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221. Portable Normothermic Cardiac Perfusion System in Donation After Cardiocirculatory Death

. The statements, conclusions, and views expressed in this report do not necessarily represent the views of those we consulted. Citation Ontario Health (Quality). Portable normothermic cardiac perfusion system in donation after cardiocirculatory death: a health technology assessment. Ont Health Technol Assess Ser [Internet]. 2020 Mar;20(3): 1–90. Available from: https://www.hqontario.ca/Evidence-to-Improve-Care/Health- Technology-Assessment/Reviews-And-Recommendations/Portable-Normothermic-Cardiac-Perfusion (...) normothermic cardiac perfusion system for the preservation and transportation of DCD hearts for adult transplantation. This included an evaluation of the effectiveness, safety, value for money, and budget impact of publicly funding this system, as well as an evaluation of patient preferences and values. Methods We performed a systematic review of the clinical literature published since 1998 that examined the clinical safety and effectiveness of a portable normothermic cardiac perfusion system for DCD heart

2020 Health Quality Ontario

222. Local alcohol services and systems improvement tool

Local alcohol services and systems improvement tool Local alcohol services and systems improvement tool - GOV.UK GOV.UK uses cookies to make the site simpler. Accept cookies You’ve accepted all cookies. You can at any time. Hide Search Guidance Local alcohol services and systems improvement tool Guidance and tools to help plan and improve local alcohol systems, services and interventions to reduce alcohol harm, using the CLeaR approach. Published 1 June 2017 Last updated 19 August 2019 — From (...) : Documents Ref: PHE publications gateway number: GW-619 HTML If you use assistive technology (such as a screen reader) and need a version of this document in a more accessible format, please email . Please tell us what format you need. It will help us if you say what assistive technology you use. Details CLeaR (Challenge services, Leadership, and Results) is an evidence-based approach to system improvement, which can help to prevent and reduce alcohol-related harm at a local level. This guidance

2020 Public Health England

223. Tisagenlecleucel for treating relapsed or refractory diffuse large B-cell lymphoma after 2 or more systemic therapies

or refractory diffuse large B-cell lymphoma after 2 or more systemic therapies (TA567) © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 6 of 253 3 Committee discussion Committee discussion The appraisal committee (section 5) considered evidence submitted by Novartis and a review of this submission by the evidence review group (ERG). See the committee papers for full details of the evidence. New treatment option (...) Tisagenlecleucel for treating relapsed or refractory diffuse large B-cell lymphoma after 2 or more systemic therapies Tisagenlecleucel for treating relapsed or Tisagenlecleucel for treating relapsed or refr refractory diffuse large B-cell lymphoma actory diffuse large B-cell lymphoma after 2 or more systemic ther after 2 or more systemic therapies apies T echnology appraisal guidance Published: 13 March 2019 nice.org.uk/guidance/ta567 © NICE 2019. All rights reserved. Subject to Notice

2019 National Institute for Health and Clinical Excellence - Technology Appraisals

224. Axicabtagene ciloleucel for treating diffuse large B-cell lymphoma and primary mediastinal large B-cell lymphoma after 2 or more systemic therapies

of the commercial arrangement. Axicabtagene ciloleucel for treating diffuse large B-cell lymphoma and primary mediastinal large B-cell lymphoma after 2 or more systemic therapies (TA559) © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 5 of 313 3 Committee discussion Committee discussion The appraisal committee (section 5) considered evidence submitted by Kite Pharma and a review of this submission by the evidence review group (...) Axicabtagene ciloleucel for treating diffuse large B-cell lymphoma and primary mediastinal large B-cell lymphoma after 2 or more systemic therapies Axicabtagene ciloleucel for treating Axicabtagene ciloleucel for treating diffuse large B-cell lymphoma and diffuse large B-cell lymphoma and primary mediastinal large B-cell primary mediastinal large B-cell lymphoma after 2 or more systemic lymphoma after 2 or more systemic ther therapies apies T echnology appraisal guidance Published: 23 January

2019 National Institute for Health and Clinical Excellence - Technology Appraisals

225. Consolidation or maintenance systemic therapy for newly diagnosed stage II, III, or IV epithelial ovary, fallopian tube, or primary peritoneal carcinoma

. Consolidation or maintenance systemic therapy for newly diagnosed stage II, III, or IV epithelial ovary, fallopian tube, or primary peritoneal carcinoma: a systematic review. Gynecologic Oncology. (Under Review). Hirte H, Yao X, Ferguson SE, May T, Elit L. An Evidence-based guideline: Consolidation or maintenance systemic therapy for newly diagnosed stage II, III, or IV epithelial ovary, fallopian tube, or primary peritoneal carcinoma. Current Oncology (manuscript preparation). Copyright This report (...) Consolidation or maintenance systemic therapy for newly diagnosed stage II, III, or IV epithelial ovary, fallopian tube, or primary peritoneal carcinoma Guideline 4-18 A Quality Initiative of the Program in Evidence-Based Care (PEBC), Ontario Health (Cancer Care Ontario) Consolidation or maintenance systemic therapy for newly diagnosed stage II, III, or IV epithelial ovary, fallopian tube, or primary peritoneal carcinoma H. Hirte, X. Yao, S.E. Ferguson, T. May, L. Elit, and the Ovarian Cancer

2020 Cancer Care Ontario

226. What clinical features or scoring system, if any, might best predict a benefit from hospital admission for patients with COVID-19?

, as they are derived from a Chinese population in unclear clinical settings, the findings may be of limited applicability to a UK, primary care setting. Guidelines Four guidelines highlight different but overlapping clinical features that may correlate with worse outcomes, sometimes in the context of considering which patients may require hospital-based care [6-9]. None of these guidelines discuss use of a tool or scoring system. It is not within the scope of this review to formally appraise these guidelines (...) What clinical features or scoring system, if any, might best predict a benefit from hospital admission for patients with COVID-19? What clinical features or scoring system, if any, might best predict a benefit from hospital admission for patients with COVID-19? - CEBM CEBM The Centre for Evidence-Based Medicine develops, promotes and disseminates better evidence for healthcare. Navigate this website What clinical features or scoring system, if any, might best predict a benefit from hospital

2020 Oxford COVID-19 Evidence Service

227. What is the role of cultural intelligence in systems leadership?

What is the role of cultural intelligence in systems leadership? Knowledge & Library Services (KLS) Evidence Briefing What is the role of cultural intelligence in systems leadership? Nicola Pearce-Smith May 20 th 2020 What is the role of cultural intelligence in systems leadership? KLS Evidence Briefing May 20 th 2020 This briefing summarises the evidence on the relationship between cultural intelligence and leadership, from January 1 st 2009 to March 10th 2020. Key messages • Cultural (...) Intelligence (CQ) captures a person’s capability to adapt effectively to new cultural contexts • No articles relating CQ and systems leadership specifically were found, but there were papers looking at CQ and leadership in general • CQ is comprised of four factors – behavioural, cognitive, metacognitive and motivational • The 20-item CQ scale has been utilised the most for measurement of CQ • Leaders with CQ can impact their team interaction, which leads to trust, a significant indicator of performance

2020 Public Health England - Evidence Briefings

228. COVID-19 and Food Safety: Guidance for competent authorities responsible for national food safety control systems

COVID-19 and Food Safety: Guidance for competent authorities responsible for national food safety control systems -1- COVID-19 and Food Safety: Guidance for competent authorities responsible for national food safety control systems Interim guidance 22 April 2020 Background The ongoing COVID-19 pandemic presents an exceptional and unprecedented challenge for competent authorities a with responsibilities for national food safety control systems b to continue conducting routine functions (...) chain, sampling and analysis of food, managing food incidents, providing advice on food safety and food regulations for the food industry, and communicating on food safety issues with the public. To preserve the integrity of the national food safety control system and to support international trade and the food supply chain, each competent authority will need to prioritize critically important services during the ongoing COVID-19 pandemic. These may include introducing temporary suspensions of low

2020 WHO Coronavirus disease (COVID-19) Pandemic

229. Should temperature screening by thermal imaging systems be part of the policy response to curb COVID-19 transmission?

Government. A rapid review of existing guidance and current evidence was undertaken, with the findings summarised in this report. HIS Evidence Conclusion: The evidence on whether screening by thermal imaging systems is effective in controlling infectious disease transmission is weak or inconclusive at best. The most recent review suggested that screening alone or alongside a questionnaire was not effective at detecting infected persons. The evidence on implementation and impact of screening during (...) Should temperature screening by thermal imaging systems be part of the policy response to curb COVID-19 transmission? A Should temperature screening by thermal imaging systems be part of the policy response to curb Covid- 19 transmission? HIS Evidence were asked to examine whether mass screening by thermal imaging systems should feature in local and national strategies being implemented to control Covid-19 transmission. This is to support the work of Public Health Scotland and the Scottish

2020 Covid-19 Ad hoc papers

230. COVID-19 and the cardiovascular system Full Text available with Trip Pro

COVID-19 and the cardiovascular system COVID-19 and the cardiovascular system | Nature Reviews Cardiology Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. A Nature Research Journal COVID-19 and the cardiovascular (...) system , , , , & ( 2020 ) 340k Accesses 8 Citations 1996 Altmetric Subjects Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects host cells through ACE2 receptors, leading to coronavirus disease (COVID-19)-related pneumonia, while also causing acute myocardial injury and chronic damage to the cardiovascular system. Therefore, particular attention should be given to cardiovascular protection during treatment for COVID-19. In December 2019, an outbreak of pneumonia caused by a novel

2020 Covid-19 Ad hoc papers

231. Covid-19: Hand Hygiene Compliance Monitoring Systems for Reducing Healthcare-associated Infections

Covid-19: Hand Hygiene Compliance Monitoring Systems for Reducing Healthcare-associated Infections CLINICAL EVIDENCE ASSESSMENT © August 2018 ECRI Lytbot Pulsed Xenon UV System (Solaris) for Environmental Disinfection The Lytbot Pulsed Xenon UV System is an ultraviolet (UV) radiation disinfection system that uses 254 nm ultraviolet-C (UVC) light delivered in a “high frequency bulb flash rate” in three-minute cycles, according to the manufacturer. The device also has a reflector system intended (...) to amplify the light energy reaching surfaces. The manufacturer asserts the device can destroy organisms on surfaces at a distance of 10 feet. This report focuses on the safety and efficacy of Lytbot for environmental disinfection. The Evidence Bar™ Evidence is inconclusive — no evidence available Share Your Feedback on how this report answered your question by visiting ly.ecri.org/rate CLINICAL EVIDENCE ASSESSMENT Lytbot Pulsed Xenon UV System (Solaris) for Environmental Disinfection © August 2018 ECRI

2020 Covid-19 Ad hoc papers

232. Covid-19: Countertop Ultraviolet Systems for Disinfecting Mobile Devices

: Searched all available literature through October 2, 2019. We reviewed full text of 2 studies reporting on 64 mobile devices. - 1 prospective, single-center nonrandomized comparison study (14 devices) compared the D6000 UV-C tabletop portable disinfection system to no disinfection in an elderly care ward and a gastroenterology surgery ward and reported on bacterial contamination of the devices. - 1 prospective, single-center before-and-after study (50 devices) compared bacterial contamination before (...) countertop UV systems used to disinfect mobile devices in a clinical setting. We excluded studies of UV lamps and handheld UV devices, studies with fewer than 10 mobile devices, case reports, laboratory studies, and conference abstracts. We also identified a systematic review published in 2019 (literature searches to July 2017) that examined the clinical literature on microbial contamination of computer devices used in healthcare settings and the effectiveness of decontamination methods for these devices

2020 Covid-19 Ad hoc papers

233. Rapid Expert Consultation on Data Elements and Systems Design for Modeling and Decision Making for the COVID-19 Pandemic

University Medical Center, Sandro Galea, Boston University, and Isaac Kohane, Harvard Medical School, reviewed this document, and Ellen Wright Clayton, Vanderbilt University, approved the document as monitor on behalf of the Report Review Committee. Should you desire more substantive and detailed recommendations on system design and content, we would be happy to take this up over a suitable time frame. My colleagues and I hope this input is helpful to you as you continue to guide the nation’s response (...) Rapid Expert Consultation on Data Elements and Systems Design for Modeling and Decision Making for the COVID-19 Pandemic Rapid Expert Consultation | Rapid Expert Consultation on Data Elements and Systems Design for Modeling and Decision Making for the COVID-19 Pandemic (March 21, 2020) | The National Academies Press (2020) Chapter: Rapid Expert Consultation Unfortunately, this book can't be printed from the OpenBook. If you need to print pages from this book, we recommend downloading

2020 Covid-19 Ad hoc papers

234. Treatment of calcinosis cutis in systemic sclerosis and dermatomyositis: a review of the literature. (Abstract)

Treatment of calcinosis cutis in systemic sclerosis and dermatomyositis: a review of the literature. We have limited data on the treatment of calcinosis cutis associated with systemic sclerosis (SSc) and dermatomyositis (DM).To assess the efficacy and tolerance of available treatments for calcinosis cutis based on previously published studies.We performed a systematic review of studies published in MEDLINE, Embase, and the Cochrane library between 1980 and July 2018. The strength of clinical

2019 Journal of American Academy of Dermatology

235. Use of Topical and Systemic Retinoids in Solid Organ Transplant Recipients: Update and Review of the Current Literature. (Abstract)

Use of Topical and Systemic Retinoids in Solid Organ Transplant Recipients: Update and Review of the Current Literature. Solid organ transplant recipients (SOTRs) are at an increased risk of epithelial malignancies, mainly squamous cell carcinoma, and its precursor lesions such as actinic keratoses, warts, and porokeratosis, which may respond to retinoid therapy.To review the published evidence on the efficacy and safety of topical and systemic retinoids for the treatment and prophylaxis (...) of malignant and premalignant conditions that mostly afflict SOTRs.Systematic review of the literature to summarize the level of evidence and grade of recommendation for retinoid therapy with emphasis in the SOTR population.Acitretin has the highest strength of recommendation (Grade A) for prophylaxis of nonmelanoma skin cancer (NMSC) and treatment and prophylaxis of actinic keratoses in SOTR. In nonimmunosuppressed patients, acitretin and isotretinoin have a Grade B recommendation for treatment

2019 Dermatologic Surgery

236. Current management of central nervous system metastasis from cholangiocarcinoma: the neurosurgical perspective. Literature review. (Abstract)

Current management of central nervous system metastasis from cholangiocarcinoma: the neurosurgical perspective. Literature review. Purpose: Central nervous system (CNS) metastasis from cholangiocarcinoma (CCA) are extremely rare and associated prognosis is poor. The involvement of the CNS by metastatic CCA may discourage any further treatment; however, data from the literature are discordant, due to recent reports of exceptionally long follow-up after surgical resection of a brain metastasis (...) . Material and Methods: Electronic databases, such as PubMed/MEDLINE and Google Scholar, were analyzed for studies published up to October 2018 using the search term "cholangiocarcinoma and central nervous system metastasis or brain metastasis". Results: We found a total of 18 studies cited in the literature of the 30 year span analyzed, and we added a new case we treated at our Institution, reaching a series of 32 patients. Among these, 7 patients had leptomeningeal dissemination and 25 presented solid

2019 British Journal of Neurosurgery

237. "Implementation Is so Difficult": Survey of National Learning Health System Decision-makers Identifies Need For Implementation Information in Evidence Reviews. Full Text available with Trip Pro

"Implementation Is so Difficult": Survey of National Learning Health System Decision-makers Identifies Need For Implementation Information in Evidence Reviews. Evidence use within learning health care systems can improve patient health outcomes. Embedded in the Veterans Health Administration (VHA) since 2007, the Veterans Affairs Evidence Synthesis Program (ESP) provides tailored evidence synthesis services to support VHA's learning health care system goals. As part of the ESP's ongoing quality (...) improvement efforts, we have been surveying our users since 2016.We reviewed data from a survey of end-users received between September 5, 2016, and June 10, 2019. The survey assessed: (1) nature of decision-making needs; (2) actions resulting from the report's findings; (3) implementation timeframe; and (4) overall perception of report content.Feedback was received from 66 of the 138 operational partners requesting ESP products during the fiscal year 2015 through 2018. Requests commonly informed clinical

2019 Medical Care

238. Sex hormones and sex hormone-targeting therapies in systemic sclerosis: A systematic literature review. (Abstract)

Sex hormones and sex hormone-targeting therapies in systemic sclerosis: A systematic literature review. The pathophysiology of systemic sclerosis (SSc) is complex and elusive, however, considering the strong female preponderance and different clinical characteristics between men and women, a contribution of sex hormones has been proposed.We undertook this systematic literature review to investigate: (1) the role played by male and female sex hormones in the pathogenesis of SSc; (2) how sex (...) hormone levels change in SSc patients and how hormonal variations modify the progression of SSc; (3) the effect of therapies targeting sex hormones on the disease course.A literature search was performed in Pubmed, Embase, Web of Science, and Cochrane library databases. Given the heterogeneity in study design, different quality assessment tools were applied where appropriate.We retrieved 300 articles and 30 were included in the review. The available evidence points to a fibrogenic, but also

2019 Seminars in arthritis and rheumatism

239. Vision-based serious games and virtual reality systems for motor rehabilitation: A review geared toward a research methodology. (Abstract)

Vision-based serious games and virtual reality systems for motor rehabilitation: A review geared toward a research methodology. Nowadays, information technologies are being widely adopted to promote healthcare and rehabilitation. Owing to their affordability and use of hand-free controllers, vision-based systems have gradually been integrated into motor rehabilitation programs and have greatly drawn the interest of healthcare practitioners and the research community. Many studies have (...) illustrated the effectiveness of these systems in rehabilitation. However, the report and design aspects of the reported clinical trials were disregarded.In this paper, we present a systematic literature review of the use of vision-based serious games and virtual reality systems in motor rehabilitation programs. We aim to propose a research methodology that engineers can use to improve the designing and reporting processes of their clinical trials.We conducted a review of published studies that entail

2019 International journal of medical informatics

240. Systematic Literature Review of Systemic Corticosteroid Use for Asthma Management. Full Text available with Trip Pro

Systematic Literature Review of Systemic Corticosteroid Use for Asthma Management. Systemic corticosteroid use to manage uncontrolled asthma and its associated health care burden may account for important health-related adverse effects. We conducted a systematic literature review to investigate the real-world extent and burden of systemic corticosteroid use in asthma. We searched MEDLINE® and Embase® databases to identify English-language articles published from 2010-2017, using search terms (...) for asthma with key words for oral corticosteroids and systemic corticosteroids. Observational studies, prescription database analyses, economic analyses, and surveys on oral/systemic corticosteroid use for children (aged >5 years), adolescents (aged 12-17 years), and adults with asthma were included. We identified and reviewed 387 full-text articles, and our review included data from 139 studies. The included studies were conducted in Europe, North America, and Asia. Overall, oral/systemic

2019 American journal of respiratory and critical care medicine

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