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Restless Legs Syndrome in Children

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1. Restless Legs Syndrome and Poor Sleep Quality in Obese Children and Adolescents Full Text available with Trip Pro

Restless Legs Syndrome and Poor Sleep Quality in Obese Children and Adolescents Adult epidemiological studies suggest that the rate of Restless Legs syndrome (RLS) in the general population may range from 5% to 15%. The aim of this study was to investigate the frequency of RLS in a community sample of obese adolescents aged 10-16 years and to assess the association with sleep quality and health-related glucose metabolism markers.The study group comprised 144 obese and overweight children aged (...) 10-16 yearsand the control group consisted of 66 age-matched healthy children. The RLS Questionnaire devised by the International RLS Study and the Pittsburgh Sleep Quality Index (PSQI), where a score >5 indicates poor sleep quality, was used to assess sleep quality.Mean body mass index (BMI) of the overweight/obese and control groups were 30.5±0.5 and 18.7±0.2, respectively. The frequency of RLS was higher in the obese group (21.7%) than the overweight (3.4%) and control (1.5%) (p<0.001) groups

2018 Journal of clinical research in pediatric endocrinology

2. Symptoms of Restless Legs Syndrome in Biological Caregivers of Children with Autism Spectrum Disorders Full Text available with Trip Pro

Symptoms of Restless Legs Syndrome in Biological Caregivers of Children with Autism Spectrum Disorders In this study, we investigated the prevalence of symptoms of restless legs syndrome (RLS) in biological caregivers of children with a diagnosis of autism spectrum disorder (ASD).The relationship of RLS symptoms to caregiver health-related quality of life (HRQoL) was also examined. Finally, we compared the sleep quality and daytime behaviors of children with ASD in caregivers with and without (...) symptoms of RLS.Biological caregivers (n = 50) of children ages 6 to 11 y with a diagnosis of ASD completed a Sleep Habits Questionnaire (SHQ) that included RLS as determined by four questions. HRQoL was assessed using the Medical Outcomes Survey (MOS) 12-Item Short Form (SF-12). Caregivers also completed the Children's Sleep Habits Questionnaire (CSHQ) and Child Behavior Checklist (CBCL6/18).Eleven caregivers (22%) fit the criteria for RLS symptomatology and caregivers with RLS reported poorer mental

2017 Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

3. A Study of Rotigotine Patch in Adolescent Subjects With Restless Legs Syndrome of Unknown Cause

in adolescent subjects with idiopathic RLS. Condition or disease Intervention/treatment Phase Restless Legs Syndrome Drug: Rotigotine 1 milligram/24 hours Drug: Rotigotine 2 milligram/24 hours Drug: Placebo Phase 3 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 138 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor) Primary (...) Agitation Restless Legs Syndrome Disease Pathologic Processes Dyskinesias Neurologic Manifestations Nervous System Diseases Psychomotor Disorders Neurobehavioral Manifestations Signs and Symptoms Sleep Disorders, Intrinsic Dyssomnias Sleep Wake Disorders Parasomnias Mental Disorders Rotigotine Dopamine Agonists Dopamine Agents Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action Physiological Effects of Drugs

2018 Clinical Trials

4. Insomnia and Psychopathological Features Associated With Restless Legs Syndrome in Chinese Adolescents. (Abstract)

Insomnia and Psychopathological Features Associated With Restless Legs Syndrome in Chinese Adolescents. Little is known about psychopathological features associated with restless legs syndrome (RLS) in pediatric populations. This study examined sleep duration, insomnia, and psychopathological profile associated with RLS in a large community sample of adolescents.Participants included 11,831 adolescents from 3 counties of Shandong, China. Mean age of the participants was 15.0 (SD = 1.5) years (...) , and 51% were boys. In November and December 2015, participants completed a structured questionnaire to assess sleep duration, sleep problems, behavioral/emotional problems, and hopelessness. RLS was assessed by the 2003 National Institutes of Health (NIH) Restless Legs Syndrome Diagnosis and Epidemiology Workshop criteria.Of the sample, 9.5% met the 2003 NIH workshop criteria for RLS, and 2.2% had RLS at least 3 times per week. Compared with adolescents without RLS, adolescents with RLS < 3 times per

2018 Journal of Clinical Psychiatry

5. Spinal Cord Stimulation for Restless Legs Syndrome

). The central hypothesis of our study is that physiological changes in lower limb blood flow as a result of thoracolumbar epidural Spinal Cord Stimulation (SCS) lead to the relief of RLS. Condition or disease Intervention/treatment Phase Restless Legs Syndrome Neuropathic Pain Diagnostic Test: Dual-energy X-ray absorptiometry Scan Other: Laboratory Measurements Other: Blood Flow Measurement Other: Continuous Blood Pressure Other: Partial pressure of oxygen Other: Microneurography Other: Anthropometric (...) ): Marshall Holland, University of Iowa Study Details Study Description Go to Brief Summary: The overall goal of this proposed study is to evaluate the underlying mechanisms of neural control of blood flow in the lower extremities in humans with restless leg syndrome (RLS). At least 15% of the general public suffers from RLS and many more may go undiagnosed. This unfortunate disorder leads primarily to a disturbing sensation within the patient's lower extremities that requires movement for relief (1, 2

2018 Clinical Trials

6. Restless Legs Syndrome in Children

Syndrome in Children Restless Legs Syndrome in Children Aka: Restless Legs Syndrome in Children , Pediatric Restless Leg Syndrome From Related Chapters II. Epidemiology : 2% in children III. Risk Factors of first degree relative with IV. Symptoms See Urge to move legs and leg discomfort (may be difficult for a child to express) V. Complications deprivation and secondary negative impact on behavior, mood, attention and cognition VI. Associated Conditions VII. Diagnosis ( ) May be needed in unclear cases (...) Restless Legs Syndrome in Children Restless Legs Syndrome in Children Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Restless Legs

2018 FP Notebook

7. Developmental rheumatology in children. Scenario: Bow legs in children

, acute or stress fracture, nerve injury). Structural conditions (for example slipped capital femoral epiphysis, joint hypermobility syndrome, patellofemoral syndrome). Metabolic conditions (for example vitamin D deficiency). Non-inflammatory pain syndromes (for example fibromyalgia and restless leg syndrome). In contrast with these conditions, the physical examination in a child with growing pains is usually normal [ ]. Heel pain Heel pain Heel pain is commonly reported in young children (...) of the foot relative to the direction in which the child is moving [ ]. It is less common than in-toeing and may be associated with bow legs and flat feet [ ; ; ]. It is normal in early infancy, usually resolving by 18–24 months of age. In older children, it may be caused by external tibial torsion or femoral retroversion [ ; ]. Other conditions that should be considered include Perthes' disease and slipped capital femoral epiphysis, particularly if the child is older, or symptoms are unilateral [ ]. Tip

2019 NICE Clinical Knowledge Summaries

8. Treatment for restless legs syndrome

for restless legs syndrome. Rockville: Agency for Healthcare Research and Quality (AHRQ). Comparative Effectiveness Review No. 86. 2012 Authors' objectives To review the comparative effectiveness, efficacy, and safety of pharmacologic and nonpharmacologic treatments for RLS. Authors' conclusions Compared to placebo, dopamine agonists and alpha-2-delta ligands reduce RLS symptoms and improve patient-reported sleep outcomes and disease-specific quality of life. Adverse effects of pharmacologic therapies (...) and long-term treatment withdrawals due to adverse effects or lack of efficacy are common. Long-term effectiveness as well as applicability for adults with milder or less frequent RLS symptoms, individuals with secondary RLS, and children is unknown. Final publication URL Additional data URL Indexing Status Subject indexing assigned by CRD MeSH Restless Legs Syndromes Language Published English Country of organisation United States English summary An English language summary is available. Address

2012 Health Technology Assessment (HTA) Database.

9. The Treatment of Restless Legs Syndrome and Periodic Limb Movement Disorder in Adults?An Update for 2012: Practice Parameters with an Evidence Based Systematic Review and Meta-Analyses

The Treatment of Restless Legs Syndrome and Periodic Limb Movement Disorder in Adults?An Update for 2012: Practice Parameters with an Evidence Based Systematic Review and Meta-Analyses Guideline Update August 2012 An important update in the recommendation about the use of rotigotine for the treatment of signs and symptoms associated with moderate-to-severe primary restless legs syndrome (RLS) is included in a letter to the editor that was published after the American Academy of Sleep Medicine (...) (AASM) Board of Directors approved the practice parameters. This letter to the editor is an essential supplement to the practice parameters document: Aurora RN; Kristo DA; Bista SR; Rowley JA; Zak RS; Casey KR; Lamm CI; Tracy SL; Rosenberg RS. Update to the AASM clinical practice guideline: “the treatment of restless legs syndrome and periodic limb movement disorder in adults—an update for 2012: practice parameters with an evidence-based systematic review and meta-analyses.” SLEEP 2012;35(8):1037

2012 American Academy of Sleep Medicine

10. Clinical Trial Assessing the Efficacy and Safety of BP1.4979 in Restless Legs Syndrome

terms: Layout table for MeSH terms Syndrome Psychomotor Agitation Restless Legs Syndrome Disease Pathologic Processes Dyskinesias Neurologic Manifestations Nervous System Diseases Psychomotor Disorders Neurobehavioral Manifestations Signs and Symptoms Sleep Disorders, Intrinsic Dyssomnias Sleep Wake Disorders Parasomnias Mental Disorders (...) to Primary Outcome Measures : Periodic Limb Movements per hour of Sleep (PLMS index) [ Time Frame: 2 weeks ] Measure of the difference from baseline (Randomization) to the end of the double blind treatment period in Periodic Limb Movements per hour of Sleep (PLMS index) measured with PolySomnoGraphy (PSG) Secondary Outcome Measures : IRLSRS (International Restless Legs Syndrome Rating Scale) [ Time Frame: 2 weeks ] Difference in IRLSRS score measured at randomization and end double blind study.treatment

2017 Clinical Trials

11. “Emplotted Narratives” and Structured “Behavioral Observations” Supporting the Diagnosis of Willis‐Ekbom Disease/Restless Legs Syndrome in Children with Neurodevelopmental Conditions Full Text available with Trip Pro

“Emplotted Narratives” and Structured “Behavioral Observations” Supporting the Diagnosis of Willis‐Ekbom Disease/Restless Legs Syndrome in Children with Neurodevelopmental Conditions Willis-Ekbom disease/restless legs syndrome (WED/RLS) seems to be a frequent cause of intractable chronic insomnia (ICI) but is under-recognized in children/adolescents with neurodevelopmental conditions (NDCs), as many patients do not have the ability to express the underlying "urge-to-move". In light (...) of this, we aim to develop a protocol for behavioral observations supporting the diagnosis of WED/RLS.We investigated 26 pediatric patients (age 1-16 years, median 8) with NDCs, ICI and evidence of familial WED/RLS employing (1) "emplotted narratives" for description of the various "urge-to-move" presentations and (2) self-description and "behavioral observations" during a "suggested clinical immobilization test" (SCIT).Parental narratives reflected typical WED/RLS-related "urge-to-move" symptoms during

2016 CNS neuroscience & therapeutics

12. Restless Leg Syndrome

Restless Leg Syndrome Restless Leg Syndrome Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Restless Leg Syndrome Restless Leg (...) "Restless Leg Syndrome." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Ontology: Restless Legs Syndrome (C0035258) Definition (MSH) A disorder characterized by aching or burning sensations in the lower and rarely the upper extremities that occur prior to sleep or may awaken the patient from sleep. Definition (MEDLINEPLUS) Restless legs syndrome (RLS) causes a powerful urge to move your legs. Your legs become uncomfortable

2018 FP Notebook

13. Restless legs syndrome

is it? Restless legs syndrome (RLS), also known as Willis-Ekbom disease, is a neurological disorder characterized by an irresistible urge to move the limbs (usually the legs) accompanied by uncomfortable sensations. Symptoms are typically worse in the evenings, and are often associated with sleep disturbance. The underlying pathophysiology of RLS is not fully understood, although it is likely that there is dysfunction of the dopaminergic system within the central nervous system. [ ; ; ] Causes What causes (...) Restless legs syndrome Restless legs syndrome - NICE CKS Share Restless legs syndrome: Summary Restless legs syndrome (RLS) is a neurological disorder characterized by an irresistible urge to move the limbs (usually the legs) accompanied by uncomfortable sensations. Symptoms are typically worse in the evenings, and are often associated with sleep disturbance. The underlying pathophysiology of RLS is not fully understood, although it is likely that there is dysfunction of the dopaminergic system

2016 NICE Clinical Knowledge Summaries

14. Somatic and neuropsychiatric comorbidities in pediatric restless legs syndrome: A systematic review of the literature. (Abstract)

Somatic and neuropsychiatric comorbidities in pediatric restless legs syndrome: A systematic review of the literature. Restless legs syndrome (RLS) is a relatively common neurological disorder in childhood, although it is usually overlooked due to the atypical presentation in children and associated comorbid conditions that may affect its clinical presentation. Here, we aimed to perform, for the first time, a systematic review of studies reporting the association between RLS in children (...) disorders, cardiovascular disease, liver and gastrointestinal disorders, and neuropsychiatric disorders (e.g., attention deficit hyperactivity disorder (ADHD), depression, and conduct disorder). Our systematic review provides empirical evidence supporting the notion that RLS in children is comorbid with a number of somatic and neuropsychiatric conditions. We posit that the awareness on comorbid diseases/disorders is pivotal to improve the diagnosis and management of RLS and might suggest fruitful

2016 Sleep medicine reviews

15. PERIODIC LIMB MOVEMENTS AND RESTLESS LEGS SYNDROME IN CHILDREN WITH A HISTORY OF PREMATURITY Full Text available with Trip Pro

PERIODIC LIMB MOVEMENTS AND RESTLESS LEGS SYNDROME IN CHILDREN WITH A HISTORY OF PREMATURITY Little is known about the pediatric population at an increased risk of restless legs syndrome (RLS) and periodic limb movement disorder (PLMD). Polysomnographic data from the Caffeine for Apnea of Prematurity-Sleep (CAPS) study showed a high prevalence of elevated periodic limb movement index (PLMI) in a cohort of ex-preterm children, but the clinical importance of this finding, such as association (...) with RLS, is unknown. We hypothesized that ex-preterm children would have a high prevalence of RLS and PLMD.Ex-preterm children enrolled in CAPS, now aged 5-12 years, completed home polysomnography (PSG) and standardized questionnaires. A diagnosis of RLS or PLMD was established by participants meeting the International Classification of Sleep Disorders, 3rd edition, criteria based on questionnaires and polysomnograms. The clinically available serum ferritin levels were assessed.In total, 167

2016 Sleep medicine Controlled trial quality: uncertain

16. Leg Movement Activity During Sleep in Adults With Attention-Deficit/Hyperactivity Disorder Full Text available with Trip Pro

in children and seems to differentiate ADHD from other pathophysiological related conditions like restless legs syndrome (RLS) or periodic limb movement disorder (PLMD). The reduced subjective sleep quality reported by ADHD adults contrasted with the normal objective polysomnographic parameters, which could suggest a sleep-state misperception in these individuals or more subtle sleep abnormalities not picked up by the traditional sleep staging. (...) Leg Movement Activity During Sleep in Adults With Attention-Deficit/Hyperactivity Disorder Objectives: To conduct a first detailed analysis of the pattern of leg movement (LM) activity during sleep in adult subjects with Attention-Deficit/Hyperactivity Disorder (ADHD) compared to healthy controls. Methods: Fifteen ADHD patients and 18 control subjects underwent an in-lab polysomnographic sleep study. The periodic character of LMs was evaluated with established markers of "periodicity," i.e

2018 Frontiers in Psychiatry

17. Is Restless Legs Syndrome Involved in Ambulation Related to Sleepwalking? Full Text available with Trip Pro

Is Restless Legs Syndrome Involved in Ambulation Related to Sleepwalking? 26856908 2016 08 17 2018 12 02 1550-9109 39 4 2016 Apr 01 Sleep Sleep Is Restless Legs Syndrome Involved in Ambulation Related to Sleepwalking? 955-6 10.5665/sleep.5662 Lopez Régis R National Reference Centre for Orphan Diseases, Narcolepsy, Idiopathic Hypersomnia and Kleine-Levin Syndrome, Sleep Disorders Center, Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier, France. Inserm, U1061, Montpellier (...) , France. Dauvilliers Yves Y National Reference Centre for Orphan Diseases, Narcolepsy, Idiopathic Hypersomnia and Kleine-Levin Syndrome, Sleep Disorders Center, Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier, France. Inserm, U1061, Montpellier, France. eng Letter Comment 2016 04 01 United States Sleep 7809084 0161-8105 IM Sleep. 2015 Nov;38(11):1667-8 26446122 Sleep. 2016 Jul 01;39(7):1481-2 27253766 Female Humans Male Pain complications diagnosis Somnambulism complications

2016 Sleep

18. Which drugs help in restless legs syndrome (RLS)?

, individuals with secondary RLS, and children is unknown.” Further detail on the analysis is in the full- text of the document which is freely available. European guidelines on management of restless legs syndrome were published in 2012 from a joint task force by the European Federation of Neurological Societies, the European Neurological Society and the European Sleep Research Society (2). These are freely available in full from the URL below. The document gives recommendations for a wide variety or drugs (...) Which drugs help in restless legs syndrome (RLS)? Which drugs help in restless legs syndrome (RLS)? - Trip Database or use your Google+ account Liberating the literature ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search

2014 TRIP Answers

19. Effects of Gabapentin Enacarbil on Arousals, Heart Rate, Blood Pressure and PLMs in Restless Legs Syndrome

for MeSH terms Syndrome Psychomotor Agitation Restless Legs Syndrome Disease Pathologic Processes Dyskinesias Neurologic Manifestations Nervous System Diseases Psychomotor Disorders Neurobehavioral Manifestations Signs and Symptoms Sleep Disorders, Intrinsic Dyssomnias Sleep Wake Disorders Parasomnias Mental Disorders Gabapentin Analgesics Sensory System Agents Peripheral Nervous System Agents Physiological Effects of Drugs Anticonvulsants Anti-Anxiety Agents Tranquilizing Agents Central Nervous System (...) , periodic limb movements per hour (PLMI), and periodic limb movements associated with arousal per hour (PLMAI). The mean change from baseline to week 4 in International Restless Legs Syndrome (IRLS) Rating Scale total score [ Time Frame: 4 weeks ] The mean change from Baseline to week 4 in proportion of responders ("much"/ "very much" improved) on the investigator-rated Clinical Global Impression-Improvement (CGI-I) scale [ Time Frame: 4 weeks ] The mean change from Baseline to week 4 in proportion

2015 Clinical Trials

20. Placebo-Controlled Study to Investigate the Efficacy and Safety of Injectafer in the Treatment of Restless Leg Syndrome (RLS)

in the study will be for approximately 1 year from Day 0. Condition or disease Intervention/treatment Phase Restless Legs Syndrome (RLS) Drug: Injectafer Other: Placebo Phase 3 Detailed Description: This will be a Phase III, double blinded, multi-center, randomized, placebo-controlled study. Eligible subjects will be randomized in a 1:1 ratio to receive Injectafer or Placebo on days 0 and 5. All treated subjects will be followed for efficacy and safety for 12 months. Subjects will visit the clinic on Days (...) Numbers: 1VIT14037 First Posted: March 24, 2015 Last Update Posted: September 28, 2018 Last Verified: September 2018 Additional relevant MeSH terms: Layout table for MeSH terms Syndrome Psychomotor Agitation Restless Legs Syndrome Disease Pathologic Processes Dyskinesias Neurologic Manifestations Nervous System Diseases Psychomotor Disorders Neurobehavioral Manifestations Signs and Symptoms Sleep Disorders, Intrinsic Dyssomnias Sleep Wake Disorders Parasomnias Mental Disorders Ferric Compounds

2015 Clinical Trials

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