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Review of Systems

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125501. Drosophila, a genetic model system to study cocaine-related behaviors: A review with focus on LIM-only proteins Full Text available with Trip Pro

Drosophila, a genetic model system to study cocaine-related behaviors: A review with focus on LIM-only proteins In the last decade, the fruit fly Drosophila melanogaster, highly accessible to genetic, behavioral and molecular analyses, has been introduced as a novel model organism to help decipher the complex genetic, neurochemical, and neuroanatomical underpinnings of behaviors induced by drugs of abuse. Here we review these data, focusing specifically on cocaine-related behaviors. Several (...) of cocaine's most characteristic properties have been recapitulated in Drosophila. First, cocaine induces motor behaviors in flies that are remarkably similar to those observed in mammals. Second, repeated cocaine administration induces behavioral sensitization a form of behavioral plasticity believed to underlie certain aspects of addiction. Third, a key role for dopaminergic systems in mediating cocaine's effects has been demonstrated through both pharmacological and genetic methods. Finally, and most

2008 Neuropharmacology

125502. The O-linked N-acetylglucosamine modification in cellular signalling and the immune system. ‘Protein Modifications: Beyond the Usual Suspects' Review Series Full Text available with Trip Pro

The O-linked N-acetylglucosamine modification in cellular signalling and the immune system. ‘Protein Modifications: Beyond the Usual Suspects' Review Series The intracellular modification of proteins by the addition of a single O-linked N-acetylglucosamine (O-GlcNAc) molecule is a ubiquitous post-translational modification in eukaryotic cells. It is catalysed by O-linked N-acetylglucosaminyltransferase, which attaches O-GlcNAc to serine/threonine residues, and it is counter-regulated by beta (...) modifications, focusing on the cells of the immune system.

2008 EMBO reports

125503. Building a Results Review System: A Critical First Step in Transitioning from Paper Medical Records Full Text available with Trip Pro

Building a Results Review System: A Critical First Step in Transitioning from Paper Medical Records Electronic health records (EHRs) are valuable tools for efficiently delivering safe and effective care, yet the majority of providers continue to rely on paper based systems. Cost is a significant barrier to adoption. Providers unable to afford a comprehensive EHR may still be capable of taking a less costly first step toward improving quality and safety with less aggressive yet effective (...) clinical information system strategies. We identified a single, clearly definable, clinical information need: Improving the delivery of results and reports. We built a results review system to improve the efficiency and reliability of access to clinical information for providers working in the New Orleans safety net for the under/uninsured. We measured provider satisfaction with clinical information delivery systems before and after implementation and analyzed the rate of adoption and ongoing system

2005 AMIA Annual Symposium Proceedings

125504. caBIGâ„¢ Compatibility Review System: Software to Support the Evaluation of Applications Using Defined Interoperability Criteria Full Text available with Trip Pro

caBIGâ„¢ Compatibility Review System: Software to Support the Evaluation of Applications Using Defined Interoperability Criteria The caBIG Compatibility Review System (CRS) is a web-based application to support compatibility reviews, which certify that software applications that pass the review meet a specific set of criteria that allow them to interoperate. The CRS contains workflows that support both semantic and syntactic reviews, which are performed by the caBIG Vocabularies and Common Data (...) Elements (VCDE) and Architecture workspaces, respectively. The CRS increases the efficiency of compatibility reviews by reducing administrative overhead and it improves uniformity by ensuring that each review is conducted according to a standard process. The CRS provides metrics that allow the review team to evaluate the level of data element reuse in an application, a first step towards quantifying the extent of harmonization between applications. Finally, functionality is being added

2008 AMIA Annual Symposium Proceedings

125505. How outbreaks of infectious disease are detected: a review of surveillance systems and outbreaks. Full Text available with Trip Pro

How outbreaks of infectious disease are detected: a review of surveillance systems and outbreaks. To learn how outbreaks of infectious disease are detected and to describe the entities and information systems that together function to identify outbreaks in the U.S., the authors drew on multiple sources of information to create a description of existing surveillance systems and how they interact to detect outbreaks. The results of this analysis were summarized in a system diagram. The authors (...) reviewed a sample of recent outbreaks to determine how they were detected, with reference to the system diagram. The de facto U.S. system for detection of outbreaks consists of five components: the clinical health care system, local/state health agencies, federal agencies, academic/professional organizations, and collaborating governmental organizations. Primary data collection occurs at the level of clinical health care systems and local health agencies. The review of a convenience sample of outbreaks

2004 Public Health Reports

125506. A case of epiphora and recurrent basal cell carcinoma of the nasal tip and review of acquired nasolacrimal system obstruction Full Text available with Trip Pro

A case of epiphora and recurrent basal cell carcinoma of the nasal tip and review of acquired nasolacrimal system obstruction A case of a 67-year-old man with recurrent basal cell carcinoma of the nasal tip and an incidental symptom of epiphora (volunteered by the patient) is presented. Epiphora is an abnormal overflow of tears that fail to drain into the inferior nasal meatus via the nasolacrimal system. Within the differential diagnosis of epiphora and nasolacrimal obstruction is neoplasm

2004 The Canadian Journal of Plastic Surgery

125507. Central venous port system associated thromboses: outcome in 3498 implantations and literature review Full Text available with Trip Pro

Central venous port system associated thromboses: outcome in 3498 implantations and literature review From 1 July 1995 to 31 June 2006 we implanted 3498 intravenous port systems. In nearly all cases the indication was vascular access for chemotherapy.We registered 199 complications (5.7%), mostly infections (n=85 i.e. 2.4%) and thromboses (n=63 i.e. 1.8%).Permanent central venous catheters have become standard in the management of patients with malignancies. Because of the improvement

2007 GMS German Medical Science

125508. Pyrogenic cytokine interleukin-6 expression by a chordoid meningioma in an adult with a systemic inflammatory syndrome. Case report and review of the literature. Full Text available with Trip Pro

Pyrogenic cytokine interleukin-6 expression by a chordoid meningioma in an adult with a systemic inflammatory syndrome. Case report and review of the literature. Chordoid meningioma is a rare meningothelial tumor characterized by chordoma-like histological features with lymphoplasmacellular infiltration. This tumor is often seen in children, but not in adults, with a systemic inflammatory syndrome (iron-resistant microcytic anemia and/or dysgammaglobulinemia) and very rarely with a persistent

2005 Journal of Neurosurgery

125509. Worsening of asthma with systemic corticosteroids. A case report and review of literature. Full Text available with Trip Pro

Worsening of asthma with systemic corticosteroids. A case report and review of literature. Despite widespread use for treatment of asthma and allergies, glucocorticoids may cause allergic reactions, even anaphylaxis. The incidence of adverse reactions to systemic glucocorticoids is 0.3%. The most commonly reported corticosteroids causing anaphylaxis like reactions are hydrocortisone, prednisone, and methylprednisolone. Most authors agree that allergic reactions to systemic corticosteroids (...) with systemic corticosteroid therapy, particularly when a history of aspirin allergy is present. TEACHING POINT: Know the differential diagnosis for worsening of asthma despite adequate treatment. Consider corticosteroid-induced bronchospasm when asthmatics fail to improve, or frankly deteriorate with systemic corticosteroid therapy. Corticosteroid-induced bronchospasm is more commonly seen in asthmatics with a history of aspirin allergy.

2006 Journal of General Internal Medicine

125510. Toward ethical review of health system transformations. Full Text available with Trip Pro

Toward ethical review of health system transformations. Efforts to transform health systems constitute social experiments on a population. Like clinical research, they deploy measures that are unproven in the context of the reform, and they often impose significant risks on some people in order to achieve a social goal: the improvement of health delivery. The rationale for proactively evaluating clinical experimentation on human subjects also applies to these social experiments. We used (...) the "benchmarks of fairness" methodology to illustrate the elements such an evidence-based review should encompass, leaving open the question of who should perform it. The review must include the ethical objectives of reform, namely, an integrated approach to equity, accountability, and efficiency; the fit between measures taken and these objectives; and the governance of the reform.

2006 American Journal of Public Health

125511. Classification systems for hallux rigidus: a review of the literature. (Abstract)

Classification systems for hallux rigidus: a review of the literature. Hallux rigidus (HR) is one of the most common causes of forefoot pain. A number of classification systems have been developed to evaluate HR. These systems are based on either radiological parameters alone or a combination of radiological and clinical features. The purpose of this paper is to critically evaluate HR classification systems by undertaking a detailed review using English language medical and paramedical (...) databases.The authors identified 18 formal HR classification systems described in the literature, some of which are variations on a theme.No clear consensus on the construction of HR classification systems appears to exist. Different criteria and methods are used which make comparison difficult. Furthermore, it appears that, no serious consideration has been given to their reliability and validity. Criteria used to justify inclusion of these parameters have been based mainly on clinical experience rather

2008 Foot & Ankle International

125512. Central nervous system vasculitis caused by propylthiouracil therapy: a case report and literature review. (Abstract)

Central nervous system vasculitis caused by propylthiouracil therapy: a case report and literature review. Antineutrophil cytoplasmic antibodies (ANCA) are associated with vasculitis, including vasculitis induced by drugs such as the thionamides. The affected organ systems in thionamide-induced vasculitis have been primarily renal, musculoskeletal, and dermatologic. We describe the first case of thionamide-induced central nervous system vasculitis presenting as confusion, with complete (...) resolution after discontinuation of propylthiouracil. We review the literature and summarize 42 additional cases of thionamide-induced ANCA-positive vasculitis since 1992. Propylthiouracil was responsible in 93% of cases and the predominant ANCA pattern on immunofluorescent staining was perinuclear (p-ANCA). Clinical improvement occurred after drug discontinuation in 93%, steroid therapy was used in some cases. The mean duration of treatment with thionamides was 35 months prior to presentation. Long-term

2005 Thyroid

125513. Hypercalcemia and Overexpression of CYP27B1 in a Patient with Nephrogenic Systemic Fibrosis: Clinical Vignette and Literature Review. Full Text available with Trip Pro

Hypercalcemia and Overexpression of CYP27B1 in a Patient with Nephrogenic Systemic Fibrosis: Clinical Vignette and Literature Review. Nephrogenic systemic fibrosis (NSF) is a disease of thickened, hard, hyperpigmented skin lesions with or without systemic fibrosis occurring in patients with renal insufficiency and associated with the administration of gadolinium-containing contrast. The pathogenesis of this disease is unclear, and there is no definitive treatment. We describe a 71-yr-old (...) in future cases to determine a connection between NSF, 1,25(OH)(2)D metabolism, and CYP27B1 activation in the skin, which may shed light on the pathogenesis of this unusual local and systemic fibrosing disorder.

2008 Journal of Bone and Mineral Research

125514. Focusing on a "Serious" review of systems in the ED. (Abstract)

Focusing on a "Serious" review of systems in the ED. We compared serious and non-serious review of systems (ROS) complaints in the Emergency Department (ED). There were 173 adults discharged from an urban county ED who were administered a 56-item ROS identical to the ED chart ROS. Blinded review of ED charts determined which ROS complaints were documented by clinicians and whether ROS complaints were addressed by ED diagnostic testing or physical examination (PE). Mean differences

2008 Journal of Emergency Medicine

125515. Pediatric patient with systemic lupus erythematosus & congenital acquired immunodeficiency syndrome: An unusual case and a review of the literature. Full Text available with Trip Pro

Pediatric patient with systemic lupus erythematosus & congenital acquired immunodeficiency syndrome: An unusual case and a review of the literature. The coexistence of systemic lupus erythematosus (SLE) in patients with congenital human immunodeficiency virus (HIV) infection is rare. This is a case report of a child diagnosed with SLE at nine years of age. She initially did well on non-steroidal anti-inflammatory agents, hydroxychloroquine, and steroids. She then discontinued her anti-lupus

2008 Pediatric Rheumatology

125516. A review of the smallpox vaccine adverse events active surveillance system. Full Text available with Trip Pro

A review of the smallpox vaccine adverse events active surveillance system. In response to concern about smallpox possibly being used as a biological weapon, the President of the United States launched the National Smallpox Pre-Event Vaccination Program on 13 December 2002. Given safety concerns, identifying potentially serious adverse events (SAEs) was an essential tool of the program. To monitor for SAEs, both enhanced passive surveillance and active surveillance systems were used (...) . The enhanced passive system was built, in part, on the existing Vaccine Adverse Event Reporting System; the active system was implemented 24 January 2003. During January 2003-May 2005, the active system detected only 1 SAE in addition to those reported through the enhanced passive system. Furthermore, the active system was not universally used by states. With the enhancements to passive surveillance, the performance of enhanced passive surveillance was comparable to that of active surveillance. However

2008 Clinical Infectious Diseases

125517. Paediatric Rapid Response Systems: a literature review. (Abstract)

Paediatric Rapid Response Systems: a literature review. Paediatric cardiorespiratory arrest carries a poor prognosis. The most common cause is respiratory insufficiency or hypotension/shock, which can be reversible. The use of RRSs in adult hospitals that proactively intervene when signs of physiological instability occur is widespread and increasing although the level of evidence for their efficiency is a matter of debate.A systematic literature review was undertaken to evaluate and summarise

2008 Acta Anaesthesiologica Scandinavica

125518. Evidence for selection of end-points for clinical trials in systemic lupus erytematosus (SLE): a systematic literature review. Report of a Task Force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT). (Abstract)

Evidence for selection of end-points for clinical trials in systemic lupus erytematosus (SLE): a systematic literature review. Report of a Task Force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT). To assess available evidence on the use of end-points (outcome measures) in clinical trials in systemic lupus erythematosus (SLE), as a part of the development of evidence-based recommendations for points to consider in clinical trials in SLE.The (...) of available evidence were identified for each recommendation. The strength of recommendation was assessed based on the category of available evidence and agreement on the statements was measured across the 19 specialists.Eight questions were generated regarding end-points for clinical trials. The evidence to support each proposition was evaluated. The literature review revealed that most outcome measures used in phase 2/3 trials in SLE have not been formally validated in clinical trials, although some

2008 Annals of the Rheumatic Diseases

125519. Review and performance evaluation of aggregate weighted 'track and trigger' systems. (Abstract)

Review and performance evaluation of aggregate weighted 'track and trigger' systems. There is no up-to-date literature review of physiologically based, aggregate weighted 'track and trigger' systems (AWTTS) and few data on their predictive ability for serious adverse outcomes. The aim of this study was to describe the AWTTS in clinical use and assess their ability to discriminate between survivors and non-survivors of hospital admission, based on an initial set of vital signs.A systematic (...) review of the literature was performed, to describe the AWTTS, their components and their differences. Their ability to discriminate between survivors and non-survivors was evaluated using the area under the receiver-operating characteristics (AUROC) curve, and a database of 9987 vital signs datasets.A total of 33 unique AWTTS were identified with AUROC (+/-95% CI) ranging from 0.657 (0.636-0.678) to 0.782 (0.767-0.797). 12 AWTTS (36%) discriminated reasonably well between survivors and non-survivors

2008 Resuscitation

125520. Risk Factors Associated with Pulmonary Arterial Hypertension in Colombian Patients with Systemic Sclerosis: Review of the Literature. (Abstract)

Risk Factors Associated with Pulmonary Arterial Hypertension in Colombian Patients with Systemic Sclerosis: Review of the Literature. Considering the significant morbidity and mortality of pulmonary arterial hypertension (PAH) in patients with systemic sclerosis (SSc) and the lack of precise information on disease in Latin America, we investigated the clinical and laboratory characteristics associated with PAH in Colombian patients with SSc and review the literature.This multicenter study (...) included patients followed at 5 rheumatology units that were systematically assessed using a pretested questionnaire on clinical and immunological variables, focusing on PAH. Conditional logistic regression was employed to assess association between PAH and specific clinical characteristics. A systematic review of the literature was performed through electronic databases.Of a total of 349 patients with SSc, 61 (17%) met the criteria for PAH. Pulmonary fibrosis [adjusted odds ratio (AOR) 7.37, 95% CI

2008 Journal of Rheumatology

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