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Restless Legs Syndrome in Children

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1. Restless Legs Syndrome and Poor Sleep Quality in Obese Children and Adolescents (PubMed)

Restless Legs Syndrome and Poor Sleep Quality in Obese Children and Adolescents Adult epidemiological studies suggest that the rate of Restless Legs syndrome (RLS) in the general population may range from 5% to 15%. The aim of this study was to investigate the frequency of RLS in a community sample of obese adolescents aged 10-16 years and to assess the association with sleep quality and health-related glucose metabolism markers.The study group comprised 144 obese and overweight children aged (...) 10-16 yearsand the control group consisted of 66 age-matched healthy children. The RLS Questionnaire devised by the International RLS Study and the Pittsburgh Sleep Quality Index (PSQI), where a score >5 indicates poor sleep quality, was used to assess sleep quality.Mean body mass index (BMI) of the overweight/obese and control groups were 30.5±0.5 and 18.7±0.2, respectively. The frequency of RLS was higher in the obese group (21.7%) than the overweight (3.4%) and control (1.5%) (p<0.001) groups

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2018 Journal of clinical research in pediatric endocrinology

2. Symptoms of Restless Legs Syndrome in Biological Caregivers of Children with Autism Spectrum Disorders (PubMed)

Symptoms of Restless Legs Syndrome in Biological Caregivers of Children with Autism Spectrum Disorders In this study, we investigated the prevalence of symptoms of restless legs syndrome (RLS) in biological caregivers of children with a diagnosis of autism spectrum disorder (ASD).The relationship of RLS symptoms to caregiver health-related quality of life (HRQoL) was also examined. Finally, we compared the sleep quality and daytime behaviors of children with ASD in caregivers with and without (...) symptoms of RLS.Biological caregivers (n = 50) of children ages 6 to 11 y with a diagnosis of ASD completed a Sleep Habits Questionnaire (SHQ) that included RLS as determined by four questions. HRQoL was assessed using the Medical Outcomes Survey (MOS) 12-Item Short Form (SF-12). Caregivers also completed the Children's Sleep Habits Questionnaire (CSHQ) and Child Behavior Checklist (CBCL6/18).Eleven caregivers (22%) fit the criteria for RLS symptomatology and caregivers with RLS reported poorer mental

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2017 Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

3. Restless Legs Syndrome in Children

Restless Legs Syndrome in Children Restless Legs Syndrome in Children Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Restless Legs (...) Syndrome in Children Restless Legs Syndrome in Children Aka: Restless Legs Syndrome in Children , Pediatric Restless Leg Syndrome From Related Chapters II. Epidemiology : 2% in children III. Risk Factors of first degree relative with IV. Symptoms See Urge to move legs and leg discomfort (may be difficult for a child to express) V. Complications deprivation and secondary negative impact on behavior, mood, attention and cognition VI. Associated Conditions VII. Diagnosis ( ) May be needed in unclear cases

2018 FP Notebook

4. “Emplotted Narratives” and Structured “Behavioral Observations” Supporting the Diagnosis of Willis‐Ekbom Disease/Restless Legs Syndrome in Children with Neurodevelopmental Conditions (PubMed)

“Emplotted Narratives” and Structured “Behavioral Observations” Supporting the Diagnosis of Willis‐Ekbom Disease/Restless Legs Syndrome in Children with Neurodevelopmental Conditions Willis-Ekbom disease/restless legs syndrome (WED/RLS) seems to be a frequent cause of intractable chronic insomnia (ICI) but is under-recognized in children/adolescents with neurodevelopmental conditions (NDCs), as many patients do not have the ability to express the underlying "urge-to-move". In light (...) " support recognition of familial WED/RLS associated movement patterns and provide a useful tool for the diagnosis of WED/RLS in children with NDCs in a clinical office setting.© 2016 The Authors. CNS Neuroscience & Therapeutics Published by John Wiley & Sons Ltd.

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2016 CNS neuroscience & therapeutics

5. PERIODIC LIMB MOVEMENTS AND RESTLESS LEGS SYNDROME IN CHILDREN WITH A HISTORY OF PREMATURITY (PubMed)

PERIODIC LIMB MOVEMENTS AND RESTLESS LEGS SYNDROME IN CHILDREN WITH A HISTORY OF PREMATURITY Little is known about the pediatric population at an increased risk of restless legs syndrome (RLS) and periodic limb movement disorder (PLMD). Polysomnographic data from the Caffeine for Apnea of Prematurity-Sleep (CAPS) study showed a high prevalence of elevated periodic limb movement index (PLMI) in a cohort of ex-preterm children, but the clinical importance of this finding, such as association (...) with RLS, is unknown. We hypothesized that ex-preterm children would have a high prevalence of RLS and PLMD.Ex-preterm children enrolled in CAPS, now aged 5-12 years, completed home polysomnography (PSG) and standardized questionnaires. A diagnosis of RLS or PLMD was established by participants meeting the International Classification of Sleep Disorders, 3rd edition, criteria based on questionnaires and polysomnograms. The clinically available serum ferritin levels were assessed.In total, 167

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2016 Sleep medicine Controlled trial quality: uncertain

6. Treatment for restless legs syndrome

and long-term treatment withdrawals due to adverse effects or lack of efficacy are common. Long-term effectiveness as well as applicability for adults with milder or less frequent RLS symptoms, individuals with secondary RLS, and children is unknown. Final publication URL Additional data URL Indexing Status Subject indexing assigned by CRD MeSH Restless Legs Syndromes Language Published English Country of organisation United States English summary An English language summary is available. Address (...) Treatment for restless legs syndrome Treatment for restless legs syndrome Treatment for restless legs syndrome Wilt TJ, MacDonald R, Ouellette J, Tacklind J, Khawaja I, Rutks I, Butler M, Fink HA Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Wilt TJ, MacDonald R, Ouellette J, Tacklind J, Khawaja I, Rutks I, Butler M, Fink HA. Treatment

2012 Health Technology Assessment (HTA) Database.

7. Somatic and neuropsychiatric comorbidities in pediatric restless legs syndrome: A systematic review of the literature. (PubMed)

Somatic and neuropsychiatric comorbidities in pediatric restless legs syndrome: A systematic review of the literature. Restless legs syndrome (RLS) is a relatively common neurological disorder in childhood, although it is usually overlooked due to the atypical presentation in children and associated comorbid conditions that may affect its clinical presentation. Here, we aimed to perform, for the first time, a systematic review of studies reporting the association between RLS in children (...) disorders, cardiovascular disease, liver and gastrointestinal disorders, and neuropsychiatric disorders (e.g., attention deficit hyperactivity disorder (ADHD), depression, and conduct disorder). Our systematic review provides empirical evidence supporting the notion that RLS in children is comorbid with a number of somatic and neuropsychiatric conditions. We posit that the awareness on comorbid diseases/disorders is pivotal to improve the diagnosis and management of RLS and might suggest fruitful

2016 Sleep medicine reviews

8. Developmental rheumatology in children. Scenario: Bow legs in children

, acute or stress fracture, nerve injury). Structural conditions (for example slipped capital femoral epiphysis, joint hypermobility syndrome, patellofemoral syndrome). Metabolic conditions (for example vitamin D deficiency). Non-inflammatory pain syndromes (for example fibromyalgia and restless leg syndrome). In contrast with these conditions, the physical examination in a child with growing pains is usually normal [ ]. Heel pain Heel pain Heel pain is commonly reported in young children (...) Developmental rheumatology in children. Scenario: Bow legs in children Developmental rheumatology in children - NICE CKS Share Developmental rheumatology in children: Summary Musculoskeletal complaints are a common cause of visits to primary care, but a large proportion of these are for children and adolescents who are entirely healthy or who are developmentally within a normal physiological range. Presentations in children include: Back pain — in school-age children and adolescents, most back

2019 NICE Clinical Knowledge Summaries

9. Which drugs help in restless legs syndrome (RLS)?

, individuals with secondary RLS, and children is unknown.” Further detail on the analysis is in the full- text of the document which is freely available. European guidelines on management of restless legs syndrome were published in 2012 from a joint task force by the European Federation of Neurological Societies, the European Neurological Society and the European Sleep Research Society (2). These are freely available in full from the URL below. The document gives recommendations for a wide variety or drugs (...) Which drugs help in restless legs syndrome (RLS)? Which drugs help in restless legs syndrome (RLS)? - Trip Database or use your Google+ account Liberating the literature ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search

2014 TRIP Answers

10. Study to Investigate Pharmacokinetics (PK) of Pramipexole in Pediatric Patients Who Are Individually Optimized to Stable Pramipexole Doses for the Treatment of Idiopathic Restless Legs Syndrome (RLS)

Study to Investigate Pharmacokinetics (PK) of Pramipexole in Pediatric Patients Who Are Individually Optimized to Stable Pramipexole Doses for the Treatment of Idiopathic Restless Legs Syndrome (RLS) Study to Investigate Pharmacokinetics (PK) of Pramipexole in Pediatric Patients Who Are Individually Optimized to Stable Pramipexole Doses for the Treatment of Idiopathic Restless Legs Syndrome (RLS) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer (...) to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Study to Investigate Pharmacokinetics (PK) of Pramipexole in Pediatric Patients Who Are Individually Optimized to Stable Pramipexole Doses for the Treatment of Idiopathic Restless Legs Syndrome (RLS) The safety and scientific validity of this study

2014 Clinical Trials

11. Restless legs syndrome in children with chronic kidney disease. (PubMed)

Restless legs syndrome in children with chronic kidney disease. Restless legs syndrome (RLS) is considerably more common among adults with chronic kidney disease (CKD) than in the general population and is associated with increased morbidity and mortality. There is limited information on RLS in children with CKD. Failure to account for conditions that might mimic RLS can lead to overdiagnosis of this syndrome.In a prospective, cross-sectional study, RLS prevalence was compared between pediatric (...) CKD patients and healthy children. RLS was assessed via a questionnaire that included exclusion of mimics. Sleep characteristics and health-related quality of life (HRQoL) were also assessed.Restless legs syndrome was more prevalent in CKD patients (n = 124) than in 85 normal children (15.3 vs. 5.9 %; p = 0.04). There was no significant association between RLS and CKD stage, CKD etiology, CKD duration, and dialysis or transplant status. Children with RLS were more likely to rate their sleep

2013 Pediatric Nephrology

12. Restless Legs Syndrome (Diagnosis)

legs syndrome in children. Sleep Med Rev . 2009 Apr. 13(2):149-56. . Kotagal S, Silber MH. Childhood-onset restless legs syndrome. Ann Neurol . 2004 Dec. 56(6):803-7. . Lane RM. SSRI-induced extrapyramidal side-effects and akathisia: implications for treatment. J Psychopharmacol . 1998. 12(2):192-214. . Hattan E, Chalk C, Postuma RB. Is there a higher risk of restless legs syndrome in peripheral neuropathy?. Neurology . 2009 Mar 17. 72(11):955-60. . Jeffrey S. FDA Okays First Device for Restless (...) Restless Legs Syndrome (Diagnosis) Restless Legs Syndrome: Practice Essentials, Background, Pathophysiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE4ODMyNy1vdmVydmlldw== processing > Restless Legs

2014 eMedicine.com

13. Restless Legs Syndrome (Treatment)

. Clin Ther . 2004 Jun. 26(6):925-35. . Ekbom K, Ulfberg J. Restless legs syndrome. J Intern Med . 2009 Nov. 266(5):419-31. . Simakajornboon N, Kheirandish-Gozal L, Gozal D. Diagnosis and management of restless legs syndrome in children. Sleep Med Rev . 2009 Apr. 13(2):149-56. . Kotagal S, Silber MH. Childhood-onset restless legs syndrome. Ann Neurol . 2004 Dec. 56(6):803-7. . Lane RM. SSRI-induced extrapyramidal side-effects and akathisia: implications for treatment. J Psychopharmacol . 1998. 12(2 (...) Restless Legs Syndrome (Treatment) Restless Legs Syndrome Treatment & Management: Approach Considerations, Pharmacologic Therapy, Nonpharmacologic Therapy Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache

2014 eMedicine.com

14. Restless Legs Syndrome (Overview)

legs syndrome in children. Sleep Med Rev . 2009 Apr. 13(2):149-56. . Kotagal S, Silber MH. Childhood-onset restless legs syndrome. Ann Neurol . 2004 Dec. 56(6):803-7. . Lane RM. SSRI-induced extrapyramidal side-effects and akathisia: implications for treatment. J Psychopharmacol . 1998. 12(2):192-214. . Hattan E, Chalk C, Postuma RB. Is there a higher risk of restless legs syndrome in peripheral neuropathy?. Neurology . 2009 Mar 17. 72(11):955-60. . Jeffrey S. FDA Okays First Device for Restless (...) Restless Legs Syndrome (Overview) Restless Legs Syndrome: Practice Essentials, Background, Pathophysiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE4ODMyNy1vdmVydmlldw== processing > Restless Legs

2014 eMedicine.com

15. Restless Legs Syndrome (Follow-up)

. Clin Ther . 2004 Jun. 26(6):925-35. . Ekbom K, Ulfberg J. Restless legs syndrome. J Intern Med . 2009 Nov. 266(5):419-31. . Simakajornboon N, Kheirandish-Gozal L, Gozal D. Diagnosis and management of restless legs syndrome in children. Sleep Med Rev . 2009 Apr. 13(2):149-56. . Kotagal S, Silber MH. Childhood-onset restless legs syndrome. Ann Neurol . 2004 Dec. 56(6):803-7. . Lane RM. SSRI-induced extrapyramidal side-effects and akathisia: implications for treatment. J Psychopharmacol . 1998. 12(2 (...) Restless Legs Syndrome (Follow-up) Restless Legs Syndrome Treatment & Management: Approach Considerations, Pharmacologic Therapy, Nonpharmacologic Therapy Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache

2014 eMedicine.com

16. Probiotics in the Treatment of Iron Deficiency in Children With Restless Leg Syndrome

Probiotics in the Treatment of Iron Deficiency in Children With Restless Leg Syndrome Probiotics in the Treatment of Iron Deficiency in Children With Restless Leg Syndrome - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before (...) adding more. Probiotics in the Treatment of Iron Deficiency in Children With Restless Leg Syndrome The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01617044 Recruitment Status : Completed First Posted : June 12, 2012 Last Update Posted : January 20, 2016 Sponsor: Children's Hospitals and Clinics

2012 Clinical Trials

17. Restless Legs Syndrome in Children

Restless Legs Syndrome in Children Restless Legs Syndrome in Children Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Restless Legs (...) Syndrome in Children Restless Legs Syndrome in Children Aka: Restless Legs Syndrome in Children , Pediatric Restless Leg Syndrome From Related Chapters II. Epidemiology : 2% in children III. Risk Factors of first degree relative with IV. Symptoms See Urge to move legs and leg discomfort (may be difficult for a child to express) V. Complications deprivation and secondary negative impact on behavior, mood, attention and cognition VI. Associated Conditions VII. Diagnosis ( ) May be needed in unclear cases

2015 FP Notebook

18. L-Dopa improves Restless Legs Syndrome and periodic limb movements in sleep but not Attention-Deficit-Hyperactivity Disorder in a double-blind trial in children. (PubMed)

L-Dopa improves Restless Legs Syndrome and periodic limb movements in sleep but not Attention-Deficit-Hyperactivity Disorder in a double-blind trial in children. In a previous open-label study, dopaminergic agents improved Restless Legs Syndrome (RLS) and Periodic Limb Movements in Sleep (PLMS), as well as Attention-Deficit-Hyperactivity Disorder (ADHD) in children with both disorders. We therefore conducted a double-blind placebo-controlled trial of L-DOPA in ADHD children with and without RLS (...) therapy, ADHD was more severe in children without RLS/PLMS than in children with RLS/PLMS (p = 0.006). L-DOPA had no effect on Conners' scales, sleep, or neuropsychometric tests when all patients treated with the drug were compared to those on placebo or when patients with ADHD only were compared to those with ADHD and RLS/PLMS.In this first double-blind study of a dopaminergic therapy in children with RLS/PLMS, L-Dopa significantly improved RLS/PLMS but not ADHD. These results, however, should

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2011 Sleep medicine Controlled trial quality: uncertain

19. Dose Escalating Study of Rotigotine in Pediatric Subjects With Restless Legs Syndrome

information Responsible Party: UCB BIOSCIENCES, Inc. ClinicalTrials.gov Identifier: Other Study ID Numbers: SP1004 2014-004383-37 ( EudraCT Number ) First Posted: December 20, 2011 Results First Posted: July 14, 2015 Last Update Posted: April 4, 2018 Last Verified: March 2018 Keywords provided by UCB Pharma ( UCB BIOSCIENCES, Inc. ): Rotigotine Restless Legs Syndrome RLS Children Adolescents Additional relevant MeSH terms: Layout table for MeSH terms Syndrome Psychomotor Agitation Restless Legs Syndrome (...) Dose Escalating Study of Rotigotine in Pediatric Subjects With Restless Legs Syndrome Dose Escalating Study of Rotigotine in Pediatric Subjects With Restless Legs Syndrome - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before

2011 Clinical Trials

20. Leg Movement Activity During Sleep in Adults With Attention-Deficit/Hyperactivity Disorder (PubMed)

in children and seems to differentiate ADHD from other pathophysiological related conditions like restless legs syndrome (RLS) or periodic limb movement disorder (PLMD). The reduced subjective sleep quality reported by ADHD adults contrasted with the normal objective polysomnographic parameters, which could suggest a sleep-state misperception in these individuals or more subtle sleep abnormalities not picked up by the traditional sleep staging. (...) Leg Movement Activity During Sleep in Adults With Attention-Deficit/Hyperactivity Disorder Objectives: To conduct a first detailed analysis of the pattern of leg movement (LM) activity during sleep in adult subjects with Attention-Deficit/Hyperactivity Disorder (ADHD) compared to healthy controls. Methods: Fifteen ADHD patients and 18 control subjects underwent an in-lab polysomnographic sleep study. The periodic character of LMs was evaluated with established markers of "periodicity," i.e

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2018 Frontiers in Psychiatry

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