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Retrobulbar Optic Neuropathy

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1. Retrobulbar optic neuropathy associated with sphenoid sinus mucormycosis Full Text available with Trip Pro

Retrobulbar optic neuropathy associated with sphenoid sinus mucormycosis Because fungi usually spread from the paranasal sinuses to the orbital apex in invasive fungal sinusitis (IFS), IFS often presents as an orbital apex syndrome (OAS) characterized by dysfunction of cranial nerves II, III, IV, V1, and VI. We report a case of sphenoid sinus mucormycosis that presented as isolated retrobulbar optic neuropathy. A 94-year-old woman presented with acute blindness in the right eye. Examination (...) revealed the absence of light perception and pupillary reflex in the right eye. Head MRI showed a mass in the right sphenoid sinus, which was contiguous with the right optic nerve. She underwent endoscopic surgery, and a histopathological diagnosis of mucormycosis was established. Treatment with intravenous liposomal amphotericin B reduced the size of the mass. She has survived for more than 1 year without recurrence. Clinicians should consider that IFS can present as isolated retrobulbar optic

2018 Neurology and clinical neuroscience

2. Acute Effect of Hypervolemic Hemodilution on Retrobulbar Hemodynamics in Anterior Ischemic Optic Neuropathy Full Text available with Trip Pro

Acute Effect of Hypervolemic Hemodilution on Retrobulbar Hemodynamics in Anterior Ischemic Optic Neuropathy Ischemic ocular disorders may be treated by hypervolemic hemodilution. The presumed therapeutic benefit is based on a volume effect and improved rheological factors. The aim was to investigate the acute effect of intravenous hydroxyethyl starch on retrobulbar hemodynamics in patients with nonarteritic anterior ischemic optic neuropathy (NAION).24 patients with acute NAION were included (...) 2.16 ± 0.56 to 2.34 ± 0.55  (p < 0.05)) and in the PCAs (PSV from 7.18 ± 1.62 to 7.56 ± 1.55  (p < 0.01); EDV from 2.48 ± 0.55 to 2.66 ± 0.6 cm/sec (p < 0.01)). The RI of all retrobulbar vessels remained unaffected. Blood pressure and heart rate remained unchanged.Hypervolemic hemodilution has an acute effect on blood flow velocities in the CRA and PCAs in NAION patients. Increased blood flow in the arteries supplying the optic nerve head may lead to a better perfusion in NAION patients. This trial

2018 BioMed research international

3. Macular ganglion cell complex measurement in bilateral retrobulbar optic neuropathy without a relative afferent pupillary defect Full Text available with Trip Pro

Macular ganglion cell complex measurement in bilateral retrobulbar optic neuropathy without a relative afferent pupillary defect This study aimed to demonstrate the clinical usefulness of measuring the macular ganglion cell complex (GCC) for the early detection of axonal loss in eyes with bilateral retrobulbar optic neuropathies.We retrospectively reviewed the medical records of three patients with bilateral toxic, ischemic, or infiltrative retrobulbar optic neuropathy.No relative afferent (...) optic disks still appeared normal.A reduction in the macular GCC thickness seemed to precede the appearance of optic disk pallor and occurs regardless of toxic, ischemic, or infiltrative retrobulbar optic neuropathy. The current case series suggested that measurement of the macular GCC facilitated early differentiation between bilateral retrobulbar optic neuropathy and nonorganic visual loss, which can otherwise be challenging in some cases.

2018 International medical case reports journal

4. Retrobulbar Optic Neuropathy

Retrobulbar Optic Neuropathy Retrobulbar Optic Neuropathy Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Retrobulbar Optic Neuropathy (...) Retrobulbar Optic Neuropathy Aka: Retrobulbar Optic Neuropathy , Optic Neuritis From Related Chapters II. Causes Encephalomyelitis vascular lesions Tumor glioma Meningioma Fungal infections Medications Aminosalicylic acid Chloramphenicol Phenothiazines Phenylbutazone Quinine III. Associated Conditions IV. Epidemiology Young patients predominate V. Symptoms Pain behind affected eye is variably present Impaired vision develops over hours to days Affects one or both eyes Rarely results in total blindness

2018 FP Notebook

5. Retrobulbar optic neuropathy secondary to isolated sphenoid sinus disease Full Text available with Trip Pro

Retrobulbar optic neuropathy secondary to isolated sphenoid sinus disease Paranasal sinus disease can cause a condition that mimics optic neuritis. Simultaneous appearance of both diseases would create etiological dilemma. We report two cases of retrobulbar optic neuropathy secondary to isolated sphenoid sinus disease. In the case of a 65-year-old female who had presented with acute loss of vision in the left eye associated with left-sided frontal headache which subsequently turned out (...) to be caused by optic nerve compression at the orbital apex due to collection in abnormally pneumatized left lesser wing of the sphenoid. In another case, a 65-year-old lady had presented with symptoms of bilateral retrobulbar optic neuropathy which was found to be due to direct compression of optic nerves at the orbital apex secondary to metastases from breast carcinoma.

2015 Journal of neurosciences in rural practice

6. The relation between retrobulbar blood flow and posterior ocular changes measured using spectral-domain optical coherence tomography in patients with obstructive sleep apnea syndrome. (Abstract)

The relation between retrobulbar blood flow and posterior ocular changes measured using spectral-domain optical coherence tomography in patients with obstructive sleep apnea syndrome. To investigate the effect of posterior ocular hemodynamics on the retinal nerve fiber layer (RNFL), choroid thickness (CT) and central macular thickness (CMT) in patients with obstructive sleep apnea syndrome (OSAS) and to reveal the association with glaucomatous optic neuropathy.The research was planned (...) values of the PCA, which supplies the optic nerve, show a linear increase as the apnea hypoxia index values in OSAS. As the grade of OSAS improves, this situation leads to a more serious ischemic optic neuropathy. Furthermore, the prevalence of glaucoma in this study is found to be higher in the severe OSAS group.

2018 International ophthalmology Controlled trial quality: uncertain

7. Optic neuropathy causing vertical unilateral hemianopsia after pars plana vitrectomy for a macular hole: A case report. Full Text available with Trip Pro

to dry-up during air/fluid exchange or retinal neurotoxicity of the dye used to visualize the internal limiting membrane (ILM), as well as unintentional removal of retinal neurofibers during ILM peeling, are responsible for such visual field disorders. In this report, we present a case of extensive visual field defect due to optic neuropathy exhibiting vertical hemianopsia after PPV.A 50-year-old woman underwent PPV and cataract surgery for a macular hole and mild cataract under retrobulbar (...) Optic neuropathy causing vertical unilateral hemianopsia after pars plana vitrectomy for a macular hole: A case report. Recent progress in medical technology has resulted in improved surgical outcomes of pars plana vitrectomy (PPV); with microincision systems, the incidence of procedure-related complications during surgery has been reduced. However, unpredictable visual field defects after PPV remain an unresolved issue. A few reports have shown that damage to the retinal neurofibers owing

2018 Medicine

8. Citicoline in Non-Arteritic Ischemic Optic Neuropathy

product Positive history for diseases of the optic nerve (retrobulbar optic neuropathy, glaucoma) or systemic diseases which could preclude the enrolment in the study according to the investigators' judgement Pregnant or nursing women, or women of potential childbearing age not using adequate contraception. Diabetes, SLE, rheumatoid arthritis, mixed connective tissue disease Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your (...) Citicoline in Non-Arteritic Ischemic Optic Neuropathy Citicoline in Non-Arteritic Ischemic Optic Neuropathy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Citicoline in Non-Arteritic Ischemic Optic

2018 Clinical Trials

9. Optic neuropathy and congenital glaucoma associated with probable Zika virus infection in Venezuelan patients Full Text available with Trip Pro

Optic neuropathy and congenital glaucoma associated with probable Zika virus infection in Venezuelan patients Although the current Zika virus (ZIKV) epidemic is a major public health concern, most reports have focused on congenital ZIKV syndrome, its most devastating manifestation. Severe ocular complications associated with ZIKV infections and possible pathogenetic factors are rarely described. Here, we describe three Venezuelan patients who developed severe ocular manifestations following (...) ZIKV infections. We also analyse their serological response to ZIKV and dengue virus (DENV).One adult with bilateral optic neuritis, a child of 4 years of age with retrobulbar uveitis and a newborn with bilateral congenital glaucoma had a recent history of an acute exanthematous infection consistent with ZIKV infection. The results of ELISA tests indicated that all patients were seropositive for ZIKV and four DENV serotypes.Patients with ZIKV infection can develop severe ocular complications. Anti

2018 JMM Case Reports

10. Stem Cell Ophthalmology Treatment Study: bone marrow derived stem cells in the treatment of non-arteritic ischemic optic neuropathy (NAION) Full Text available with Trip Pro

Stem Cell Ophthalmology Treatment Study: bone marrow derived stem cells in the treatment of non-arteritic ischemic optic neuropathy (NAION) Ten patients with bilateral visual loss due to sequential non-arteritic ischemic optic neuropathy (NAION) underwent autologous Bone Marrow Derived Stem Cell (BMSC) therapy within the Stem Cell Ophthalmology Treatment Study (SCOTS). SCOTS is an Institutional Review Board approved clinical study utilizing autologous BMSC in the treatment of optic nerve (...) and retinal diseases that meet inclusion criteria.The average age of the patients treated was 69.8 years. The average duration of visual loss in eyes treated was 9.8 years and ranged from 1 to 35 years. Affected eyes were treated with either retrobulbar, subtenons and intravenous BMSC or, following vitrectomy, intra-optic nerve, subtenons and intravenous BMSC. The primary outcome was visual acuity as measured by Snellen or converted to LogMAR.Following therapy in SCOTS, 80% of patients experienced

2017 Stem Cell Investigation

11. Retrobulbar Optic Neuropathy

Retrobulbar Optic Neuropathy Retrobulbar Optic Neuropathy Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Retrobulbar Optic Neuropathy (...) Retrobulbar Optic Neuropathy Aka: Retrobulbar Optic Neuropathy , Optic Neuritis From Related Chapters II. Causes Encephalomyelitis vascular lesions Tumor glioma Meningioma Fungal infections Medications Aminosalicylic acid Chloramphenicol Phenothiazines Phenylbutazone Quinine III. Associated Conditions IV. Epidemiology Young patients predominate V. Symptoms Pain behind affected eye is variably present Impaired vision develops over hours to days Affects one or both eyes Rarely results in total blindness

2015 FP Notebook

12. Optic neuritis

Optic neuritis Optic neuritis - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Optic neuritis Last reviewed: February 2019 Last updated: March 2018 Summary May involve the retrobulbar (retrobulbar neuritis) or the intrabulbar (papillitis) portion of the optic nerve, or both. Idiopathic ON, the most common form of ON, is an inflammatory optic neuropathy in the absence of evidence of a systemic inflammatory disease. May (...) in the treatment of idiopathic acute ON. Definition Optic neuritis (ON) represents inflammation of the optic nerve. By far the most common form is idiopathic ON, which is a primary demyelinating disease occurring in isolation or as part of multiple sclerosis (MS). Ebers GC. Optic neuritis and multiple sclerosis. Arch Neurol. 1985;42:702-704. http://www.ncbi.nlm.nih.gov/pubmed/4015469?tool=bestpractice.com Optic Neuritis Study Group. The clinical profile of optic neuritis: experience of the Optic Neuritis

2018 BMJ Best Practice

13. Stem Cell Ophthalmology Treatment Study (SCOTS): bone marrow-derived stem cells in the treatment of Leber's hereditary optic neuropathy Full Text available with Trip Pro

Stem Cell Ophthalmology Treatment Study (SCOTS): bone marrow-derived stem cells in the treatment of Leber's hereditary optic neuropathy The Stem Cell Ophthalmology Treatment Study (SCOTS) is currently the largest-scale stem cell ophthalmology trial registered at ClinicalTrials.gov (identifier: NCT01920867). SCOTS utilizes autologous bone marrow-derived stem cells (BMSCs) to treat optic nerve and retinal diseases. Treatment approaches include a combination of retrobulbar, subtenon, intravitreal (...) , intra-optic nerve, subretinal, and intravenous injection of autologous BMSCs according to the nature of the disease, the degree of visual loss, and any risk factors related to the treatments. Patients with Leber's hereditary optic neuropathy had visual acuity gains on the Early Treatment Diabetic Retinopathy Study (ETDRS) of up to 35 letters and Snellen acuity improvements from hand motion to 20/200 and from counting fingers to 20/100. Visual field improvements were noted. Macular and optic nerve

2016 Neural Regeneration Research

14. Electrical synapses interconnecting axons revealed in the optic nerve head - a novel model of gap junctions' involvement in optic nerve function. Full Text available with Trip Pro

wave up to 160% after 30 min (p < 0.001).Optic nerve (ON) axons are equipped with electrical synapses composed of neuronal connexins, especially Cx45, creating direct morphological and functional connections between each other. This finding could have substantial implications for understanding of the pathogenesis of various optic neuropathies and identifies a new potential target for a therapeutic approach.© 2019 The Authors. Acta Ophthalmologica published by John Wiley & Sons Ltd on behalf of Acta (...) Electrical synapses interconnecting axons revealed in the optic nerve head - a novel model of gap junctions' involvement in optic nerve function. To characterize newly discovered electrical synapses, formed by connexin (Cx) 36 and 45, between neighbouring axons within the optic nerve head.Twenty-five Wistar rats were killed by CO2 inhalation. Proximal and distal optic nerve (ON) stumps were collected and processed for immunostainings, electron microscopy (EM) with immunogold labelling, PCR

2019 Acta ophthalmologica

15. Toxic/Nutritional Optic Neuropathy (Diagnosis)

. . Miller NR. Anterior toxic optic neuropathies. Walsh and Hoyt's Clinical Neuro-Ophthalmology . 4th ed. Baltimore: Lippincott Williams & Wilkins; 1982. 254-260. Miller NR. Retrobulbar toxic and deficiency optic neuropathies. Walsh and Hoyt's Clinical Neuro-ophthalmology . 4th ed. Baltimore: Lippincott Williams & Wilkins; 1982. 289-307. Phillips PH. Toxic and deficiency optic neuropathies. Miller NR, Newman NJ, eds. Walsh and Hoyt's Clinical Neuro-ophthalmology . 6th ed. Baltimore: Lippincott Williams (...) Toxic/Nutritional Optic Neuropathy (Diagnosis) Toxic/Nutritional Optic Neuropathy: Background, Pathophysiology, Epidemiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTIxNzY2MS1vdmVydmlldw== processing

2014 eMedicine.com

16. Toxic/Nutritional Optic Neuropathy (Treatment)

& Wilkins; 1982. 254-260. Miller NR. Retrobulbar toxic and deficiency optic neuropathies. Walsh and Hoyt's Clinical Neuro-ophthalmology . 4th ed. Baltimore: Lippincott Williams & Wilkins; 1982. 289-307. Phillips PH. Toxic and deficiency optic neuropathies. Miller NR, Newman NJ, eds. Walsh and Hoyt's Clinical Neuro-ophthalmology . 6th ed. Baltimore: Lippincott Williams & Wilkins; 2005. 447-463. Rizzo JF 3rd, Lessell S. Tobacco amblyopia. Am J Ophthalmol . 1993 Jul 15. 116(1):84-7. . Sadun AA. Metabolic (...) Toxic/Nutritional Optic Neuropathy (Treatment) Toxic/Nutritional Optic Neuropathy Treatment & Management: Medical Care, Consultations, Diet Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTIxNzY2MS10cmVhdG1lbnQ

2014 eMedicine.com

17. Toxic/Nutritional Optic Neuropathy (Overview)

. . Miller NR. Anterior toxic optic neuropathies. Walsh and Hoyt's Clinical Neuro-Ophthalmology . 4th ed. Baltimore: Lippincott Williams & Wilkins; 1982. 254-260. Miller NR. Retrobulbar toxic and deficiency optic neuropathies. Walsh and Hoyt's Clinical Neuro-ophthalmology . 4th ed. Baltimore: Lippincott Williams & Wilkins; 1982. 289-307. Phillips PH. Toxic and deficiency optic neuropathies. Miller NR, Newman NJ, eds. Walsh and Hoyt's Clinical Neuro-ophthalmology . 6th ed. Baltimore: Lippincott Williams (...) Toxic/Nutritional Optic Neuropathy (Overview) Toxic/Nutritional Optic Neuropathy: Background, Pathophysiology, Epidemiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTIxNzY2MS1vdmVydmlldw== processing

2014 eMedicine.com

18. Toxic/Nutritional Optic Neuropathy (Follow-up)

& Wilkins; 1982. 254-260. Miller NR. Retrobulbar toxic and deficiency optic neuropathies. Walsh and Hoyt's Clinical Neuro-ophthalmology . 4th ed. Baltimore: Lippincott Williams & Wilkins; 1982. 289-307. Phillips PH. Toxic and deficiency optic neuropathies. Miller NR, Newman NJ, eds. Walsh and Hoyt's Clinical Neuro-ophthalmology . 6th ed. Baltimore: Lippincott Williams & Wilkins; 2005. 447-463. Rizzo JF 3rd, Lessell S. Tobacco amblyopia. Am J Ophthalmol . 1993 Jul 15. 116(1):84-7. . Sadun AA. Metabolic (...) Toxic/Nutritional Optic Neuropathy (Follow-up) Toxic/Nutritional Optic Neuropathy Treatment & Management: Medical Care, Consultations, Diet Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTIxNzY2MS10cmVhdG1lbnQ

2014 eMedicine.com

19. Vascular hypoperfusion in acute optic neuritis is a potentially new neurovascular model for demyelinating diseases. Full Text available with Trip Pro

September 1 2012, to August 31, 2015. Two hundred and forty-one patients with non-glaucomatous acute optic neuropathy were screened, and 42 non-highly myopic patients who had suffered their first episode of unilaterally idiopathic AON were studied. All cases received spectral-domain optical coherence tomography (OCT) examination, general survey, and standard corticosteroid therapy. OCT images were analyzed using a customized MATLAB program for measuring peripapillary choroidal thickness (PCT (...) is also correlated with poorer trough vision, which may lead to poorer final vision. These findings were obvious in patients with optic papillitis but not in patients with retrobulbar neuritis.Peripapillary vascular hypoperfusion was found in patients experiencing AON combined with disc swelling. These findings are unlike those for other ocular inflammatory diseases but are consistent with cerebral hypoperfusion, which is found in brain demyelinating diseases; thus, these findings may represent a new

2017 PLoS ONE

20. Rhinogenic Optic Neuritis Caused by Sphenoid Mucocele with Sinusitis Full Text available with Trip Pro

Rhinogenic Optic Neuritis Caused by Sphenoid Mucocele with Sinusitis A 59-year-old male who presented with a nonspecific headache at the vertex, resembling retrobulbar optic neuritis, was treated as such but did not show any improvement. Although optic nerve compression from sphenoid mucocele was finally discovered, the delayed diagnosis and improper treatment led to a permanent visual loss. Optic neuritis could be caused by a common problem, "mucocele/sinusitis," but might be easily overlooked (...) in general practice. Rhinogenic optic neuropathy should, therefore, be considered in every case of optic neuritis whenever atypical presentation occurs or is unresponsive to high-dose steroid treatment.

2018 Case Reports in Radiology

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