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125661. The structure and mechanism of neurotransmitter receptors. Implications for the structure and function of the central nervous system. Full Text available with Trip Pro

The structure and mechanism of neurotransmitter receptors. Implications for the structure and function of the central nervous system. 2893605 1988 03 23 2018 11 13 0264-6021 249 2 1988 Jan 15 The Biochemical journal Biochem. J. The structure and mechanism of neurotransmitter receptors. Implications for the structure and function of the central nervous system. 309-18 Strange P G PG Biological Laboratory, University, Canterbury, Kent, U.K. eng Journal Article Review England Biochem J 2984726R (...) 0264-6021 0 Neurotransmitter Agents 0 Receptors, Neurotransmitter IM Alzheimer Disease metabolism Animals Central Nervous System metabolism Humans Neurotransmitter Agents metabolism Parkinson Disease metabolism Receptors, Neurotransmitter metabolism 162 1988 1 15 1988 1 15 0 1 1988 1 15 0 0 ppublish 2893605 PMC1148704 Nature. 1987 Apr 30-May 6;326(6116):824-5 3574457 Nature. 1987 May 7-13;327(6117):67-70 3033513 Science. 1987 May 1;236(4801):600-5 3107123 Brain Res. 1987 Apr 21;409(2):403-8 2884017

1988 Biochemical Journal

125662. Exposure reduction in cephalography with a digital photostimulable phosphor imaging system. (Abstract)

Exposure reduction in cephalography with a digital photostimulable phosphor imaging system. The effect on the determination of the cephalometric landmarks of exposure reduction using computed radiography with a photostimulable storage phosphor was evaluated. Forty patients attending for regular review were divided into four groups of 10. The first group was exposed to the same amount of radiation as that required for a conventional calcium tungstate screen-film combination. The other three (...) groups were exposed to approximately 50, 20 and 10% respectively of the radiation dose of the first group. Ten dentists determined the landmarks. The coordinates of the points were recorded to measure the consistency of landmark identification. It was found that in comparison with the conventional screen-film system, a substantial reduction of exposure could be achieved with computed radiography for cephalography without clinical detriment.

1993 Dento maxillo facial radiology Controlled trial quality: uncertain

125663. Diazepam's effect on systemic vascular resistance during cardiopulmonary bypass is not caused by its vehicle (alcohol-propylene glycol). (Abstract)

Diazepam's effect on systemic vascular resistance during cardiopulmonary bypass is not caused by its vehicle (alcohol-propylene glycol). Control of hemodynamic parameters during cardiopulmonary bypass (CPB) is a desirable goal of the anesthesiologist. Diazepam is known to reduce systemic vascular resistance (SVR) during CPB. This study tested the hypothesis that diazepam reduces SVR during CPB through the action of its vehicle, alcohol-propylene glycol (APG). The study protocol was approved (...) by the Institution's Human Experimentation Review Board and all patients gave informed consent. Premedication, induction, and maintenance of anesthesia were standardized. Thirty consecutive patients undergoing nonemergent cardiac surgical procedures were randomized to receive a standardized amount of diazepam, diazemuls, or alcohol-propylene glycol during stable CPB. SVR in the diazepam group decreased significantly (1,242 to 968 dyne.s.cm-5, P < 0.05) compared to baseline; whereas there was no significant change

1993 Journal of cardiothoracic and vascular anesthesia Controlled trial quality: uncertain

125664. Prevalence of systemic and ocular disease in infantile exotropia: comparison with infantile esotropia. (Abstract)

series.Medical records of 70 patients diagnosed with exotropia in the first year of life were reviewed and compared with records of 136 patients diagnosed with esotropia before 1 year of age.Patients with no disorders (other than latent nystagmus, dissociated vertical deviation, or oblique muscle overaction) were grouped as "simple" strabismus. Patients with systemic disorders (including prematurity, neurologic disease, and genetic disease) and patients with ocular disorders (including congenital nystagmus (...) Prevalence of systemic and ocular disease in infantile exotropia: comparison with infantile esotropia. Exotropia in infancy is believed to be associated with an increased prevalence of neurologic, ocular, and craniofacial abnormalities; however, the prevalence of coexisting ocular and systemic disease in these patients is unknown. In this study, the prevalence of ocular disease and systemic illness was determined in patients diagnosed with exotropia in infancy.Observational comparative case

1999 Ophthalmology

125665. Use of granulocyte colony-stimulating factor (G-CSF) in patients receiving myelosuppressive chemotherapy for the treatment of cancer. Provincial Systemic Treatment Disease Site Group. (Abstract)

receiving myelosuppressive chemotherapy for the treatment of cancer.Clinical outcomes reflecting events that may affect quality of life and/or resource utilization (e.g., rates and duration of hospitalization, antibiotic use); outcomes reflecting the effect of treatment on infection rates, tumour response and survival and those related to the biological effect of G-CSF.Evidence was selected, reviewed and synthesized by members of the Provincial Systemic Treatment Disease Site Group (DSG) of the Cancer (...) Care Ontario Practice Guidelines Initiative. Drafts of this document have been circulated and reviewed by members of the Systemic Treatment DSG. The DSG comprises medical oncologists, pharmacists, supportive care personnel and administrators. Evaluation by clinicians was considered in the final practice guideline. Community representatives did not participate in the development of this report but will in future reports. Guidelines approval does require participation by community representatives.Two

1998 Cancer prevention & control : CPC = Prévention & contrôle en cancérologie : PCC Controlled trial quality: predicted high

125666. PACS in sonography: accuracy of interpretation using film compared with monitor display. Picture archiving and communication systems. (Abstract)

PACS in sonography: accuracy of interpretation using film compared with monitor display. Picture archiving and communication systems. The goal of this study was to determine the relative accuracy of interpretation of sonography when viewed on a monitor or on film.Four radiologists twice interpreted a series of 440 sonograms using the following sequences of display formats for initial and second interpretations: film-film, film-monitor, monitor-film, and monitor-monitor. Reporting discrepancies (...) between the initial and subsequent interpretation were reviewed by an arbitration panel unaware of the display mode. Results were analyzed for differences in error rate attributable to film versus monitor display format, chronology of interpretation, individual observer, and observer seniority.We found no statistically significant difference in the error rate for film (10.3%) versus monitor display format (14.6%) (p = .09). Likewise, we found no significant differences in the error rates attributable

1999 AJR. American journal of roentgenology Controlled trial quality: uncertain

125667. A new objective digital computerized vision screening system. (Abstract)

A new objective digital computerized vision screening system. Fewer than 40% of children in the crucial younger-than-4 age group are evaluated for visual problems by pediatricians. This is due to impracticality from either a clinical or practice efficiency standpoint. Current photoscreening methods require trained readers and suffer from significant subjectivity and interobserver variability. We report a cross-sectional, double-masked study using new digital imaging with objective, automated (...) , computerized image analysis.Two-hundred six children aged 9 months to 16 years were prospectively studied in a University-based pediatric ophthalmology practice. Images were taken by volunteers with a modified digital camera which, when downloaded, were analyzed within 35 seconds by new image analysis software. The analysis was compared to a masked review of a complete pediatric ophthalmic exam.Overall agreement between physician and the objective computerized analysis was 86.9%. Positive predictive value

1999 Journal of pediatric ophthalmology and strabismus Controlled trial quality: uncertain

125668. A clinical comparison of the safety and efficacy of MultiHance (gadobenate dimeglumine) and Omniscan (Gadodiamide) in magnetic resonance imaging in patients with central nervous system pathology. (Abstract)

A clinical comparison of the safety and efficacy of MultiHance (gadobenate dimeglumine) and Omniscan (Gadodiamide) in magnetic resonance imaging in patients with central nervous system pathology. The safety and diagnostic efficacy of MultiHance (gadobenate dimeglumine) in the central nervous system (CNS) were evaluated in a double-blind, multicenter, phase III clinical trial.Two hundred five patients highly suspected of having a CNS lesion (by previous imaging exam) were enrolled at 16 sites (...) of lesions detected, and contrast-to-noise ratio measurements. The level of diagnostic information from gadobenate dimeglumine at 0.1 mmol/kg was equivalent to that with gadodiamide at the same dose. One of the two blinded reviewers found equivalence between the gadobenate dimeglumine 0.05 mmol/kg dose and gadodiamide at 0.1 mmol/kg. Both reviewers found the level of diagnostic information to be equivalent after the second dose of contrast for all three dosing regimens. The cumulative doses of gadobenate

2001 Investigative radiology Controlled trial quality: uncertain

125669. Impact of the Edmonton Labeled Visual Information System on physician recall of metastatic cancer patient histories. a randomized controlled trial. (Abstract)

Impact of the Edmonton Labeled Visual Information System on physician recall of metastatic cancer patient histories. a randomized controlled trial. The Edmonton Labeled Visual Information System (ELVIS) is a novel method of documenting clinical information because it is a pictorial method of representing cancer burden and treatment. This randomized, crossover, multiperiod trial involved 16 physicians who each reviewed two ELVIS and two control (text) cancer patient cases (total 32 ELVIS and 32

2001 Journal of pain and symptom management Controlled trial quality: uncertain

125670. Central nervous system stimulants and sport practice. Full Text available with Trip Pro

Central nervous system stimulants and sport practice. Central nervous system (CNS) stimulants may be used to reduce tiredness and increase alertness, competitiveness, and aggression. They are more likely to be used in competition but may be used during training to increase the intensity of the training session. There are several potential dangers involving their misuse in contact sports. This paper reviews the three main CNS stimulants, ephedrine, amfetamine, and cocaine, in relation to misuse

2006 British Journal of Sports Medicine

125671. Supplements and the endocrine system in athletes. (Abstract)

Supplements and the endocrine system in athletes. In the world of athletes' nutrition, there are many ethical concerns, because there is the suspicion that in practice, large doses of supplements in athletes are not taken for nutritional purposes. It is beyond the scope of this article to highlight the possible roles of supplements or methods of supplementation in the improvement of athletic performance in elite athletes. Instead, the author briefly reviews some of the substances taken (...) by athletes, with particular attention to their mechanisms of action and the pathways involved. Very often, the effects of many supplements are hormone-related, or supplements influence hormone secretion. Examples of possible links between "supplements or ergogenic compounds" and the endocrine/metabolic system are addressed.

2008 Clinics in Sports Medicine

125672. Three year follow up of a self certification system for the assessment of fitness to dive in Scotland. Full Text available with Trip Pro

Three year follow up of a self certification system for the assessment of fitness to dive in Scotland. The need for routine medical examinations of sport divers in the Scottish Sub-Aqua Club (Scot-SAC) was revised in March 2000, and a new system using a self administered screening questionnaire was developed to allow divers to be assessed when necessary by doctors with diving medicine experience.To assess the effect of the new medical system on medical referee workload, diver exclusion rates (...) , and diving incident frequency.All divers were required to complete a questionnaire to screen for conditions that might affect fitness to dive. Divers answering "Yes" to any of the questions had their medical background assessed by a diving doctor, and, if necessary, received a clinical examination or investigation. The rate of diver exclusions based on the questionnaire response was recorded in conjunction with analysis of the incident reports.The number of forms requiring review by diving doctors

2004 British Journal of Sports Medicine

125673. Chiropractic consultation requests in the Veterans Affairs Health Care System: demographic characteristics of the initial 100 patients at the Western New York medical center. (Abstract)

Chiropractic consultation requests in the Veterans Affairs Health Care System: demographic characteristics of the initial 100 patients at the Western New York medical center. The objectives of this study were to review the demographic characteristics of Veterans Affairs (VA) chiropractic patients and to determine the level of appropriateness of chiropractic consultation requests within a VA chiropractic clinic. Information regarding the volume of requests and wait times for appointments were (...) obtained to provide insight on the demand for and access to VA chiropractic services.A purposive sample of the first 100 chiropractic consultation requests received through the Computerized Patient Record System at the VA of Western New York Health Care System was selected for data collection and analysis.The VA chiropractic patients in this study were primarily older men with chronic low-back pain that had not responded to medical management and other treatment modalities. More than half

2006 Journal of Manipulative and Physiological Therapeutics

125674. Adjuvant endocrine therapy compared with no systemic therapy for elderly women with early breast cancer: 21-year results of International Breast Cancer Study Group Trial IV. (Abstract)

Adjuvant endocrine therapy compared with no systemic therapy for elderly women with early breast cancer: 21-year results of International Breast Cancer Study Group Trial IV. Increasing numbers of older women are affected by early breast cancer, because of prolonged life expectancy and the increasing incidence of breast cancer with age. The role of adjuvant therapy for this population is still a matter of debate. We reviewed the long-term outcome of a mature trial comparing endocrine treatment (...) continue to be observed in older patients treated for 1 year with p+T. Despite issues relating to competing causes of failure, older breast cancer patients can benefit from treatment and should be considered for trials of adjuvant systemic therapy.

2003 Journal of clinical oncology : official journal of the American Society of Clinical Oncology Controlled trial quality: uncertain

125675. Impact of an encounter-based prompting system on resident vaccine administration performance and immunization knowledge. (Abstract)

Impact of an encounter-based prompting system on resident vaccine administration performance and immunization knowledge. To evaluate an encounter-based immunization prompting system on resident performance in administering vaccines and knowledge of immunization guidelines.Prospective randomized, controlled trial. Subjects were first- and second-year pediatric residents in a hospital-based continuity clinic. The intervention group received manual prompts of immunizations due. Postclinic chart (...) review compared immunizations due with those administered. Acceptable and unacceptable reasons for not administering vaccines were assigned. Resident knowledge was measured by a 70-item examination.The intervention group had significantly less missed opportunities/vaccine administration errors (11.4% vs 21.6%). The most common reason for unacceptable errors in the intervention group: vaccine was given too early; in the control group: vaccine was postponed to next visit. Pre- and postintervention

2000 Pediatrics Controlled trial quality: uncertain

125676. A clinical trial of tailored office systems for preventive service delivery. The Study to Enhance Prevention by Understanding Practice (STEP-UP). (Abstract)

A clinical trial of tailored office systems for preventive service delivery. The Study to Enhance Prevention by Understanding Practice (STEP-UP). The potential of primary care practice settings to prevent disease and morbidity through health habit counseling, screening for asymptomatic disease, and immunizations has been incompletely met. This study was designed to test a practice-tailored approach to increasing preventive service delivery with particular emphasis on health habit (...) for consecutive patients during randomly selected chart review days.A significant increase (p=0.015) in global preventive service delivery rates at the 1-year follow-up was found in the intervention group (31% to 42%) compared to the control group (35% to 37%). Rates specifically for health habit counseling (p=0.007) and screening services (p=0.048) were increased, but not for immunizations.An approach to increasing preventive service delivery that is individualized to meet particular practice needs can

2001 American journal of preventive medicine Controlled trial quality: uncertain

125677. A retrospective analysis of the relationship between changes in serum PSA, palliative response and survival following systemic treatment in a Canadian randomized trial for symptomatic hormone-refractory prostate cancer. (Abstract)

A retrospective analysis of the relationship between changes in serum PSA, palliative response and survival following systemic treatment in a Canadian randomized trial for symptomatic hormone-refractory prostate cancer. To investigate the relationship between changes in serum PSA, palliative response and survival following systemic treatment for symptomatic hormone-refractory prostate cancer (HRPC).A retrospective review of 161 patients, treated with mitoxantrone and prednisone (M + P) (n = 80

2001 Annals of oncology : official journal of the European Society for Medical Oncology / ESMO Controlled trial quality: uncertain

125678. Initial feasibility study of a sprayable hydrogel adhesion barrier system in patients undergoing laparoscopic ovarian surgery. (Abstract)

Initial feasibility study of a sprayable hydrogel adhesion barrier system in patients undergoing laparoscopic ovarian surgery. To assess the safety and effectiveness of SprayGel as a barrier to reduce the frequency of adhesion formation and reformation after ovarian surgery, and to determine the feasibility of the study design for a larger, multicenter pivotal trial.Prospective, randomized, internally controlled trial (Canadian Task Force classification I).Two metropolitan, academic-affiliated (...) , nonprofit hospitals.Fourteen women.Bilateral adnexal surgery.On completion of surgery, one adnexa was randomized to receive optimal surgical treatment plus application of the adhesion barrier, and the contralateral one to receive optimal surgical treatment alone. Patients returned in 3 to 16 weeks for second-look laparoscopy. All initial and second-look procedures were videotaped and reviewed by a blinded surgeon reviewer, and assessed for frequency, extent, and severity of adhesions. The frequency

2003 The Journal of the American Association of Gynecologic Laparoscopists Controlled trial quality: uncertain

125679. The efficacy of an automated feedback system for general practitioners. (Abstract)

participant groups of GPs in a computer laboratory setting.The GPs reviewed a random sample of 30 request forms they filled in earlier that year. If deemed necessary, they could make changes in the tests requested. Next, the system displayed critical comments about their non-adherence to the guidelines as apparent from the (updated) request forms.Twenty-four randomly selected GPs participated.The number of requested diagnostic tests (17% with 95% confidence interval [CI]: 12-22%) and the fraction of tests (...) The efficacy of an automated feedback system for general practitioners. An automated feedback system that produces comments about the non-adherence of general practitioners (GPs) to accepted practice guidelines for ordering diagnostic tests was developed. Before implementing the automated feedback system in daily practice, we assessed the potential effect of the system on the test ordering behaviour of GPs.We used a randomised controlled trial with balanced block design.Five times six

2003 Informatics in primary care Controlled trial quality: uncertain

125680. Neutropenia and the development of the systemic inflammatory response syndrome. (Abstract)

Neutropenia and the development of the systemic inflammatory response syndrome. To determine outcome and natural course of systemic inflammatory response syndrome (SIRS) stages in adult febrile neutropenic patients.Retrospective cohort study in the medicine department and intensive care unit of a university hospital.Adults with cancer-related neutropenia and community-acquired fever.Patients were classified on admission according to SIRS parameters, tumor type, and degree of neutropenia (...) . Records of clinical and laboratory data during hospitalization were reviewed. Univariate and logistic regression analyses were performed. Seventy-nine events in 62 patients were analyzed. Overall mortality rate was 20.2% (16/79). Mortality increased as SIRS stage worsened on admission. No patients with stage 2 SIRS died (neutropenia and fever alone) but 11.1% of patients with SIRS 3, 43.4% with SIRS 4, 66.6% with sepsis induced hypotension, and 90% with septic shock. SIRS stage on admission

2003 Intensive Care Medicine

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