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121. Ultrasound in the assessment of interstitial lung disease in systemic sclerosis. A systematic literature review by the OMERACT Ultrasound Group. (Abstract)

Ultrasound in the assessment of interstitial lung disease in systemic sclerosis. A systematic literature review by the OMERACT Ultrasound Group. To provide an overview of the role of lung ultrasound (LUS) in the assessment of interstitial lung disease (ILD) in systemic sclerosis (SSc) and to discuss the state of validation supporting its clinical relevance and application in daily clinical practice.Original articles, published between January 1997 and October 2017 were included. To identify all (...) available studies, a detailed research pertaining to the topic of review was conducted according to PRISMA guidelines. A systematic research was performed in PubMed and EMBASE. The Quality assessment of retrieved articles was performed according the Oxford Center for Evidence-based Medicine. The methodological quality of the studies was assessed using the Cochrane Handbook for Systematic Reviews and QUADAS-2 tool.From 300 papers identified, 12 were included for the analysis. LUS passed the filter

2019 Journal of Rheumatology

122. The association between schizophrenia and the immune system: Review of the evidence from unbiased 'omic-studies'. (Abstract)

The association between schizophrenia and the immune system: Review of the evidence from unbiased 'omic-studies'. A role for immune processes in the pathogenesis of schizophrenia has been suggested by genetic and epidemiological studies, as well as cross-sectional studies on blood and brain samples. However, results are heterogeneous, which is likely caused by low samples sizes, insufficient control of confounders that influence immune processes, and potentially publication bias. Large (...) hypothesis-free 'omic' studies partially circumvent these problems and could provide further evidence for a role of immune pathways in schizophrenia. In this review we assessed whether the largest genome, transcriptome and methylome studies in schizophrenia to date support a link with the immune system. We constructed an overview of the schizophrenia-associated genes and transcripts that were identified in these large 'omic' studies. We then performed a hypothesis-driven analysis to examine

2019 Schizophrenia Research

123. Musculoskeletal Ultrasound in Systemic Lupus Erythematosus: Systematic Literature Review by the Lupus Task Force of the OMERACT Ultrasound Working Group. (Abstract)

Musculoskeletal Ultrasound in Systemic Lupus Erythematosus: Systematic Literature Review by the Lupus Task Force of the OMERACT Ultrasound Working Group. To identify and synthesize the best available evidence on the application of musculoskeletal ultrasound (US) in patients with systemic lupus erythematosus (SLE) and to present the measurement properties of US in different elementary lesion and pathologies.A systematic literature search of PubMed, Embase and the Cochrane Library was performed (...) (3/15, 20%) evaluated inter-observer reliability but none had evaluated intra-observer reliability. Criterion validity was assessed in 1 study (1/15, 7%). Responsiveness was not considered in any of the studies.This literature review demonstrates the need of further research and validation work to define the role of US as an outcome measurement instrument for the musculoskeletal manifestations in SLE patients.

2019 Journal of Rheumatology

124. A Review and Update of Treatment Options Using the Acne Scar Classification System. (Abstract)

A Review and Update of Treatment Options Using the Acne Scar Classification System. An unfortunate consequence of acne vulgaris is residual scarring that can negatively affect a patient's quality of life.Jacob and colleagues have previously described an acne scar classification system based on acne scar pathology that divided atrophic acne scars into icepick, rolling, and boxcar scars, and this review will evaluate new and developing treatment options for acne scarring.A Medline search (...) was performed on the various treatments for acne scars, and particular attention was placed on articles that used the acne scar classification system of icepick, rolling, and boxcar scars.Therapies for acne scarring included surgical modalities, such as subcision, and punch excision and elevation, injectable fillers, chemical peels, dermabrasion, microneedling, and energy-based devices. In the past decade, there has been a trend toward using cosmetic fillers and energy-based devices to improve acne

2019 Dermatologic Surgery

125. Review: Using diffusion-weighted magnetic resonance imaging techniques to explore the microstructure and connectivity of subcortical white matter tracts in the human auditory system. (Abstract)

Review: Using diffusion-weighted magnetic resonance imaging techniques to explore the microstructure and connectivity of subcortical white matter tracts in the human auditory system. Since its inception 30 years ago, diffusion-weighted magnetic resonance imaging (dMRI) has advanced to become a common component of routine clinical MRI examinations. Diffusion-weighted magnetic resonance offers a way to measure anisotropic diffusion in-vivo, which has led to the development of techniques capable (...) of characterising the orientation of diffusion within living tissue. These modelling techniques can be used to investigate the microstructure and connectivity of white matter tracts within the human brain. Such techniques have been used to study many neural networks within the human body. There is, however, a notable paucity of research utilising dMRI techniques to investigate the white matter tracts of the auditory brainstem. In this review we provide a brief introduction to the basic principles of dMRI

2019 Hearing Research

126. Local Anesthetic Systemic Toxicity: A Narrative Literature Review and Clinical Update on Prevention, Diagnosis and Management. (Abstract)

Local Anesthetic Systemic Toxicity: A Narrative Literature Review and Clinical Update on Prevention, Diagnosis and Management. The objective of this narrative review of local anesthetic systemic toxicity is to provide an update on its prevention, diagnosis and management.The authors employed a MEDLINE search using human, animal studies and case reports and summarize findings following the American Society of Regional Anesthesia and Pain Medicine practice advisories on local anesthetic systemic (...) toxicity.Between March 2014 and November 2016, there were 47 cases of systemic toxicity described. Twenty-two patients (47%) were treated with intravenous lipid emulsion and two patients (4.3%) died. Seizures were the most common presentation. The spectrum of presenting neurologic and cardiovascular symptoms and signs are broad and can be obscured by perioperative processes. Local anesthetic type, dosage and volume, site of injection and patient comorbidities influence the rate of absorption from site

2019 Plastic and reconstructive surgery

127. Vision-based serious games and virtual reality systems for motor rehabilitation: A review geared toward a research methodology. (Abstract)

Vision-based serious games and virtual reality systems for motor rehabilitation: A review geared toward a research methodology. Nowadays, information technologies are being widely adopted to promote healthcare and rehabilitation. Owing to their affordability and use of hand-free controllers, vision-based systems have gradually been integrated into motor rehabilitation programs and have greatly drawn the interest of healthcare practitioners and the research community. Many studies have (...) illustrated the effectiveness of these systems in rehabilitation. However, the report and design aspects of the reported clinical trials were disregarded.In this paper, we present a systematic literature review of the use of vision-based serious games and virtual reality systems in motor rehabilitation programs. We aim to propose a research methodology that engineers can use to improve the designing and reporting processes of their clinical trials.We conducted a review of published studies that entail

2019 International journal of medical informatics

128. Prenatally diagnosed developmental abnormalities of the central nervous system and genetic syndromes: A practical review. Full Text available with Trip Pro

Prenatally diagnosed developmental abnormalities of the central nervous system and genetic syndromes: A practical review. Developmental brain abnormalities are complex and can be difficult to diagnose by prenatal imaging because of the ongoing growth and development of the brain throughout pregnancy and the limitations of ultrasound, often requiring fetal magnetic resonance imaging as an additional tool. As for all major structural congenital anomalies, amniocentesis with chromosomal microarray (...) and a karyotype is the first-line recommended test for the genetic work-up of prenatally diagnosed central nervous system (CNS) abnormalities. Many CNS defects, especially neuronal migration defects affecting the cerebral and cerebellar cortex, are caused by single-gene mutations in a large number of different genes. Early data suggest that prenatal diagnostic exome sequencing for fetal CNS defects will have a high diagnostic yield, but interpretation of sequencing results can be complex. Yet a genetic

2019 Prenatal diagnosis

129. Cutaneous candidiasis - an evidence-based review of topical and systemic treatments to inform clinical practice. (Abstract)

Cutaneous candidiasis - an evidence-based review of topical and systemic treatments to inform clinical practice. Cutaneous candidiasis is a common skin disease, and several treatments have been investigated within the last fifty years. Yet, systematic reviews are lacking, and evidence-based topical and systemic treatment strategies remain unclear. Thus, the aim of this review was to summarize efficacy and adverse effects of topical and oral therapies for cutaneous candidiasis in all age groups (...) . Two individual researchers searched PubMed and EMBASE for 'cutaneous candidiasis' and 'cutaneous candidiasis treatment', 'intertrigo', 'diaper dermatitis' and 'cheilitis'. Searches were limited to 'English language', 'clinical trials' and 'human subjects', and prospective clinical trials published in abstracts or articles were included. In total, 149 studies were identified, of which 44 were eligible, comprising 41 studies of 19 topical therapies and four studies of three systemic therapies

2019 Journal of the European Academy of Dermatology and Venereology

130. Sex hormones and sex hormone-targeting therapies in systemic sclerosis: A systematic literature review. (Abstract)

Sex hormones and sex hormone-targeting therapies in systemic sclerosis: A systematic literature review. The pathophysiology of systemic sclerosis (SSc) is complex and elusive, however, considering the strong female preponderance and different clinical characteristics between men and women, a contribution of sex hormones has been proposed.We undertook this systematic literature review to investigate: (1) the role played by male and female sex hormones in the pathogenesis of SSc; (2) how sex (...) hormone levels change in SSc patients and how hormonal variations modify the progression of SSc; (3) the effect of therapies targeting sex hormones on the disease course.A literature search was performed in Pubmed, Embase, Web of Science, and Cochrane library databases. Given the heterogeneity in study design, different quality assessment tools were applied where appropriate.We retrieved 300 articles and 30 were included in the review. The available evidence points to a fibrogenic, but also

2019 Seminars in arthritis and rheumatism

131. Systematic Literature Review of Systemic Corticosteroid Use for Asthma Management. Full Text available with Trip Pro

Systematic Literature Review of Systemic Corticosteroid Use for Asthma Management. Systemic corticosteroid use to manage uncontrolled asthma and its associated health care burden may account for important health-related adverse effects. We conducted a systematic literature review to investigate the real-world extent and burden of systemic corticosteroid use in asthma. We searched MEDLINE® and Embase® databases to identify English-language articles published from 2010-2017, using search terms (...) for asthma with key words for oral corticosteroids and systemic corticosteroids. Observational studies, prescription database analyses, economic analyses, and surveys on oral/systemic corticosteroid use for children (aged >5 years), adolescents (aged 12-17 years), and adults with asthma were included. We identified and reviewed 387 full-text articles, and our review included data from 139 studies. The included studies were conducted in Europe, North America, and Asia. Overall, oral/systemic

2019 American journal of respiratory and critical care medicine

132. How does feedback shared with interprofessional health care teams shape nursing performance improvement systems? A rapid realist review protocol. Full Text available with Trip Pro

How does feedback shared with interprofessional health care teams shape nursing performance improvement systems? A rapid realist review protocol. Nursing care quality varies between hospitals, and even between departments within the same institution. Suboptimal care can have deleterious consequences for patients such as lengthened hospital stay, nosocomial infection, pressure ulcers or death. Experts recommend the implementation of nursing performance improvement systems to assess team (...) to theorise operational feedback.The innovative combination of Actor-Network Theory with a realist methodology holds promise for the identification of explanatory equations in complex systems and theory development. A rapid realist review is relevant to address an enduring knowledge gap which requires theory development. This preliminary study lays the groundwork for a pioneering theory on feedback in nursing performance improvement systems that will subsequently inform a multiple case study.Prospero

2019 Systematic reviews

133. "Implementation Is so Difficult": Survey of National Learning Health System Decision-makers Identifies Need For Implementation Information in Evidence Reviews. Full Text available with Trip Pro

"Implementation Is so Difficult": Survey of National Learning Health System Decision-makers Identifies Need For Implementation Information in Evidence Reviews. Evidence use within learning health care systems can improve patient health outcomes. Embedded in the Veterans Health Administration (VHA) since 2007, the Veterans Affairs Evidence Synthesis Program (ESP) provides tailored evidence synthesis services to support VHA's learning health care system goals. As part of the ESP's ongoing quality (...) improvement efforts, we have been surveying our users since 2016.We reviewed data from a survey of end-users received between September 5, 2016, and June 10, 2019. The survey assessed: (1) nature of decision-making needs; (2) actions resulting from the report's findings; (3) implementation timeframe; and (4) overall perception of report content.Feedback was received from 66 of the 138 operational partners requesting ESP products during the fiscal year 2015 through 2018. Requests commonly informed clinical

2019 Medical Care

134. Current management of central nervous system metastasis from cholangiocarcinoma: the neurosurgical perspective. Literature review. (Abstract)

Current management of central nervous system metastasis from cholangiocarcinoma: the neurosurgical perspective. Literature review. Purpose: Central nervous system (CNS) metastasis from cholangiocarcinoma (CCA) are extremely rare and associated prognosis is poor. The involvement of the CNS by metastatic CCA may discourage any further treatment; however, data from the literature are discordant, due to recent reports of exceptionally long follow-up after surgical resection of a brain metastasis (...) . Material and Methods: Electronic databases, such as PubMed/MEDLINE and Google Scholar, were analyzed for studies published up to October 2018 using the search term "cholangiocarcinoma and central nervous system metastasis or brain metastasis". Results: We found a total of 18 studies cited in the literature of the 30 year span analyzed, and we added a new case we treated at our Institution, reaching a series of 32 patients. Among these, 7 patients had leptomeningeal dissemination and 25 presented solid

2019 British Journal of Neurosurgery

135. Treatment of calcinosis cutis in systemic sclerosis and dermatomyositis: a review of the literature. (Abstract)

Treatment of calcinosis cutis in systemic sclerosis and dermatomyositis: a review of the literature. We have limited data on the treatment of calcinosis cutis associated with systemic sclerosis (SSc) and dermatomyositis (DM).To assess the efficacy and tolerance of available treatments for calcinosis cutis based on previously published studies.We performed a systematic review of studies published in MEDLINE, Embase, and the Cochrane library between 1980 and July 2018. The strength of clinical

2019 Journal of American Academy of Dermatology

136. Review article: the role of the autonomic nervous system in the pathogenesis and therapy of IBD. Full Text available with Trip Pro

Review article: the role of the autonomic nervous system in the pathogenesis and therapy of IBD. There is a growing body of evidence implicating a role for the brain-gut axis in the pathogenesis of inflammation in patients with IBD.To perform a narrative review of published literature regarding the association of the autonomic nervous system and intestinal inflammation and to describe the rationale for and emerging use of autonomic manipulation as a therapeutic agent METHODS: Current relevant (...) literature was summarised and critically examined.There is substantial pre-clinical and clinical evidence for a multifaceted anti-inflammatory effect of the vagus at both systemic and local intestinal levels. It acts via acetylcholine-mediated activation of α-7-acetylcholine receptors involving multiple cell types in innate and adaptive immunity and the enteric nervous system with subsequent protective influences on the intestinal barrier, inflammatory mechanisms and the microbiome. In patients with IBD

2019 Alimentary Pharmacology & Therapeutics

137. Classification of patients with cold sensation by a review of systems database: A single-centre observational study. (Abstract)

Classification of patients with cold sensation by a review of systems database: A single-centre observational study. In Kampo medicine, a traditional medicine pattern(TM1) refers to the complete clinical presentation of the patient at a given moment in time. Candidate herbal formulas are chosen for a chief complaint, and an appropriate formula is determined on the basis of the pattern(TM1) diagnosis. In this study, we demonstrated the importance of accompanying symptoms in diagnosing (...) traditional medicine patterns(TM1).Single centre observational study.We analysed data from 524 new patients with a hypersensitivity to cold sensation as their primary diagnosis (mean age 51.6 ± 17.8 years; female ratio 82.1%) who visited the Keio University Hospital Kampo Clinic between 2008 and 2013.Accompanying symptoms were recorded on the browser-based e-questionnaire system, which contained 128 items. The Japan Society for Oriental Medicine's board certified Kampo specialists diagnosed

2019 Complementary Therapies In Medicine

138. Molecular mechanisms of action of systemic lidocaine in acute and chronic pain: a narrative review. (Abstract)

Molecular mechanisms of action of systemic lidocaine in acute and chronic pain: a narrative review. Systemic administration of the local anaesthetic lidocaine is antinociceptive in both acute and chronic pain states, especially in acute postoperative and chronic neuropathic pain. These effects cannot be explained by its voltage-gated sodium channel blocking properties alone, but the responsible mechanisms are still elusive. This narrative review focuses on available experimental evidence (...) of the molecular mechanisms by which systemic lidocaine exerts its clinically documented analgesic effects. These include effects on the peripheral nervous system and CNS, where lidocaine acts via silencing ectopic discharges, suppression of inflammatory processes, and modulation of inhibitory and excitatory neurotransmission. We highlight promising objectives for future research to further unravel these antinociceptive mechanisms, which subsequently may facilitate the development of new analgesic strategies

2019 British Journal of Anaesthesia

139. The State of the Evidence for Whole-System, Multi-Modality Naturopathic Medicine: A Systematic Scoping Review. Full Text available with Trip Pro

The State of the Evidence for Whole-System, Multi-Modality Naturopathic Medicine: A Systematic Scoping Review. To summarize the current state of the research evidence for whole-system, multi-modality naturopathic medicine.A systematic search for research articles from around the world was undertaken using MEDLINE, Embase, CINAHL, AMED, and WHO regional indexes. Naturopathic journals and gray literature were hand searched. No language restrictions were imposed.All human research evaluating (...) the effectiveness of naturopathic medicine, where two or more naturopathic modalities are delivered by naturopathic clinicians, were included in the review. Case studies of five or more cases were included.Thirty-three published studies (n = 9859) met inclusion criteria (11 American; 4 Canadian; 6 German; 7 Indian; 3 Australian; 1 United Kingdom; and 1 Japanese) across a range of mainly chronic clinical conditions. The studies predominantly showed evidence for the efficacy of naturopathic medicine

2019 Journal of Alternative and Complementary Medicine

140. Whole Systems Research Methods in Health Care: A Scoping Review. Full Text available with Trip Pro

Whole Systems Research Methods in Health Care: A Scoping Review. This scoping review evaluates two decades of methodological advances made by "whole systems research" (WSR) pioneers in the fields of traditional, complementary, and integrative medicine (TCIM). Rooted in critiques of the classical randomized controlled trial (RCT)'s suitability for evaluating holistic, complex TCIM interventions, WSR centralizes the principle of "model validity," representing a "fit" between research design (...) and therapeutic paradigm.In consultation with field experts, 41 clinical research exemplars were selected for review from across 13 TCIM disciplines, with the aim of mapping the range and methodological characteristics of WSR studies. Using an analytic charting approach, these studies' primary and secondary features are characterized with reference to three focal areas: research method, intervention design, and outcome assessment.The reviewed WSR exemplars investigate a wide range of multimodal

2019 Journal of Alternative and Complementary Medicine

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