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Restrictive Lung Disease

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1. Chronic lung allograft dysfunction: Definition and update of restrictive allograft syndrome?A consensus report from the Pulmonary Council of the ISHLT Full Text available with Trip Pro

Chronic lung allograft dysfunction: Definition and update of restrictive allograft syndrome?A consensus report from the Pulmonary Council of the ISHLT Chronic lung allograft dysfunction: Definition and update of restrictive allograft syndrome―A consensus report from the Pulmonary Council of the ISHLT - The Journal of Heart and Lung Transplantation Email/Username: Password: Remember me Search Terms Search within Search Volume 38, Issue 5, Pages 483–492 To read this article in full, please review (...) your options for gaining access at the bottom of the page. Chronic lung allograft dysfunction: Definition and update of restrictive allograft syndrome―A consensus report from the Pulmonary Council of the ISHLT x Allan R. Glanville Affiliations Lung Transplant Unit, St. Vincent's Hospital, Sydney, New South Wales, Australia , MBBS, MD a , 1 , x Geert M. Verleden Affiliations University Hospital Gasthuisberg, Leuven, Belgium Correspondence Reprint requests: Geert Verleden, MD, PhD, Lung

2019 International Society for Heart and Lung Transplantation

2. Fluid restriction for treatment of preterm infants with chronic lung disease. Full Text available with Trip Pro

Fluid restriction for treatment of preterm infants with chronic lung disease. Fluid restriction is often recommended as part of the management of infants with early or established bronchopulmonary dysplasia (BPD).To determine whether fluid restriction as part of the therapeutic intervention for early or established BPD improves clinical outcomes.We used the standard search strategy of Cochrane Neonatal to search the Cochrane Central Register of Controlled Trials (CENTRAL; 2016, Issue 1 (...) tolerance, apnoea, necrotizing enterocolitis, renal dysfunction or nephrocalcinosis, lung mechanics, and use of diuretic therapy (secondary outcome measures).One trial was found, including 60 preterm infants at 28 days of age with persistent oxygen requirements. Infants were randomised to either 180 mL/kg/day of standard formula or 145 mL/kg/day of concentrated formula. This single study did not provide data regarding our primary outcome. No effects of the intervention were found on any of our secondary

2017 Cochrane

3. The repeatability of computed tomography lung volume measurements: Comparisons in healthy subjects, patients with obstructive lung disease, and patients with restrictive lung disease. Full Text available with Trip Pro

The repeatability of computed tomography lung volume measurements: Comparisons in healthy subjects, patients with obstructive lung disease, and patients with restrictive lung disease. In this study, we examined the repeatability of computed tomography (CT) lung volume measurements in healthy individuals and patients with obstructive and restrictive lung diseases. To do this, we retrospectively enrolled 200 healthy individuals (group 1), 100 patients with obstructive lung disease (group 2 (...) ), and 100 patients with restrictive lung disease (group 3) who underwent two consecutive chest CT scans within a 1-year period. The CT lung volume was measured using a threshold-based, three-dimensional auto-segmentation technique at a default range from -200 to -1024 HU. The within-subject standard deviation, repeatability coefficient, within-subject coefficient variability, and intraclass correlation coefficient were evaluated. No significant differences were identified between the two consecutive CT

2017 PLoS ONE

4. Restrictive lung disorder is common in patients with kidney failure and associates with protein-energy wasting, inflammation and cardiovascular disease. Full Text available with Trip Pro

Restrictive lung disorder is common in patients with kidney failure and associates with protein-energy wasting, inflammation and cardiovascular disease. Cardiovascular disease (CVD), protein-energy wasting (PEW), and inflammation are common interrelated features of chronic kidney disease (CKD). Less is known about lung dysfunction in CKD and its possible role in this context. We evaluated lung function and its association with estimated glomerular filtration rate (GFR), CVD, PEW (...) , and inflammation in individuals with normal to severely reduced GFR.In 404 individuals with GFR category G1 (n = 31; GFR >90mL/min/1.73 m2), G2 (n = 46), G3 (n = 33), G4 (n = 49) and G5 (n = 245; GFR<15mL/min/1.73 m2), pulmonary function was assessed by spirometry. Obstructive (OLD) and restrictive (RLD) lung dysfunction was defined based on forced vital capacity (FVC), forced expiratory volume in the first second (FEV1) and peak expiratory flow (PEF), expressed as percentages of predicted values (%FEV1, %FVC

2018 PLoS ONE

5. Physiotherapy in restrictive lung disease. Are current physiotherapy interventions effective at improving lung function and quality of life in patients with restrictive lung diseases?

Physiotherapy in restrictive lung disease. Are current physiotherapy interventions effective at improving lung function and quality of life in patients with restrictive lung diseases? Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email (...) no). For stratified analyses, a minimum number of 8 studies per subgroup is required. ">Subgroup analyses A sensitivity analysis is conducted to assess the impact of decisions taken in the review process on the meta-analysis outcome. These decisions may have been made in various stages of the review, e.g. the decision to exclude certain disease models, the decision to pool certain units of measurement for an outcome, the choice of effect measure, how subgroup variables are stratified etc. In order to assess

2018 PROSPERO

6. Reversible Restrictive Lung Disease in Pseudomesotheliomatous Carcinoma in a Lung Harboring a HER2-mutation Full Text available with Trip Pro

Reversible Restrictive Lung Disease in Pseudomesotheliomatous Carcinoma in a Lung Harboring a HER2-mutation Pseudomesotheliomatous carcinoma of the lung is very rare, and reversible restrictive lung disease with pseudomesotheliomatous carcinoma has not yet been previously reported. We herein report a patient with HER2-positive non-small-cell lung cancer (NSCLC) showing pseudomesotheliomatous carcinoma who was successfully treated with bevacizumab combination chemotherapy. A 56-year-old Japanese (...) woman with advanced NSCLC presented with dyspnea. We administered chemotherapy with cisplatin (75 mg/m2) plus pemetrexed (500 mg/m2) plus bevacizumab (15 mg/kg), followed by pemetrexed plus bevacizumab. After eight cycles of maintenance chemotherapy, chest CT demonstrated a marked tumor reduction and an improvement of the right lung volume. The vital capacity was thereafter found to have significantly increased according to pulmonary function tests.

2018 Internal Medicine

7. Evaluation of the effects of dexmedetomidine infusion on oxygenation and lung mechanics in morbidly obese patients with restrictive lung disease. Full Text available with Trip Pro

Evaluation of the effects of dexmedetomidine infusion on oxygenation and lung mechanics in morbidly obese patients with restrictive lung disease. Dexmedetomidine infusion improves oxygenation and lung mechanics in patients with chronic obstructive lung disease; however, its effect in patients with restrictive lung disease has not been thoroughly investigated yet. The aim of this work was to evaluate the effects of dexmedetomidine infusion on oxygenation and lung mechanics in morbidly obese (...) patients with restrictive lung disease.Forty-two morbidly obese patients scheduled for bariatric surgery were included in the study. Patients were randomized to receive either dexmedetomidine infusion at a bolus dose of 1mcg/Kg followed by infusion at 1 mcg/Kg/hour for 90 min (Dexmedetomidine group), or normal saline infusion (Control group). Both groups were compared with regard to: oxygenation {P/F ratio: PaO2/fraction of inspired oxygen (FiO2)}, lung compliance, dead space, plateau pressure, blood

2018 BMC Anesthesiology Controlled trial quality: uncertain

8. Comparative study of mid-thoracic spinal versus epidural anesthesia for open nephrectomy in patients with obstructive/restrictive lung disease: A randomized controlled study. (Abstract)

Comparative study of mid-thoracic spinal versus epidural anesthesia for open nephrectomy in patients with obstructive/restrictive lung disease: A randomized controlled study. The aim of this randomized controlled study is to compare the safety and efficacy of thoracic spinal versus thoracic epidural anesthesia for open nephrectomy in patients with obstructive/restrictive lung disease.Sixty patients with mild to moderate chronic obstructive/restrictive lung disease undergoing open nephrectomy (...) existed in intraoperative VAS, and hemodynamics between the two groups. Postoperative adverse effects were negligible and insignificant, with no case reporting any neurological sequel.Ultrasound guided thoracic spinal anesthesia can be performed safely and effectively for open nephrectomy in patients with obstructive/restrictive lung disease with the potential for an early ambulation and great patient satisfaction.

2019 Saudi journal of anaesthesia Controlled trial quality: uncertain

9. Restriction of oral intake of water for aspiration lung disease in children. Full Text available with Trip Pro

Restriction of oral intake of water for aspiration lung disease in children. Primary aspiration of food and fluid is commonly seen in children with feeding and swallowing difficulties associated with a range of diseases and complex medical conditions. Respiratory sequelae and pneumonia are known to be associated with primary aspiration of ingested material, however causality between primary aspiration of specific food and fluid types and pulmonary effects in children is yet to be established (...) in controlled trials. The relative pulmonary morbidity of aspiration of ingested food and fluid materials versus other causes of respiratory disease such as viral and bacterial causes, secondary aspiration of gastrointestinal contents and predisposing lung conditions such as chronic neonatal lung disease in a developing immune system is also unclear. Current management decisions for children who aspirate have to optimise oral nutrition and hydration, while reducing the risk of aspiration to preserve

2012 Cochrane

10. Role of 18F-FDG PET/CT in Restrictive Allograft Syndrome after lung transplantation. (Abstract)

Role of 18F-FDG PET/CT in Restrictive Allograft Syndrome after lung transplantation. Differential diagnosis of phenotypes of chronic lung allograft dysfunction (CLAD) remains troublesome. We hypothesized that F-fluorodeoxyglucose positron emission tomography with computed tomography (F-FDG PET/CT) may help in differential diagnosis of CLAD phenotypes, as it showed promising results regarding diagnosis and prognosis in interstitial lung diseases.A monocentric, retrospective study was performed (...) including all lung transplant recipients suffering from bronchiolitis obliterans syndrome (BOS) or restrictive allograft syndrome (RAS) who underwent F-FDG PET/CT scan, in comparison with stable lung transplant recipients. Maximum standardized uptake value (SUVmax) was associated with pulmonary function and survival. Proof-of-concept microCT and glucose transporter-1 staining served as morphologic validation for regions with different SUVmax.Maximum standardized uptake value was higher in RAS (median

2018 Transplantation

11. Pirfenidone in restrictive allograft syndrome after lung transplantation: A case series. Full Text available with Trip Pro

Pirfenidone in restrictive allograft syndrome after lung transplantation: A case series. Pirfenidone may attenuate the decline of pulmonary function in restrictive allograft syndrome (RAS) after lung transplantation. We retrospectively assessed all lung transplant recipients with RAS who were treated with pirfenidone for at least 3 months (n = 11) in our lung transplant center and report on their long-term outcomes following initiation of pirfenidone. Main outcome parameters included evolution (...) and nausea, necessitating pirfenidone dose de-escalation in 55% of patients, as well as calcineurin dose increase requirements with about 20% are important complications during pirfenidone treatment after lung transplantation. Our findings provide further evidence that pirfenidone appears to be safe and may attenuate the rate of decline in lung function in patients with RAS, but the actual clinical benefit cannot be assessed in the context of this study design and requires further investigation

2018 American Journal of Transplantation

12. Fluid restriction reduces pulmonary edema in a model of acute lung injury in mechanically ventilated rats. Full Text available with Trip Pro

Fluid restriction reduces pulmonary edema in a model of acute lung injury in mechanically ventilated rats. Experimental acute lung injury models are often used to increase our knowledge on the acute respiratory distress syndrome (ARDS), however, existing animal models often do not take into account the impact of specific fluid strategies on the development of lung injury. In contrast, the current literature strongly suggests that fluid management strategies have a significant impact on clinical (...) outcome of patients with ARDS. Thus, it is important to characterize the role of fluid management strategies in experimental models of lung injury. In this study we investigated the effect of two different fluid strategies on commonly used outcome variables in a short-term model of acute lung injury, in relation to age. Infant (2-3 weeks) and adult (3-4 months) Wistar rats received intratracheal instillations of lipopolysaccharide and 24 hours later were mechanically ventilated for 6 hours. During

2019 PLoS ONE

13. Development of a Multivariate Prediction Model for Early-Onset Bronchiolitis Obliterans Syndrome and Restrictive Allograft Syndrome in Lung Transplantation Full Text available with Trip Pro

Development of a Multivariate Prediction Model for Early-Onset Bronchiolitis Obliterans Syndrome and Restrictive Allograft Syndrome in Lung Transplantation Chronic lung allograft dysfunction and its main phenotypes, bronchiolitis obliterans syndrome (BOS) and restrictive allograft syndrome (RAS), are major causes of mortality after lung transplantation (LT). RAS and early-onset BOS, developing within 3 years after LT, are associated with particularly inferior clinical outcomes. Prediction (...) with BOS and RAS, whereas pre-LT diagnoses of interstitial lung disease and chronic obstructive pulmonary disease were associated with RAS.Although these findings need further validation, results indicate that specific baseline and year-1 parameters may serve as predictors of BOS or RAS by 3 years post-LT. Their identification may allow intervention or guide risk stratification, aiming for an individualized patient management approach.

2017 Frontiers in medicine

14. Standard of Care for Fibrotic Interstitial Lung Disease

Standard of Care for Fibrotic Interstitial Lung Disease Full Terms & Conditions of access and use can be found at https://www.tandfonline.com/action/journalInformation?journalCode=ucts20 Canadian Journal of Respiratory, Critical Care, and Sleep Medicine Revue canadienne des soins respiratoires et critiques et de la médecine du sommeil ISSN: 2474-5332 (Print) 2474-5340 (Online) Journal homepage: https://www.tandfonline.com/loi/ucts20 Comprehensive management of fibrotic interstitial lung (...) leading to restriction) may impact suitability for transplantation and can influence long-term outcomes. However, recent observa- tional studies suggest that overall post-transplant outcomes may be similar to that of other lung diseases in appropri- ately selected patients. 61,62 Although there is a theoretical concern that anti-fibrotic medications might increase the risk of peri-operative bleeding, the limited available data do not suggest clinically significant risks associated with these agents

2018 Canadian Thoracic Society

15. Thoracic Spinal Versus Epidural Anesthesia for Nephrectomy in Obstructive/Restrictive Lung Disease Patients

for open nephrectomy in patients with obstructive/restrictive lung disease. Condition or disease Intervention/treatment Phase Nephrectomy Lung Diseases Anesthesia Procedure: Thoracic Spinal Anesthesia Procedure: Thoracic Epidural Anesthesia Drug: Bupivacaine 0.5% (hyperbaric) Drug: Bupivacaine 0.5% (isobaric) Drug: Fentanyl Drug: Dexmedetomidine Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 60 participants (...) Mild to moderate obstructive or restrictive lung disease Open nephrectomy candidate patients Exclusion Criteria: Any condition contra-indicating regional anesthesia Allergic to any of the drugs used during the procedure Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov

2017 Clinical Trials

16. Reply: Decline of Lung Function in Children with Sickle Cell Disease Is Not Associated with Restrictive Defects Full Text available with Trip Pro

Reply: Decline of Lung Function in Children with Sickle Cell Disease Is Not Associated with Restrictive Defects 28248586 2018 11 13 2325-6621 14 3 2017 Mar Annals of the American Thoracic Society Ann Am Thorac Soc Reply: Decline of Lung Function in Children with Sickle Cell Disease Is Not Associated with Restrictive Defects. 478 10.1513/AnnalsATS.201612-1019LE Cohen Robyn T RT http://orcid.org/0000-0002-6902-3118 1 Boston University School of Medicine Boston, Massachusetts. Rodeghier Mark M

2017 Annals of the American Thoracic Society

17. Restrictive Lung Disease in the Cu/Zn Superoxide-Dismutase 1 G93A Amyotrophic Lateral Sclerosis Mouse Model Full Text available with Trip Pro

Restrictive Lung Disease in the Cu/Zn Superoxide-Dismutase 1 G93A Amyotrophic Lateral Sclerosis Mouse Model 28248134 2018 02 21 2018 11 13 1535-4989 56 3 2017 03 American journal of respiratory cell and molecular biology Am. J. Respir. Cell Mol. Biol. Restrictive Lung Disease in the Cu/Zn Superoxide-Dismutase 1 G93A Amyotrophic Lateral Sclerosis Mouse Model. 405-408 10.1165/rcmb.2016-0258LE Stoica Lorelei L 1 University of Massachusetts Medical School Worcester, Massachusetts. Keeler Allison M (...) United States Am J Respir Cell Mol Biol 8917225 1044-1549 EC 1.15.1.1 SOD1 G93A protein EC 1.15.1.1 Superoxide Dismutase IM Amyotrophic Lateral Sclerosis enzymology genetics Animals Humans Lung Diseases enzymology genetics Mice Mice, Mutant Strains Superoxide Dismutase genetics metabolism 2017 3 2 6 0 2017 3 2 6 0 2018 2 22 6 0 ppublish 28248134 10.1165/rcmb.2016-0258LE PMC5359540 J Appl Physiol (1985). 2007 Mar;102(3):926-32 17110520 N Engl J Med. 2001 May 31;344(22):1688-700 11386269 Nature. 1993

2017 American journal of respiratory cell and molecular biology

18. Restrictive lung disease: Low EPAP – Good ventilation. Is it real? Full Text available with Trip Pro

Restrictive lung disease: Low EPAP – Good ventilation. Is it real? 28393535 2017 08 15 2018 12 02 1479-9731 14 3 2017 08 Chronic respiratory disease Chron Respir Dis Restrictive lung disease: Low EPAP - Good ventilation. Is it real? 321-322 10.1177/1479972317702142 Fiorentino Giuseppe G 1 Respiratory Unit, AO Ospedali dei Colli Monaldi Naples, Naples, Italy. Esquinas Antonio M AM 2 Intensive Care Unit, Hospital Morales Meseguer, Murcia, Spain. eng Letter Comment 2017 04 10 England Chron (...) Respir Dis 101197408 1479-9723 IM Chron Respir Dis. 2017 Aug;14 (3):323 28413895 Chron Respir Dis. 2017 May;14 (2):105-109 27923982 Humans Lung Diseases Positive-Pressure Respiration Tidal Volume Ventilation Non-invasive ventilation expiratory positive airway pressure inspiratory positive airway pressure pressure support ventilation tidal volume 2017 4 11 6 0 2017 8 16 6 0 2017 4 11 6 0 ppublish 28393535 10.1177/1479972317702142 PMC5720238 Respiration. 2006;73(4):488-94 16205051 Respiration. 1989;55

2017 Chronic respiratory disease

19. Transplant Size Mismatch in Restrictive Lung Disease Full Text available with Trip Pro

Transplant Size Mismatch in Restrictive Lung Disease To maximize the benefit of lung transplantation, the effect of size mismatch on survival in lung transplant recipients with restrictive lung disease (RLD) was examined. All single and bilateral RLD lung transplants from 1987 to 2011 in the United Network for Organ Sharing (UNOS) Database were identified. Donor predicted total lung capacity (pTLC):Recipient pTLC ratio (pTLCr) quantified mismatch. pTLCr was segregated into five strata. A Cox (...) proportional hazards model evaluated the association of pTLCr with mortality hazard. To identify a critical pTLCr, a Cox model using a restricted cubic spline for pTLCr was used. A total of 6656 transplants for RLD were identified. Median pTLCr for single orthotopic lung transplant (SOLT) and bilateral orthotopic lung transplant (BOLT) was 1.0 (0.69-1.47) and 0.98 (0.66-1.45). Examination of pTLCr as a categorical variable revealed that undersizing (pTLCr <0.8) for SOLT and moderate oversizing (pTLCr = 1.1

2017 Transplant international : official journal of the European Society for Organ Transplantation

20. Response to restrictive lung disease: low EPAP - good ventilation. Is it real? Full Text available with Trip Pro

Response to restrictive lung disease: low EPAP - good ventilation. Is it real? 28413895 2017 08 15 2018 12 02 1479-9731 14 3 2017 08 Chronic respiratory disease Chron Respir Dis Response to restrictive lung disease: low EPAP - good ventilation. Is it real? 323 10.1177/1479972317702143 Kinnear William W Nottingham NHS Treatment Centre - Gateway B, Queens Medical Centre, Nottingham, UK. eng Journal Article Comment 2017 04 17 England Chron Respir Dis 101197408 1479-9723 IM Chron Respir Dis. 2017 (...) Aug;14 (3):321-322 28393535 Humans Lung Diseases Positive-Pressure Respiration Ventilation EPAP IPAP Lung disease non-invasive ventilation ventilation 2017 4 18 6 0 2017 8 16 6 0 2017 4 18 6 0 ppublish 28413895 10.1177/1479972317702143 PMC5720239

2017 Chronic respiratory disease

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