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Restrictive Lung Disease

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1. Fluid restriction for treatment of preterm infants with chronic lung disease. (PubMed)

Fluid restriction for treatment of preterm infants with chronic lung disease. Fluid restriction is often recommended as part of the management of infants with early or established bronchopulmonary dysplasia (BPD).To determine whether fluid restriction as part of the therapeutic intervention for early or established BPD improves clinical outcomes.We used the standard search strategy of Cochrane Neonatal to search the Cochrane Central Register of Controlled Trials (CENTRAL; 2016, Issue 1 (...) tolerance, apnoea, necrotizing enterocolitis, renal dysfunction or nephrocalcinosis, lung mechanics, and use of diuretic therapy (secondary outcome measures).One trial was found, including 60 preterm infants at 28 days of age with persistent oxygen requirements. Infants were randomised to either 180 mL/kg/day of standard formula or 145 mL/kg/day of concentrated formula. This single study did not provide data regarding our primary outcome. No effects of the intervention were found on any of our secondary

2017 Cochrane

2. A Meta-Analysis of Arsenic Exposure and Lung Function: Is There Evidence of Restrictive or Obstructive Lung Disease? (PubMed)

A Meta-Analysis of Arsenic Exposure and Lung Function: Is There Evidence of Restrictive or Obstructive Lung Disease? Hundreds of millions of people worldwide are exposed to arsenic via contaminated water. The goal of this study was to identify whether arsenic-associated lung function deficits resemble obstructive- or restrictive-like lung disease, in order to help illuminate a mechanistic pathway and identify at-risk populations.We recently published a qualitative systematic review outlining (...) on inverse associations between arsenic and FEV1 and FVC, but not with FEV1/FVC. Future studies should confirm whether low-level arsenic exposure is a restrictive lung disease risk factor in order to identify at-risk populations in the USA.

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2018 Current environmental health reports

3. The repeatability of computed tomography lung volume measurements: Comparisons in healthy subjects, patients with obstructive lung disease, and patients with restrictive lung disease. (PubMed)

The repeatability of computed tomography lung volume measurements: Comparisons in healthy subjects, patients with obstructive lung disease, and patients with restrictive lung disease. In this study, we examined the repeatability of computed tomography (CT) lung volume measurements in healthy individuals and patients with obstructive and restrictive lung diseases. To do this, we retrospectively enrolled 200 healthy individuals (group 1), 100 patients with obstructive lung disease (group 2 (...) ), and 100 patients with restrictive lung disease (group 3) who underwent two consecutive chest CT scans within a 1-year period. The CT lung volume was measured using a threshold-based, three-dimensional auto-segmentation technique at a default range from -200 to -1024 HU. The within-subject standard deviation, repeatability coefficient, within-subject coefficient variability, and intraclass correlation coefficient were evaluated. No significant differences were identified between the two consecutive CT

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2017 PLoS ONE

4. Chronic lung allograft dysfunction: Definition and update of restrictive allograft syndrome?A consensus report from the Pulmonary Council of the ISHLT

Chronic lung allograft dysfunction: Definition and update of restrictive allograft syndrome?A consensus report from the Pulmonary Council of the ISHLT Chronic lung allograft dysfunction: Definition and update of restrictive allograft syndrome―A consensus report from the Pulmonary Council of the ISHLT - The Journal of Heart and Lung Transplantation Email/Username: Password: Remember me Search Terms Search within Search Volume 38, Issue 5, Pages 483–492 To read this article in full, please review (...) your options for gaining access at the bottom of the page. Chronic lung allograft dysfunction: Definition and update of restrictive allograft syndrome―A consensus report from the Pulmonary Council of the ISHLT x Allan R. Glanville Affiliations Lung Transplant Unit, St. Vincent's Hospital, Sydney, New South Wales, Australia , MBBS, MD a , 1 , x Geert M. Verleden Affiliations University Hospital Gasthuisberg, Leuven, Belgium Correspondence Reprint requests: Geert Verleden, MD, PhD, Lung

2019 International Society for Heart and Lung Transplantation

5. Evaluation of the effects of dexmedetomidine infusion on oxygenation and lung mechanics in morbidly obese patients with restrictive lung disease. (PubMed)

Evaluation of the effects of dexmedetomidine infusion on oxygenation and lung mechanics in morbidly obese patients with restrictive lung disease. Dexmedetomidine infusion improves oxygenation and lung mechanics in patients with chronic obstructive lung disease; however, its effect in patients with restrictive lung disease has not been thoroughly investigated yet. The aim of this work was to evaluate the effects of dexmedetomidine infusion on oxygenation and lung mechanics in morbidly obese (...) patients with restrictive lung disease.Forty-two morbidly obese patients scheduled for bariatric surgery were included in the study. Patients were randomized to receive either dexmedetomidine infusion at a bolus dose of 1mcg/Kg followed by infusion at 1 mcg/Kg/hour for 90 min (Dexmedetomidine group), or normal saline infusion (Control group). Both groups were compared with regard to: oxygenation {P/F ratio: PaO2/fraction of inspired oxygen (FiO2)}, lung compliance, dead space, plateau pressure, blood

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2018 BMC Anesthesiology

6. Reversible Restrictive Lung Disease in Pseudomesotheliomatous Carcinoma in a Lung Harboring a HER2-mutation (PubMed)

Reversible Restrictive Lung Disease in Pseudomesotheliomatous Carcinoma in a Lung Harboring a HER2-mutation Pseudomesotheliomatous carcinoma of the lung is very rare, and reversible restrictive lung disease with pseudomesotheliomatous carcinoma has not yet been previously reported. We herein report a patient with HER2-positive non-small-cell lung cancer (NSCLC) showing pseudomesotheliomatous carcinoma who was successfully treated with bevacizumab combination chemotherapy. A 56-year-old Japanese (...) woman with advanced NSCLC presented with dyspnea. We administered chemotherapy with cisplatin (75 mg/m2) plus pemetrexed (500 mg/m2) plus bevacizumab (15 mg/kg), followed by pemetrexed plus bevacizumab. After eight cycles of maintenance chemotherapy, chest CT demonstrated a marked tumor reduction and an improvement of the right lung volume. The vital capacity was thereafter found to have significantly increased according to pulmonary function tests.

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2018 Internal Medicine

7. Restriction of oral intake of water for aspiration lung disease in children. (PubMed)

Restriction of oral intake of water for aspiration lung disease in children. Primary aspiration of food and fluid is commonly seen in children with feeding and swallowing difficulties associated with a range of diseases and complex medical conditions. Respiratory sequelae and pneumonia are known to be associated with primary aspiration of ingested material, however causality between primary aspiration of specific food and fluid types and pulmonary effects in children is yet to be established (...) in controlled trials. The relative pulmonary morbidity of aspiration of ingested food and fluid materials versus other causes of respiratory disease such as viral and bacterial causes, secondary aspiration of gastrointestinal contents and predisposing lung conditions such as chronic neonatal lung disease in a developing immune system is also unclear. Current management decisions for children who aspirate have to optimise oral nutrition and hydration, while reducing the risk of aspiration to preserve

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2012 Cochrane

8. Forced expiration measurements in mouse models of obstructive and restrictive lung diseases. (PubMed)

Forced expiration measurements in mouse models of obstructive and restrictive lung diseases. Pulmonary function measurements are important when studying respiratory disease models. Both resistance and compliance have been used to assess lung function in mice. Yet, it is not always clear how these parameters relate to forced expiration (FE)-related parameters, most commonly used in humans. We aimed to characterize FE measurements in four well-established mouse models of lung diseases.Detailed (...) respiratory mechanics and FE measurements were assessed concurrently in Balb/c mice, using the forced oscillation and negative pressure-driven forced expiration techniques, respectively. Measurements were performed at baseline and following increasing methacholine challenges in control Balb/c mice as well as in four disease models: bleomycin-induced fibrosis, elastase-induced emphysema, LPS-induced acute lung injury and house dust mite-induced asthma.Respiratory mechanics parameters (airway resistance

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2017 Respiratory research

9. Thoracic Spinal Versus Epidural Anesthesia for Nephrectomy in Obstructive/Restrictive Lung Disease Patients

Thoracic Spinal Versus Epidural Anesthesia for Nephrectomy in Obstructive/Restrictive Lung Disease Patients Thoracic Spinal Versus Epidural Anesthesia for Nephrectomy in Obstructive/Restrictive Lung Disease Patients - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (...) (100). Please remove one or more studies before adding more. Thoracic Spinal Versus Epidural Anesthesia for Nephrectomy in Obstructive/Restrictive Lung Disease Patients The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03324490 Recruitment Status : Active, not recruiting First Posted : October 27

2017 Clinical Trials

10. Reply: Decline of Lung Function in Children with Sickle Cell Disease Is Not Associated with Restrictive Defects (PubMed)

Reply: Decline of Lung Function in Children with Sickle Cell Disease Is Not Associated with Restrictive Defects 28248586 2018 11 13 2325-6621 14 3 2017 Mar Annals of the American Thoracic Society Ann Am Thorac Soc Reply: Decline of Lung Function in Children with Sickle Cell Disease Is Not Associated with Restrictive Defects. 478 10.1513/AnnalsATS.201612-1019LE Cohen Robyn T RT http://orcid.org/0000-0002-6902-3118 1 Boston University School of Medicine Boston, Massachusetts. Rodeghier Mark M

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2017 Annals of the American Thoracic Society

11. Restrictive Lung Disease in the Cu/Zn Superoxide-Dismutase 1 G93A Amyotrophic Lateral Sclerosis Mouse Model (PubMed)

Restrictive Lung Disease in the Cu/Zn Superoxide-Dismutase 1 G93A Amyotrophic Lateral Sclerosis Mouse Model 28248134 2018 02 21 2018 11 13 1535-4989 56 3 2017 03 American journal of respiratory cell and molecular biology Am. J. Respir. Cell Mol. Biol. Restrictive Lung Disease in the Cu/Zn Superoxide-Dismutase 1 G93A Amyotrophic Lateral Sclerosis Mouse Model. 405-408 10.1165/rcmb.2016-0258LE Stoica Lorelei L 1 University of Massachusetts Medical School Worcester, Massachusetts. Keeler Allison M (...) United States Am J Respir Cell Mol Biol 8917225 1044-1549 EC 1.15.1.1 SOD1 G93A protein EC 1.15.1.1 Superoxide Dismutase IM Amyotrophic Lateral Sclerosis enzymology genetics Animals Humans Lung Diseases enzymology genetics Mice Mice, Mutant Strains Superoxide Dismutase genetics metabolism 2017 3 2 6 0 2017 3 2 6 0 2018 2 22 6 0 ppublish 28248134 10.1165/rcmb.2016-0258LE PMC5359540 J Appl Physiol (1985). 2007 Mar;102(3):926-32 17110520 N Engl J Med. 2001 May 31;344(22):1688-700 11386269 Nature. 1993

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2017 American journal of respiratory cell and molecular biology

12. Transplant Size Mismatch in Restrictive Lung Disease (PubMed)

Transplant Size Mismatch in Restrictive Lung Disease To maximize the benefit of lung transplantation, the effect of size mismatch on survival in lung transplant recipients with restrictive lung disease (RLD) was examined. All single and bilateral RLD lung transplants from 1987 to 2011 in the United Network for Organ Sharing (UNOS) Database were identified. Donor predicted total lung capacity (pTLC):Recipient pTLC ratio (pTLCr) quantified mismatch. pTLCr was segregated into five strata. A Cox (...) proportional hazards model evaluated the association of pTLCr with mortality hazard. To identify a critical pTLCr, a Cox model using a restricted cubic spline for pTLCr was used. A total of 6656 transplants for RLD were identified. Median pTLCr for single orthotopic lung transplant (SOLT) and bilateral orthotopic lung transplant (BOLT) was 1.0 (0.69-1.47) and 0.98 (0.66-1.45). Examination of pTLCr as a categorical variable revealed that undersizing (pTLCr <0.8) for SOLT and moderate oversizing (pTLCr = 1.1

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2017 Transplant international : official journal of the European Society for Organ Transplantation

13. Response to restrictive lung disease: low EPAP - good ventilation. Is it real? (PubMed)

Response to restrictive lung disease: low EPAP - good ventilation. Is it real? 28413895 2017 08 15 2018 12 02 1479-9731 14 3 2017 08 Chronic respiratory disease Chron Respir Dis Response to restrictive lung disease: low EPAP - good ventilation. Is it real? 323 10.1177/1479972317702143 Kinnear William W Nottingham NHS Treatment Centre - Gateway B, Queens Medical Centre, Nottingham, UK. eng Journal Article Comment 2017 04 17 England Chron Respir Dis 101197408 1479-9723 IM Chron Respir Dis. 2017 (...) Aug;14 (3):321-322 28393535 Humans Lung Diseases Positive-Pressure Respiration Ventilation EPAP IPAP Lung disease non-invasive ventilation ventilation 2017 4 18 6 0 2017 8 16 6 0 2017 4 18 6 0 ppublish 28413895 10.1177/1479972317702143 PMC5720239

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2017 Chronic respiratory disease

14. Restrictive lung disease: Low EPAP – Good ventilation. Is it real? (PubMed)

Restrictive lung disease: Low EPAP – Good ventilation. Is it real? 28393535 2017 08 15 2018 12 02 1479-9731 14 3 2017 08 Chronic respiratory disease Chron Respir Dis Restrictive lung disease: Low EPAP - Good ventilation. Is it real? 321-322 10.1177/1479972317702142 Fiorentino Giuseppe G 1 Respiratory Unit, AO Ospedali dei Colli Monaldi Naples, Naples, Italy. Esquinas Antonio M AM 2 Intensive Care Unit, Hospital Morales Meseguer, Murcia, Spain. eng Letter Comment 2017 04 10 England Chron (...) Respir Dis 101197408 1479-9723 IM Chron Respir Dis. 2017 Aug;14 (3):323 28413895 Chron Respir Dis. 2017 May;14 (2):105-109 27923982 Humans Lung Diseases Positive-Pressure Respiration Tidal Volume Ventilation Non-invasive ventilation expiratory positive airway pressure inspiratory positive airway pressure pressure support ventilation tidal volume 2017 4 11 6 0 2017 8 16 6 0 2017 4 11 6 0 ppublish 28393535 10.1177/1479972317702142 PMC5720238 Respiration. 2006;73(4):488-94 16205051 Respiration. 1989;55

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2017 Chronic respiratory disease

15. Disruption of the Hepcidin/Ferroportin Regulatory System Causes Pulmonary Iron Overload and Restrictive Lung Disease (PubMed)

Disruption of the Hepcidin/Ferroportin Regulatory System Causes Pulmonary Iron Overload and Restrictive Lung Disease Emerging evidence suggests that pulmonary iron accumulation is implicated in a spectrum of chronic lung diseases. However, the mechanism(s) involved in pulmonary iron deposition and its role in the in vivo pathogenesis of lung diseases remains unknown. Here we show that a point mutation in the murine ferroportin gene, which causes hereditary hemochromatosis type 4 (Slc40a1C326S (...) ), increases iron levels in alveolar macrophages, epithelial cells lining the conducting airways and lung parenchyma, and in vascular smooth muscle cells. Pulmonary iron overload is associated with oxidative stress, restrictive lung disease with decreased total lung capacity and reduced blood oxygen saturation in homozygous Slc40a1C326S/C326S mice compared to wild-type controls. These findings implicate iron in lung pathology, which is so far not considered a classical iron-related disorder.Copyright ©

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2017 EBioMedicine

16. Static lung volume should be used to confirm restrictive lung disease (PubMed)

Static lung volume should be used to confirm restrictive lung disease 27660433 2018 11 13 1178-2005 11 2016 International journal of chronic obstructive pulmonary disease Int J Chron Obstruct Pulmon Dis Static lung volume should be used to confirm restrictive lung disease. 2157-2158 Rasam Shweta A SA Department of Pulmonary Function Laboratory, Chest Research Foundation, Pune, Maharashtra, India. Vanjare Nitin V NV Department of Pulmonary Function Laboratory, Chest Research Foundation, Pune

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2016 International journal of chronic obstructive pulmonary disease

17. Galectin-3 is Associated with Restrictive Lung Disease and Interstitial Lung Abnormalities. (PubMed)

Galectin-3 is Associated with Restrictive Lung Disease and Interstitial Lung Abnormalities. Galectin-3 (Gal-3) has been implicated in the development of pulmonary fibrosis in experimental studies, and Gal-3 levels have been found to be elevated in small studies of human pulmonary fibrosis.We sought to study whether circulating Gal-3 concentrations are elevated early in the course of pulmonary fibrosis.We examined 2,596 Framingham Heart Study participants (mean age, 57 yr; 54% women; 14% current (...) coupled with a restrictive pattern, including decreased lung volumes and altered gas exchange. These findings suggest a potential role for Gal-3 in early stages of pulmonary fibrosis.

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2016 American Journal of Respiratory and Critical Care Medicine

18. Physiotherapy in restrictive lung disease. Are current physiotherapy interventions effective at improving lung function and quality of life in patients with restrictive lung diseases?

Physiotherapy in restrictive lung disease. Are current physiotherapy interventions effective at improving lung function and quality of life in patients with restrictive lung diseases? Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email (...) no). For stratified analyses, a minimum number of 8 studies per subgroup is required. ">Subgroup analyses A sensitivity analysis is conducted to assess the impact of decisions taken in the review process on the meta-analysis outcome. These decisions may have been made in various stages of the review, e.g. the decision to exclude certain disease models, the decision to pool certain units of measurement for an outcome, the choice of effect measure, how subgroup variables are stratified etc. In order to assess

2018 PROSPERO

19. Standard of Care for Fibrotic Interstitial Lung Disease

leading to restriction) may impact suitability for transplantation and can influence long-term outcomes. However, recent observa- tional studies suggest that overall post-transplant outcomes may be similar to that of other lung diseases in appropri- ately selected patients. 61,62 Although there is a theoretical concern that anti-fibrotic medications might increase the risk of peri-operative bleeding, the limited available data do not suggest clinically significant risks associated with these agents (...) Standard of Care for Fibrotic Interstitial Lung Disease Full Terms & Conditions of access and use can be found at https://www.tandfonline.com/action/journalInformation?journalCode=ucts20 Canadian Journal of Respiratory, Critical Care, and Sleep Medicine Revue canadienne des soins respiratoires et critiques et de la médecine du sommeil ISSN: 2474-5332 (Print) 2474-5340 (Online) Journal homepage: https://www.tandfonline.com/loi/ucts20 Comprehensive management of fibrotic interstitial lung

2018 Canadian Thoracic Society

20. Restrictive Lung Disease

Restrictive Lung Disease Restrictive Lung Disease Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Restrictive Lung Disease Restrictive (...) Lung Disease Aka: Restrictive Lung Disease , Restrictive Pulmonary Disease , Restrictive Lung Function II. Causes: Chest Wall Kyphosis Morbid III. Causes: Medications Pulmonary fibrosis Pulmonary fibrosis Hypersensitivity Pneumonitis IV. Causes: Interstitial Lung Disease See ic Hypersensitivity pneumonitis Silicosis (late stage) V. Causes: Neuromuscular (ALS) VI. Diagnosis: Pulmonary Function Test See Criteria FEV1 to FVC Ratio >0.7 (or >LLN or for children>85% of predicted) AND FVC < LLN

2018 FP Notebook

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