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Review of Systems

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201. Three cases of localized cutaneous nodular amyloidosis in patients with limited systemic sclerosis and a brief literature review Full Text available with Trip Pro

Three cases of localized cutaneous nodular amyloidosis in patients with limited systemic sclerosis and a brief literature review Localized cutaneous nodular amyloidosis (LCNA) is the rarest form of localized cutaneous amyloidosis. In patients with LCNA, local plasma cells secrete immunoglobulin light chains called amyloid L via an unknown mechanism. LCNA has been associated with autoimmune connective tissue diseases such as most commonly Sjögren syndrome. A few reported cases of LCNA (...) are associated with limited systemic sclerosis (LSSc). We report three cases of LCNA in patients with LSSc to add to the existing literature, discuss the disease association and proposed pathophysiology, and briefly review the existing information in current literature. It is important to closely follow patients with LCNA to monitor progression to systemic amyloidosis.

2017 International journal of women's dermatology

202. Prostate Imaging Reporting and Data System Version 2 (PI-RADS v2): A pictorial review Full Text available with Trip Pro

Prostate Imaging Reporting and Data System Version 2 (PI-RADS v2): A pictorial review The most recent edition of the prostate imaging reporting and data system (PI-RADS version 2) was developed based on expert consensus of the international working group on prostate cancer. It provides the minimum acceptable technical standards for MR image acquisition and suggests a structured method for multiparametric prostate MRI (mpMRI) reporting. T1-weighted, T2-weighted (T2W), diffusion-weighted (DWI (...) ), and dynamic contrast-enhanced (DCE) imaging are the suggested sequences to include in mpMRI. The PI-RADS version 2 scoring system enables the reader to assess and rate all focal lesions detected at mpMRI to determine the likelihood of a clinically significant cancer. According to PI-RADS v2, a lesion with a Gleason score ≥7, volume >0.5 cc, or extraprostatic extension is considered clinically significant. PI-RADS v2 uses the concept of a dominant MR sequence based on zonal location of the lesion rather

2017 Abdominal radiology (New York)

203. What is health systems responsiveness? Review of existing knowledge and proposed conceptual framework Full Text available with Trip Pro

What is health systems responsiveness? Review of existing knowledge and proposed conceptual framework Responsiveness is a key objective of national health systems. Responsive health systems anticipate and adapt to existing and future health needs, thus contributing to better health outcomes. Of all the health systems objectives, responsiveness is the least studied, which perhaps reflects lack of comprehensive frameworks that go beyond the normative characteristics of responsive services (...) . This paper contributes to a growing, yet limited, knowledge on this topic. Herewith, we review the current frameworks for understanding health systems responsiveness and drawing on these, as well as key frameworks from the wider public services literature, propose a comprehensive conceptual framework for health systems responsiveness. This paper should be of interest to different stakeholders who are engaged in analysing and improving health systems responsiveness. Our review shows that existing

2017 BMJ global health

204. Epidemiology of burn injuries in Nepal: a systemic review Full Text available with Trip Pro

Epidemiology of burn injuries in Nepal: a systemic review Burn is a global public health problem associated with significant morbidity and mortality, mostly in low- and middle-income countries. Southeast-Asian countries share a big burden of burn injuries, and Nepal is not an exception. We performed a systemic review to examine the epidemiological characteristics of burn injures in Nepal. Relevant epidemiological studies were identified through systemic search in PubMed, EMBASE, and Google (...) Scholar. Reference lists from relevant review articles were also searched. Studies were included if they meet our selection criteria. Eight studies were included in our systemic review. Most of the burn victims belong to the working age group between 15-60 years old. Flame burns were found to be the most common cause of burn injury followed by scald burns, whereas scald burns were the most common cause of burn injury among the pediatric population. Most patients sustained less severe burn injuries

2017 Burns & trauma

205. Erratum to: Epidemiology of burn injuries in Nepal: a systemic review Full Text available with Trip Pro

Erratum to: Epidemiology of burn injuries in Nepal: a systemic review [This corrects the article DOI: 10.1186/s41038-017-0075-y.].

2017 Burns & trauma

206. Health policy and systems research: towards a better understanding and review of ethical issues Full Text available with Trip Pro

Health policy and systems research: towards a better understanding and review of ethical issues Given the focus on health systems in the post-millennium development goal era and moving towards the sustainable development goals, there is a compelling need for a common framework for health policy and systems research ethics to guide researchers and facilitate review by research ethics committees. A consultation of global health policy and systems research and ethics experts was convened (...) to identify ethical considerations relevant to health policy and systems research based on existing knowledge and to identify knowledge gaps through a scoping review and further expert deliberation. Health policy and systems research is highly complex and, in the absence of guidance documents, there is significant variability in ethics review. Although fundamental ethical principles pertain to both traditional clinical research and health policy and systems research, the application of these principles

2017 BMJ global health

207. Aneurysm of the ascending aorta in systemic lupus erythematosus: Case report and review of the literature Full Text available with Trip Pro

Aneurysm of the ascending aorta in systemic lupus erythematosus: Case report and review of the literature Cardiovascular manifestations in patients with systemic lupus erythematosus (SLE) are common, but aortic aneurysm formation is rare. We present a 63-year-old male SLE patient with a two-year history of skin lesions, leucopenia, pericarditis, mitral valve vegetations consistent with Liebman-Sacks endocarditis, and an aneurysm of the ascending aorta, which was successfully repaired surgically

2017 European journal of rheumatology

208. Is There Evidence of Cost Benefits of Electronic Medical Records, Standards, or Interoperability in Hospital Information Systems? Overview of Systematic Reviews Full Text available with Trip Pro

Is There Evidence of Cost Benefits of Electronic Medical Records, Standards, or Interoperability in Hospital Information Systems? Overview of Systematic Reviews Electronic health (eHealth) interventions may improve the quality of care by providing timely, accessible information about one patient or an entire population. Electronic patient care information forms the nucleus of computerized health information systems. However, interoperability among systems depends on the adoption of information (...) standards. Additionally, investing in technology systems requires cost-effectiveness studies to ensure the sustainability of processes for stakeholders.The objective of this study was to assess cost-effectiveness of the use of electronically available inpatient data systems, health information exchange, or standards to support interoperability among systems.An overview of systematic reviews was conducted, assessing the MEDLINE, Cochrane Library, LILACS, and IEEE Library databases to identify relevant

2017 JMIR medical informatics

209. Does an integrated information technology system provide support for community pharmacists undertaking Discharge Medicines Reviews? An exploratory study Full Text available with Trip Pro

Does an integrated information technology system provide support for community pharmacists undertaking Discharge Medicines Reviews? An exploratory study The aim of this study was to explore the views of community pharmacists participating in the pilot of a secure online platform in Wales, the Choose Pharmacy application (CPA), with particular interest in the electronic Discharge Advice Letters (e-DALs) and online Discharge Medicines Review (DMR) form.A qualitative approach with semi-structured

2017 Integrated pharmacy research & practice

210. Timeliness of notification systems for infectious diseases: A systematic literature review. Full Text available with Trip Pro

Timeliness of notification systems for infectious diseases: A systematic literature review. Timely notification of infectious diseases is crucial for prompt response by public health services. Adequate notification systems facilitate timely notification. A systematic literature review was performed to assess outcomes of studies on notification timeliness and to determine which aspects of notification systems are associated with timely notification.Articles reviewing timeliness of notifications (...) published between 2000 and 2017 were searched in Pubmed and Scopus. Using a standardized notification chain, timeliness of reporting system for each article was defined as either sufficient (≥ 80% notifications in time), partly sufficient (≥ 50-80%), or insufficient (< 50%) according to the article's predefined timeframe, a standardized timeframe for all articles, and a disease specific timeframe. Electronic notification systems were compared with conventional methods (postal mail, fax, telephone, email

2018 PLoS ONE

211. Prevena incision management system for closed surgical incisions

Prevena incision management system for closed surgical incisions Pre Prev vena incision management system for closed ena incision management system for closed surgical incisions surgical incisions Medtech innovation briefing Published: 28 February 2019 www.nice.org.uk/guidance/mib173 pathways Summary Summary The technology technology described in this briefing is Prevena. It is a single-use technology for the management of closed surgical incisions that may be at increased risk of infection (...) #notice-of-rights). Page 1 of 12considered in this briefing. The technology The technology Prevena (Kinetic Concepts Inc. an Acelity Company) is a wound management system that is placed over a closed surgical incision. The device applies continuous negative pressure. This helps promote healing by holding the incision edges together, drawing fluid and exudate out of the wound, reducing oedema and stimulating perfusion. The device is single use and can stay in place for up to 7 days. Prevena

2019 National Institute for Health and Clinical Excellence - Advice

212. Biomarker-based tests to support the decision for or against adjuvant systemic chemotherapy in primary breast cancer - state of knowledge

Biomarker-based tests to support the decision for or against adjuvant systemic chemotherapy in primary breast cancer - state of knowledge 1 Translation of the executive summary of the rapid report Biomarkerbasierte Tests zur Entscheidung für oder gegen eine adjuvante systemische Chemotherapie beim primären Mammakarzinom – Aktualisierung zum Auftrag D14-01 (Version 1.1; Status: 26 February 2020). Please note: This translation is provided as a service by IQWiG to English-language readers. However (...) , solely the German original text is absolutely authoritative and legally binding. Extract IQWiG Reports – Commission No. D19-01 Biomarker-based tests to support the decision for or against adjuvant systemic chemotherapy in primary breast cancer – update to Commission D14-01 1 Extract of rapid report D19-01 Version 1.1 Biomarkers in breast cancer 26 February 2020 Institute for Quality and Efficiency in Health Care (IQWiG) - i - Publishing details Publisher: Institute for Quality and Efficiency

2020 Institute for Quality and Efficiency in Healthcare (IQWiG)

213. Systemic treatments for eczema: a network meta-analysis. (Abstract)

Systemic treatments for eczema: a network meta-analysis. Eczema is a common and chronic, relapsing, inflammatory skin disorder. It seriously impacts quality of life and economic outcomes, especially for those with moderate to severe eczema. Various treatments allow sustained control of the disease; however, their relative benefit remains unclear due to the limited number of trials directly comparing treatments.To assess the comparative efficacy and safety of different types of systemic (...) immunosuppressive treatments for moderate to severe eczema using NMA and to generate rankings of available systemic immunosuppressive treatments for eczema according to their efficacy and safety.We searched the following databases up to August 2019: the Cochrane Skin Specialised Register, CENTRAL, MEDLINE, and Embase.All randomised controlled trials (RCTs) of systemic immunosuppressive agents for moderate to severe atopic eczema when compared against placebo or any other eligible eczema treatment.We synthesised

2020 Cochrane

214. Levonorgestrel-releasing intrauterine system for endometrial hyperplasia. (Abstract)

Levonorgestrel-releasing intrauterine system for endometrial hyperplasia. In the absence of treatment, endometrial hyperplasia (EH) can progress to endometrial cancer, particularly in the presence of histologic nuclear atypia. The development of EH results from exposure of the endometrium to oestrogen unopposed by progesterone. Oral progestogens have been used as treatment for EH without atypia, and in some cases of EH with atypia in women who wish to preserve fertility or who cannot tolerate (...) surgery. EH without atypia is associated with a low risk of progression to atypia and cancer; EH with atypia is where the cells are structurally abnormal, and has a higher risk of developing cancer. Oral progestogen is not always effective at reversing the hyperplasia, can be associated with side effects, and depends on patient adherence. The levonorgestrel-intrauterine system (LNG-IUS) is an alternative method of administration of progestogen and may have some advantages over non-intrauterine

2020 Cochrane

215. Patient-initiated appointment systems for adults with chronic conditions in secondary care. (Abstract)

status or disease activity (including harms), quality of life, service utilisation or cost, adverse effects, patient or clinician satisfaction, or failures of the 'system'.Two review authors independently screened all references at title/abstract stage and full-text stage using prespecified inclusion criteria. We resolved disagreements though discussion. Two review authors independently completed data extraction for all included studies. We discussed and resolved discrepancies with a third review (...) Patient-initiated appointment systems for adults with chronic conditions in secondary care. Missed hospital outpatient appointments is a commonly reported problem in healthcare services around the world; for example, they cost the National Health Service (NHS) in the UK millions of pounds every year and can cause operation and scheduling difficulties worldwide. In 2002, the World Health Organization (WHO) published a report highlighting the need for a model of care that more readily meets

2020 Cochrane

216. superDimension Navigation System to help diagnostic sampling of peripheral lung lesions

unquantifiable instances of multiple-counting of patients in the systematic reviews. T able 2 summarises the clinical evidence as well as its strengths and limitations. Overall assessment of the evidence The body of evidence for superDimension Navigation System is large, with several systematic reviews and meta-analyses including a large number of primary studies and thousands of patients worldwide, although none in a UK setting. Primary outcomes include diagnostic yield and safety parameters (...) . (2018) superDimension Navigation System to help diagnostic sampling of peripheral lung lesions (MIB194) © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 7 of 17Study size, design and location Systematic review with limited meta-analysis (search dates January 2000 to November 2017). n=1,648 ENB cases from 31 selected studies. China. Intervention and comparator(s) ENB biopsy of lesion in lung parenchyma and mediastinal

2019 National Institute for Health and Clinical Excellence - Advice

217. The SpyGlass direct visualisation system for diagnostic and therapeutic procedures during endoscopy of the biliary system

as an ERCP session. One specialist commentator also noted that in his experience of working in a specialist unit, patients can be selected to have ERCP with the SpyGlass as a first-line procedure after the clinicians have reviewed their MRI or CT scan findings. One specialist commentator stated that the SpyGlass is currently used in The SpyGlass direct visualisation system for diagnostic and therapeutic procedures during endoscopy of the biliary system (MIB21) © NICE 2018. All rights reserved. Subject (...) The SpyGlass direct visualisation system for diagnostic and therapeutic procedures during endoscopy of the biliary system The Sp The SpyGlass direct visualisation system for yGlass direct visualisation system for diagnostic and ther diagnostic and therapeutic procedures during apeutic procedures during endoscop endoscopy of the biliary system y of the biliary system Medtech innovation briefing Published: 12 February 2015 nice.org.uk/guidance/mib21 pathways Summary Summary The SpyGlass system

2015 National Institute for Health and Clinical Excellence - Advice

218. Classification systems for lower extremity amputation prediction in subjects with active diabetic foot ulcer: a systematic review and meta-analysis

Classification systems for lower extremity amputation prediction in subjects with active diabetic foot ulcer: a systematic review and meta-analysis Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2014 DARE.

219. Do either early warning systems or emergency response teams improve hospital patient survival? A systematic review

Do either early warning systems or emergency response teams improve hospital patient survival? A systematic review Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2014 DARE.

220. Examining the Role of Coaching in Health-system Transformations

, selection, assessment, synthesis or presentation of the research evidence profiled in the rapid synthesis. Merit review The rapid synthesis was reviewed by a small number of policymakers, stakeholders and researchers in order to ensure its scientific rigour and system relevance. Acknowledgments The authors wish to thank Chloe Gao for her help in reviewing the literature for this synthesis. We are especially grateful to William Hogg and Sudah Kutty for their insightful comments and suggestions. Citation (...) ; 4) drafting the rapid synthesis in such a way as to present concisely and in accessible language the research evidence; and 5) finalizing the rapid synthesis based on the input of at least two merit reviewers. McMaster Health Forum 5 Evidence >> Insight >> Action implementation coaching infrastructure for these OHTs, we have undertaken a rapid synthesis about the role of coaching in implementing health-system reforms. WHAT WE FOUND We found three systematic reviews and 14 primary studies

2020 McMaster Health Forum

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