from 2007-2018. Cochrane Library (...) of males, mild-moderate mean baseline EASI scores, and no blinding. For NRS-/VRS-itch, placebo-response was associated with a higher proportion of males, moderate-severe mean baseline itch scores. For DLQI, placebo-response was associated with a higher proportion of males, moderate-severe mean baseline itch scores.Placebo-responses can be reduced in clinical trials of systemic therapy in AD by incorporating double/triple-blinding, balancing the sex distribution of patients, disallowing concomitant

2019 Journal of American Academy of Dermatology

148. Renal Denervation Update From the International Sympathetic Nervous System Summit: JACC State-of-the-Art Review. (Abstract)

Renal Denervation Update From the International Sympathetic Nervous System Summit: JACC State-of-the-Art Review. Three recent renal denervation studies in both drug-naïve and drug-treated hypertensive patients demonstrated a significant reduction of ambulatory blood pressure compared with respective sham control groups. Improved trial design, selection of relevant patient cohorts, and optimized interventional procedures have likely contributed to these positive findings. However, substantial (...) variability in the blood pressure response to renal denervation can still be observed and remains a challenging and important problem. The International Sympathetic Nervous System Summit was convened to bring together experts in both experimental and clinical medicine to discuss the current evidence base, novel developments in our understanding of neural interplay, procedural aspects, monitoring of technical success, and others. Identification of relevant trends in the field and initiation of tailored

2019 Journal of the American College of Cardiology

149. Ultrasound in the assessment of interstitial lung disease in systemic sclerosis. A systematic literature review by the OMERACT Ultrasound Group. (Abstract)

Ultrasound in the assessment of interstitial lung disease in systemic sclerosis. A systematic literature review by the OMERACT Ultrasound Group. To provide an overview of the role of lung ultrasound (LUS) in the assessment of interstitial lung disease (ILD) in systemic sclerosis (SSc) and to discuss the state of validation supporting its clinical relevance and application in daily clinical practice.Original articles, published between January 1997 and October 2017 were included. To identify all (...) available studies, a detailed research pertaining to the topic of review was conducted according to PRISMA guidelines. A systematic research was performed in PubMed and EMBASE. The Quality assessment of retrieved articles was performed according the Oxford Center for Evidence-based Medicine. The methodological quality of the studies was assessed using the Cochrane Handbook for Systematic Reviews and QUADAS-2 tool.From 300 papers identified, 12 were included for the analysis. LUS passed the filter

2019 Journal of Rheumatology

150. The association between schizophrenia and the immune system: Review of the evidence from unbiased 'omic-studies'. (Abstract)

The association between schizophrenia and the immune system: Review of the evidence from unbiased 'omic-studies'. A role for immune processes in the pathogenesis of schizophrenia has been suggested by genetic and epidemiological studies, as well as cross-sectional studies on blood and brain samples. However, results are heterogeneous, which is likely caused by low samples sizes, insufficient control of confounders that influence immune processes, and potentially publication bias. Large (...) hypothesis-free 'omic' studies partially circumvent these problems and could provide further evidence for a role of immune pathways in schizophrenia. In this review we assessed whether the largest genome, transcriptome and methylome studies in schizophrenia to date support a link with the immune system. We constructed an overview of the schizophrenia-associated genes and transcripts that were identified in these large 'omic' studies. We then performed a hypothesis-driven analysis to examine

2019 Schizophrenia Research

151. Musculoskeletal Ultrasound in Systemic Lupus Erythematosus: Systematic Literature Review by the Lupus Task Force of the OMERACT Ultrasound Working Group. (Abstract)

Musculoskeletal Ultrasound in Systemic Lupus Erythematosus: Systematic Literature Review by the Lupus Task Force of the OMERACT Ultrasound Working Group. To identify and synthesize the best available evidence on the application of musculoskeletal ultrasound (US) in patients with systemic lupus erythematosus (SLE) and to present the measurement properties of US in different elementary lesion and pathologies.A systematic literature search of PubMed, Embase and the Cochrane Library was performed (...) (3/15, 20%) evaluated inter-observer reliability but none had evaluated intra-observer reliability. Criterion validity was assessed in 1 study (1/15, 7%). Responsiveness was not considered in any of the studies.This literature review demonstrates the need of further research and validation work to define the role of US as an outcome measurement instrument for the musculoskeletal manifestations in SLE patients.

2019 Journal of Rheumatology

152. Does Adjuvant Treatment with Chinese Herbal Medicine to Antidiabetic Agents Have Additional Benefits in Patients with Type 2 Diabetes? A System Review and Meta-Analysis of Randomized Controlled Trials. Full Text available with Trip Pro

Does Adjuvant Treatment with Chinese Herbal Medicine to Antidiabetic Agents Have Additional Benefits in Patients with Type 2 Diabetes? A System Review and Meta-Analysis of Randomized Controlled Trials. In the present meta-analysis, we aimed to determine the effects of adjuvant treatment with Chinese herbal medicine (CHM) on antidiabetic agents having additional benefits in patients with type 2 diabetes.Randomized controlled trials were identified by searching the Cochrane Library, PUBMED

2019 Evidence-based Complementary and Alternative Medicine (eCAM)

153. Evaluation of three stone-scoring systems for predicting SFR and complications after percutaneous nephrolithotomy: a systematic review and meta-analysis. Full Text available with Trip Pro

Evaluation of three stone-scoring systems for predicting SFR and complications after percutaneous nephrolithotomy: a systematic review and meta-analysis. Clinical studies assessing the feasibility and accuracy of three stone scoring systems's (SSSs: Guy's stone score, CROES nomogram and S.T.O.N.E nephrolithometry scoring system) have reported contradictory outcomes. This systematic evaluation was performed to obtain comprehensive evidence with regard to the feasibility and accuracy of three (...) SSSs. Nonetheless, Guy score was the only stone scoring system that predicted complications after PCNL (WMD = -0.29, 95% CI: - 0.57 to - 0.02, P = 0.03).Our meta-analysis indicated that the three SSSs were equally, feasible and accurate for predicting SFR after PCNL. However, Guy score was the only stone scoring system that predicted complications after PCNL.

2019 BMC Urology

154. Management of hyperglycaemia in persons with non-insulin-dependent type 2 diabetes mellitus who are started on systemic glucocorticoid therapy: a systematic review. (Abstract)

Management of hyperglycaemia in persons with non-insulin-dependent type 2 diabetes mellitus who are started on systemic glucocorticoid therapy: a systematic review. What is the most effective pharmacological intervention for glycaemic control in known type 2 diabetes mellitus (DM) without prior insulin treatment and newly started on systemic glucocorticoid therapy?We conducted a systematic literature review.We searched MEDLINE, Embase and Cochrane Library databases and Google for articles from (...) 2002 to July 2018.We combined search terms relating to DM (patients, >16 years of age), systemic glucocorticoids, glycaemic control, randomised controlled trials (RCTs) and observational studies.We screened and evaluated articles, extracted data and assessed risk of bias and quality of evidence according to Grading of Recommendations Assessment, Development and Evaluation guidelines.Eight of 2365 articles met full eligibility criteria. Basal-bolus insulin (BBI) strategy for patients under systemic

2019 BMJ open

155. Performance of triage systems in emergency care: a systematic review and meta-analysis. Full Text available with Trip Pro

Performance of triage systems in emergency care: a systematic review and meta-analysis. To assess and compare the performance of triage systems for identifying high and low-urgency patients in the emergency department (ED).Systematic review and meta-analysis.EMBASE, Medline OvidSP, Cochrane central, Web of science and CINAHL databases from 1980 to 2016 with the final update in December 2018.Studies that evaluated an emergency medical triage system, assessed validity using any reference standard (...) as proxy for true patient urgency and were written in English. Studies conducted in low(er) income countries, based on case scenarios or involving less than 100 patients were excluded.Reviewers identified studies, extracted data and assessed the quality of the evidence independently and in duplicate. The Quality Assessment of studies of Diagnostic Accuracy included in Systematic Reviews -2 checklist was used to assess risk of bias. Raw data were extracted to create 2×2 tables and calculate sensitivity

2019 BMJ open

156. Integrating the prevention and control of rheumatic heart disease into country health systems: a systematic review protocol. Full Text available with Trip Pro

Integrating the prevention and control of rheumatic heart disease into country health systems: a systematic review protocol. Rheumatic heart disease (RHD) is a preventable chronic condition affecting the valves of the heart. RHD prevention and care programmes have historically originated in more developed countries, implemented in a targeted (or vertical) manner and evaluated using non-controlled approaches. Taking a broad view of the integration of RHD activities within the whole system (...) is critical for health planning in low-income regions with a high burden of RHD and less robust health systems. Therefore, we propose to conduct a systematic review to assess RHD programme models in order to gain a better understanding of the extent of integration within relevant health systems.A predefined search strategy will be used to search for relevant articles published in English from January 1990 to December 2017. Electronic databases PubMed, Scopus, Web of Science, Africa Wide, CINAHL, Cochrane

2019 BMJ open

157. A Review and Update of Treatment Options Using the Acne Scar Classification System. (Abstract)

A Review and Update of Treatment Options Using the Acne Scar Classification System. An unfortunate consequence of acne vulgaris is residual scarring that can negatively affect a patient's quality of life.Jacob and colleagues have previously described an acne scar classification system based on acne scar pathology that divided atrophic acne scars into icepick, rolling, and boxcar scars, and this review will evaluate new and developing treatment options for acne scarring.A Medline search (...) was performed on the various treatments for acne scars, and particular attention was placed on articles that used the acne scar classification system of icepick, rolling, and boxcar scars.Therapies for acne scarring included surgical modalities, such as subcision, and punch excision and elevation, injectable fillers, chemical peels, dermabrasion, microneedling, and energy-based devices. In the past decade, there has been a trend toward using cosmetic fillers and energy-based devices to improve acne

2019 Dermatologic Surgery

158. Multifocal versus monofocal intraocular lenses for age related cataract patients: A system review and meta-analysis based on randomized controlled trials. Full Text available with Trip Pro

Multifocal versus monofocal intraocular lenses for age related cataract patients: A system review and meta-analysis based on randomized controlled trials. We compare multifocal intraocular lenses (MFIOLs) to monofocal IOLs for visual acuity, contrast sensitivity, and adverse events using data from 21 randomized controlled trials with 2951 subjects. There was no statistical difference between uncorrected distance visual acuity (VA) and corrected distance VA. Compared with monofocal IOLs, MFIOLs

2019 Survey of Ophthalmology

159. Review: Using diffusion-weighted magnetic resonance imaging techniques to explore the microstructure and connectivity of subcortical white matter tracts in the human auditory system. (Abstract)

Review: Using diffusion-weighted magnetic resonance imaging techniques to explore the microstructure and connectivity of subcortical white matter tracts in the human auditory system. Since its inception 30 years ago, diffusion-weighted magnetic resonance imaging (dMRI) has advanced to become a common component of routine clinical MRI examinations. Diffusion-weighted magnetic resonance offers a way to measure anisotropic diffusion in-vivo, which has led to the development of techniques capable (...) of characterising the orientation of diffusion within living tissue. These modelling techniques can be used to investigate the microstructure and connectivity of white matter tracts within the human brain. Such techniques have been used to study many neural networks within the human body. There is, however, a notable paucity of research utilising dMRI techniques to investigate the white matter tracts of the auditory brainstem. In this review we provide a brief introduction to the basic principles of dMRI

2019 Hearing Research

160. Retropubic versus transobturator midurethral slings in patients at a high risk of recurrent stress incontinence: A systemic review and meta-analysis. (Abstract)

Retropubic versus transobturator midurethral slings in patients at a high risk of recurrent stress incontinence: A systemic review and meta-analysis. The efficacy and safety of retropubic (RP) and transobturator (TO) tension-free vaginal tape (TVT) midurethral slings (MUSs) for SUI patients with risk factors for recurrence remain controversial. We compare the techniques within selected groups (patients with obesity, intrinsic sphincter deficiency [ISD], pelvic organ prolapse [POP], and SUI (...) recurrence after initial MUS).We used the PRISMA statement to report the methods and results of the present review. Randomized controlled trials and observational studies were included. Objective cure rate, subjective cure rate, and complication rate were assessed using odds ratio (ORs) with 95% confidence intervals (CIs). The protocol for the present meta-analysis was registered in the PROSPERO database (No. CRD42018102233).We retrieved 28 studies (n=2607) to compare the efficacy and safety of RP-TVT

2019 Journal of Urology

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