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61. Primary central nervous system lymphoma in a patient with systemic lupus erythematosus mimicking high-grade glioma: A case report and review of literature. (Full text)

Primary central nervous system lymphoma in a patient with systemic lupus erythematosus mimicking high-grade glioma: A case report and review of literature. Primary central nervous system lymphoma (PCNSL) is a rare disease. Studies of PCNSL in patients with rheumatic diseases are lacking. Neither clinical symptoms nor radiographic manifestation is specific to PCNSL. Therefore, it could be misdiagnosed with other diseases such as brain tumors. Chemotherapy is the primary treatment for PCNSL (...) , while the role of surgery remains controversial.We reported a 39-year-old woman with systemic lupus erythematosus (SLE) developed PCNSL after 15-year treatment with multiple immunosuppressants.Cranial magnetic resonance imaging (MRI) showed multi-focal lesions with ring-like enhancement post-contrast in the right hemisphere, which mimicked glioma radiographically. Owing to the severe symptoms of intracranial hypertension, gross tumor resection was performed. Pathological exam showed perivascular

2018 Medicine PubMed abstract

62. Performance of the 2012 systemic lupus international collaborating clinics classification criteria versus the 1997 American College of Rheumatology Classification Criteria in adult and juvenile systemic lupus Erythematosus. A systematic review and meta-an (Full text)

Performance of the 2012 systemic lupus international collaborating clinics classification criteria versus the 1997 American College of Rheumatology Classification Criteria in adult and juvenile systemic lupus Erythematosus. A systematic review and meta-an To evaluate the performance in classifying systemic lupus erythematosus by the 2012 Systemic Lupus International Collaborating Clinics criteria (SLICC'12), versus the revised American College of Rheumatology criteria from 1997 (ACR'97

2018 Autoimmunity reviews PubMed abstract

63. A Natural Language Processing System That Links Medical Terms in Electronic Health Record Notes to Lay Definitions: System Development Using Physician Reviews. (Full text)

A Natural Language Processing System That Links Medical Terms in Electronic Health Record Notes to Lay Definitions: System Development Using Physician Reviews. Many health care systems now allow patients to access their electronic health record (EHR) notes online through patient portals. Medical jargon in EHR notes can confuse patients, which may interfere with potential benefits of patient access to EHR notes.The aim of this study was to develop and evaluate the usability and content quality (...) of NoteAid, a Web-based natural language processing system that links medical terms in EHR notes to lay definitions, that is, definitions easily understood by lay people.NoteAid incorporates two core components: CoDeMed, a lexical resource of lay definitions for medical terms, and MedLink, a computational unit that links medical terms to lay definitions. We developed innovative computational methods, including an adapted distant supervision algorithm to prioritize medical terms important for EHR

2018 Journal of medical Internet research PubMed abstract

64. Olfactory function in systemic lupus erythematosus and systemic sclerosis. A longitudinal study and review of the literature. (Abstract)

Olfactory function in systemic lupus erythematosus and systemic sclerosis. A longitudinal study and review of the literature. To evaluate olfactory function in systemic lupus erythematosus (SLE), systemic sclerosis (SSc) and healthy controls over a 2-year period, and to determine the association of olfactory dysfunction with age, disease activity, disease damage, treatment, anxiety and depression symptoms and limbic structures volumes.Consecutive SLE and SSc patients were enrolled in this study

2018 Autoimmunity reviews

65. A Comparison of the Quick-SOFA and Systemic Inflammatory Response Syndrome Criteria for the Diagnosis of Sepsis and Prediction of Mortality: A Systematic Review and Meta-Analysis (Abstract)

A Comparison of the Quick-SOFA and Systemic Inflammatory Response Syndrome Criteria for the Diagnosis of Sepsis and Prediction of Mortality: A Systematic Review and Meta-Analysis Several studies were published to validate the quick Sepsis-related Organ Failure Assessment (qSOFA), namely in comparison with the systemic inflammatory response syndrome (SIRS) criteria. We performed a systematic review and meta-analysis with the aim of comparing the qSOFA and SIRS in patients outside the ICU.We (...) Reporting Items for Systematic Reviews and Meta-Analyses statement.From 4,022 citations, 10 studies met the inclusion criteria. Pooling all the studies, a total of 229,480 patients were evaluated. The meta-analysis of sensitivity for the diagnosis of sepsis comparing the qSOFA and SIRS was in favor of SIRS (risk ratio [RR], 1.32; 95% CI, 0.40-2.24; P < .0001; I2 = 100%). One study described the specificity for the diagnosis of infection comparing SIRS (84.4%; 95% CI, 76.2-90.6) with the qSOFA (97.3%; 95

2018 EvidenceUpdates

66. Geographic Information Systems, spatial analysis, and HIV in Africa: A scoping review. (Full text)

Geographic Information Systems, spatial analysis, and HIV in Africa: A scoping review. Geographic Information Systems (GIS) and spatial analysis are emerging tools for global health, but it is unclear to what extent they have been applied to HIV research in Africa. To help inform researchers and program implementers, this scoping review documents the range and depth of published HIV-related GIS and spatial analysis research studies conducted in Africa.A systematic literature search for articles (...) related to GIS and spatial analysis was conducted through PubMed, EMBASE, and Web of Science databases. Using pre-specified inclusion criteria, articles were screened and key data were abstracted. Grounded, inductive analysis was conducted to organize studies into meaningful thematic areas.The search returned 773 unique articles, of which 65 were included in the final review. 15 different countries were represented. Over half of the included studies were published after 2014. Articles were categorized

2019 PLoS ONE PubMed abstract

67. Early warning systems in obstetrics: A systematic literature review. (Full text)

Early warning systems in obstetrics: A systematic literature review. Several versions of Early Warning Systems (EWS) are used in obstetrics to detect and treat early clinical deterioration to avert morbidity and mortality. EWS can potentially be useful to improve the quality of care and reduce the risk of maternal mortality in resource-limited settings. We conducted a systematic literature review of published obstetric early warning systems, define their predictive accuracy for morbidity (...) and mortality, and their effectiveness in triggering corrective actions and improving health outcomes.We systematically searched for primary research articles on obstetric EWS published in peer-reviewed journals between January 1997 and March 2018 in Medline, CINAHL, SCOPUS, Science Direct, and Science Citation Index. We also searched reference lists of relevant articles and websites of professional societies. We included studies that assessed the predictive accuracy of EWS to detect clinical deterioration

2019 PLoS ONE PubMed abstract

68. Health-related quality of life in paediatric patients with Type 1 diabetes mellitus using insulin infusion systems. A systematic review and meta-analysis. (Full text)

Health-related quality of life in paediatric patients with Type 1 diabetes mellitus using insulin infusion systems. A systematic review and meta-analysis. In 2017, more than 1.1 million children were living with type 1 diabetes mellitus (T1DM) globally. The goal in paediatric diabetes therapy is reaching optimal glycaemic control as early as possible in order to avoid complications and early mortality without compromising the quality of life (QoL) of children. Several different insulin regimens (...) are available for T1DM patients to reach this goal.This review set out to analyse whether continuous subcutaneous insulin infusion (CSII) regimens are superior to multiple daily injection (MDI) therapy in T1DM youth regarding QoL. Additionally, it assessed glycaemic control and adverse events as secondary outcomes and discussed potential future public health implications and justifications for using CSII as a first-line therapy in diabetic youth.A systematic review and random effects meta-analysis

2019 PLoS ONE PubMed abstract

69. Asian patients versus non-Asian patients in the efficacy and safety of direct oral anticoagulants relative to vitamin K antagonist for venous thromboembolism: A systemic review and meta-analysis (Abstract)

Asian patients versus non-Asian patients in the efficacy and safety of direct oral anticoagulants relative to vitamin K antagonist for venous thromboembolism: A systemic review and meta-analysis The standard for treatment and secondary prevention of venous thromboembolism (VTE) has been vitamin K antagonist (VKA), which might be associated with a higher risk of bleeding particularly in Asian patients. Direct oral anticoagulants (DOAC) have been shown to be safer alternatives for VTE. It remains

2018 EvidenceUpdates

70. Systematic Review of Systemic Therapies and Therapeutic Combinations with Local Treatments for High-risk Localized Prostate Cancer (Abstract)

Systematic Review of Systemic Therapies and Therapeutic Combinations with Local Treatments for High-risk Localized Prostate Cancer Systemic therapies, combined with local treatment for high-risk prostate cancer, are recommended by the international guidelines for specific subgroups of patients; however, for many of the clinical scenarios, it remains a research field.To perform a systematic review, and describe current evidence and perspectives about the multimodal treatment of high-risk (...) prostate cancer.We performed a systematic review of PubMED, Embase, Cochrane Library, European Society of Medical Oncology/American Society of Clinical Oncology Annual proceedings, and clinicalTrial.gov between January 2010 and February 2018 following the Preferred Reporting Items for Systematic Reviews and Meta-analysis statement.Seventy-seven prospective trials were identified. According to multiple randomized trials, combining androgen deprivation therapy (ADT) with external-beam radiotherapy (EBRT

2018 EvidenceUpdates

71. First-line Systemic Therapy for Metastatic Renal Cell Carcinoma: A Systematic Review and Network Meta-analysis (Abstract)

First-line Systemic Therapy for Metastatic Renal Cell Carcinoma: A Systematic Review and Network Meta-analysis In the last decade, there has been a proliferation of treatment options for metastatic renal cell carcinoma (mRCC). However, direct comparative data are lacking for most of these agents.To indirectly compare the efficacy and safety of systemic therapies used in the first-line treatment of mRCC.Medline, EMBASE, Web of Science, and Scopus databases were searched using the OvidSP platform (...) for studies indexed from database inception to October 23, 2017. Abstracts of conferences of relevant medical societies were included, and the systematic search was supplemented by hand search. For the systematic review, we identified any parallel-group randomized controlled trials assessing first-line systemic therapy. For network meta-analysis, we limited these to a clinically-relevant network based on standard practice patterns. Progression-free survival (PFS) was the primary outcome. Overall survival

2018 EvidenceUpdates

72. Systemic Antibiotics for the Treatment of Skin and Soft Tissue Abscesses: A Systematic Review and Meta-Analysis (Full text)

Systemic Antibiotics for the Treatment of Skin and Soft Tissue Abscesses: A Systematic Review and Meta-Analysis The addition of antibiotics to standard incision and drainage is controversial, with earlier studies demonstrating no significant benefit. However, 2 large, multicenter trials have recently been published that have challenged the previous literature. The goal of this review was to determine whether systemic antibiotics for abscesses after incision and drainage improve cure (...) rates.PubMed, the Cumulative Index of Nursing and Allied Health Literature, Scopus, the Cochrane Database of Systematic Reviews, the Cochrane Central Register of Controlled Trials, and bibliographies of selected articles were assessed for all randomized controlled trials comparing adjuvant antibiotics with placebo in the treatment of drained abscesses, with an outcome of treatment failure assessed within 21 days. Data were dual extracted into a predefined worksheet and quality analysis was performed

2018 EvidenceUpdates PubMed abstract

73. Oxygen Therapy in Patients with Acute Myocardial Infarction: A Systemic Review and Meta-Analysis (Full text)

Oxygen Therapy in Patients with Acute Myocardial Infarction: A Systemic Review and Meta-Analysis Oxygen therapy is frequently used for patients with acute myocardial infarction. The aim of this study is to perform a systematic review and meta-analysis to compare the outcomes of oxygen therapy versus no oxygen therapy in post-acute myocardial infarction settings.A systematic search of electronic databases was conducted for randomized studies, which reported cardiovascular events in oxygen versus

2018 EvidenceUpdates PubMed abstract

74. Diagnostic Accuracy of Different Surgical Procedures for Axillary Staging After Neoadjuvant Systemic Therapy in Node-positive Breast Cancer: A Systematic Review and Meta-analysis (Full text)

Diagnostic Accuracy of Different Surgical Procedures for Axillary Staging After Neoadjuvant Systemic Therapy in Node-positive Breast Cancer: A Systematic Review and Meta-analysis The aim of this study was to perform a systematic review and meta-analysis to assess the accuracy of different surgical axillary staging procedures compared with ALND.Optimal axillary staging after neoadjuvant systemic therapy (NST) in node-positive breast cancer is an area of controversy. Several less invasive

2018 EvidenceUpdates PubMed abstract

75. Integrated sensor-augmented pump therapy systems for managing blood glucose levels in type 1 diabetes (the MiniMed Paradigm Veo system and the Vibe and G4 PLATINUM CGM system)

Additional clinical-effectiveness analyses for the economic model 21 Costs and cost effectiveness 21 6 Considerations 32 Current practice 32 Clinical evidence 33 Cost effectiveness 36 Additional considerations 39 7 Recommendations for further research 40 8 Implementation 41 9 Review 42 10 Diagnostics Advisory Committee members and NICE project team 43 Diagnostics Advisory Committee 43 NICE project team 45 Integrated sensor-augmented pump therapy systems for managing blood glucose levels in type 1 (...) are in the committee papers. How outcomes were assessed 5.1 The assessment consisted of a systematic review of the clinical-effectiveness data for the MiniMed Paradigm Veo system, the Vibe and G4 PLATINUM CGM system and comparator technologies. 5.2 In total, 54 publications reporting the results of 19 studies met the inclusion criteria. These studies included either the intervention or comparator technologies in a treatment arm. Two studies included data for the MiniMed Paradigm Veo system, 1 of which compared

2016 National Institute for Health and Clinical Excellence - Diagnostics Guidance

76. Orthotic management of instability of the knee related to neuromuscular and central nervous system disorders: systematic review, qualitative study, survey and costing analysis

Orthotic management of instability of the knee related to neuromuscular and central nervous system disorders: systematic review, qualitative study, survey and costing analysis Orthotic management of instability of the knee related to neuromuscular and central nervous system disorders: systematic review, qualitative study, survey and costing analysis Orthotic management of instability of the knee related to neuromuscular and central nervous system disorders: systematic review, qualitative study (...) , O'Connor RJ, Phillips M, Ramdharry G. Orthotic management of instability of the knee related to neuromuscular and central nervous system disorders: systematic review, qualitative study, survey and costing analysis. Health Technology Assessment 2016; 20(55) Authors' objectives To assess existing evidence on the effectiveness of orthoses; patient perspectives; types of orthotic devices prescribed in the UK NHS; and associated costs. Patients who have knee instability that is associated with neuromuscular

2016 Health Technology Assessment (HTA) Database.

77. Clinical care review systems in healthcare: a systematic review. (Full text)

Clinical care review systems in healthcare: a systematic review. Clinical care review is the process of retrospectively examining potential errors or gaps in medical care, aiming for future practice improvement. The objective of our systematic review is to identify the current state of care review reported in peer-reviewed publications and to identify domains that contribute to successful systems of care review.A librarian designed and conducted a comprehensive literature search of eight (...) electronic databases. We evaluated publications from January 1, 2000, through May 31, 2016, and identified common domains for care review. Sixteen domains were identified for further abstraction.We found that there were few publications that described a comprehensive care review system and more focus on individual pathways within the overall systems. There is inconsistent inclusion of the identified domains of care review.While guidelines for some aspects of care review exist and have gained traction

2018 International journal of emergency medicine PubMed abstract

78. Midostaurin (Rydapt) - for the treatment of adult patients with aggressive systemic mastocytosis, systemic mastocytosis with associated haematological neoplasm, or mast cell leukaemia

review: as monotherapy for the treatment of adult patients with aggressive systemic mastocytosis, systemic mastocytosis with associated haematological neoplasm, or mast cell leukaemia. The holder of the marketing authorisation has not made a submission to SMC regarding this product in this indication. As a result we cannot recommend its use within NHSScotland. Advice context: No part of this advice may be used without the whole of the advice being quoted in full. This advice represents the view (...) Midostaurin (Rydapt) - for the treatment of adult patients with aggressive systemic mastocytosis, systemic mastocytosis with associated haematological neoplasm, or mast cell leukaemia Published 9 July 2018 Statement of Advice: midostaurin 25mg soft capsules (Rydapt ® ) SMC2100 Novartis Pharmaceuticals UK Ltd 8 June 2018 ADVICE: in the absence of a submission from the holder of the marketing authorisation midostaurin (Rydapt ® ) is not recommended for use within NHSScotland. Indication under

2018 Scottish Medicines Consortium

79. Adhesive Systems, Preferably Etch-and-Rinse Systems, Are Valuable Underneath A Fissure Sealant For Sealant Retention

sealant placement, be more effective in long-term sealant retention? Clinical Bottom Line Sealant retention is important in helping to prevent dental decay on susceptible grooves in children with deep occlusal anatomy. In order to improve sealant retention, two systematic reviews have concluded that using a thin layer of adhesive, preferably an etch and rinse system, is beneficial. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (...) (level of evidence) #1) Bagherian/2016 12 Studies Systematic review and meta-analysis Key results A meta-analysis of five studies evaluated fissure sealant retention with and without the use of an adhesive system. “The OR was 3.294 (95% CI, 1.292-8.401; P=.013)…and the risk difference was 0.180 (95% CI, 0.067-0.292; P=.002).” This showed that the “the use of adhesive systems had a positive effect on fissure sealant” placement. A second meta-analysis of three studies compared fissure sealant retention

2018 UTHSCSA Dental School CAT Library

80. Integrating clinical decision support systems for pharmacogenomic testing into clinical routine - a scoping review of designs of user-system interactions in recent system development. (Full text)

Integrating clinical decision support systems for pharmacogenomic testing into clinical routine - a scoping review of designs of user-system interactions in recent system development. Pharmacogenomic clinical decision support systems (CDSS) have the potential to help overcome some of the barriers for translating pharmacogenomic knowledge into clinical routine. Before developing a prototype it is crucial for developers to know which pharmacogenomic CDSS features and user-system interactions have (...) yet been developed, implemented and tested in previous pharmacogenomic CDSS efforts and if they have been successfully applied. We address this issue by providing an overview of the designs of user-system interactions of recently developed pharmacogenomic CDSS.We searched PubMed for pharmacogenomic CDSS published between January 1, 2012 and November 15, 2016. Thirty-two out of 118 identified articles were summarized and included in the final analysis. We then compared the designs of user-system

2017 Medical Informatics and Decision Making PubMed abstract

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