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Review of Systems

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281. Septic Embolic Stroke Followed by Hemorrhage and Brain Abscess in a Patient with Systemic Infections: A Case Report and Literature Review Full Text available with Trip Pro

Septic Embolic Stroke Followed by Hemorrhage and Brain Abscess in a Patient with Systemic Infections: A Case Report and Literature Review We report a case of 50-year-old man with a severe acute ischemic stroke followed by intracerebral hemorrhage and brain abscess due to systemic infection. His initial intracranial radiographic findings were normal but three days later MRI scan of the brain revealed well-defined rounded cystic lesion on the T2-weighted and T1-weighted images in the right basal (...) ganglia; the lesion presented an area of diffusion restriction on DWI; lately the lesion was confirmed to be an early stage of cerebral abscess. A week later the patient was noted to have worsening neurological status and left extremity weakness, and emergency brain CT scan revealed massive intracerebral hemorrhage in the right occipital lobe; he underwent intracranial hematoma evacuation surgery. The hematoma was removed successfully, and the systemic infections were treated with antibiotics.

2018 Case Reports in Radiology

282. A Review on the Nonlinear Dynamical System Analysis of Electrocardiogram Signal Full Text available with Trip Pro

A Review on the Nonlinear Dynamical System Analysis of Electrocardiogram Signal Electrocardiogram (ECG) signal analysis has received special attention of the researchers in the recent past because of its ability to divulge crucial information about the electrophysiology of the heart and the autonomic nervous system activity in a noninvasive manner. Analysis of the ECG signals has been explored using both linear and nonlinear methods. However, the nonlinear methods of ECG signal analysis (...) are gaining popularity because of their robustness in feature extraction and classification. The current study presents a review of the nonlinear signal analysis methods, namely, reconstructed phase space analysis, Lyapunov exponents, correlation dimension, detrended fluctuation analysis (DFA), recurrence plot, Poincaré plot, approximate entropy, and sample entropy along with their recent applications in the ECG signal analysis.

2018 Journal of healthcare engineering

283. A review of scoring systems for ocular involvement in chronic cutaneous bullous diseases Full Text available with Trip Pro

A review of scoring systems for ocular involvement in chronic cutaneous bullous diseases Epidermolysis bullosa (EB) and autoimmune blistering diseases (AIBD) describe a group of rare chronic dermatoses characterized by cutaneous fragility and blistering. Although uncommon, significant ocular surface disease (OSD) may occur in both and require ophthalmological assessment. Disease scoring systems have a critical role in providing objective and accurate assessment of disease severity (...) . The objectives of this report were, firstly, to document the prevalence and severity of ocular involvement in EB/AIBD. Secondly, to review and evaluate existing ocular and systemic scoring systems for EB/AIBD. Finally, to identify areas where further development of ocular specific tools in EB/AIBD could be pursued.A literature search was performed in October 2017 utilising Medline, Embase, and Scopus databases. The results were restricted by date of publication, between 01.01.1950 and 31.10.2017

2018 Orphanet journal of rare diseases

284. Different Types of Sounds and Their Relationship With the Electrocardiographic Signals and the Cardiovascular System – Review Full Text available with Trip Pro

Different Types of Sounds and Their Relationship With the Electrocardiographic Signals and the Cardiovascular System – Review Background: For some time now, the effects of sound, noise, and music on the human body have been studied. However, despite research done through time, it is still not completely clear what influence, interaction, and effects sounds have on human body. That is why it is necessary to conduct new research on this topic. Thus, in this paper, a systematic review (...) and its effects over ECG signals. Methods: This review was carried out by independent researchers, through three search equations, in four different databases, including: engineering, medicine, and psychology. Inclusion and exclusion criteria were applied and studies published between 1999 and 2017 were considered. The selected documents were read and analyzed independently by each group of researchers and subsequently conclusions were established between all of them. Results: Despite the differences

2018 Frontiers in physiology

285. Telemedicine-based system for quality management and peer review in radiology Full Text available with Trip Pro

Telemedicine-based system for quality management and peer review in radiology Quality assurance is the key component of modern radiology. A telemedicine-based quality assurance system helps to overcome the "scoring" approach and makes the quality control more accessible and objective.A concept for quality assurance in radiology is developed. Its realization is a set of strategies, actions, and tools. The latter is based on telemedicine-based peer review of 23,199 computed tomography (CT (...) ) and magnetic resonance imaging (MRI) images.The conception of the system for quality management in radiology represents a chain of actions: "discrepancies evaluation - routine support - quality improvement activity - discrepancies evaluation". It is realized by an audit methodology, telemedicine, elearning, and other technologies. After a year of systemic telemedicine-based peer reviews, the authors have estimated that clinically significant discrepancies were detected in 6% of all cases, while clinically

2018 Insights into imaging

286. System Development Guidelines From a Review of Motion-Based Technology for People With Dementia or MCI Full Text available with Trip Pro

System Development Guidelines From a Review of Motion-Based Technology for People With Dementia or MCI As the population ages and the number of people living with dementia or mild cognitive impairment (MCI) continues to increase, it is critical to identify creative and innovative ways to support and improve their quality of life. Motion-based technology has shown significant potential for people living with dementia or MCI by providing opportunities for cognitive stimulation, physical activity (...) and participation in meaningful leisure activities, while simultaneously functioning as a useful tool for research and development of interventions. However, many of the current systems created using motion-based technology have not been designed specifically for people with dementia or MCI. Additionally, the usability and accessibility of these systems for these populations has not been thoroughly considered. This paper presents a set of system development guidelines derived from a review of the state

2018 Frontiers in Psychiatry

287. Genes and their single nucleotide polymorphism involved in innate immune response in central nervous system in bacterial meningitis: review of literature data Full Text available with Trip Pro

Genes and their single nucleotide polymorphism involved in innate immune response in central nervous system in bacterial meningitis: review of literature data There are many studies analysing the effect of SNPs in genes coding proteins which are involved in innate immune response on susceptibility to invasive bacterial disease. Many of them gave inconclusive results. Regarding the complexity of immune response and cooperation between particular elements, number of SNPs may have a cumulative

2018 Inflammation Research

288. Emerging Viral Infections in Sub-Saharan Africa and the Developing Nervous System: A Mini Review Full Text available with Trip Pro

Emerging Viral Infections in Sub-Saharan Africa and the Developing Nervous System: A Mini Review The global public health concern is heightened over the increasing number of emerging viruses, i.e., newly discovered or previously known that have expanded into new geographical zones. These viruses challenge the health-care systems in sub-Saharan Africa (SSA) countries from which several of them have originated and been transmitted by insects worldwide. Some of these viruses are neuroinvasive (...) , but have been relatively neglected by neuroscientists. They may provide experiments by nature to give a time window for exposure to a new virus within sizeable, previously non-infected human populations, which, for instance, enables studies on potential long-term or late-onset effects on the developing nervous system. Here, we briefly summarize studies on the developing brain by West Nile, Zika, and Chikungunya viruses, which are mosquito-borne and have spread worldwide out of SSA. They can all

2018 Frontiers in neurology

289. Impact of Aging on the Auditory System and Related Cognitive Functions: A Narrative Review Full Text available with Trip Pro

Impact of Aging on the Auditory System and Related Cognitive Functions: A Narrative Review Age-related hearing loss (ARHL), presbycusis, is a chronic health condition that affects approximately one-third of the world's population. The peripheral and central hearing alterations associated with age-related hearing loss have a profound impact on perception of verbal and non-verbal auditory stimuli. The high prevalence of hearing loss in the older adults corresponds to the increased frequency (...) of dementia in this population. Therefore, researchers have focused their attention on age-related central effects that occur independent of the peripheral hearing loss as well as central effects of peripheral hearing loss and its association with cognitive decline and dementia. Here we review the current evidence for the age-related changes of the peripheral and central auditory system and the relationship between hearing loss and pathological cognitive decline and dementia. Furthermore

2018 Frontiers in neuroscience

290. Fundamentals of siRNA and miRNA therapeutics and a review of targeted nanoparticle delivery systems in breast cancer Full Text available with Trip Pro

Fundamentals of siRNA and miRNA therapeutics and a review of targeted nanoparticle delivery systems in breast cancer Gene silencing via RNA interference (RNAi) is rapidly evolving as a personalized approach to cancer treatment. The effector molecules-small interfering RNAs (siRNAs) and microRNAs (miRNAs)-can be used to silence or "switch off" specific cancer genes. Currently, the main barrier to implementing siRNA- and miRNA-based therapies in clinical practice is the lack of an effective (...) delivery system that can protect the RNA molecules from nuclease degradation, deliver to them to tumor tissue, and release them into the cytoplasm of the target cancer cells, all without inducing adverse effects. Here, we review the fundamentals of RNAi, cell membrane transport pathways, and factors that affect intracellular delivery. We discuss the advantages and disadvantages of the various types of nanoparticle delivery systems, with a focus on those that have been investigated in breast cancer

2018 Biophysical reviews

291. Systemic air embolism after computed tomography-guided hook wire localization: two case reports and literature review Full Text available with Trip Pro

Systemic air embolism after computed tomography-guided hook wire localization: two case reports and literature review Computed tomography (CT)-guided hook wire localization is often used to identify small nodules prior to video-assisted thoracoscopic surgery (VATS). Pneumothorax, intrapulmonary hemorrhage, and wire dislodgement are well-known complications associated with the former procedure, but systemic air embolism (SAE) is an extremely rare and potentially fatal complication. We (...) encountered two cases of SAE; one patient showed neurologic symptoms, whereas the other did not. With the patient in the supine position, 100% oxygen was inhaled via a face mask. Subsequently, symptoms were resolved, and we performed planned surgeries on that day. Operative and postoperative courses were uneventful, and both patients were discharged without any sequelae. In this case report, we describe our experience with the two patients and review related literature.

2018 Journal of thoracic disease

292. Ophthalmic Drug Delivery Systems for Antibiotherapy—A Review Full Text available with Trip Pro

Ophthalmic Drug Delivery Systems for Antibiotherapy—A Review The last fifty years, ophthalmic drug delivery research has made much progress, challenging scientists about the advantages and limitations of this drug delivery approach. Topical eye drops are the most commonly used formulation in ocular drug delivery. Despite the good tolerance for patients, this topical administration is only focus on the anterior ocular diseases and had a high precorneal loss of drugs due to the tears production (...) and ocular barriers. Antibiotics are popularly used in solution or in ointment for the ophthalmic route. However, their local bioavailability needs to be improved in order to decrease the frequency of administrations and the side effects and to increase their therapeutic efficiency. For this purpose, sustained release forms for ophthalmic delivery of antibiotics were developed. This review briefly describes the ocular administration with the ocular barriers and the currently topical forms. It focuses

2018 Pharmaceutics

293. Internal Spreading of Papillary Thyroid Carcinoma: A Case Report and Systemic Review Full Text available with Trip Pro

Internal Spreading of Papillary Thyroid Carcinoma: A Case Report and Systemic Review An 18-year-old female diagnosed finally as PTC with intrathyroid spread was reported, and the diagnosis and surgical treatment of internal spreading of PTC were discussed. One lump was found on the thyroid isthmus by physical examination and B ultrasound, and multiple nodular shadows were found by CT. This patient finally underwent total thyroidectomy with bilateral central node dissection due to multifocal

2018 Case reports in endocrinology

294. miR-149 in Human Cancer: A Systemic Review Full Text available with Trip Pro

miR-149 in Human Cancer: A Systemic Review MicroRNAs (miRNAs) are small noncoding RNAs that regulate post-transcriptional gene expression via binding to the 3'-untranslated region (3'-UTR) of targeted mRNAs. They are reported to play important roles in tumorigenesis and progression of various cancers. Among them, miR-149 was confirmed to be aberrantly regulated in various tumors. In this review, we provide a complex overview of miR-149, particularly summarize the critical roles of it in cancers

2018 Journal of Cancer

295. Primary Central Nervous System Germ Cell Tumors: A Review and Update Full Text available with Trip Pro

Primary Central Nervous System Germ Cell Tumors: A Review and Update Primary central nervous system (CNS) germ cell tumors (GCT) are a heterogeneous group of tumors that are still poorly understood. In North America, GCTs comprise approximately 1% of primary brain tumors in pediatric and young adult patients. GCTs can occur as pure or mixed subtypes; they are divided into germinomas, which are the most common subtype, and non-germinomatous germ cell tumors (NGGCTs), which consist

2018 Medical research archives

296. From Neurons to Social Beings: Short Review of the Mirror Neuron System Research and Its Socio-Psychological and Psychiatric Implications Full Text available with Trip Pro

From Neurons to Social Beings: Short Review of the Mirror Neuron System Research and Its Socio-Psychological and Psychiatric Implications The mirror neuron system (MNS) is a brain network activated when we move our body parts and when we observe the actions of other agent. Since the mirror neuron's discovery in research on monkeys, several studies have examined its network and properties in both animals and humans. This review discusses MNS studies of animals and human MNS studies related

2018 Clinical Psychopharmacology and Neuroscience

297. Magnetic resonance imaging ancillary features used in Liver Imaging Reporting and Data System: An illustrative review Full Text available with Trip Pro

Magnetic resonance imaging ancillary features used in Liver Imaging Reporting and Data System: An illustrative review Hepatocellular carcinoma (HCC) usually develops in the setting of chronic liver disease. In the adequate clinical context, both multiphasic contrast-enhanced CT and magnetic resonance imaging are non-invasive modalities that allow accurate diagnosis and staging of HCC, although the latter demonstrates greater sensitivity and specificity. Imaging criteria for HCC diagnosis rely (...) , especially in Liver Imaging Reporting and Data System. In this paper, ancillary imaging features will be reviewed and illustrated.

2018 World journal of radiology

298. Circulating Protein Biomarkers in Systemic Sclerosis Related Pulmonary Arterial Hypertension: A Review of Published Data Full Text available with Trip Pro

Circulating Protein Biomarkers in Systemic Sclerosis Related Pulmonary Arterial Hypertension: A Review of Published Data Pulmonary arterial hypertension (PAH) develops in 7-12% of patients with systemic sclerosis (SSc) and is associated with a 3 year survival of 52%. Early detection by screening is therefore recommended for all patients with SSc. Historically, screening has been performed using echocardiography and measurement of gas transfer. More recently the DETECT protocol, using (...) endothelial growth factor alpha, resistin-like molecule beta, and soluble thrombomodulin. This review summarizes the current knowledge of these protein changes in patients with SSc and PAH.

2018 Frontiers in medicine

299. Reviewing guppy color vision: integrating the molecular and physiological variation in visual tuning of a classic system for sensory drive Full Text available with Trip Pro

Reviewing guppy color vision: integrating the molecular and physiological variation in visual tuning of a classic system for sensory drive Sensory drive predicts coevolution of mate choice signals with the sensory systems detecting those signals. Guppies are a classic model for sensory drive as mate preferences based on coloration differ across individuals and populations. A large body of work has identified variation in color vision, yet we lack a direct tie between how such variation in color (...) vision influences variation in color preference. Here we bring together studies that have investigated guppy vision over the past 40 years to: (1) highlight our current understanding of where variation occurs in the guppy color vision pathway and (2) suggest future avenues of research into sources of visual system variation that could influence guppy color preference. This will allow researchers to design careful studies that couple measures of color preference with measures of visual system

2018 Current zoology

300. It’s Time We Fix the Peer Review System Full Text available with Trip Pro

It’s Time We Fix the Peer Review System 30013250 2018 11 14 1553-6467 82 5 2018 Jun American journal of pharmaceutical education Am J Pharm Educ It's Time We Fix the Peer Review System. 7144 10.5688/ajpe7144 Malcom Daniel D Sullivan University College of Pharmacy, Louisville, Kentucky. Associate Editor, American Journal of Pharmaceutical Education, Arlington, Virginia. eng Journal Article United States Am J Pharm Educ 0372650 0002-9459 peer review publishing reviewing scholarship 2018 7 18 6

2018 American journal of pharmaceutical education

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